BR112014029709A2 - composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença mediados por uma fgfr cinase - Google Patents
composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença mediados por uma fgfr cinaseInfo
- Publication number
- BR112014029709A2 BR112014029709A2 BR112014029709A BR112014029709A BR112014029709A2 BR 112014029709 A2 BR112014029709 A2 BR 112014029709A2 BR 112014029709 A BR112014029709 A BR 112014029709A BR 112014029709 A BR112014029709 A BR 112014029709A BR 112014029709 A2 BR112014029709 A2 BR 112014029709A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treatment
- prophylaxis
- pharmaceutical composition
- disease state
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Abstract
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261653081P | 2012-05-30 | 2012-05-30 | |
US61/653,081 | 2012-05-30 | ||
GBGB1209613.7A GB201209613D0 (en) | 2012-05-30 | 2012-05-30 | New compounds |
GB1209613.7 | 2012-05-30 | ||
US201361782233P | 2013-03-14 | 2013-03-14 | |
US61/782,233 | 2013-03-14 | ||
PCT/GB2013/051427 WO2013179033A1 (en) | 2012-05-30 | 2013-05-30 | Pteridines as fgfr inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014029709A2 true BR112014029709A2 (pt) | 2017-06-27 |
BR112014029709B1 BR112014029709B1 (pt) | 2022-03-22 |
Family
ID=46546195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014029709-6A BR112014029709B1 (pt) | 2012-05-30 | 2013-05-30 | Composto, composição farmacêutica, combinação, produto, e, uso de um composto |
Country Status (19)
Country | Link |
---|---|
US (2) | US9447098B2 (pt) |
EP (1) | EP2855480B1 (pt) |
JP (1) | JP6363068B2 (pt) |
KR (1) | KR102149759B1 (pt) |
CN (1) | CN104507944B (pt) |
AU (1) | AU2013269316C1 (pt) |
BR (1) | BR112014029709B1 (pt) |
CA (1) | CA2874967C (pt) |
DK (1) | DK2855480T3 (pt) |
ES (1) | ES2739348T3 (pt) |
GB (1) | GB201209613D0 (pt) |
HR (1) | HRP20191202T1 (pt) |
HU (1) | HUE045663T2 (pt) |
IN (1) | IN2014MN02069A (pt) |
LT (1) | LT2855480T (pt) |
MX (1) | MX359418B (pt) |
RU (1) | RU2702906C2 (pt) |
SI (1) | SI2855480T1 (pt) |
WO (1) | WO2013179033A1 (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
JP6980385B2 (ja) | 2014-03-26 | 2021-12-15 | アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited | Fgfr阻害剤とigf1r阻害剤の組合せ |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
HUE053654T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR- és CMET-inhibitorok kombinációi a rák kezelésére |
US10363349B2 (en) | 2014-04-15 | 2019-07-30 | Tc1 Llp | Heart pump providing adjustable outflow |
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JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
KR20180052631A (ko) | 2015-09-23 | 2018-05-18 | 얀센 파마슈티카 엔.브이. | 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도 |
BR112018005637B1 (pt) * | 2015-09-23 | 2023-11-28 | Janssen Pharmaceutica Nv | Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos |
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2012
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JP2015518039A (ja) | 2015-06-25 |
GB201209613D0 (en) | 2012-07-11 |
US9447098B2 (en) | 2016-09-20 |
HUE045663T2 (hu) | 2020-01-28 |
MX359418B (es) | 2018-09-27 |
US20170000796A1 (en) | 2017-01-05 |
CA2874967A1 (en) | 2013-12-05 |
AU2013269316B2 (en) | 2017-10-19 |
CN104507944A (zh) | 2015-04-08 |
EP2855480B1 (en) | 2019-06-26 |
EP2855480A1 (en) | 2015-04-08 |
KR20150016595A (ko) | 2015-02-12 |
AU2013269316C1 (en) | 2018-04-12 |
RU2702906C2 (ru) | 2019-10-14 |
HRP20191202T1 (hr) | 2019-10-18 |
AU2013269316A1 (en) | 2014-10-30 |
MX2014014110A (es) | 2015-06-17 |
US10272087B2 (en) | 2019-04-30 |
DK2855480T3 (da) | 2019-07-22 |
IN2014MN02069A (pt) | 2015-08-21 |
BR112014029709B1 (pt) | 2022-03-22 |
RU2014153050A (ru) | 2016-07-20 |
CN104507944B (zh) | 2017-04-12 |
ES2739348T3 (es) | 2020-01-30 |
SI2855480T1 (sl) | 2019-09-30 |
WO2013179033A1 (en) | 2013-12-05 |
CA2874967C (en) | 2021-11-09 |
US20150291589A1 (en) | 2015-10-15 |
LT2855480T (lt) | 2019-08-12 |
KR102149759B1 (ko) | 2020-08-31 |
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