DE19929076A1 - Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen - Google Patents
Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische ZubereitungenInfo
- Publication number
- DE19929076A1 DE19929076A1 DE19929076A DE19929076A DE19929076A1 DE 19929076 A1 DE19929076 A1 DE 19929076A1 DE 19929076 A DE19929076 A DE 19929076A DE 19929076 A DE19929076 A DE 19929076A DE 19929076 A1 DE19929076 A1 DE 19929076A1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 206010003662 Atrial flutter Diseases 0.000 title claims description 6
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 40
- 150000003839 salts Chemical class 0.000 claims abstract description 35
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- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims abstract description 30
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- 238000002360 preparation method Methods 0.000 claims abstract description 5
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- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/26—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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Priority Applications (32)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19929076A DE19929076A1 (de) | 1999-06-25 | 1999-06-25 | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| HK02108652.0A HK1047575B (zh) | 1999-06-25 | 2000-06-10 | 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 |
| DK00940359T DK1194403T3 (da) | 1999-06-25 | 2000-06-10 | Indanylsubstituerede benzencarboxamider, fremgangsmåde til deres fremstilling, deres anvendelse som lægemiddel samt farmaceutiske tilberedninger med indhold deraf |
| HU0201711A HUP0201711A3 (en) | 1999-06-25 | 2000-06-10 | N-indanyl-benzamide derivatives, method for their production, their use and pharmaceutical preparations containing them |
| SI200030224T SI1194403T1 (en) | 1999-06-25 | 2000-06-10 | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same |
| CNB008094500A CN1157372C (zh) | 1999-06-25 | 2000-06-10 | 二氢茚基取代的苯甲酰胺、其制备方法、其作为药物的应用、和含有它们的药物制剂 |
| KR1020017016458A KR20020023962A (ko) | 1999-06-25 | 2000-06-10 | 인다닐-치환된 벤졸 카본아미드, 이의 제조방법,의약으로서의 이의 용도 및 이를 함유하는 약제 |
| JP2001506984A JP4527918B2 (ja) | 1999-06-25 | 2000-06-10 | インダニル置換ベンゼンカルボキサミド、その製造方法、薬剤としてのその使用およびそれを含有する医薬処方物 |
| DE50003555T DE50003555D1 (de) | 1999-06-25 | 2000-06-10 | Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
| YU88801A YU88801A (sh) | 1999-06-25 | 2000-06-10 | Indalinom supstituisan benzolkarbonamid, postupak za njegovu proizvodnju, njegova prrimena kao medikamenata kao i farmaceutski preparati koji ga sadrže |
| NZ516347A NZ516347A (en) | 1999-06-25 | 2000-06-10 | Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them |
| AU55318/00A AU771601B2 (en) | 1999-06-25 | 2000-06-10 | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same |
| SK1909-2001A SK19092001A3 (sk) | 1999-06-25 | 2000-06-10 | Indanylsubstituované benzénkarboxamidy, spôsob ich prípravy, ich použitie ako liečiva, a farmaceutické prostriedky, ktoré ich obsahujú |
| CZ20014523A CZ20014523A3 (cs) | 1999-06-25 | 2000-06-10 | Indanylsubstituované benzenkarbonamidy, způsob jejich přípravy, jejich pouľití jako léčiva, a farmaceutické prostředky, které je obsahují |
| IL14722000A IL147220A0 (en) | 1999-06-25 | 2000-06-10 | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same |
| EEP200100684A EE04464B1 (et) | 1999-06-25 | 2000-06-10 | Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid |
| PT00940359T PT1194403E (pt) | 1999-06-25 | 2000-06-10 | Benzenocarbonamidas substituidas com indanilo, processo para a sua preparacao, sua utilizacao como medicamento bem como preparacoes farmaceuticas que as contem |
| TR2001/03701T TR200103701T2 (tr) | 1999-06-25 | 2000-06-10 | İndanil ikameli benzolkarbonamidleri, imalat yöntemleri, ilaç olarak kullanımları |
| PL00352985A PL352985A1 (en) | 1999-06-25 | 2000-06-10 | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same |
