KR102356388B1 - 안지오포이에틴-유사 3 발현을 조절하기 위한 조성물 및 방법 - Google Patents
안지오포이에틴-유사 3 발현을 조절하기 위한 조성물 및 방법 Download PDFInfo
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- KR102356388B1 KR102356388B1 KR1020167031179A KR20167031179A KR102356388B1 KR 102356388 B1 KR102356388 B1 KR 102356388B1 KR 1020167031179 A KR1020167031179 A KR 1020167031179A KR 20167031179 A KR20167031179 A KR 20167031179A KR 102356388 B1 KR102356388 B1 KR 102356388B1
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- modified oligonucleotide
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- 0 CCCNC(CCOCC(COCCC(NCC(CC)C*CO[C@@](C1*)OC(CC)CC1(CC)O)=O)(COCCC(NC*(C)C*COCC(*)(COC(CC)[C@@]1C)C1O)=O)NC(CCCC(NC*(C)C*(C)CO*)=O)=O)=O Chemical compound CCCNC(CCOCC(COCCC(NCC(CC)C*CO[C@@](C1*)OC(CC)CC1(CC)O)=O)(COCCC(NC*(C)C*COCC(*)(COC(CC)[C@@]1C)C1O)=O)NC(CCCC(NC*(C)C*(C)CO*)=O)=O)=O 0.000 description 43
- HTENSGOZPYEMCG-UHFFFAOYSA-N CC1=CC2CC1CC2 Chemical compound CC1=CC2CC1CC2 HTENSGOZPYEMCG-UHFFFAOYSA-N 0.000 description 1
- NFWSQSCIDYBUOU-UHFFFAOYSA-N CC1=CC=CC1 Chemical compound CC1=CC=CC1 NFWSQSCIDYBUOU-UHFFFAOYSA-N 0.000 description 1
- MAAOZEYGHBMGDG-UHFFFAOYSA-N CCCC(NCCOCCOCCC)=O Chemical compound CCCC(NCCOCCOCCC)=O MAAOZEYGHBMGDG-UHFFFAOYSA-N 0.000 description 1
- ASACXRYJSYHERA-UHFFFAOYSA-N CCCOC1CCC(CC)CC1 Chemical compound CCCOC1CCC(CC)CC1 ASACXRYJSYHERA-UHFFFAOYSA-N 0.000 description 1
- SDVGDBABZRZRBL-UHFFFAOYSA-N CCOC(CCOCC(COCCC(OCC)=O)(COCCC(OCC)=O)N)=O Chemical compound CCOC(CCOCC(COCCC(OCC)=O)(COCCC(OCC)=O)N)=O SDVGDBABZRZRBL-UHFFFAOYSA-N 0.000 description 1
- MMNVXPHCQCCAPQ-UHFFFAOYSA-N COP(O)(OC1=CC=CC1)=O Chemical compound COP(O)(OC1=CC=CC1)=O MMNVXPHCQCCAPQ-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N NC(CO)(CO)CO Chemical compound NC(CO)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- WVGIPXCHHNFYPP-UHFFFAOYSA-N NC(COCCC#N)(COCCC#N)COCCC#N Chemical compound NC(COCCC#N)(COCCC#N)COCCC#N WVGIPXCHHNFYPP-UHFFFAOYSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- A61P9/12—Antihypertensives
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/3341—5-Methylcytosine
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- C12N2310/351—Conjugate
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
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- Obesity (AREA)
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- Epidemiology (AREA)
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- Crystallography & Structural Chemistry (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987467P | 2014-05-01 | 2014-05-01 | |
| US61/987,467 | 2014-05-01 | ||
| US201462049230P | 2014-09-11 | 2014-09-11 | |
| US62/049,230 | 2014-09-11 | ||
| PCT/US2015/028837 WO2015168589A2 (en) | 2014-05-01 | 2015-05-01 | Compositions and methods for modulating angiopoietin-like 3 expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160147803A KR20160147803A (ko) | 2016-12-23 |
| KR102356388B1 true KR102356388B1 (ko) | 2022-01-26 |
Family
ID=54354816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167031179A Expired - Fee Related KR102356388B1 (ko) | 2014-05-01 | 2015-05-01 | 안지오포이에틴-유사 3 발현을 조절하기 위한 조성물 및 방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9382540B2 (enExample) |
| EP (2) | EP3137605B1 (enExample) |
| JP (4) | JP2017521045A (enExample) |
| KR (1) | KR102356388B1 (enExample) |
| CN (2) | CN106255755B (enExample) |
| AU (2) | AU2015252895B2 (enExample) |
| BR (2) | BR112016024850B1 (enExample) |
| CA (1) | CA2946003A1 (enExample) |
| DK (1) | DK3137605T3 (enExample) |
| ES (1) | ES2844593T3 (enExample) |
| HU (1) | HUE052931T2 (enExample) |
| IL (1) | IL248269B (enExample) |
| MX (2) | MX382230B (enExample) |
| PL (1) | PL3137605T3 (enExample) |
| PT (1) | PT3137605T (enExample) |
| RU (1) | RU2734658C2 (enExample) |
| SI (1) | SI3137605T1 (enExample) |
| WO (1) | WO2015168589A2 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744987C (en) | 2008-12-02 | 2018-01-16 | Chiralgen, Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| KR20230107908A (ko) | 2011-06-21 | 2023-07-18 | 알닐람 파마슈티칼스 인코포레이티드 | 안지오포이에틴-유사 3(ANGPTL3) iRNA 조성물 및 그사용 방법 |
| WO2013012758A1 (en) | 2011-07-19 | 2013-01-24 | Ontorii, Inc. | Methods for the synthesis of functionalized nucleic acids |
| EP3336189A1 (en) * | 2012-04-20 | 2018-06-20 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| JP6268157B2 (ja) | 2012-07-13 | 2018-01-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| KR102712879B1 (ko) | 2012-07-13 | 2024-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| US9127276B2 (en) | 2013-05-01 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| KR102298476B1 (ko) * | 2013-12-24 | 2021-09-03 | 아이오니스 파마수티컬즈, 인코포레이티드 | 안지오포이에틴-유사 3 발현의 조절 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP4137572A1 (en) | 2014-01-16 | 2023-02-22 | Wave Life Sciences Ltd. | Chiral design |
| CN110903337A (zh) | 2014-05-01 | 2020-03-24 | Ionis制药公司 | 用于调节生长激素受体表达的组合物和方法 |
| CN106255755B (zh) * | 2014-05-01 | 2020-07-24 | Ionis制药公司 | 用于调节血管生成素样蛋白3表达的组合物和方法 |
| SG11201702877TA (en) | 2014-10-10 | 2017-05-30 | Hoffmann La Roche | Galnac phosphoramidites, nucleic acid conjugates thereof and their use |
| EP3283631A1 (en) * | 2015-04-13 | 2018-02-21 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| WO2016209862A1 (en) * | 2015-06-23 | 2016-12-29 | Alnylam Pharmaceuticals, Inc. | Glucokinase (gck) irna compositions and methods of use thereof |
| SI3331892T1 (sl) | 2015-08-06 | 2019-10-30 | Hoffmann La Roche | Postopki za pripravo derivatov gaINAc kisline |
| SG10201912902TA (en) | 2015-10-09 | 2020-02-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| PT4119569T (pt) | 2015-11-06 | 2024-10-23 | Ionis Pharmaceuticals Inc | Compostos antissentido conjugados para utilização em terapia |
| CN113952353A (zh) * | 2015-11-06 | 2022-01-21 | Ionis制药公司 | 调节载脂蛋白(a)表达 |
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St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20250125 |