KR102452571B1 - 수신된 광자들의 시간 비닝을 위한 집적 디바이스 - Google Patents

수신된 광자들의 시간 비닝을 위한 집적 디바이스 Download PDF

Info

Publication number
KR102452571B1
KR102452571B1 KR1020227011326A KR20227011326A KR102452571B1 KR 102452571 B1 KR102452571 B1 KR 102452571B1 KR 1020227011326 A KR1020227011326 A KR 1020227011326A KR 20227011326 A KR20227011326 A KR 20227011326A KR 102452571 B1 KR102452571 B1 KR 102452571B1
Authority
KR
South Korea
Prior art keywords
time
charge
region
carrier
bin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020227011326A
Other languages
English (en)
Korean (ko)
Other versions
KR20220047677A (ko
Inventor
조나단 엠. 로스버그
키스 지. 파이프
데이비드 보이스버트
Original Assignee
퀀텀-에스아이 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 퀀텀-에스아이 인코포레이티드 filed Critical 퀀텀-에스아이 인코포레이티드
Priority to KR1020227034502A priority Critical patent/KR102585730B1/ko
Publication of KR20220047677A publication Critical patent/KR20220047677A/ko
Application granted granted Critical
Publication of KR102452571B1 publication Critical patent/KR102452571B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/80—Constructional details of image sensors
    • H10F39/802—Geometry or disposition of elements in pixels, e.g. address-lines or gate electrodes
    • H01L27/14603—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483—Details of pulse systems
    • G01S7/486—Receivers
    • G01S7/4865—Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
    • H01L27/14812—
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70—SSIS architectures; Circuits associated therewith
    • H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70—SSIS architectures; Circuits associated therewith
    • H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H04N25/771—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising storage means other than floating diffusion
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70—SSIS architectures; Circuits associated therewith
    • H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H04N25/772—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising A/D, V/T, V/F, I/T or I/F converters
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/011—Manufacture or treatment of image sensors covered by group H10F39/12
    • H10F39/026—Wafer-level processing
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/10—Integrated devices
    • H10F39/12—Image sensors
    • H10F39/15—Charge-coupled device [CCD] image sensors
    • H10F39/151—Geometry or disposition of pixel elements, address lines or gate electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
    • G01N2201/0696—Pulsed
    • G01N2201/0697—Pulsed lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S17/00—Systems using the reflection or reradiation of electromagnetic waves other than radio waves, e.g. lidar systems
    • G01S17/88—Lidar systems specially adapted for specific applications
    • G01S17/89—Lidar systems specially adapted for specific applications for mapping or imaging
    • G01S17/894—3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483—Details of pulse systems
    • G01S7/486—Receivers
    • G01S7/4861—Circuits for detection, sampling, integration or read-out
    • G01S7/4863—Detector arrays, e.g. charge-transfer gates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Remote Sensing (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Molecular Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Light Receiving Elements (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Communication System (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
KR1020227011326A 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스 Active KR102452571B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227034502A KR102585730B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462035377P 2014-08-08 2014-08-08
US62/035,377 2014-08-08
US201562164506P 2015-05-20 2015-05-20
US62/164,506 2015-05-20
KR1020177006550A KR102384909B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스
PCT/US2015/044360 WO2016022998A2 (en) 2014-08-08 2015-08-07 Integrated device for temporal binning of received photons

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177006550A Division KR102384909B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227034502A Division KR102585730B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스

Publications (2)

Publication Number Publication Date
KR20220047677A KR20220047677A (ko) 2022-04-18
KR102452571B1 true KR102452571B1 (ko) 2022-10-07

Family

ID=54064569

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020227011326A Active KR102452571B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스
KR1020177006550A Active KR102384909B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스
KR1020227034502A Active KR102585730B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020177006550A Active KR102384909B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스
KR1020227034502A Active KR102585730B1 (ko) 2014-08-08 2015-08-07 수신된 광자들의 시간 비닝을 위한 집적 디바이스

Country Status (10)