| EP00940359A EP1194403B1 (de) | 1999-06-25 | 2000-06-10 | Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
| AT00940359T ATE248811T1 (de) | 1999-06-25 | 2000-06-10 | Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
| ES00940359T ES2200886T3 (es) | 1999-06-25 | 2000-06-10 | Bencenocarbonamidas sustituidas con indamilo, procedimiento para su preparacion, su uso como medicamento, asi como preparados farmaceuticos que las contienen. |
| CA002377087A CA2377087A1 (en) | 1999-06-25 | 2000-06-10 | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same |
| BR0011938-5A BR0011938A (pt) | 1999-06-25 | 2000-06-10 | Benzenocarbonamidas substituìdas por indanila, processos para a sua preparação, seu emprego como medicamento bem como preparados farmacêuticos contendo as mesmas |
| MXPA01012281A MXPA01012281A (es) | 1999-06-25 | 2000-06-10 | Benzol carbonamidas sustituidas con indanilo, metodo para su preparacion, su uso como medicamento y preparaciones farmaceuticas que la contienen. |
| RU2002101723/04A RU2238934C2 (ru) | 1999-06-25 | 2000-06-10 | Инданилзамещенные бензолкарбонамиды, способ их получения, а также содержащие их фармацевтические композиции |
| PCT/EP2000/005370 WO2001000573A1 (de) | 1999-06-25 | 2000-06-10 | Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
| ARP000103128A AR024443A1 (es) | 1999-06-25 | 2000-06-22 | Benzolcarbonamidas indanil-sustituidas, procedimientos para su preparacion, su utilizacion como medicamento como tambien los preparados farmaceuticos quelas contienen |
| TW089112238A TWI256950B (en) | 1999-06-25 | 2000-06-22 | Indanyl-substituted benzenecarboxamides, processes for their preparation, their use as a medicament and pharmaceutical formulations containing them |
| US09/603,436 US6221866B1 (en) | 1999-06-25 | 2000-06-23 | Indanyl-substituted benzenecarboxamides, processes for their preparation, their use as a medicament, and pharmaceutical formulations containing them |
| ZA200109732A ZA200109732B (en) | 1999-06-25 | 2001-11-27 | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same. |
| NO20015816A NO20015816D0 (no) | 1999-06-25 | 2001-11-29 | Indanylsubstituerte benzenkarbonamider, fremgangsmåter for fremstilling derav, anvendelse derav som medikament ogfarmasöytiske preparater inneholdende disse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19929076A DE19929076A1 (de) | 1999-06-25 | 1999-06-25 | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19929076A1 true DE19929076A1 (de) | 2000-12-28 |
Family
ID=7912468
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19929076A Withdrawn DE19929076A1 (de) | 1999-06-25 | 1999-06-25 | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE50003555T Expired - Lifetime DE50003555D1 (de) | 1999-06-25 | 2000-06-10 | Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50003555T Expired - Lifetime DE50003555D1 (de) | 1999-06-25 | 2000-06-10 | Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6221866B1 (enExample) |
| EP (1) | EP1194403B1 (enExample) |
| JP (1) | JP4527918B2 (enExample) |
| KR (1) | KR20020023962A (enExample) |
| CN (1) | CN1157372C (enExample) |
| AR (1) | AR024443A1 (enExample) |
| AT (1) | ATE248811T1 (enExample) |
| AU (1) | AU771601B2 (enExample) |
| BR (1) | BR0011938A (enExample) |
| CA (1) | CA2377087A1 (enExample) |
| CZ (1) | CZ20014523A3 (enExample) |
| DE (2) | DE19929076A1 (enExample) |
| DK (1) | DK1194403T3 (enExample) |
| EE (1) | EE04464B1 (enExample) |
| ES (1) | ES2200886T3 (enExample) |
| HK (1) | HK1047575B (enExample) |
| HU (1) | HUP0201711A3 (enExample) |
| IL (1) | IL147220A0 (enExample) |
| MX (1) | MXPA01012281A (enExample) |
| NO (1) | NO20015816D0 (enExample) |
| NZ (1) | NZ516347A (enExample) |
| PL (1) | PL352985A1 (enExample) |
| PT (1) | PT1194403E (enExample) |
| RU (1) | RU2238934C2 (enExample) |
| SI (1) | SI1194403T1 (enExample) |
| SK (1) | SK19092001A3 (enExample) |
| TR (1) | TR200103701T2 (enExample) |
| TW (1) | TWI256950B (enExample) |
