JP6470756B2 - 二環式複素環化合物および治療におけるそれらの使用 - Google Patents

二環式複素環化合物および治療におけるそれらの使用 Download PDF

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JP6470756B2
JP6470756B2 JP2016541373A JP2016541373A JP6470756B2 JP 6470756 B2 JP6470756 B2 JP 6470756B2 JP 2016541373 A JP2016541373 A JP 2016541373A JP 2016541373 A JP2016541373 A JP 2016541373A JP 6470756 B2 JP6470756 B2 JP 6470756B2
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methyl
cancer
compound
formula
compounds
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JP2017500338A (ja
JP2017500338A5 (enExample
Inventor
ジャンニ、チェサーリ
クリストファー、ノルベルト、ジョンソン
スティーブン、ハワード
ジェームズ、エドワード、ハーベイ、デイ
イルディコ、マリア、バック
シャーロット、メアリー、グリフィス−ジョーンズ
ゴードン、サクスティ
エミリアノ、タマニーニ
ニコラ、エリザベス、ウィルシャー
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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Priority claimed from GBGB1322755.8A external-priority patent/GB201322755D0/en
Priority claimed from GB201406986A external-priority patent/GB201406986D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Pain & Pain Management (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
JP2016541373A 2013-12-20 2014-12-19 二環式複素環化合物および治療におけるそれらの使用 Active JP6470756B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1322755.8 2013-12-20
GBGB1322755.8A GB201322755D0 (en) 2013-12-20 2013-12-20 Bicyclic heterocycle compounds and their uses in therapy
GB201406986A GB201406986D0 (en) 2014-04-17 2014-04-17 Bicyclic heterocycle compounds and their uses in therapy
GB1406986.8 2014-04-17
PCT/GB2014/053778 WO2015092420A1 (en) 2013-12-20 2014-12-19 Bicyclic heterocycle compounds and their uses in therapy

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JP2017500338A JP2017500338A (ja) 2017-01-05
JP2017500338A5 JP2017500338A5 (enExample) 2018-02-01
JP6470756B2 true JP6470756B2 (ja) 2019-02-13

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JP2016541373A Active JP6470756B2 (ja) 2013-12-20 2014-12-19 二環式複素環化合物および治療におけるそれらの使用
JP2019005876A Active JP6735369B2 (ja) 2013-12-20 2019-01-17 二環式複素環化合物および治療におけるそれらの使用
JP2020119260A Active JP7110279B2 (ja) 2013-12-20 2020-07-10 二環式複素環化合物および治療におけるそれらの使用

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JP2020119260A Active JP7110279B2 (ja) 2013-12-20 2020-07-10 二環式複素環化合物および治療におけるそれらの使用

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US (6) US9783538B2 (enExample)
EP (2) EP3686200A3 (enExample)
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CN (3) CN109336883B (enExample)
AU (2) AU2014369446C1 (enExample)
BR (2) BR122022015241B1 (enExample)
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Cited By (1)

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JP2019070030A (ja) * 2013-12-20 2019-05-09 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 二環式複素環化合物および治療におけるそれらの使用

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