Country Link
US (8) US9759658B2 (enExample)
EP (2) EP3194935B1 (enExample)
JP (2) JP6707520B2 (enExample)
KR (3) KR102452571B1 (enExample)
CN (2) CN107112333B (enExample)
AU (2) AU2015300766B2 (enExample)
BR (1) BR112017002485B1 (enExample)
CA (1) CA2957540A1 (enExample)
MX (2) MX384613B (enExample)
WO (1) WO2016022998A2 (enExample)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX392471B (es) 2013-11-17 2025-03-24 Quantum Si Inc Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas
EP3194935B1 (en) 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
KR102472061B1 (ko) 2014-08-08 2022-11-29 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
BR112017002501B1 (pt) 2014-08-08 2022-06-07 Quantum-Si Incorporated Dispositivos integrados, sistemas, método de detecção de presença de molécula em amostra, método de formação de dispositivo integrado e método de análise de espécime
KR101725099B1 (ko) * 2014-12-05 2017-04-26 삼성전자주식회사 컴퓨터 단층 촬영장치 및 그 제어방법
AU2015203591A1 (en) * 2015-06-26 2017-01-19 Canon Kabushiki Kaisha System and method for object matching
JP2017098809A (ja) * 2015-11-26 2017-06-01 キヤノン株式会社 光電変換装置、および、撮像システム
KR20180111999A (ko) * 2016-02-17 2018-10-11 테서렉트 헬스, 인코포레이티드 수명 촬상 및 검출 응용을 위한 센서 및 디바이스
AU2017274412B2 (en) * 2016-06-01 2022-07-21 Quantum-Si Incorporated Pulse caller and base caller
CN109155322B (zh) * 2016-06-08 2023-02-21 因维萨热技术公司 具有电子快门的图像传感器
JP6908819B2 (ja) * 2016-09-29 2021-07-28 ミツミ電機株式会社 近接センサ
EP3305170B1 (en) * 2016-10-04 2020-12-02 ams AG Fluorescence lifetime sensor module and method of determining a fluorescence lifetime using a sensor module
JP6808463B2 (ja) * 2016-11-30 2021-01-06 キヤノン株式会社 光電変換装置および光電変換システム
WO2018112170A1 (en) 2016-12-16 2018-06-21 Quantum-Si Incorporated Compact beam shaping and steering assembly
CA3046680A1 (en) 2016-12-19 2018-06-28 Quantum-Si Incorporated Loading molecules into sample wells for analysis
CN110168732B (zh) 2016-12-22 2024-03-08 宽腾矽公司 具有直接合并像素的整合式光电侦测器
GB201622429D0 (en) * 2016-12-30 2017-02-15 Univ Court Of The Univ Of Edinburgh The Photon sensor apparatus
WO2018204810A1 (en) 2017-05-05 2018-11-08 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
CN111133293A (zh) 2017-07-24 2020-05-08 宽腾矽公司 手持式大规模并行生物光电仪器
KR102786367B1 (ko) * 2017-07-24 2025-03-26 퀀텀-에스아이 인코포레이티드 광학 거부 광자 구조체들
EP3669018A4 (en) 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
WO2019084537A1 (en) * 2017-10-29 2019-05-02 Rourk Christopher J ELECTRON TRANSPORT DOOR CIRCUITS AND METHODS OF MANUFACTURE, OPERATION AND USE
US10817780B2 (en) 2017-10-29 2020-10-27 Christopher J. Rourk Electron transport gate circuits and methods of manufacture, operation and use
EP3813356B1 (en) * 2017-10-30 2025-02-05 Sony Semiconductor Solutions Corporation Solid-state imaging device
MX2020007904A (es) 2018-01-26 2020-09-07 Quantum Si Inc Llamado de pulso y base habilitado por maquina de aprendizaje para dispositivos de secuenciacion.
KR20210021018A (ko) * 2018-06-15 2021-02-24 퀀텀-에스아이 인코포레이티드 펄스형 광학 소스들을 갖는 고급 분석 기기들을 위한 데이터 취득 제어
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CN112567632B (zh) 2018-07-16 2024-03-22 吉加焦特技术公司 具有非雪崩光电检测器的高灵敏度深度传感器
CN108760641B (zh) * 2018-08-17 2023-05-16 龙岩学院 基于单光子探测的熔焊过程监测装置及监测方法
EP3844486A1 (en) * 2018-08-29 2021-07-07 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors
JP2020072317A (ja) * 2018-10-30 2020-05-07 ソニーセミコンダクタソリューションズ株式会社 センサ及び制御方法
MX2021005757A (es) 2018-11-15 2021-08-11 Quantum Si Inc Metodos y composiciones para la secuenciacion de proteinas.
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
US11607119B2 (en) * 2018-12-17 2023-03-21 Qatar University Fluorescence lifetime spectroscopy based capsule endoscopy
DE102018222118A1 (de) * 2018-12-18 2020-06-18 Robert Bosch Gmbh CCD-Photodetektor und zugehöriges Verfahren zum Betrieb
JP2020118569A (ja) * 2019-01-24 2020-08-06 ソニーセミコンダクタソリューションズ株式会社 受光装置および測距装置