| WO (1) | WO2001000573A1 (enExample) |
| YU (1) | YU88801A (enExample) |
| ZA (1) | ZA200109732B (enExample) |
Cited By (2)
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| DE102005028845A1 (de) * | 2005-06-22 | 2006-12-28 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| EP1605752A4 (en) * | 2003-03-27 | 2008-05-07 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
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| US6970362B1 (en) | 2000-07-31 | 2005-11-29 | Intel Corporation | Electronic assemblies and systems comprising interposer with embedded capacitors |
| US6775150B1 (en) | 2000-08-30 | 2004-08-10 | Intel Corporation | Electronic assembly comprising ceramic/organic hybrid substrate with embedded capacitors and methods of manufacture |
| JP2004509894A (ja) | 2000-09-20 | 2004-04-02 | ファルマシア・アンド・アップジョン・カンパニー | 置換アゼピノ［４，５−ｂ］インドリン誘導体 |
| DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10121002A1 (de) * | 2001-04-28 | 2002-11-14 | Aventis Pharma Gmbh | Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| US7368582B2 (en) | 2003-10-17 | 2008-05-06 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| JPWO2007023775A1 (ja) * | 2005-08-23 | 2009-02-26 | アステラス製薬株式会社 | 心房細動治療剤 |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| CN101636154B (zh) * | 2006-04-27 | 2011-12-14 | 塞诺菲-安万特德国有限公司 | Task-1和task-3离子通道抑制剂 |
| WO2008014199A2 (en) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 receptor |
| KR20090069318A (ko) | 2006-09-25 | 2009-06-30 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃｂ2 수용체를 조절하는 화합물 |
| WO2008098025A1 (en) * | 2007-02-08 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Arylsulfonamide compounds which modulate the cb2 receptor |
| JP4891111B2 (ja) * | 2007-02-16 | 2012-03-07 | 富士フイルム株式会社 | ズームレンズ |
| CL2008000835A1 (es) | 2007-03-23 | 2008-10-03 | Icagen Inc Pfizer Ltd | Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm |
| EP2217565B1 (en) * | 2007-11-07 | 2013-05-22 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| EP2326629B1 (en) * | 2008-07-10 | 2013-10-02 | Boehringer Ingelheim International GmbH | Sulfone compounds which modulate the cb2 receptor |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| CA2737645A1 (en) * | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| WO2010147791A1 (en) | 2009-06-16 | 2010-12-23 | Boehringer Ingelheim International Gmbh | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
| EP2480544A1 (en) * | 2009-09-22 | 2012-08-01 | Boehringer Ingelheim International GmbH | Compounds which selectively modulate the cb2 receptor |
| EP2523936A1 (en) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (enExample) | 2011-07-01 | 2018-04-28 | ||
| JP2015504923A (ja) | 2012-01-27 | 2015-02-16 | ギリアード サイエンシーズ， インコーポレイテッド | 後期ナトリウムイオンチャネル遮断剤およびカリウムイオンチャネル遮断剤を使用する併用療法 |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| EP4446314A3 (en) * | 2019-05-03 | 2025-03-12 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| EP4110317B1 (en) | 2020-02-28 | 2025-11-19 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| WO2023211855A1 (en) * | 2022-04-25 | 2023-11-02 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors comprising a thiophene core and methods of use |
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| US5234944A (en) | 1986-08-21 | 1993-08-10 | Roussel Uclaf | Novel indanes |
| ES2052593T3 (es) | 1986-08-21 | 1994-07-16 | Roussel Uclaf | Procedimiento para preparar derivados del indano. |
| DK626889A (da) | 1988-12-16 | 1990-06-17 | Roussel Uclaf | Indanderivater, deres fremstilling samt laegemidler med indhold deraf |
| US5348971A (en) | 1988-12-16 | 1994-09-20 | Roussel Uclaf | Indanes useful as analgesics |
| RU2043337C1 (ru) * | 1990-07-20 | 1995-09-10 | Институт биохимии Литовской АН | Способ получения 5-аргиниламинонафталин-1-сульфамидов |
| FR2708608B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant. |
