HK1047575B - 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 - Google Patents

二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 Download PDF

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Publication number
HK1047575B
HK1047575B HK02108652.0A HK02108652A HK1047575B HK 1047575 B HK1047575 B HK 1047575B HK 02108652 A HK02108652 A HK 02108652A HK 1047575 B HK1047575 B HK 1047575B
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Hong Kong
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hydrogen
carbon atoms
formula
alkyl
group
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HK02108652.0A
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English (en)
Chinese (zh)
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HK1047575A1 (en
Inventor
J‧布兰德尔
J‧布蘭德爾
U‧格兰克
H‧U‧斯蒂尔兹
U‧格蘭克
H-J‧兰
H‧U‧斯蒂爾兹
H-J‧蘭
Original Assignee
萨诺费－阿文蒂斯德国有限公司
薩諾費-阿文蒂斯德國有限公司
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Publication of HK1047575A1 publication Critical patent/HK1047575A1/xx
Publication of HK1047575B publication Critical patent/HK1047575B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/26—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
HK02108652.0A 1999-06-25 2000-06-10 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑 HK1047575B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19929076A DE19929076A1 (de) 1999-06-25 1999-06-25 Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE19929076.8 1999-06-25
PCT/EP2000/005370 WO2001000573A1 (de) 1999-06-25 2000-06-10 Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number Publication Date
HK1047575A1 HK1047575A1 (en) 2003-02-28
HK1047575B true HK1047575B (zh) 2004-12-31

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HK02108652.0A HK1047575B (zh) 1999-06-25 2000-06-10 二氫茚基取代的苯甲酰胺、其製備方法、其作為藥物的應用、和含有它們的藥物製劑

Country Status (31)

Country Link
US (1) US6221866B1 (enExample)
EP (1) EP1194403B1 (enExample)
JP (1) JP4527918B2 (enExample)
KR (1) KR20020023962A (enExample)
CN (1) CN1157372C (enExample)
AR (1) AR024443A1 (enExample)
AT (1) ATE248811T1 (enExample)
AU (1) AU771601B2 (enExample)
BR (1) BR0011938A (enExample)
CA (1) CA2377087A1 (enExample)
CZ (1) CZ20014523A3 (enExample)
DE (2) DE19929076A1 (enExample)
DK (1) DK1194403T3 (enExample)
EE (1) EE04464B1 (enExample)
ES (1) ES2200886T3 (enExample)
HK (1) HK1047575B (enExample)
HU (1) HUP0201711A3 (enExample)
IL (1) IL147220A0 (enExample)
MX (1) MXPA01012281A (enExample)
NO (1) NO20015816D0 (enExample)
NZ (1) NZ516347A (enExample)
PL (1) PL352985A1 (enExample)
PT (1) PT1194403E (enExample)
RU (1) RU2238934C2 (enExample)
SI (1) SI1194403T1 (enExample)
SK (1) SK19092001A3 (enExample)
TR (1) TR200103701T2 (enExample)
TW (1) TWI256950B (enExample)
WO (1) WO2001000573A1 (enExample)
YU (1) YU88801A (enExample)
ZA (1) ZA200109732B (enExample)

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CA2737645A1 (en) * 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
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WO2010147791A1 (en) 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
EP2480544A1 (en) * 2009-09-22 2012-08-01 Boehringer Ingelheim International GmbH Compounds which selectively modulate the cb2 receptor
EP2523936A1 (en) 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
US8329735B2 (en) 2010-03-05 2012-12-11 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the CB2 receptor
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Publication number Publication date
NZ516347A (en) 2004-01-30
US6221866B1 (en) 2001-04-24
IL147220A0 (en) 2002-08-14
EE200100684A (et) 2003-04-15
ZA200109732B (en) 2002-08-30
HUP0201711A3 (en) 2005-05-30
TWI256950B (en) 2006-06-21
CA2377087A1 (en) 2001-01-04
DE19929076A1 (de) 2000-12-28
CN1157372C (zh) 2004-07-14
AR024443A1 (es) 2002-10-02
KR20020023962A (ko) 2002-03-29
PL352985A1 (en) 2003-09-22
SK19092001A3 (sk) 2002-06-04
HUP0201711A2 (en) 2002-09-28
CN1358172A (zh) 2002-07-10
AU771601B2 (en) 2004-03-25
WO2001000573A1 (de) 2001-01-04
BR0011938A (pt) 2002-03-19
SI1194403T1 (en) 2003-12-31
NO20015816L (no) 2001-11-29
NO20015816D0 (no) 2001-11-29
MXPA01012281A (es) 2002-07-30
PT1194403E (pt) 2004-01-30
CZ20014523A3 (cs) 2002-04-17
YU88801A (sh) 2004-09-03
DE50003555D1 (de) 2003-10-09
ES2200886T3 (es) 2004-03-16
TR200103701T2 (tr) 2002-05-21
HK1047575A1 (en) 2003-02-28
JP2003503385A (ja) 2003-01-28
RU2238934C2 (ru) 2004-10-27
JP4527918B2 (ja) 2010-08-18
EP1194403B1 (de) 2003-09-03
ATE248811T1 (de) 2003-09-15
DK1194403T3 (da) 2003-12-08
EP1194403A1 (de) 2002-04-10
AU5531800A (en) 2001-01-31
EE04464B1 (et) 2005-04-15

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