KR102408262B1 - 비시클릭 헤테로사이클 화합물 및 요법에서의 그의 용도 - Google Patents
비시클릭 헤테로사이클 화합물 및 요법에서의 그의 용도 Download PDFInfo
- Publication number
- KR102408262B1 KR102408262B1 KR1020167019182A KR20167019182A KR102408262B1 KR 102408262 B1 KR102408262 B1 KR 102408262B1 KR 1020167019182 A KR1020167019182 A KR 1020167019182A KR 20167019182 A KR20167019182 A KR 20167019182A KR 102408262 B1 KR102408262 B1 KR 102408262B1
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- methyl
- compound
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- pyridin
- pyrrolo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Virology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
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- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Biotechnology (AREA)
- Psychology (AREA)
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- Hospice & Palliative Care (AREA)
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- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1322755.8 | 2013-12-20 | ||
| GBGB1322755.8A GB201322755D0 (en) | 2013-12-20 | 2013-12-20 | Bicyclic heterocycle compounds and their uses in therapy |
| GB201406986A GB201406986D0 (en) | 2014-04-17 | 2014-04-17 | Bicyclic heterocycle compounds and their uses in therapy |
| GB1406986.8 | 2014-04-17 | ||
| PCT/GB2014/053778 WO2015092420A1 (en) | 2013-12-20 | 2014-12-19 | Bicyclic heterocycle compounds and their uses in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160095160A KR20160095160A (ko) | 2016-08-10 |
| KR102408262B1 true KR102408262B1 (ko) | 2022-06-10 |
Family
ID=52134239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167019182A Active KR102408262B1 (ko) | 2013-12-20 | 2014-12-19 | 비시클릭 헤테로사이클 화합물 및 요법에서의 그의 용도 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9783538B2 (enExample) |
| EP (2) | EP3083616B1 (enExample) |
| JP (3) | JP6470756B2 (enExample) |
| KR (1) | KR102408262B1 (enExample) |
| CN (3) | CN115368356B (enExample) |
| AU (2) | AU2014369446C1 (enExample) |
| BR (2) | BR112016014561B1 (enExample) |
| CA (1) | CA2933939C (enExample) |
| CY (1) | CY1124436T1 (enExample) |
| DK (1) | DK3083616T3 (enExample) |
| ES (1) | ES2883289T3 (enExample) |
| HR (1) | HRP20211406T1 (enExample) |
| HU (1) | HUE056297T2 (enExample) |
| IL (1) | IL246239B (enExample) |
| LT (1) | LT3083616T (enExample) |
| MX (1) | MX380469B (enExample) |
| MY (2) | MY186311A (enExample) |
| NZ (2) | NZ719905A (enExample) |
| PH (1) | PH12016501139A1 (enExample) |
| PL (1) | PL3083616T3 (enExample) |
| PT (1) | PT3083616T (enExample) |
| RS (1) | RS62301B1 (enExample) |
| RU (1) | RU2696310C1 (enExample) |
| SA (1) | SA516371360B1 (enExample) |
| SG (2) | SG11201604795RA (enExample) |
| SI (1) | SI3083616T1 (enExample) |
| SM (1) | SMT202100497T1 (enExample) |
| TW (1) | TWI649319B (enExample) |
| WO (1) | WO2015092420A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| PL3083616T3 (pl) | 2013-12-20 | 2021-12-06 | Astex Therapeutics Limited | Bicykliczne związki heterocykliczne i ich zastosowania w terapii |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EP3957304A1 (en) | 2015-11-25 | 2022-02-23 | IO Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
| EA201891904A1 (ru) * | 2016-02-24 | 2019-04-30 | Чилдрен'С Хоспитал Оф Истерн Онтарио Рисерч Инститьют Инк. | Smc комбинированная терапия для лечения злокачественного новообразования |
| KR20180135038A (ko) | 2016-04-20 | 2018-12-19 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Ripk2 억제제를 포함하는 컨쥬게이트 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| GB201610147D0 (en) | 2016-06-10 | 2016-07-27 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| AU2017278220C1 (en) | 2016-06-10 | 2022-10-13 | Io Therapeutics, Inc. | Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy |
| LT3689868T (lt) | 2016-12-01 | 2023-12-27 | Arvinas Operations, Inc. | Tetrahidronaftaleno ir tetrahidroizochinolino dariniai kaip estrogenų receptorių destruktoriai |
| IL272014B2 (en) | 2017-07-13 | 2023-09-01 | Io Therapeutics Inc | A combination of a rexinoid and retinoid substance with immunomodulatory properties and immunomodulatory substances for cancer treatment |
| US10363272B2 (en) | 2017-08-31 | 2019-07-30 | Io Therapeutics, Inc. | RAR selective agonists in combination with immune modulators for cancer immunotherapy |
| EP3911316A1 (en) | 2019-01-17 | 2021-11-24 | Debiopharm International SA | Combination product for the treatment of cancer |
| WO2020206137A1 (en) | 2019-04-04 | 2020-10-08 | Dana-Farber Cancer Institute, Inc. | Cdk2/5 degraders and uses thereof |
| TW202120486A (zh) * | 2019-08-09 | 2021-06-01 | 英商阿帝歐斯製藥有限公司 | 新穎化合物 |
| JP7656589B2 (ja) | 2019-08-26 | 2025-04-03 | アルビナス・オペレーションズ・インコーポレイテッド | エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法 |
| BR112022005624A2 (pt) | 2019-09-25 | 2022-07-12 | Debiopharm Int Sa | Regimes de dosagem para tratamento de pacientes com carcinoma de células escamosas localmente avançado |
| GB201919219D0 (en) * | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| CN120247907A (zh) * | 2020-05-04 | 2025-07-04 | 大塚制药株式会社 | Iap拮抗剂化合物和中间体及其合成方法 |
| PL4146617T3 (pl) * | 2020-05-04 | 2025-12-08 | Taiho Pharmaceutical Co., Ltd. | Sposoby syntezy bezwodnego kwasu mlekowego |
| KR20230020942A (ko) * | 2020-06-04 | 2023-02-13 | 베이진 엘티디 | Iap 길항제로서 피리도[2,3-b][1,4]옥사진 또는 테트라하이드로피리도[2,3-b][1,4]옥사제핀 |
| WO2022035610A1 (en) * | 2020-08-12 | 2022-02-17 | Archer Daniels Midland Company | Purification of 2,5-furandicarboxylic acid, dimethyl ester and other esterified products |
| AU2021333983A1 (en) | 2020-08-27 | 2023-01-05 | Otsuka Pharmaceutical Co., Ltd. | Biomarkers for cancer therapy using MDM2 antagonists |
| TW202214236A (zh) * | 2020-09-14 | 2022-04-16 | 美商亞文納營運公司 | 用於靶向降解雌激素受體之化合物之結晶及非晶形形式 |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| MX2024002214A (es) | 2021-08-20 | 2024-03-12 | Otsuka Pharma Co Ltd | Farmaco de combinacion. |
| WO2023239422A2 (en) * | 2021-10-22 | 2023-12-14 | University Of Houston System | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
| CA3236956A1 (en) * | 2021-11-05 | 2023-05-11 | Haihe Biopharma Co., Ltd. | Solid dispersion, preparation method therefor, and solid formulation comprising same |
| JP2025508016A (ja) | 2022-03-04 | 2025-03-21 | 大鵬薬品工業株式会社 | Iapアンタゴニスト化合物を用いたがんの治療方法及び併用療法 |
| WO2023230432A1 (en) | 2022-05-23 | 2023-11-30 | Inhibrx, Inc. | Dr5 agonist and iap antagonist combination therapy |
| CA3266274A1 (en) | 2022-08-31 | 2024-03-07 | Taiho Pharmaceutical Co., Ltd. | Combination therapies for the treatment of T-cell lymphoma with tolinapant, cedazuridine, and decitabin |
| CN118027138A (zh) * | 2022-11-07 | 2024-05-14 | 南京中澳转化医学研究院有限公司 | 吡啶酮类化合物及其制备方法、药物组合物和应用 |
| CN116375700B (zh) * | 2023-01-10 | 2024-12-17 | 中国科学院成都生物研究所 | 一种4-氮杂吲哚啉类化合物及其合成方法与应用 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
| TW202510888A (zh) | 2023-07-31 | 2025-03-16 | 日商大塚製藥股份有限公司 | 包含托利那泮(tolinapant)之醫藥組合物及包裝 |
| WO2025235719A1 (en) * | 2024-05-08 | 2025-11-13 | Viiv Healthcare Company | Dimeric smac mimetics useful in hiv therapy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012143726A1 (en) | 2011-04-21 | 2012-10-26 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080330A (en) | 1975-06-23 | 1978-03-21 | Delmar Chemicals Limited | Phenylindolines and process for their production |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| DE3822792C2 (de) | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| TW218875B (enExample) | 1992-03-09 | 1994-01-11 | Takeda Pharm Industry Co Ltd | |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| WO1998004689A1 (en) | 1995-07-31 | 1998-02-05 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
