KR102172228B1 - 재조합 프로바이오틱 세균 - Google Patents
재조합 프로바이오틱 세균 Download PDFInfo
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- KR102172228B1 KR102172228B1 KR1020177024852A KR20177024852A KR102172228B1 KR 102172228 B1 KR102172228 B1 KR 102172228B1 KR 1020177024852 A KR1020177024852 A KR 1020177024852A KR 20177024852 A KR20177024852 A KR 20177024852A KR 102172228 B1 KR102172228 B1 KR 102172228B1
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- lactobacillus
- growth factor
- acid sequence
- recombinant probiotic
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| PCT/EP2015/052345 WO2016124239A1 (en) | 2015-02-04 | 2015-02-04 | Recombinant probiotic bacteria for use in the treatment of a skin dysfunction |
| EPPCT/EP2015/052345 | 2015-02-04 | ||
| PCT/EP2015/075484 WO2016124266A1 (en) | 2015-02-04 | 2015-11-02 | Recombinant probiotic bacteria |
Publications (2)
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|---|---|
| KR20170118772A KR20170118772A (ko) | 2017-10-25 |
| KR102172228B1 true KR102172228B1 (ko) | 2020-11-02 |
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| KR1020177024852A KR102172228B1 (ko) | 2015-02-04 | 2015-11-02 | 재조합 프로바이오틱 세균 |
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| EP (1) | EP3253402B1 (ru) |
| JP (1) | JP6726419B2 (ru) |
| KR (1) | KR102172228B1 (ru) |
| CN (1) | CN107438666B (ru) |
| AU (1) | AU2015381262B2 (ru) |
| BR (1) | BR112017016772A2 (ru) |
| CA (1) | CA2975636C (ru) |
| CY (2) | CY20182200002T2 (ru) |
| DE (1) | DE15821025T8 (ru) |
| DK (1) | DK3253402T3 (ru) |
| ES (1) | ES2673007T3 (ru) |
| HR (1) | HRP20200973T1 (ru) |
| HU (1) | HUE050790T2 (ru) |
| IL (1) | IL253782B (ru) |
| LT (1) | LT3253402T (ru) |
| MX (1) | MX2017010150A (ru) |
| NZ (1) | NZ734579A (ru) |
| PL (1) | PL3253402T3 (ru) |
| PT (1) | PT3253402T (ru) |
| RS (1) | RS60437B1 (ru) |
| RU (1) | RU2723324C2 (ru) |
| SG (1) | SG11201706398VA (ru) |
| SI (1) | SI3253402T1 (ru) |
| TR (1) | TR201808169T3 (ru) |
| WO (2) | WO2016124239A1 (ru) |
| ZA (1) | ZA201705812B (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6581208B2 (ja) | 2014-12-23 | 2019-09-25 | イリヤ ファーマ エービー | 創傷治癒の方法 |
| CN109983028B (zh) | 2016-09-13 | 2023-10-20 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 黏膜黏附性微生物 |
| US11850270B2 (en) | 2017-12-04 | 2023-12-26 | The BioCollective, LLC | Probiotics and methods of use |
| AU2019223439A1 (en) * | 2018-02-24 | 2020-09-10 | Clearskin Ltd | Compositions, devices, systems, kits and methods for the treatment of a skin condition |
| US20230240348A1 (en) * | 2018-06-19 | 2023-08-03 | Coenbio Co., Ltd. | Composition for improving liver function comprising leuconostoc sp. strain |
| EP3837993A4 (en) * | 2018-06-19 | 2022-04-20 | Coenbio Co., Ltd. | COMPOSITION FOR IMPROVING INTESTINAL FUNCTION WITH LEUCONOSTOC SP. STRAIN |
| KR102283127B1 (ko) * | 2018-06-19 | 2021-07-29 | 주식회사 엠디헬스케어 | 류코노스톡속 균주를 포함하는 간 기능 개선용 조성물 |
| KR102173168B1 (ko) * | 2018-06-19 | 2020-11-03 | 주식회사 엠디헬스케어 | 류코노스톡속 균주를 포함하는 장 기능 개선용 조성물 |
| WO2020031204A1 (en) * | 2018-08-08 | 2020-02-13 | Sree Chitra Tirunal Institute For Medical Science And Technology | Recombinant tgf α for wound healing purposes, and the process thereof |
| CN109078171A (zh) * | 2018-09-10 | 2018-12-25 | 因之彩生物科技（武汉）有限公司 | 一种外用组合物及其应用以及外用治疗剂 |
| IT201900003115A1 (it) * | 2019-03-04 | 2020-09-04 | Univ Degli Studi Roma La Sapienza | Lattococco ingegnerizzato |
| HRP20240085T1 (hr) * | 2019-03-04 | 2024-03-29 | Aurealis Therapeutics AG | Prokariotski ekspresijski sustav indukciran kloridom |
| CN112175890A (zh) * | 2019-07-02 | 2021-01-05 | 深伦生物科技（深圳）有限公司 | 一种以食用菌分泌乙醇脱氢酶的基因工程菌 |
| KR102343938B1 (ko) * | 2020-09-02 | 2021-12-28 | 주식회사 비피도 | 재조합 비피도박테리움 비피덤 bgn4를 포함하는 염증 개선용 조성물 |
