TWI649319B - 雙環雜環化合物及其治療用途 - Google Patents
雙環雜環化合物及其治療用途 Download PDFInfo
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- TWI649319B TWI649319B TW103144450A TW103144450A TWI649319B TW I649319 B TWI649319 B TW I649319B TW 103144450 A TW103144450 A TW 103144450A TW 103144450 A TW103144450 A TW 103144450A TW I649319 B TWI649319 B TW I649319B
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- 0 C[C@]1N[C@](C)[C@](*)OC1 Chemical compound C[C@]1N[C@](C)[C@](*)OC1 0.000 description 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
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- Epidemiology (AREA)
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- Molecular Biology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
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- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ??1322755.8 | 2013-12-20 | ||
| GBGB1322755.8A GB201322755D0 (en) | 2013-12-20 | 2013-12-20 | Bicyclic heterocycle compounds and their uses in therapy |
| ??1406986.8 | 2014-04-17 | ||
| GB201406986A GB201406986D0 (en) | 2014-04-17 | 2014-04-17 | Bicyclic heterocycle compounds and their uses in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201609724A TW201609724A (zh) | 2016-03-16 |
| TWI649319B true TWI649319B (zh) | 2019-02-01 |
Family
ID=52134239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW103144450A TWI649319B (zh) | 2013-12-20 | 2014-12-19 | 雙環雜環化合物及其治療用途 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9783538B2 (enExample) |
| EP (2) | EP3686200A3 (enExample) |
| JP (3) | JP6470756B2 (enExample) |
| KR (1) | KR102408262B1 (enExample) |
| CN (3) | CN109336883B (enExample) |
| AU (2) | AU2014369446C1 (enExample) |
| BR (2) | BR112016014561B1 (enExample) |
| CA (1) | CA2933939C (enExample) |
| CY (1) | CY1124436T1 (enExample) |
| DK (1) | DK3083616T3 (enExample) |
| ES (1) | ES2883289T3 (enExample) |
| HR (1) | HRP20211406T1 (enExample) |
| HU (1) | HUE056297T2 (enExample) |
| IL (1) | IL246239B (enExample) |
| LT (1) | LT3083616T (enExample) |
| MX (1) | MX380469B (enExample) |
| MY (2) | MY193649A (enExample) |
| NZ (2) | NZ719905A (enExample) |
| PH (1) | PH12016501139B1 (enExample) |
| PL (1) | PL3083616T3 (enExample) |
| PT (1) | PT3083616T (enExample) |
| RS (1) | RS62301B1 (enExample) |
| RU (1) | RU2696310C1 (enExample) |
| SA (1) | SA516371360B1 (enExample) |
| SG (2) | SG11201604795RA (enExample) |
| SI (1) | SI3083616T1 (enExample) |
| SM (1) | SMT202100497T1 (enExample) |
| TW (1) | TWI649319B (enExample) |
| WO (1) | WO2015092420A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| ES2883289T3 (es) | 2013-12-20 | 2021-12-07 | Astex Therapeutics Ltd | Compuestos heterocíclicos bicíclicos y sus usos en terapia |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| PL3380086T3 (pl) | 2015-11-25 | 2022-02-21 | Io Therapeutics, Inc. | Oporne na cyp26 agonisty selektywne względem rar-alfa w leczeniu nowotworu |
| EP3419643A4 (en) * | 2016-02-24 | 2020-04-01 | Children's Hospital of Eastern Ontario Research Institute Inc. | SMC-BASED ANTI-CANCER THERAPY |