CN119510370A (zh) * 2019-03-14 2025-02-25 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
EP3963091A4 (en) 2019-04-29 2023-07-19 Nautilus Biotechnology, Inc. METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION
US11423306B2 (en) * 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
KR20220025853A (ko) * 2019-06-28 2022-03-03 퀀텀-에스아이 인코포레이티드 광학적 및 전기적 2차 경로 제거
US20220291380A1 (en) * 2019-07-12 2022-09-15 Sony Group Corporation Semiconductor device
WO2021034838A1 (en) * 2019-08-20 2021-02-25 Intuitive Surgical Operations, Inc. Systems and a method for directing an imaging device to detect fluorescence and for determining a lifetime of the fluorescence
AU2020364058A1 (en) 2019-10-11 2022-05-26 Quantum-Si Incorporated Surface modification in the vapor phase
CN110579460B (zh) * 2019-10-14 2023-04-18 深圳大学 一种寻址扫描快速荧光寿命显微成像系统及方法
AU2020372908A1 (en) 2019-10-29 2022-06-02 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
KR20220091534A (ko) * 2019-10-31 2022-06-30 퀀텀-에스아이 인코포레이티드 강화된 드레인을 갖는 픽셀
US11869917B2 (en) 2020-01-14 2024-01-09 Quantum-Si Incorporated Integrated sensor for lifetime characterization
CN115210969A (zh) 2020-01-14 2022-10-18 宽腾矽公司 调幅激光器
EP4088319A1 (en) 2020-01-14 2022-11-16 Quantum-si Incorporated Sensor for lifetime plus spectral characterization
WO2021154977A1 (en) 2020-01-28 2021-08-05 Daylight Solutions, Inc. Fluid analyzer with self-check, leak detection, and adjustable gain
US11719639B2 (en) 2020-03-02 2023-08-08 Quantum-Si Incorporated Integrated sensor for multi-dimensional signal analysis
WO2021207400A2 (en) * 2020-04-08 2021-10-14 Quantum-Si Incorporated Integrated sensor with reduced skew
JP2023527764A (ja) 2020-05-20 2023-06-30 クアンタム－エスアイ インコーポレイテッド タンパク質シーケンスのための方法及び組成物
US11532150B1 (en) * 2020-06-02 2022-12-20 Honeywell Federal Manufacturing & Technologies, Llc Method for determining a histogram of variable sample rate waveforms
CA3182266A1 (en) 2020-06-11 2021-12-16 Vadim Lobanov Methods and systems for computational decoding of biological, chemical, and physical entities
US20220065785A1 (en) * 2020-07-23 2022-03-03 Quantum-Si Incorporated System and method for detecting change points
KR20230093003A (ko) 2020-10-22 2023-06-26 퀀텀-에스아이 인코포레이티드 순차적으로 결합된 전하 저장소를 갖는 집적 회로 및 연관된 기술들
CA3199745A1 (en) * 2020-10-27 2022-05-05 Quantum-Si Incorporated Calibration of single-molecule detection system
JP2024500353A (ja) * 2020-12-11 2024-01-09 クアンタム－エスアイ インコーポレイテッド 電荷移動効率を向上した集積回路および関連技術
JP2023554368A (ja) 2020-12-15 2023-12-27 クアンタム－エスアイ インコーポレイテッド 単一分子速度論による分子バーコード分析
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
TW202249269A (zh) 2021-04-08 2022-12-16 美商寬騰矽公司 具有鏡像像素組態之積體電路
CN113268142B (zh) * 2021-06-09 2024-04-02 江苏集萃脑机融合智能技术研究所有限公司 基于直接测量飞行时间技术的脑机接口系统、脑机接口穿戴设备及其控制方法
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
EP4405683A1 (en) 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
AU2023241893A1 (en) 2022-03-29 2024-09-26 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024019988A1 (en) * 2022-07-18 2024-01-25 Cellsbin, Inc. Devices for biological analysis
US12159887B2 (en) 2022-08-19 2024-12-03 Quantum-Si Incorporated Backside illuminated structures with parallel charge transfer
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
CN115588678A (zh) * 2022-11-02 2023-01-10 华中科技大学 一种电荷耦合器件以及电荷耦合器件的制备方法
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
CN120418452A (zh) * 2022-12-30 2025-08-01 深圳华大智造科技股份有限公司 基因数据的编码和解码方法、装置及基因检测系统
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
WO2024243237A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
DE102023127992A1 (de) * 2023-10-13 2025-04-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Anregung und Messung von Fluoreszenzlebensdauern mittels optischer 3D Vermessung
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040169842A1 (en) 2002-03-27 2004-09-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse

Family Cites Families (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890500A (en) 1974-02-11 1975-06-17 Gen Electric Apparatus for sensing radiation and providing electrical readout
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5355165A (en) * 1992-08-06 1994-10-11 Princeton Scientific Instruments, Inc. Very high frame rate CCD imager
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
US6456326B2 (en) 1994-01-28 2002-09-24 California Institute Of Technology Single chip camera device having double sampling operation
PL317379A1 (en) 1994-05-27 1997-04-01 Ciba Geigy Ag Supercritically excited luminescence detecting process
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5990506A (en) 1996-03-20 1999-11-23 California Institute Of Technology Active pixel sensors with substantially planarized color filtering elements
US6198869B1 (en) 1996-11-18 2001-03-06 Novartis Ag Measuring device and its use
ATE273381T1 (de) 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
IT1290553B1 (it) 1997-02-27 1998-12-10 Ist Nazionale Fisica Nucleare Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata
EP2208789B1 (en) 1997-03-12 2015-07-22 Applied Biosystems, LLC DNA polymerases having improved labeled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) * 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
WO1999049082A2 (en) 1998-03-23 1999-09-30 Invitrogen Corporation Modified nucleotides and methods useful for nucleic acid sequencing
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
WO1999057321A1 (en) 1998-05-01 1999-11-11 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
JP4326050B2 (ja) * 1998-09-22 2009-09-02 ハイスペック合資会社 高速撮像素子
US6232075B1 (en) 1998-12-14 2001-05-15 Li-Cor, Inc. Heterogeneous assay for pyrophosphate detection
US6445491B2 (en) 1999-01-29 2002-09-03 Irma America, Inc. Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
EP1681356B1 (en) 1999-05-19 2011-10-19 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
CN2433618Y (zh) * 1999-10-29 2001-06-06 中国科学院上海原子核研究所 基因芯片检测装置
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
JP4433347B2 (ja) * 2000-01-17 2010-03-17 富士フイルム株式会社 蛍光撮像装置
US20020090650A1 (en) 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US7175811B2 (en) 2000-04-28 2007-02-13 Edgelight Biosciences Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
JP2004516810A (ja) 2000-06-07 2004-06-10 リ−コール インコーポレーティッド 電荷スイッチヌクレオチド
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
EP1320596A4 (en) 2000-08-30 2005-01-12 Univ Rochester REVERSE TRANSCRIPTION REACTION METHOD USING REVERSE TRANSCRIPTASE CODED BY RETROTRANSPOSON NON-LTR
WO2002023167A1 (en) 2000-09-11 2002-03-21 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
EP1207387A1 (en) 2000-11-20 2002-05-22 Institut Curie Multi-photon imaging installation.
JP4270742B2 (ja) 2000-11-30 2009-06-03 Ｎｅｃエレクトロニクス株式会社 固体撮像装置
AU2002258997A1 (en) 2001-04-24 2002-11-05 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
US7727722B2 (en) 2001-08-29 2010-06-01 General Electric Company Ligation amplification
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
US7041812B2 (en) 2001-08-29 2006-05-09 Amersham Biosciences Corp Labeled nucleoside polyphosphates
JP2005508630A (ja) 2001-09-14 2005-04-07 インヴィトロジェン コーポレーション Ｄｎａポリメラーゼとその変異体
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB2382648B (en) 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
CN1138862C (zh) * 2002-01-28 2004-02-18 国前 一种核酸分析用收集装置及其应用方法
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US8238993B2 (en) 2002-04-04 2012-08-07 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime
US20040144927A1 (en) 2003-01-28 2004-07-29 Auner Gregory W. Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040106163A1 (en) 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
WO2004047353A2 (en) 2002-11-19 2004-06-03 Safetzone Technologies Corporation Guest communication system and method
JP4896708B2 (ja) 2003-02-05 2012-03-14 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 新規リンカー類を有する末端リン酸標識ヌクレオチド類
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
FR2857158B1 (fr) 2003-07-01 2006-04-28 St Microelectronics Sa Procede de commande d'un photocopieur de type mos
