KR102357235B1 - 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 - Google Patents

영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 Download PDF

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KR102357235B1
KR102357235B1 KR1020217006198A KR20217006198A KR102357235B1 KR 102357235 B1 KR102357235 B1 KR 102357235B1 KR 1020217006198 A KR1020217006198 A KR 1020217006198A KR 20217006198 A KR20217006198 A KR 20217006198A KR 102357235 B1 KR102357235 B1 KR 102357235B1
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imaging moiety
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KR20210027519A (ko
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리차드 알. 세사티
헤이케 에스. 라데케
수레쉬 케이. 팬데이
아제이 푸로히트
사이몬 피. 로빈슨
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랜티우스 메디컬 이메징, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0421—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
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    • C07F7/12—Organo silicon halides
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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
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  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nuclear Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217006198A 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 Active KR102357235B1 (ko)

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Application Number Priority Date Filing Date Title
KR1020227002791A KR20220018624A (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템

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Application Number Priority Date Filing Date Title
US201261682185P 2012-08-10 2012-08-10
US61/682,185 2012-08-10
US201361794277P 2013-03-15 2013-03-15
US61/794,277 2013-03-15
KR1020157005764A KR102223883B1 (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
PCT/US2013/054268 WO2014026079A2 (en) 2012-08-10 2013-08-09 Compositions, methods, and systems of the synthesis and use of imaging agents

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KR20210027519A KR20210027519A (ko) 2021-03-10
KR102357235B1 true KR102357235B1 (ko) 2022-02-08

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KR1020157005764A Expired - Fee Related KR102223883B1 (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020227002791A Withdrawn KR20220018624A (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020217006198A Active KR102357235B1 (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템

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KR1020157005764A Expired - Fee Related KR102223883B1 (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020227002791A Withdrawn KR20220018624A (ko) 2012-08-10 2013-08-09 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템

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US (6) US9713651B2 (enExample)
EP (2) EP2882719B1 (enExample)
JP (3) JP6297561B2 (enExample)
KR (3) KR102223883B1 (enExample)
CN (3) CN107311935B (enExample)
AU (3) AU2013203000B9 (enExample)
BR (1) BR112015002767A2 (enExample)
CA (2) CA2881001C (enExample)
ES (1) ES2763960T3 (enExample)
HK (1) HK1210781A1 (enExample)
IL (4) IL267696B (enExample)
IN (1) IN2015DN01830A (enExample)
SG (3) SG11201500925TA (enExample)
TW (3) TWI767496B (enExample)
WO (1) WO2014026079A2 (enExample)
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JP6190240B2 (ja) * 2013-10-16 2017-08-30 浜松ホトニクス株式会社 癌に対する治療効果の診断剤
KR102630720B1 (ko) 2015-08-28 2024-01-29 세키스이 메디칼 가부시키가이샤 벤질 화합물
KR101720288B1 (ko) 2016-05-11 2017-03-28 (주)바이오액츠 뇌 영상용 염료 및 이의 제조방법
WO2019173709A1 (en) * 2018-03-09 2019-09-12 Nearing Bruce D High throughput ecg heterogeneity assessment to determine presence of coronary artery stenosis
WO2020037430A1 (en) * 2018-08-24 2020-02-27 Radialis Medical, Inc. Liquid cooling system for precise temperature control of radiation detector for positron emission mammography
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CN111333638A (zh) * 2020-03-17 2020-06-26 四川大学华西医院 18f标记的异喹啉并哒嗪酮类化合物及其合成方法和应用
JP7599289B2 (ja) * 2020-07-14 2024-12-13 浜松ホトニクス株式会社 膵臓機能の診断剤
EP4247241A4 (en) * 2020-11-19 2025-10-29 Cerecin Inc Radiopharmaceutical Ketone and Dual Tracer Imaging in Alzheimer's Disease, Cognitive Impairment, and Other States of Altered Cerebral Metabolic Disorder
CN112321509A (zh) * 2020-11-30 2021-02-05 深圳鼎邦生物科技有限公司 一种氘代哌啶酮及其制备方法与应用
JP2024525160A (ja) 2021-06-18 2024-07-10 アリゴス セラピューティクス インコーポレイテッド Ｐｄ－ｌ１を標的とするための方法及び組成物
WO2023013757A1 (ja) * 2021-08-05 2023-02-09 積水メディカル株式会社 アルキルシリルオキシ置換ベンジル化合物の製造方法
TW202328139A (zh) 2021-12-16 2023-07-16 美商艾利格斯醫療公司 用於靶向ｐｄ－ｌ１之方法及組成物
CN114478395B (zh) * 2022-04-08 2022-08-05 北京先通国际医药科技股份有限公司 一种tcpb-oh单晶
CN114478394B (zh) * 2022-04-08 2022-08-12 北京先通国际医药科技股份有限公司 Tcpb-oh单晶的制备方法及tcpb-oh单晶的用途
CN114716415B (zh) * 2022-06-09 2022-09-02 北京先通国际医药科技股份有限公司 生产液体组合物的设备及其制备方法和用途
WO2024132895A1 (en) * 2022-12-19 2024-06-27 Syngenta Crop Protection Ag Microbiocidal dihydrooxadiazinyl pyridazinone compounds

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