| AU2017253560B2 (en) | 2016-04-20 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Conjugates comprising RIPK2 inhibitors |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| GB201610147D0 (en) | 2016-06-10 | 2016-07-27 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| SG11201810951RA (en) | 2016-06-10 | 2019-01-30 | Io Therapeutics Inc | Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy |
| KR102674902B1 (ko) | 2016-12-01 | 2024-06-14 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 및 테트라히드로이소퀴놀린 유도체 |
| AU2018301810A1 (en) | 2017-07-13 | 2020-01-23 | Io Therapeutics, Inc. | Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy |
| JP2020532537A (ja) | 2017-08-31 | 2020-11-12 | アイオー セラピューティクス インコーポレイテッド | がん免疫治療法のための免疫調節物質と併せたｒａｒ選択的アゴニスト |
| US20220096436A1 (en) | 2019-01-17 | 2022-03-31 | Debiopharm International S.A. | Combination product for the treatment of cancer |
| WO2020206137A1 (en) | 2019-04-04 | 2020-10-08 | Dana-Farber Cancer Institute, Inc. | Cdk2/5 degraders and uses thereof |
| TW202120486A (zh) * | 2019-08-09 | 2021-06-01 | 英商阿帝歐斯製藥有限公司 | 新穎化合物 |
| IL320609A (en) | 2019-08-26 | 2025-07-01 | Arvinas Operations Inc | Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents |
| PH12022550721A1 (en) | 2019-09-25 | 2024-05-13 | Debiopharm Int Sa | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
| GB201919219D0 (en) * | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| EP4146617B8 (en) * | 2020-05-04 | 2025-10-15 | Taiho Pharmaceutical Co., Ltd. | Methods for synthesizing anhydrous lactic acid |
| US20230183234A1 (en) * | 2020-05-04 | 2023-06-15 | Otsuka Pharmaceutical Co., Ltd. | Iap antagonist compounds and intermediates and methods for synthesizing the same |
| WO2021244608A1 (en) | 2020-06-04 | 2021-12-09 | Beigene, Ltd. | Pyrido[2,3-b] [1,4] oxazines or tetrahydropyrido[2,3-b][1,4] oxazepines as iap antagonists |
| WO2022035610A1 (en) * | 2020-08-12 | 2022-02-17 | Archer Daniels Midland Company | Purification of 2,5-furandicarboxylic acid, dimethyl ester and other esterified products |
| KR20230058124A (ko) | 2020-08-27 | 2023-05-02 | 오츠카 세이야쿠 가부시키가이샤 | Mdm2 길항제를 사용하는 암 치료를 위한 생체표지자 |
| WO2022056368A1 (en) * | 2020-09-14 | 2022-03-17 | Arvinas Operations, Inc. | Crystalline forms of a compound for the targeted degradation of estrogen receptor |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| CN117835983A (zh) | 2021-08-20 | 2024-04-05 | 大塚制药株式会社 | 组合药物 |
| US20230233691A1 (en) | 2021-10-22 | 2023-07-27 | University Of Houston System | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
| CN118139620A (zh) * | 2021-11-05 | 2024-06-04 | 上海海和药物研究开发股份有限公司 | 一种固体分散体、其制备方法及包含其的固体制剂 |
| JP2025508016A (ja) | 2022-03-04 | 2025-03-21 | 大鵬薬品工業株式会社 | Ｉａｐアンタゴニスト化合物を用いたがんの治療方法及び併用療法 |
| AU2023275703A1 (en) | 2022-05-23 | 2024-11-21 | Inhibrx Biosciences, Inc. | Dr5 agonist and iap antagonist combination therapy |
| EP4580635A1 (en) | 2022-08-31 | 2025-07-09 | Taiho Pharmaceutical Co., Ltd. | Combination therapies for treatment of t-cell lymphomas with tolinapant, cedazuridine and decitabine |
| CN118027138A (zh) * | 2022-11-07 | 2024-05-14 | 南京中澳转化医学研究院有限公司 | 吡啶酮类化合物及其制备方法、药物组合物和应用 |
| CN116375700B (zh) * | 2023-01-10 | 2024-12-17 | 中国科学院成都生物研究所 | 一种4-氮杂吲哚啉类化合物及其合成方法与应用 |
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