TR200103701T2 - İndanil ikameli benzolkarbonamidleri, imalat yöntemleri, ilaç olarak kullanımları - Google Patents

İndanil ikameli benzolkarbonamidleri, imalat yöntemleri, ilaç olarak kullanımları

Info

Publication number
TR200103701T2
TR200103701T2 TR2001/03701T TR200103701T TR200103701T2 TR 200103701 T2 TR200103701 T2 TR 200103701T2 TR 2001/03701 T TR2001/03701 T TR 2001/03701T TR 200103701 T TR200103701 T TR 200103701T TR 200103701 T2 TR200103701 T2 TR 200103701T2
Authority
TR
Turkey
Prior art keywords
benzolcarbonamides
atrial
drugs
manufacturing methods
indanyl substituted
Prior art date
Application number
TR2001/03701T
Other languages
English (en)
Inventor
Brendel Joachim
Gerlach Uwe
Ulrich Stilz Hans
Jochen Lang Hans
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200103701T2 publication Critical patent/TR200103701T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/26—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Indanil ikameli benzolkarbonamid'leri, imalatlarina yönelik yöntem, ilaç olarak kullanilmalari ve içerildikleri farmasötik preparatlar. Formül I'in içlerinde R(1) ila R(8)'in istemlerde belirtilmis olan anlamlara sahip oldugu bilesiler Kv 1.5 potasyum kanalina etki etmektedirler ve insan kalp kulakçiginda ''ultra-rapidly activating delayed rectifier'' olarak tanimlanan bir potasyum akimini önlerler. Bu nedenle yeni türde antiaritmik etkin maddeler olarak, özellikle de kulakçik aritmilerinin, örnegin kulakçik titresimlerinin (atriyal fibrilasyon, AF) yada kulakçik çarpintilarinin (atriyal çarpinti) tedavisine ve profilaksisine çok uygundurlar.
TR2001/03701T 1999-06-25 2000-06-10 İndanil ikameli benzolkarbonamidleri, imalat yöntemleri, ilaç olarak kullanımları TR200103701T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19929076A DE19929076A1 (de) 1999-06-25 1999-06-25 Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number Publication Date
TR200103701T2 true TR200103701T2 (tr) 2002-05-21

Family

ID=7912468

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03701T TR200103701T2 (tr) 1999-06-25 2000-06-10 İndanil ikameli benzolkarbonamidleri, imalat yöntemleri, ilaç olarak kullanımları

Country Status (31)

Country Link
US (1) US6221866B1 (tr)
EP (1) EP1194403B1 (tr)
JP (1) JP4527918B2 (tr)
KR (1) KR20020023962A (tr)
CN (1) CN1157372C (tr)
AR (1) AR024443A1 (tr)
AT (1) ATE248811T1 (tr)
AU (1) AU771601B2 (tr)
BR (1) BR0011938A (tr)
CA (1) CA2377087A1 (tr)
CZ (1) CZ20014523A3 (tr)
DE (2) DE19929076A1 (tr)
DK (1) DK1194403T3 (tr)
EE (1) EE04464B1 (tr)
ES (1) ES2200886T3 (tr)
HK (1) HK1047575B (tr)
HU (1) HUP0201711A3 (tr)
IL (1) IL147220A0 (tr)
MX (1) MXPA01012281A (tr)
NO (1) NO20015816L (tr)
NZ (1) NZ516347A (tr)
PL (1) PL352985A1 (tr)
PT (1) PT1194403E (tr)
RU (1) RU2238934C2 (tr)
SI (1) SI1194403T1 (tr)
SK (1) SK19092001A3 (tr)
TR (1) TR200103701T2 (tr)
TW (1) TWI256950B (tr)
WO (1) WO2001000573A1 (tr)
YU (1) YU88801A (tr)
ZA (1) ZA200109732B (tr)

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Also Published As

Publication number Publication date
EE200100684A (et) 2003-04-15
CZ20014523A3 (cs) 2002-04-17
NO20015816D0 (no) 2001-11-29
CA2377087A1 (en) 2001-01-04
IL147220A0 (en) 2002-08-14
HK1047575B (zh) 2004-12-31
DE50003555D1 (de) 2003-10-09
WO2001000573A1 (de) 2001-01-04
ATE248811T1 (de) 2003-09-15
AR024443A1 (es) 2002-10-02
SK19092001A3 (sk) 2002-06-04
MXPA01012281A (es) 2002-07-30
PL352985A1 (en) 2003-09-22
NO20015816L (no) 2001-11-29
DK1194403T3 (da) 2003-12-08
CN1157372C (zh) 2004-07-14
EP1194403A1 (de) 2002-04-10
JP2003503385A (ja) 2003-01-28
EP1194403B1 (de) 2003-09-03
KR20020023962A (ko) 2002-03-29
PT1194403E (pt) 2004-01-30
SI1194403T1 (en) 2003-12-31
JP4527918B2 (ja) 2010-08-18
AU5531800A (en) 2001-01-31
YU88801A (sh) 2004-09-03
NZ516347A (en) 2004-01-30
HUP0201711A3 (en) 2005-05-30
ES2200886T3 (es) 2004-03-16
HK1047575A1 (en) 2003-02-28
ZA200109732B (en) 2002-08-30
AU771601B2 (en) 2004-03-25
BR0011938A (pt) 2002-03-19
TWI256950B (en) 2006-06-21
RU2238934C2 (ru) 2004-10-27
EE04464B1 (et) 2005-04-15
HUP0201711A2 (en) 2002-09-28
US6221866B1 (en) 2001-04-24
CN1358172A (zh) 2002-07-10
DE19929076A1 (de) 2000-12-28

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