MX2018001756A - Benzimidazoles sustituidos, su preparacion y su uso como productos farmaceuticos. - Google Patents
Benzimidazoles sustituidos, su preparacion y su uso como productos farmaceuticos.Info
- Publication number
- MX2018001756A MX2018001756A MX2018001756A MX2018001756A MX2018001756A MX 2018001756 A MX2018001756 A MX 2018001756A MX 2018001756 A MX2018001756 A MX 2018001756A MX 2018001756 A MX2018001756 A MX 2018001756A MX 2018001756 A MX2018001756 A MX 2018001756A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted benzimidazoles
- disorders
- pharmaceuticals
- preparation
- treatment
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000001805 Bromodomains Human genes 0.000 abstract 2
- 108050009021 Bromodomains Proteins 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Esta solicitud se relaciona con benzimidazoles sustituidos, las composiciones que los comprenden y sus usos en el tratamiento de enfermedades y condiciones en las cuales se indica la inhibición de un bromodominio. Por ejemplo, la solicitud se relaciona con benzimidazoles sustituidos y con su uso como inhibidores de bromodominio. La presente solicitud también se relaciona con el tratamiento o prevención de trastornos proliferativos, trastornos auto-inmunes, trastornos inflamatorios, trastornos dérmicos, y neoplasmas, entre los que se incluyen tumores y/o cánceres.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562204178P | 2015-08-12 | 2015-08-12 | |
US201662358101P | 2016-07-04 | 2016-07-04 | |
PCT/CA2016/050952 WO2017024412A1 (en) | 2015-08-12 | 2016-08-12 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018001756A true MX2018001756A (es) | 2018-09-06 |
Family
ID=57982882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018001756A MX2018001756A (es) | 2015-08-12 | 2016-08-12 | Benzimidazoles sustituidos, su preparacion y su uso como productos farmaceuticos. |
Country Status (13)
Country | Link |
---|---|
US (2) | US10703740B2 (es) |
EP (1) | EP3334719B1 (es) |
JP (1) | JP6912039B2 (es) |
KR (1) | KR20180039669A (es) |
CN (2) | CN114605387A (es) |
AU (2) | AU2016305515A1 (es) |
BR (1) | BR112018002547A2 (es) |
CA (1) | CA2994478C (es) |
ES (1) | ES2904258T3 (es) |
HK (1) | HK1256752A1 (es) |
IL (1) | IL257340B2 (es) |
MX (1) | MX2018001756A (es) |
WO (1) | WO2017024412A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
GB201617627D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
JP7165501B2 (ja) * | 2017-03-15 | 2022-11-04 | 住友ファーマ株式会社 | 新規ベンズイミダゾール化合物からなる医薬 |
WO2018207882A1 (ja) * | 2017-05-12 | 2018-11-15 | 武田薬品工業株式会社 | 複素環化合物 |
GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
WO2020093162A1 (en) * | 2018-11-07 | 2020-05-14 | Neomed Institute | Treatment of bet inhibitor-resistant cancers and other diseases responsive to dual bet and cbp/ep300 inhibition therapy |
JP2022053557A (ja) * | 2019-02-08 | 2022-04-06 | マルホ株式会社 | ピリドン誘導体 |
CN112174945B (zh) * | 2019-07-02 | 2022-06-07 | 四川大学 | 具有抗癌作用的吲唑类化合物及其制备方法和用途 |
CN115232074A (zh) * | 2022-08-22 | 2022-10-25 | 湖南复瑞生物医药技术有限责任公司 | 一种1-烷基取代-2-甲基-5-溴苯并咪唑的合成方法 |
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GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
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2016
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- 2016-08-12 IL IL257340A patent/IL257340B2/en unknown
- 2016-08-12 CN CN202111621671.6A patent/CN114605387A/zh active Pending
- 2016-08-12 AU AU2016305515A patent/AU2016305515A1/en not_active Abandoned
- 2016-08-12 CN CN201680059249.7A patent/CN108137539B/zh active Active
- 2016-08-12 US US15/751,801 patent/US10703740B2/en active Active
- 2016-08-12 KR KR1020187006581A patent/KR20180039669A/ko not_active Application Discontinuation
- 2016-08-12 EP EP16834372.1A patent/EP3334719B1/en active Active
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2018
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2020
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2021
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AU2021200147B2 (en) | 2022-09-08 |
KR20180039669A (ko) | 2018-04-18 |
IL257340B1 (en) | 2023-06-01 |
JP2018522925A (ja) | 2018-08-16 |
US20180237417A1 (en) | 2018-08-23 |
CN114605387A (zh) | 2022-06-10 |
BR112018002547A2 (pt) | 2018-09-18 |
EP3334719B1 (en) | 2021-09-15 |
AU2021200147A1 (en) | 2021-03-18 |
JP6912039B2 (ja) | 2021-07-28 |
HK1256752A1 (zh) | 2019-10-04 |
US20210107893A1 (en) | 2021-04-15 |
WO2017024412A1 (en) | 2017-02-16 |
US11365186B2 (en) | 2022-06-21 |
IL257340B2 (en) | 2023-10-01 |
ES2904258T3 (es) | 2022-04-04 |
AU2016305515A1 (en) | 2018-03-08 |
CA2994478A1 (en) | 2017-02-16 |
EP3334719A1 (en) | 2018-06-20 |
IL257340A (en) | 2018-03-29 |
US10703740B2 (en) | 2020-07-07 |
EP3334719A4 (en) | 2019-02-06 |
CN108137539A (zh) | 2018-06-08 |
US20230120413A1 (en) | 2023-04-20 |
CA2994478C (en) | 2023-10-03 |
CN108137539B (zh) | 2022-01-11 |
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