US7078670B2 (en) * 2003-09-15 2006-07-18 Imagerlabs, Inc. Low noise charge gain circuit and CCD using same
WO2005073407A1 (en) 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
CA2542774A1 (en) 2003-10-18 2005-05-12 Bayer Healthcare Ag Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime
DE10348949A1 (de) * 2003-10-18 2005-05-19 Bayer Healthcare Ag Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005069737A2 (en) 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Method and system for detecting analytes
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
EP1583150A1 (en) 2004-03-31 2005-10-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA Image sensor with large-area, high-sensitivity and high-speed pixels
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US20060019265A1 (en) 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
EP1622200A1 (en) 2004-07-26 2006-02-01 CSEM Centre Suisse d'Electronique et de Microtechnique SA Solid-state photodetector pixel and photodetecting method
WO2006044078A2 (en) 2004-09-17 2006-04-27 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US7365299B2 (en) 2005-05-09 2008-04-29 Sensors Unlimited, Inc. Method and apparatus for providing flexible photodetector binning
EP1907584A2 (en) 2005-06-28 2008-04-09 Agencourt Personal Genomics Corporation Methods of producing and sequencing modified polynucleotides
WO2007045998A2 (en) 2005-07-01 2007-04-26 Dako Denmark A/S New nucleic acid base pairs
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US7501631B2 (en) 2005-10-07 2009-03-10 Schick Technologies, Inc. Shielding an imaging array from X-ray noise
DE602006016984D1 (de) 2005-12-12 2010-10-28 Us Gov Health & Human Serv Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren
AU2006331512B2 (en) 2005-12-22 2012-02-23 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
CA2633524A1 (en) 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
WO2007119626A1 (ja) 2006-03-31 2007-10-25 National University Corporation Shizuoka University 半導体測距素子及び固体撮像装置
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
CA2662521C (en) 2006-09-01 2016-08-09 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP4710017B2 (ja) 2006-10-20 2011-06-29 国立大学法人静岡大学 Ｃｍｏｓイメージセンサ
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
KR101030263B1 (ko) 2006-11-30 2011-04-22 고쿠리츠 다이가꾸 호우진 시즈오까 다이가꾸 반도체 거리 측정 소자 및 고체 촬상 장치
JP5270835B2 (ja) 2006-12-29 2013-08-21 パナソニック株式会社 光検出素子、空間情報の検出装置
ATE509265T1 (de) 2007-03-22 2011-05-15 Univ Strasbourg Etablissement Public A Caractere Scient Culturel Et Professionel Gerät zur sortierung und konzentration elektromagnetischer energie und vorrichtung mit mindestens einem derartigen gerät
EP2134871B1 (en) 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. Systems and methods for enhancing fluorescent signals
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
WO2009091847A2 (en) 2008-01-14 2009-07-23 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
AU2009212165A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. CIS reactive oxygen quenchers integrated into linkers
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
WO2009102470A2 (en) 2008-02-12 2009-08-20 Pacific Biosciences Of California, Inc. Compositions and methods for use in analytical reactions
US7968702B2 (en) 2008-03-13 2011-06-28 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
US8236499B2 (en) 2008-03-28 2012-08-07 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
US8143030B2 (en) 2008-09-24 2012-03-27 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
CN102084001B (zh) 2008-03-28 2015-03-18 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序的组合物和方法
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
AU2009251883B2 (en) 2008-03-31 2014-09-11 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
WO2009145818A1 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc Single molecule loading methods and compositions
WO2009145828A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
WO2010044932A2 (en) * 2008-07-11 2010-04-22 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
JP5283216B2 (ja) * 2008-07-31 2013-09-04 国立大学法人静岡大学 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置