| CN112359049B (zh) * | 2020-12-10 | 2022-01-28 | 昆明理工大学 | 一种岷江百合几丁质酶基因LrCHI2及其应用 |
| KR102253283B1 (ko) * | 2020-12-21 | 2021-05-18 | 주식회사 비피도 | 비피도박테리움 비피덤을 이용한 인간 egf 단백질의 생산방법 및 이를 함유하는 조성물 |
| JP2024508541A (ja) * | 2021-03-05 | 2024-02-27 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア | 皮膚プロバイオティクス |
| CN114395514B (zh) * | 2022-02-28 | 2023-09-01 | 鲁东大学 | 一株嗜酸乳杆菌、菌剂及其应用 |
| CN114957437B (zh) * | 2022-06-06 | 2023-03-21 | 陕西理工大学 | 一种leap-2重组蛋白和一种重组乳酸乳球菌及其应用 |
| CN115181710B (zh) * | 2022-09-13 | 2022-11-25 | 北京量化健康科技有限公司 | 一株唾液乳杆菌b12wu及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008155120A2 (en) | 2007-06-20 | 2008-12-24 | Actogenix Nv | Methods and compositions for treating mucositis |
| WO2009114702A2 (en) | 2008-03-14 | 2009-09-17 | Humanzyme Limited | Recombinant production of authentic human proteins using human cell expression systems |
| WO2011150127A2 (en) | 2010-05-25 | 2011-12-01 | The Board Of Trustees Of The University Of Illinois | Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells |
| WO2011159880A1 (en) | 2010-06-18 | 2011-12-22 | North Carolina State University | Recombinant lactobacillus with decreased lipoteichoic acid to reduce inflammatory responses |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1751270A1 (en) | 2004-05-18 | 2007-02-14 | VIB vzw | Self-containing lactobacillus strain |
| US8682619B2 (en) * | 2005-12-14 | 2014-03-25 | The Invention Science Fund I, Llc | Device including altered microorganisms, and methods and systems of use |
| KR101557509B1 (ko) | 2007-01-12 | 2015-10-06 | 액토제닉스 엔.브이. | 락토코커스 프로모터 및 그것의 용도 |
| JP2012504390A (ja) * | 2008-09-30 | 2012-02-23 | ノボザイムス，インコーポレイティド | 糸状菌細胞におけるポジティブ及びネガティブ選択遺伝子の使用方法 |
| AU2009314165B2 (en) | 2008-11-11 | 2014-05-15 | Signum Biosciences, Inc. | Isoprenyl compounds and methods thereof |
| JP2012515721A (ja) * | 2009-01-20 | 2012-07-12 | シグナム バイオサイエンシーズ， インコーポレイテッド | 抗炎症性複合体 |
| FR2948868B1 (fr) * | 2009-08-07 | 2011-10-07 | Anthogyr Sa | Piece a main a moyens de connexion electrique |
| BR112012016982B8 (pt) * | 2010-01-14 | 2022-12-20 | Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement | bactéria de ácido lático recombinante de grau alimentício e composição terapêutica |
| CN101892189B (zh) | 2010-07-05 | 2012-07-04 | 浙江大学 | 一种口服免疫阻断猪生长抑素作用的转化子及其应用 |
| JP2012019768A (ja) * | 2010-07-16 | 2012-02-02 | Osaka Univ | Ｊｍｊｄ３遺伝子改変非ヒト哺乳動物、Ｊｍｊｄ３遺伝子改変骨髄キメラ非ヒト哺乳動物、及びその利用 |
| TWI566701B (zh) | 2012-02-01 | 2017-01-21 | 日本農藥股份有限公司 | 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法 |
| GB201206599D0 (en) | 2012-04-13 | 2012-05-30 | Univ Manchester | Probiotic bacteria |
| TWI613833B (zh) | 2012-11-09 | 2018-02-01 | Sony Corp | 光電變換元件、固體攝像裝置及電子機器 |
| CN104797251A (zh) * | 2012-11-16 | 2015-07-22 | 阿勒根公司 | 用前列腺素ep4激动剂组合进行皮肤创伤治愈和疤痕减少 |
| CN106661543A (zh) * | 2014-06-17 | 2017-05-10 | Xycrobe治疗公司 | 经遗传修饰的细菌和用于细菌的遗传修饰的方法 |
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2015
- 2015-02-04 WO PCT/EP2015/052345 patent/WO2016124239A1/en active Application Filing
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008155120A2 (en) | 2007-06-20 | 2008-12-24 | Actogenix Nv | Methods and compositions for treating mucositis |
| WO2009114702A2 (en) | 2008-03-14 | 2009-09-17 | Humanzyme Limited | Recombinant production of authentic human proteins using human cell expression systems |
| WO2011150127A2 (en) | 2010-05-25 | 2011-12-01 | The Board Of Trustees Of The University Of Illinois | Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells |
| WO2011159880A1 (en) | 2010-06-18 | 2011-12-22 | North Carolina State University | Recombinant lactobacillus with decreased lipoteichoic acid to reduce inflammatory responses |
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