KR102483783B1 - 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법 - Google Patents

안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법 Download PDF

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KR102483783B1
KR102483783B1 KR1020217024701A KR20217024701A KR102483783B1 KR 102483783 B1 KR102483783 B1 KR 102483783B1 KR 1020217024701 A KR1020217024701 A KR 1020217024701A KR 20217024701 A KR20217024701 A KR 20217024701A KR 102483783 B1 KR102483783 B1 KR 102483783B1
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KR20210099204A (ko
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션 코니 차오
선영 조
진 리
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아벨리노 랩 유에스에이, 인크.
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
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KR1020217024701A 2013-11-15 2014-11-17 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법 Active KR102483783B1 (ko)

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KR1020227046070A KR20230007558A (ko) 2013-11-15 2014-11-17 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법

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US201361905051P 2013-11-15 2013-11-15
US61/905,051 2013-11-15
PCT/US2014/065975 WO2015073978A2 (en) 2013-11-15 2014-11-17 Methods for multiplex detection of alleles associated with ophthalmic conditions
KR1020167015852A KR102293785B1 (ko) 2013-11-15 2014-11-17 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법

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KR1020167015852A Active KR102293785B1 (ko) 2013-11-15 2014-11-17 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법
KR1020217024701A Active KR102483783B1 (ko) 2013-11-15 2014-11-17 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법

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KR1020167015852A Active KR102293785B1 (ko) 2013-11-15 2014-11-17 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법

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US (2) US11525160B2 (enExample)
EP (2) EP3872192A1 (enExample)
JP (2) JP6672147B2 (enExample)
KR (3) KR20230007558A (enExample)
CN (2) CN113604551A (enExample)
AU (2) AU2014348279B2 (enExample)
SG (1) SG10201804076RA (enExample)
TW (3) TW202346604A (enExample)
WO (1) WO2015073978A2 (enExample)

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US10889850B2 (en) 2013-03-15 2021-01-12 Avellino Lab Usa, Inc. Methods for improved isolation of genomic DNA templates for allele detection
KR102240332B1 (ko) * 2013-03-15 2021-04-14 아벨리노 랩 유에스에이, 인크. 대립유전자 검출을 위한 게놈 dna 주형의 개선된 단리 방법
EP3872192A1 (en) 2013-11-15 2021-09-01 Avellino Lab USA, Inc. Methods for multiplex detection of alleles associated with ophthalmic conditions
JP6929865B2 (ja) * 2015-11-13 2021-09-01 タラ ムーア 角膜ジストロフィーの治療方法
CN106480200A (zh) * 2016-10-25 2017-03-08 北京亿昊基因技术有限公司 一种快速高效的与角膜营养不良相关基因突变位点的检测方法
CN108085375B (zh) * 2016-11-07 2020-10-16 北京华大通瀛科技有限公司 检测角膜营养不良基因多态性位点的基因型的方法及其试剂盒
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CN107523635A (zh) * 2017-10-09 2017-12-29 湖南大地同年生物科技有限公司 一种tgfbi基因多态性快速检测试剂盒及其检测方法
CN107858420A (zh) * 2017-11-17 2018-03-30 奥斯汀生命科学技术公司 用于诊断人TGFβI基因124位点变异引起角膜营养不良的引物探针及检测方法
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CN108796062A (zh) * 2018-06-06 2018-11-13 无锡正则精准医学检验有限公司 一种检测tgfbi基因多态性的试剂盒
CN109406469B (zh) * 2018-10-24 2021-04-09 中国医科大学 基于蛋白结合诱导dna双链变构的检测色氨酸的方法
KR102241836B1 (ko) * 2019-06-14 2021-04-21 솔젠트 (주) 듀얼 체크 올리고를 이용한 유전자 다형성 검사 방법
CN113088569A (zh) * 2020-01-09 2021-07-09 北京中因科技有限公司 一种多重荧光定量pcr试剂盒
CN113999899A (zh) * 2020-07-28 2022-02-01 首都医科大学附属北京同仁医院 一种检测tgfbi基因突变的试剂盒
CN115820837A (zh) * 2022-11-04 2023-03-21 温州谱希基因科技有限公司 一种角膜营养不良的pcr检测试剂盒及其应用
CN118222692A (zh) * 2022-12-21 2024-06-21 北京中因医学检验实验室有限公司 一种人tgfbi基因分型检测的引物探针组合物及其应用
CN117417997B (zh) * 2023-10-26 2025-07-29 上海谱希和光基因科技有限公司 一种诊断圆锥角膜的基因组生物标志物组合
TWI879353B (zh) * 2023-12-27 2025-04-01 台南應用科技大學 兩對交叉引子的多目標設計方法

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EP3068908A2 (en) 2016-09-21
US20230348984A1 (en) 2023-11-02
SG10201804076RA (en) 2018-06-28
KR20230007558A (ko) 2023-01-12
WO2015073978A3 (en) 2015-07-16
TW202346604A (zh) 2023-12-01
WO2015073978A9 (en) 2016-06-23
AU2021202884A1 (en) 2021-06-03
EP3068908B1 (en) 2021-01-06
EP3872192A1 (en) 2021-09-01
AU2021202884B2 (en) 2023-04-06
TW201610167A (zh) 2016-03-16
JP7077289B2 (ja) 2022-05-30
CN113604551A (zh) 2021-11-05
JP2017501685A (ja) 2017-01-19
JP6672147B2 (ja) 2020-03-25
KR20210099204A (ko) 2021-08-11
TW202223098A (zh) 2022-06-16
US11525160B2 (en) 2022-12-13
CN105899681B (zh) 2021-06-22
CN105899681A (zh) 2016-08-24
US20160319357A1 (en) 2016-11-03
JP2020039339A (ja) 2020-03-19
KR102293785B1 (ko) 2021-08-26
EP3068908A4 (en) 2017-08-23
AU2014348279A9 (en) 2016-07-28
AU2014348279B2 (en) 2021-02-18
TWI755350B (zh) 2022-02-21
WO2015073978A2 (en) 2015-05-21
KR20160079117A (ko) 2016-07-05
TWI812047B (zh) 2023-08-11
AU2014348279A1 (en) 2016-06-09

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