| EP0778277B1 (en) | 1995-12-08 | 2003-06-25 | Pfizer Inc. | Substituted heterocyclic derivatives as CRF antagonists |
| AU2056197A (en) | 1996-02-22 | 1997-09-10 | Du Pont Merck Pharmaceutical Company, The | M-amidino phenyl analogs as factor xa inhibitors |
| CA2249601A1 (en) | 1996-04-03 | 1997-10-23 | Thorsten E. Fisher | Inhibitors of farnesyl-protein transferase |
| WO1998000401A1 (en) | 1996-06-28 | 1998-01-08 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
| US5977134A (en) | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU7526798A (en) | 1997-04-18 | 1998-11-27 | Smithkline Beecham Plc | Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders |
| JP2001524116A (ja) | 1997-04-18 | 2001-11-27 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht1a、5ht1bおよび5ht1d受容体アンタゴニスト活性を合わせ持つインドール誘導体 |
| US6084098A (en) | 1999-02-26 | 2000-07-04 | Neurogen Corporation | Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands |
| HUP0100926A3 (en) | 1998-02-26 | 2003-03-28 | Neurogen Corp Branford | Benzylpiperazinyl- and benzylpiperidinyl ethanone derivatives, their preparation and their use as dopamine d4 receptor antagonists |
| MXPA00009569A (es) | 1998-03-31 | 2002-08-06 | Acadia Pharm Inc | Compuestos con actividad en receptores muscarinicos. |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| BR9913222A (pt) | 1998-08-26 | 2001-10-16 | Aventis Pharma Ltd | Aza-biciclos que modulam a inibição de adesão das células |
| GB9905010D0 (en) | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| AU3555200A (en) | 1999-03-17 | 2000-10-04 | F. Hoffmann-La Roche Ag | Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators |
| GB9929552D0 (en) | 1999-12-14 | 2000-02-09 | Proteus Molecular Design | Compounds |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| DE60039359D1 (de) | 1999-09-04 | 2008-08-14 | Astrazeneca Ab | Amide als pyruvatdehydrogenaseinhibitoren |
| GB0031088D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| EP1354882A1 (en) | 2000-12-27 | 2003-10-22 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
| AU2002303264A1 (en) | 2001-04-09 | 2002-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic inhibitors of factor xa |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| WO2003090748A1 (fr) | 2002-04-24 | 2003-11-06 | Takeda Pharmaceutical Compay Limited. | Utilisation de composes a antagonisme anti-ccr |
| TW200402417A (en) | 2002-06-21 | 2004-02-16 | Akzo Nobel Nv | 1-[(Indol-3-yl)carbonyl]piperazine derivatives |
| EP1602645A4 (en) | 2003-03-07 | 2008-12-03 | Astellas Pharma Inc | NITROGENIC HETEROCYCLIC DERIVATIVE WITH 2,6-DISUBSTITUTED STYRYL REST |
| GB0307891D0 (en) | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| MXPA06001636A (es) | 2003-08-13 | 2006-04-28 | Amgen Inc | Antagonista del receptor de la hormona concentradora de melanina. |
| TW200524887A (en) | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
| PL2253614T3 (pl) | 2004-04-07 | 2013-03-29 | Novartis Ag | Inhibitory IAP |
| NZ588799A (en) * | 2004-07-02 | 2012-06-29 | Genentech Inc | Inhibitors of iap |
| WO2006010118A2 (en) | 2004-07-09 | 2006-01-26 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| WO2006032987A1 (en) | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Indoline compounds and their use in the treatment of arteriosclerosis |
| JP5007235B2 (ja) | 2004-12-20 | 2012-08-22 | ジェネンテック, インコーポレイテッド | Iapのピロリジンインヒビター |
| MX2007010371A (es) | 2005-02-25 | 2008-01-11 | Tetralogic Pharmaceuticals | Inhibidores dimericos iap. |