EP2316221A1 (en) * 2008-08-28 2011-05-04 MESA Imaging AG Demodulation pixel with daisy chain charge storage sites and method of operation therefor
US20100148221A1 (en) 2008-11-13 2010-06-17 Zena Technologies, Inc. Vertical photogate (vpg) pixel structure with nanowires
CA2735979A1 (en) 2008-09-05 2010-03-11 Pacific Biosciences Of California, Inc. Engineering polymerases and reaction conditions for modified incorporation properties
CA2974241C (en) 2008-09-16 2020-01-07 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8247216B2 (en) 2008-09-30 2012-08-21 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
EP2182523B1 (en) * 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
US8519340B2 (en) 2008-12-22 2013-08-27 Koninklijke Philips N.V. High dynamic range light sensor
US8338248B2 (en) * 2008-12-25 2012-12-25 National University Corporation Shizuoka University Semiconductor element and solid-state imaging device
CA2750874A1 (en) 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Hybridization linkers
WO2010102621A1 (en) 2009-03-12 2010-09-16 Rsp Systems A/S Optical probe for measuring light signals in vivo
US20100261185A1 (en) 2009-03-27 2010-10-14 Life Technologies Corporation Labeled enzyme compositions, methods and systems
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5415805B2 (ja) 2009-03-31 2014-02-12 オリンパスメディカルシステムズ株式会社 診断支援装置
BRPI1006740A2 (pt) * 2009-04-15 2017-07-11 Koninklijke Philips Electronics Nv Dispositivo para detecção de fluorescência com tempo controlado para aplicações de sequenciamento de dna e estrutura de dados
JP4798254B2 (ja) 2009-05-13 2011-10-19 株式会社デンソー 受光デバイス及びその制御方法
US20120224053A1 (en) 2009-06-17 2012-09-06 Board Of Regents, The University Of Texas System Method and apparatus for quantitative microimaging
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
EP2284897B1 (en) * 2009-08-14 2021-06-30 Heptagon Micro Optics Pte. Ltd. Demodulation pixel incorporating majority carrier current, buried channel and high-low junction
DE102009037596B4 (de) 2009-08-14 2014-07-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pixelstruktur, System und Verfahren zur optischen Abstandsmessung sowie Steuerschaltung für die Pixelstruktur
WO2011040971A2 (en) 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
JP5648922B2 (ja) 2009-10-05 2015-01-07 国立大学法人静岡大学 半導体素子及び固体撮像装置
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US9579402B2 (en) 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
US20110236983A1 (en) 2009-12-29 2011-09-29 Joseph Beechem Single molecule detection and sequencing using fluorescence lifetime imaging
EP2362207A1 (de) 2010-01-28 2011-08-31 F. Hoffmann-La Roche AG Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
CA2789932A1 (en) 2010-02-19 2011-08-25 Glysure Ltd Intravascular glucose sensor
EP2537053B1 (en) 2010-02-19 2016-11-02 Pacific Biosciences of California, Inc. An analytical device comprising an optode array chip
JP2013534614A (ja) 2010-03-25 2013-09-05 モコン・インコーポレーテッド 発光寿命に基づく分析物検出装置及び校正技術
WO2011150431A1 (en) 2010-05-28 2011-12-01 The Regents Of The University Of Colorado, A Body Corporate Multi-photon tissue imaging
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
JP2012132741A (ja) 2010-12-21 2012-07-12 Fujifilm Corp 時間分解蛍光測定装置、及び方法
JP2012134827A (ja) 2010-12-22 2012-07-12 Toshiba Corp 放射線画像検出器
US8946845B1 (en) 2011-02-02 2015-02-03 Aptina Imaging Corporation Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors
WO2012117670A1 (ja) 2011-03-01 2012-09-07 パナソニック株式会社 固体撮像装置
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US9968258B2 (en) 2011-09-12 2018-05-15 Tufts University Imaging fluorescence or luminescence lifetime
US20130090537A1 (en) 2011-10-07 2013-04-11 2M Engineering Limited Blood glucose sensor
US8778849B2 (en) 2011-10-28 2014-07-15 Illumina, Inc. Microarray fabrication system and method
WO2013066959A1 (en) 2011-10-31 2013-05-10 The Trustees Of Columbia University In The City Of New York Systems and methods for imaging using single photon avalanche diodes
US8804021B2 (en) 2011-11-03 2014-08-12 Omnivision Technologies, Inc. Method, apparatus and system for providing improved full well capacity in an image sensor pixel
US9606060B2 (en) * 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
