KR20020023962A - 인다닐-치환된 벤졸 카본아미드, 이의 제조방법,의약으로서의 이의 용도 및 이를 함유하는 약제 - Google Patents

인다닐-치환된 벤졸 카본아미드, 이의 제조방법,의약으로서의 이의 용도 및 이를 함유하는 약제 Download PDF

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Publication number
KR20020023962A
KR20020023962A KR1020017016458A KR20017016458A KR20020023962A KR 20020023962 A KR20020023962 A KR 20020023962A KR 1020017016458 A KR1020017016458 A KR 1020017016458A KR 20017016458 A KR20017016458 A KR 20017016458A KR 20020023962 A KR20020023962 A KR 20020023962A
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South Korea
Prior art keywords
carbon atoms
hydrogen
alkyl
formula
group
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Ceased
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KR1020017016458A
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English (en)
Korean (ko)
Inventor
브렌델요아힘
게를라히우베
슈틸쯔한스울리히
랑한스요헨
Original Assignee
로버트 흐라이탁, 미쉘 베스트
아벤티스 파마 도이칠란트 게엠베하
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Application filed by 로버트 흐라이탁, 미쉘 베스트, 아벤티스 파마 도이칠란트 게엠베하 filed Critical 로버트 흐라이탁, 미쉘 베스트
Publication of KR20020023962A publication Critical patent/KR20020023962A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/26—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR1020017016458A 1999-06-25 2000-06-10 인다닐-치환된 벤졸 카본아미드, 이의 제조방법,의약으로서의 이의 용도 및 이를 함유하는 약제 Ceased KR20020023962A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19929076A DE19929076A1 (de) 1999-06-25 1999-06-25 Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE19929076.8 1999-06-25
PCT/EP2000/005370 WO2001000573A1 (de) 1999-06-25 2000-06-10 Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (1)

Publication Number Publication Date
KR20020023962A true KR20020023962A (ko) 2002-03-29

Family

ID=7912468

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017016458A Ceased KR20020023962A (ko) 1999-06-25 2000-06-10 인다닐-치환된 벤졸 카본아미드, 이의 제조방법,의약으로서의 이의 용도 및 이를 함유하는 약제

Country Status (31)

Country Link
US (1) US6221866B1 (enExample)
EP (1) EP1194403B1 (enExample)
JP (1) JP4527918B2 (enExample)
KR (1) KR20020023962A (enExample)
CN (1) CN1157372C (enExample)
AR (1) AR024443A1 (enExample)
AT (1) ATE248811T1 (enExample)
AU (1) AU771601B2 (enExample)
BR (1) BR0011938A (enExample)
CA (1) CA2377087A1 (enExample)
CZ (1) CZ20014523A3 (enExample)
DE (2) DE19929076A1 (enExample)
DK (1) DK1194403T3 (enExample)
EE (1) EE04464B1 (enExample)
ES (1) ES2200886T3 (enExample)
HK (1) HK1047575B (enExample)
HU (1) HUP0201711A3 (enExample)
IL (1) IL147220A0 (enExample)
MX (1) MXPA01012281A (enExample)
NO (1) NO20015816D0 (enExample)
NZ (1) NZ516347A (enExample)
PL (1) PL352985A1 (enExample)
PT (1) PT1194403E (enExample)
RU (1) RU2238934C2 (enExample)
SI (1) SI1194403T1 (enExample)
SK (1) SK19092001A3 (enExample)
TR (1) TR200103701T2 (enExample)
TW (1) TWI256950B (enExample)
WO (1) WO2001000573A1 (enExample)
YU (1) YU88801A (enExample)
ZA (1) ZA200109732B (enExample)

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US7119112B2 (en) * 2002-02-28 2006-10-10 Icagen, Inc. Sulfonamides as potassium channel blockers
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GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
US7368582B2 (en) 2003-10-17 2008-05-06 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
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US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
DE102005028845A1 (de) * 2005-06-22 2006-12-28 Sanofi-Aventis Deutschland Gmbh Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
CA2617519A1 (en) * 2005-08-23 2007-03-01 Astellas Pharma Inc. Agent for treating atrial fibrillation
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NZ572231A (en) * 2006-04-27 2010-12-24 Sanofi Aventis Deutschland Inhibitors of the task-1 and task-3 ion channel
JP5448164B2 (ja) 2006-07-28 2014-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を変調する化合物
US7928123B2 (en) 2006-09-25 2011-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
WO2008098025A1 (en) * 2007-02-08 2008-08-14 Boehringer Ingelheim International Gmbh Arylsulfonamide compounds which modulate the cb2 receptor
JP4891111B2 (ja) * 2007-02-16 2012-03-07 富士フイルム株式会社 ズームレンズ
ES2340640T3 (es) 2007-03-23 2010-06-07 Icagen, Inc. Inhibidores de canales de iones.
WO2009061652A1 (en) * 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2010005782A1 (en) * 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
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GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
AP2011005674A0 (en) * 2008-09-25 2011-04-30 Boehringer Ingelheim Int Sulfonyl compounds which selectively modulate the CB2 receptor.
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
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US8329735B2 (en) 2010-03-05 2012-12-11 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the CB2 receptor
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Also Published As

Publication number Publication date
PL352985A1 (en) 2003-09-22
PT1194403E (pt) 2004-01-30
US6221866B1 (en) 2001-04-24
NO20015816L (no) 2001-11-29
EP1194403A1 (de) 2002-04-10
YU88801A (sh) 2004-09-03
AU771601B2 (en) 2004-03-25
ATE248811T1 (de) 2003-09-15
EE04464B1 (et) 2005-04-15
HUP0201711A2 (en) 2002-09-28
BR0011938A (pt) 2002-03-19
TWI256950B (en) 2006-06-21
AR024443A1 (es) 2002-10-02
JP2003503385A (ja) 2003-01-28
HK1047575A1 (en) 2003-02-28
ES2200886T3 (es) 2004-03-16
DE50003555D1 (de) 2003-10-09
DK1194403T3 (da) 2003-12-08
TR200103701T2 (tr) 2002-05-21
MXPA01012281A (es) 2002-07-30
DE19929076A1 (de) 2000-12-28
HUP0201711A3 (en) 2005-05-30
NZ516347A (en) 2004-01-30
SI1194403T1 (en) 2003-12-31
CA2377087A1 (en) 2001-01-04
AU5531800A (en) 2001-01-31
ZA200109732B (en) 2002-08-30
EE200100684A (et) 2003-04-15
SK19092001A3 (sk) 2002-06-04
CN1358172A (zh) 2002-07-10
CZ20014523A3 (cs) 2002-04-17
HK1047575B (zh) 2004-12-31
RU2238934C2 (ru) 2004-10-27
WO2001000573A1 (de) 2001-01-04
EP1194403B1 (de) 2003-09-03
JP4527918B2 (ja) 2010-08-18
IL147220A0 (en) 2002-08-14
CN1157372C (zh) 2004-07-14
NO20015816D0 (no) 2001-11-29

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