| JP4955009B2 (ja) | 2005-11-11 | 2012-06-20 | エフ.ホフマン−ラ ロシュ アーゲー | 凝固因子Xaの阻害剤としての炭素環式縮合環アミン |
| RU2451025C2 (ru) * | 2005-12-19 | 2012-05-20 | Дженентек, Инк. | Ингибиторы iap |
| US7674802B2 (en) | 2005-12-21 | 2010-03-09 | Decode Genetics, Ehf | N-linked aryl heteroaryl inhibitors of LTA4H for treating inflammation |
| FR2896504B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| GB0602335D0 (en) | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
| WO2007125325A1 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AR064235A1 (es) * | 2006-07-24 | 2009-03-25 | Tetralogic Pharmaceuticals Cor | Dipeptidos antagonistas de iap, una composicion farmaceutica que los comprende y el uso de los mismos para el tratamiento del cancer |
| AU2007307763A1 (en) | 2006-10-12 | 2008-04-17 | Novartis Ag | Pyrrolydine derivatives as IAP inhibitors |
| MX2009005938A (es) | 2006-12-07 | 2009-06-17 | Novartis Ag | 6-oxo-1,6-dihidro-pirimidin-2-ilos en el tratamiento de enfermedades proliferativas. |
| WO2008109180A2 (en) | 2007-03-07 | 2008-09-12 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors containing a heterocyclic moiety |
| US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| JP5298128B2 (ja) | 2007-08-08 | 2013-09-25 | グラクソスミスクライン エルエルシー | 癌の治療用のIGF−1R阻害剤としての2−[(2−{フェニルアミノ}−1H−ピロロ[2,3−d]ピリミジン−4−イル)アミノ]ベンズアミド誘導体 |
| WO2009067233A1 (en) | 2007-11-20 | 2009-05-28 | Millennium Pharmaceuticals, Inc. | Beta carbolines and uses thereof |
| EP2242362A4 (en) | 2008-01-24 | 2012-04-11 | Tetralogic Pharm Corp | INHIBITORS OF APOPTOSIS PROTEINS |
| WO2009147476A1 (en) | 2008-06-02 | 2009-12-10 | Matrix Laboratories Ltd. | Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation |
| GB0810902D0 (en) * | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010011666A2 (en) | 2008-07-21 | 2010-01-28 | University Of South Florida | Indoline scaffold shp-2 inhibitors and cancer treatment method |
| WO2010048149A2 (en) | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| DE102008059578A1 (de) | 2008-11-28 | 2010-06-10 | Merck Patent Gmbh | Benzo-Naphtyridin Verbindungen |
| CN102427731B (zh) | 2009-02-27 | 2015-05-13 | 英安塔制药有限公司 | 丙型肝炎病毒抑制剂 |
| WO2010121212A2 (en) | 2009-04-17 | 2010-10-21 | H. Lee Moffit Cancer Center And Research Institute, Inc. | Indoline scaffold shp-2 inhibitors and method of treating cancer |
| SG175877A1 (en) | 2009-05-04 | 2011-12-29 | Plexxikon Inc | Compounds and methods for inhibition of renin, and indications therefor |
| US8415486B2 (en) | 2009-05-28 | 2013-04-09 | Tetralogic Pharmaceuticals Corp. | IAP inhibitors |
| UY33794A (es) * | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| AU2012319188B2 (en) | 2011-10-03 | 2016-11-24 | Sloan-Kettering Institute For Cancer Research | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
| AU2013202982C1 (en) | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| PL3083616T3 (pl) | 2013-12-20 | 2021-12-06 | Astex Therapeutics Limited | Bicykliczne związki heterocykliczne i ich zastosowania w terapii |
| US10087151B2 (en) | 2014-01-09 | 2018-10-02 | The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone | Substituted benzoxazine and related compounds |
| CN120247907A (zh) | 2020-05-04 | 2025-07-04 | 大塚制药株式会社 | Iap拮抗剂化合物和中间体及其合成方法 |
| PL4146617T3 (pl) | 2020-05-04 | 2025-12-08 | Taiho Pharmaceutical Co., Ltd. | Sposoby syntezy bezwodnego kwasu mlekowego |
| JP2025508016A (ja) | 2022-03-04 | 2025-03-21 | 大鵬薬品工業株式会社 | Iapアンタゴニスト化合物を用いたがんの治療方法及び併用療法 |
| CA3266274A1 (en) | 2022-08-31 | 2024-03-07 | Taiho Pharmaceutical Co., Ltd. | Combination therapies for the treatment of T-cell lymphoma with tolinapant, cedazuridine, and decitabin |
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