DE102012206089B4 (de) 2012-03-15 2017-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren
US20130256822A1 (en) 2012-03-28 2013-10-03 Omnivision Technologies, Inc. Method and device with enhanced ion doping
CN102914525B (zh) 2012-04-10 2016-06-01 广东工业大学 基于光学加法外差调制的新型荧光寿命显微成像装置及方法
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
CA2881823C (en) * 2012-08-20 2019-06-11 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
WO2014068951A1 (ja) 2012-10-30 2014-05-08 パナソニック株式会社 試料保持担体およびそれを用いた蛍光検出装置
NL2011568A (en) 2012-10-31 2014-05-06 Asml Netherlands Bv Sensor and lithographic apparatus.
EP3734255B1 (en) 2012-12-18 2022-10-19 Pacific Biosciences Of California, Inc. An optical analytical device
GB201302664D0 (en) 2013-02-15 2013-04-03 Cmosis Nv A pixel structure
US10206561B2 (en) 2013-02-28 2019-02-19 DePuy Synthes Products, Inc. Videostroboscopy of vocal cords with CMOS sensors
US9741754B2 (en) 2013-03-06 2017-08-22 Apple Inc. Charge transfer circuit with storage nodes in image sensors
KR102007277B1 (ko) 2013-03-11 2019-08-05 삼성전자주식회사 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서
US9260251B2 (en) 2013-07-09 2016-02-16 Nd Industries, Inc. Multi-row magnetic dial for the conveyance of workpieces and related method
US20150042954A1 (en) 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
MX392471B (es) 2013-11-17 2025-03-24 Quantum Si Inc Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas
WO2015084991A1 (en) 2013-12-04 2015-06-11 Rambus Inc. High dynamic-range image sensor
CN103728446B (zh) * 2013-12-11 2016-02-24 天津大学 光子计数型多通道时间分辨荧光免疫分析系统及计数方法
US9736388B2 (en) 2013-12-13 2017-08-15 Bio-Rad Laboratories, Inc. Non-destructive read operations with dynamically growing images
WO2015163957A2 (en) 2014-01-31 2015-10-29 The General Hospital Corporation System and method for photoluminescence detection
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
KR20150134543A (ko) 2014-05-22 2015-12-02 삼성전자주식회사 소자 제조용 기판 및 반도체 소자
CN115989999A (zh) 2014-07-24 2023-04-21 大学健康网络 用于诊断目的的数据的收集和分析
EP3194935B1 (en) 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
BR112017002501B1 (pt) 2014-08-08 2022-06-07 Quantum-Si Incorporated Dispositivos integrados, sistemas, método de detecção de presença de molécula em amostra, método de formação de dispositivo integrado e método de análise de espécime
KR102472061B1 (ko) 2014-08-08 2022-11-29 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
JP2018505565A (ja) 2014-12-19 2018-02-22 ジーレイ スイッツァーランド エスアー モノリシックｃｍｏｓ集積ピクセル検出器ならびに様々な用途を含む粒子検出および撮像のためのシステムおよび方法
US9871065B2 (en) 2014-12-22 2018-01-16 Google Inc. RGBZ pixel unit cell with first and second Z transfer gates
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
CN107003410B (zh) 2015-02-09 2018-08-24 埃斯普罗光电股份公司 Tof距离传感器
EP4220256A1 (en) 2015-03-16 2023-08-02 Pacific Biosciences of California, Inc. Analytical system comprising integrated devices and systems for free-space optical coupling
TWI569008B (zh) 2015-04-27 2017-02-01 財團法人工業技術研究院 尿素濃度檢測元件以及尿素濃度檢測方法
EP3298389B1 (en) 2015-05-20 2021-09-29 Quantum-Si Incorporated Method of determining the sequence of a nucleic acid using time resolved luminescence
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10976257B2 (en) 2015-06-08 2021-04-13 The Regents Of The University Of Michigan Pixel circuit and method for optical sensing
CN105300949B (zh) 2015-11-26 2019-06-11 浙江大学 一种荧光寿命测量方法及装置
KR20180111999A (ko) 2016-02-17 2018-10-11 테서렉트 헬스, 인코포레이티드 수명 촬상 및 검출 응용을 위한 센서 및 디바이스
AU2017274412B2 (en) 2016-06-01 2022-07-21 Quantum-Si Incorporated Pulse caller and base caller
US10249656B2 (en) 2016-06-07 2019-04-02 Semiconductor Components Industries, Llc Charge packet signal processing using pinned photodiode devices
EP4250361A3 (en) 2016-12-13 2024-04-17 STMicroelectronics (Research & Development) Limited A charge storage cell and method of manufacturing a charge storage cell
CN110168732B (zh) 2016-12-22 2024-03-08 宽腾矽公司 具有直接合并像素的整合式光电侦测器
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
EP3844486A1 (en) 2018-08-29 2021-07-07 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040169842A1 (en) 2002-03-27 2004-09-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse

Also Published As

Publication number Publication date
WO2016022998A3 (en) 2016-04-14
EP3471402B1 (en) 2023-05-31
AU2015300766B2 (en) 2021-02-04
MX2017001806A (es) 2018-01-30
US20160377543A1 (en) 2016-12-29
US20160380025A1 (en) 2016-12-29
US20210025823A1 (en) 2021-01-28
CN111710687B (zh) 2023-11-14
KR20220047677A (ko) 2022-04-18
JP6935541B2 (ja) 2021-09-15
US12203854B2 (en) 2025-01-21
KR102384909B1 (ko) 2022-04-11
AU2021202729B2 (en) 2023-06-29
US9945779B2 (en) 2018-04-17
MX384613B (es) 2025-03-14
BR112017002485A2 (pt) 2017-12-05
US9759658B2 (en) 2017-09-12
US10775305B2 (en) 2020-09-15
US20170322153A1 (en) 2017-11-09
JP2017531356A (ja) 2017-10-19
WO2016022998A2 (en) 2016-02-11
CN107112333B (zh) 2020-07-10
US11209363B2 (en) 2021-12-28
KR20170042663A (ko) 2017-04-19
BR112017002485B1 (pt) 2020-12-01
JP6707520B2 (ja) 2020-06-10
US20160133668A1 (en) 2016-05-12
JP2020162127A (ja) 2020-10-01
AU2021202729A1 (en) 2021-05-27
MX2021007934A (es) 2023-01-17
KR20220139454A (ko) 2022-10-14
EP3194935B1 (en) 2018-10-31
US20220155229A1 (en) 2022-05-19
EP3471402A1 (en) 2019-04-17
US9606058B2 (en) 2017-03-28
US9696258B2 (en) 2017-07-04
CN107112333A (zh) 2017-08-29
US11719636B2 (en) 2023-08-08
US20180259456A1 (en) 2018-09-13
CA2957540A1 (en) 2016-02-11
EP3194935A2 (en) 2017-07-26
AU2015300766A1 (en) 2017-03-16
KR102585730B1 (ko) 2023-10-10
CN111710687A (zh) 2020-09-25
US20230408411A1 (en) 2023-12-21

Similar Documents

Publication Publication Date Title
AU2021202729B2 (en) Integrated device for temporal binning of received photons
TWI796311B (zh) 具有直接合併像素之整合式光電偵測器
JP2022113726A (ja) 寿命イメージングおよび検出用途のためのセンサおよびデバイス
HK40007164B (en) Integrated device for temporal binning of received photons
HK40007164A (en) Integrated device for temporal binning of received photons
HK1241966A1 (en) Integrated device for temporal binning of received photons
HK1241966B (en) Integrated device for temporal binning of received photons

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

A107 Divisional application of patent
GRNT Written decision to grant
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000