| US5914349A (en) | 1994-01-10 | 1999-06-22 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| EP0738149B1 (en) * | 1994-01-10 | 2006-11-29 | Teva Pharmaceutical Industries, Ltd. | 1-aminoindan derivatives and compositions thereof |
| US6083986A (en) * | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| DE19707656A1 (de) * | 1997-02-26 | 1998-08-27 | Hoechst Ag | Sulfonamid-substituierte anellierte 7-Ring-Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| AU8684598A (en) * | 1997-08-05 | 1999-03-01 | American Home Products Corporation | Anthranilic acid analogs |
| DE19749453A1 (de) * | 1997-11-10 | 1999-05-12 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte anellierte 5-Ring-Verbindungen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
-
1999
- 1999-06-25 DE DE19929076A patent/DE19929076A1/de not_active Withdrawn
-
2000
- 2000-06-10 PL PL00352985A patent/PL352985A1/xx not_active Application Discontinuation
- 2000-06-10 CZ CZ20014523A patent/CZ20014523A3/cs unknown
- 2000-06-10 EP EP00940359A patent/EP1194403B1/de not_active Expired - Lifetime
- 2000-06-10 WO PCT/EP2000/005370 patent/WO2001000573A1/de not_active Ceased
- 2000-06-10 CN CNB008094500A patent/CN1157372C/zh not_active Expired - Fee Related
- 2000-06-10 DK DK00940359T patent/DK1194403T3/da active
- 2000-06-10 KR KR1020017016458A patent/KR20020023962A/ko not_active Ceased
- 2000-06-10 JP JP2001506984A patent/JP4527918B2/ja not_active Expired - Fee Related
- 2000-06-10 DE DE50003555T patent/DE50003555D1/de not_active Expired - Lifetime
- 2000-06-10 AT AT00940359T patent/ATE248811T1/de not_active IP Right Cessation
- 2000-06-10 MX MXPA01012281A patent/MXPA01012281A/es unknown
- 2000-06-10 CA CA002377087A patent/CA2377087A1/en not_active Abandoned
- 2000-06-10 TR TR2001/03701T patent/TR200103701T2/xx unknown
- 2000-06-10 SI SI200030224T patent/SI1194403T1/xx unknown
- 2000-06-10 HU HU0201711A patent/HUP0201711A3/hu unknown
- 2000-06-10 BR BR0011938-5A patent/BR0011938A/pt not_active IP Right Cessation
- 2000-06-10 NZ NZ516347A patent/NZ516347A/xx unknown
- 2000-06-10 EE EEP200100684A patent/EE04464B1/xx not_active IP Right Cessation
- 2000-06-10 IL IL14722000A patent/IL147220A0/xx unknown
- 2000-06-10 PT PT00940359T patent/PT1194403E/pt unknown
- 2000-06-10 YU YU88801A patent/YU88801A/sh unknown
- 2000-06-10 HK HK02108652.0A patent/HK1047575B/zh not_active IP Right Cessation
- 2000-06-10 AU AU55318/00A patent/AU771601B2/en not_active Ceased
- 2000-06-10 RU RU2002101723/04A patent/RU2238934C2/ru not_active IP Right Cessation
- 2000-06-10 SK SK1909-2001A patent/SK19092001A3/sk unknown
- 2000-06-10 ES ES00940359T patent/ES2200886T3/es not_active Expired - Lifetime
- 2000-06-22 AR ARP000103128A patent/AR024443A1/es unknown
- 2000-06-22 TW TW089112238A patent/TWI256950B/zh not_active IP Right Cessation
- 2000-06-23 US US09/603,436 patent/US6221866B1/en not_active Expired - Fee Related
-
2001
- 2001-11-27 ZA ZA200109732A patent/ZA200109732B/en unknown
- 2001-11-29 NO NO20015816A patent/NO20015816D0/no not_active Application Discontinuation
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1605752A4 (en) * | 2003-03-27 | 2008-05-07 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| US7595322B2 (en) | 2003-03-27 | 2009-09-29 | Cytokinetics, Inc. | Heterocyclic sulfonamides as modulators of cardiac sarcomeres |
| US7888373B2 (en) | 2003-03-27 | 2011-02-15 | Cytokinetics, Inc. | Heterocyclic sulfonamides as modulators of cardiac sarcomeres |
| US8101620B2 (en) | 2003-03-27 | 2012-01-24 | Cytokinetics, Inc. | Heterocyclic sulfonamides |
| US8202859B2 (en) | 2003-03-27 | 2012-06-19 | Cytokinetics, Inc. | Heterocyclic sulfonamides |
| US8367661B2 (en) | 2003-03-27 | 2013-02-05 | Cytokinetics, Inc. | Heterocyclic sulfonamides |
| US8604025B2 (en) | 2003-03-27 | 2013-12-10 | Cytokinetics, Inc. | Heterocyclic sulfonamides |
| DE102005028845A1 (de) * | 2005-06-22 | 2006-12-28 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
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