KR102149759B1 - Fgfr 억제제로서의 프테리딘 - Google Patents
Fgfr 억제제로서의 프테리딘 Download PDFInfo
- Publication number
- KR102149759B1 KR102149759B1 KR1020147036357A KR20147036357A KR102149759B1 KR 102149759 B1 KR102149759 B1 KR 102149759B1 KR 1020147036357 A KR1020147036357 A KR 1020147036357A KR 20147036357 A KR20147036357 A KR 20147036357A KR 102149759 B1 KR102149759 B1 KR 102149759B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- substituted
- cancer
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*1ICCC1 Chemical compound C*1ICCC1 0.000 description 4
- DGOJHYZMDAOBKI-UHFFFAOYSA-N CNCCN(c(c(F)c(cc1OC)OC)c1F)c(nc1)nc2c1ncc(-c1c[n](C)nc1)n2 Chemical compound CNCCN(c(c(F)c(cc1OC)OC)c1F)c(nc1)nc2c1ncc(-c1c[n](C)nc1)n2 DGOJHYZMDAOBKI-UHFFFAOYSA-N 0.000 description 1
- WSUPCMWAOFTWES-UHFFFAOYSA-O COc1cc(OC)cc(Nc(nc2)nc(N)c2[NH+]=O)c1 Chemical compound COc1cc(OC)cc(Nc(nc2)nc(N)c2[NH+]=O)c1 WSUPCMWAOFTWES-UHFFFAOYSA-O 0.000 description 1
- PJCDHPDVXHONTD-UHFFFAOYSA-N C[NH+]([N](C)(C)C)[O-] Chemical compound C[NH+]([N](C)(C)C)[O-] PJCDHPDVXHONTD-UHFFFAOYSA-N 0.000 description 1
- QANHPRIWWFSGTM-UHFFFAOYSA-N C[n]1ncc(-c2nc(nc(N(CCO)c3cc(OC)cc(OC)c3)nc3)c3nc2)c1 Chemical compound C[n]1ncc(-c2nc(nc(N(CCO)c3cc(OC)cc(OC)c3)nc3)c3nc2)c1 QANHPRIWWFSGTM-UHFFFAOYSA-N 0.000 description 1
- IANQNWVOZRBDPD-UHFFFAOYSA-N C[n]1ncc(-c2nc3nc(N(CC(CC4)NC4=O)c(c(F)c(cc4OC)OC)c4F)ncc3nc2)c1 Chemical compound C[n]1ncc(-c2nc3nc(N(CC(CC4)NC4=O)c(c(F)c(cc4OC)OC)c4F)ncc3nc2)c1 IANQNWVOZRBDPD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653081P | 2012-05-30 | 2012-05-30 | |
| US61/653,081 | 2012-05-30 | ||
| GBGB1209613.7A GB201209613D0 (en) | 2012-05-30 | 2012-05-30 | New compounds |
| GB1209613.7 | 2012-05-30 | ||
| US201361782233P | 2013-03-14 | 2013-03-14 | |
| US61/782,233 | 2013-03-14 | ||
| PCT/GB2013/051427 WO2013179033A1 (en) | 2012-05-30 | 2013-05-30 | Pteridines as fgfr inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150016595A KR20150016595A (ko) | 2015-02-12 |
| KR102149759B1 true KR102149759B1 (ko) | 2020-08-31 |
Family
ID=46546195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147036357A Active KR102149759B1 (ko) | 2012-05-30 | 2013-05-30 | Fgfr 억제제로서의 프테리딘 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9447098B2 (https=) |
| EP (1) | EP2855480B1 (https=) |
| JP (1) | JP6363068B2 (https=) |
| KR (1) | KR102149759B1 (https=) |
| CN (1) | CN104507944B (https=) |
| AU (1) | AU2013269316C1 (https=) |
| BR (1) | BR112014029709B1 (https=) |
| CA (1) | CA2874967C (https=) |
| DK (1) | DK2855480T3 (https=) |
| ES (1) | ES2739348T3 (https=) |
| GB (1) | GB201209613D0 (https=) |
| HR (1) | HRP20191202T1 (https=) |
| HU (1) | HUE045663T2 (https=) |
| IN (1) | IN2014MN02069A (https=) |
| LT (1) | LT2855480T (https=) |
| MX (1) | MX359418B (https=) |
| RU (1) | RU2702906C2 (https=) |
| SI (1) | SI2855480T1 (https=) |
| WO (1) | WO2013179033A1 (https=) |
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| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB2504177B (en) | 2012-05-14 | 2014-12-10 | Thoratec Corp | Sheath system for catheter pump |
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| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) * | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| RU2715236C2 (ru) | 2014-03-26 | 2020-02-26 | Астекс Терапьютикс Лтд | Комбинации |
| HRP20210319T1 (hr) | 2014-03-26 | 2021-04-30 | Astex Therapeutics Ltd. | Kombinacije inhibitora fgfr i inhibitora igf1r |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| US10363349B2 (en) | 2014-04-15 | 2019-07-30 | Tc1 Llp | Heart pump providing adjustable outflow |
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| TWI719960B (zh) | 2015-02-10 | 2021-03-01 | 英商阿斯迪克治療公司 | 新穎組成物 |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| US11155555B2 (en) | 2015-09-23 | 2021-10-26 | Janssen Pharmaceutica Nv | Compounds |
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| PT3722282T (pt) * | 2017-12-07 | 2024-10-04 | Harbin Zhenbao Pharmaceutical Co Ltd | Forma de sal e forma cristalina que servem como compostos inibidores de fgfr e vegfr, e método de preparação para esse fim |
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