BR0011938A - Benzenocarbonamidas substituìdas por indanila, processos para a sua preparação, seu emprego como medicamento bem como preparados farmacêuticos contendo as mesmas - Google Patents

Benzenocarbonamidas substituìdas por indanila, processos para a sua preparação, seu emprego como medicamento bem como preparados farmacêuticos contendo as mesmas

Info

Publication number
BR0011938A
BR0011938A BR0011938-5A BR0011938A BR0011938A BR 0011938 A BR0011938 A BR 0011938A BR 0011938 A BR0011938 A BR 0011938A BR 0011938 A BR0011938 A BR 0011938A
Authority
BR
Brazil
Prior art keywords
atrial
indanila
benzenocarbonamides
medicine
processes
Prior art date
Application number
BR0011938-5A
Other languages
English (en)
Inventor
Joachim Brendel
Uwe Gerlach
Hans Ulrich Stilz
Hans-Jochen Lang
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0011938A publication Critical patent/BR0011938A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/26—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: "BENZENOCARBONAMIDAS SUBSTITUìDAS POR INDANILA, PROCESSOS PARA A SUA PREPARAçãO, SEU EMPREGO COMO MEDICAMENTO BEM COMO PREPARADOS FARMACêUTICOS CONTENDO AS MESMAS". Compostos da fórmula I na qual R(1) até R(8) têm os significados indicados na reivindicações, atuam sobre o canal de potássio Kv1.5 e inibem uma corrente de potássio denominada como "ultra-rapidly activating delayed rectifier" na aurícula do coração humano. Por isso, eles são muito particularmente bem adequados como modernas substâncias ativas antiarrítmicas, especialmente para o tratamento e profilaxia de arritmias auriculares, por exemplo, fibrilação auricular (fibrilação atrial, AF) ou oscilação auricular (oscilação atrial).
BR0011938-5A 1999-06-25 2000-06-10 Benzenocarbonamidas substituìdas por indanila, processos para a sua preparação, seu emprego como medicamento bem como preparados farmacêuticos contendo as mesmas BR0011938A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19929076A DE19929076A1 (de) 1999-06-25 1999-06-25 Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2000/005370 WO2001000573A1 (de) 1999-06-25 2000-06-10 Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (1)

Publication Number Publication Date
BR0011938A true BR0011938A (pt) 2002-03-19

Family

ID=7912468

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011938-5A BR0011938A (pt) 1999-06-25 2000-06-10 Benzenocarbonamidas substituìdas por indanila, processos para a sua preparação, seu emprego como medicamento bem como preparados farmacêuticos contendo as mesmas

Country Status (31)

Country Link
US (1) US6221866B1 (pt)
EP (1) EP1194403B1 (pt)
JP (1) JP4527918B2 (pt)
KR (1) KR20020023962A (pt)
CN (1) CN1157372C (pt)
AR (1) AR024443A1 (pt)
AT (1) ATE248811T1 (pt)
AU (1) AU771601B2 (pt)
BR (1) BR0011938A (pt)
CA (1) CA2377087A1 (pt)
CZ (1) CZ20014523A3 (pt)
DE (2) DE19929076A1 (pt)
DK (1) DK1194403T3 (pt)
EE (1) EE04464B1 (pt)
ES (1) ES2200886T3 (pt)
HK (1) HK1047575B (pt)
HU (1) HUP0201711A3 (pt)
IL (1) IL147220A0 (pt)
MX (1) MXPA01012281A (pt)
NO (1) NO20015816L (pt)
NZ (1) NZ516347A (pt)
PL (1) PL352985A1 (pt)
PT (1) PT1194403E (pt)
RU (1) RU2238934C2 (pt)
SI (1) SI1194403T1 (pt)
SK (1) SK19092001A3 (pt)
TR (1) TR200103701T2 (pt)
TW (1) TWI256950B (pt)
WO (1) WO2001000573A1 (pt)
YU (1) YU88801A (pt)
ZA (1) ZA200109732B (pt)

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US6775150B1 (en) 2000-08-30 2004-08-10 Intel Corporation Electronic assembly comprising ceramic/organic hybrid substrate with embedded capacitors and methods of manufacture
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DE10121002A1 (de) * 2001-04-28 2002-11-14 Aventis Pharma Gmbh Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen
US7119112B2 (en) * 2002-02-28 2006-10-10 Icagen, Inc. Sulfonamides as potassium channel blockers
ATE524452T1 (de) 2003-03-27 2011-09-15 Cytokinetics Inc Sulfonamide zur behandlung von kongestivem herzversagen, deren zusammensetzungen und verwendungen.
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US7368582B2 (en) 2003-10-17 2008-05-06 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
DE102005028845A1 (de) * 2005-06-22 2006-12-28 Sanofi-Aventis Deutschland Gmbh Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
WO2007023775A1 (ja) * 2005-08-23 2007-03-01 Astellas Pharma Inc. 心房細動治療剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
JP5161871B2 (ja) * 2006-04-27 2013-03-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｔａｓｋ−１およびｔａｓｋ−３イオンチャンネルの阻害剤
EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
JP5030114B2 (ja) 2006-09-25 2012-09-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体をモジュレートする化合物
WO2008098025A1 (en) * 2007-02-08 2008-08-14 Boehringer Ingelheim International Gmbh Arylsulfonamide compounds which modulate the cb2 receptor
JP4891111B2 (ja) * 2007-02-16 2012-03-07 富士フイルム株式会社 ズームレンズ
US8357711B2 (en) 2007-03-23 2013-01-22 Pfizer Limited Heterocyclic sulfonamides as inhibitors of ion channels
JP5492092B2 (ja) * 2007-11-07 2014-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
CA2730037A1 (en) * 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
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CA2737639A1 (en) 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
US8383651B2 (en) * 2009-09-22 2013-02-26 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
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Also Published As

Publication number Publication date
EE200100684A (et) 2003-04-15
CZ20014523A3 (cs) 2002-04-17
NO20015816D0 (no) 2001-11-29
CA2377087A1 (en) 2001-01-04
IL147220A0 (en) 2002-08-14
HK1047575B (zh) 2004-12-31
DE50003555D1 (de) 2003-10-09
WO2001000573A1 (de) 2001-01-04
ATE248811T1 (de) 2003-09-15
AR024443A1 (es) 2002-10-02
SK19092001A3 (sk) 2002-06-04
MXPA01012281A (es) 2002-07-30
PL352985A1 (en) 2003-09-22
NO20015816L (no) 2001-11-29
DK1194403T3 (da) 2003-12-08
CN1157372C (zh) 2004-07-14
EP1194403A1 (de) 2002-04-10
JP2003503385A (ja) 2003-01-28
EP1194403B1 (de) 2003-09-03
KR20020023962A (ko) 2002-03-29
PT1194403E (pt) 2004-01-30
TR200103701T2 (tr) 2002-05-21
SI1194403T1 (en) 2003-12-31
JP4527918B2 (ja) 2010-08-18
AU5531800A (en) 2001-01-31
YU88801A (sh) 2004-09-03
NZ516347A (en) 2004-01-30
HUP0201711A3 (en) 2005-05-30
ES2200886T3 (es) 2004-03-16
HK1047575A1 (en) 2003-02-28
ZA200109732B (en) 2002-08-30
AU771601B2 (en) 2004-03-25
TWI256950B (en) 2006-06-21
RU2238934C2 (ru) 2004-10-27
EE04464B1 (et) 2005-04-15
HUP0201711A2 (en) 2002-09-28
US6221866B1 (en) 2001-04-24
CN1358172A (zh) 2002-07-10
DE19929076A1 (de) 2000-12-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.