KR102136090B1 - The skin cosmetic composition for anti-oxidation and anti-inflammation of skin comprising natural complex extracts - Google Patents

Abstract

The present invention relates to a skin cosmetic composition for skin anti-oxidation and anti-inflammatory, which contains a natural complex extract, and more specifically, a situational mushroom in a complex extract extracted from self-grown, gardenia, kyokyo, county, gosam, hyeonsam, marchi and licorice , Youngji mushroom, chaga mushroom, leafy mushrooms, pine mushrooms, and a skin cosmetic composition for skin anti-oxidation and anti-inflammatory, which contains a complex extract composed of mixed extracts.

Description

The skin cosmetic composition for anti-oxidation and anti-inflammation of skin comprising natural complex extracts}

The present invention relates to a skin cosmetic composition for skin anti-oxidation and anti-inflammatory, which contains a natural complex extract, and more specifically, a situational mushroom in a complex extract extracted from self-grown, gardenia, kyokyo, county, gosam, hyeonsam, marchi and licorice , Youngji mushroom, chaga mushroom, leafy mushrooms, pine mushrooms, and a skin cosmetic composition for skin anti-oxidation and anti-inflammatory, which contains a complex extract composed of mixed extracts.

Cells of the human skin are oxidative stressed by reactive oxygen species generated in a biochemical reaction constantly occurring in order to supply the energy required in the human body to supply the energy required in the living body. , It causes various diseases such as skin cancer by changing oxidative damage and enzyme activity of carbohydrates and DNA, and promotes aging.

In addition, the largest part of the causes of external aging is photoaging due to ultraviolet rays, which causes acute and chronic skin injury such as skin cancer through continuous exposure to UV.

As described above, active oxygen introduced from outside the body or generated in the living body is a cause of many problems such as promoting aging of the living body or generating cancer, and thus development of an antioxidant that suppresses oxidation by free radicals And a lot of research is being done.

Antioxidants are widely distributed in animals and plants, and many phenolic compounds, flavonoids, tocopherols, vitamin C, and selenium are known in fruits and vegetables. However, antioxidants existing in nature are not expected to have a substantially sufficient effect when applied to the skin. Accordingly, although synthetic antioxidants having excellent antioxidant power and low price are frequently used, their use is limited due to safety concerns such as human side effects.

On the other hand, inflammation is an immune response of the human body that responds to wounds and diseases, and oxidative stress, such as ultraviolet rays, free radicals, and free radicals, activates inflammatory factors, causing various diseases and skin aging. Vascularly active polypeptides, such as kinin, plasmin, and complement, act to expand and contract blood vessels and chemotaxis. In addition, lymphokas such as interleukin-6 (IL-6) Phosphorus and arachidonic acid are responsible for the inflammatory response.

Arachidonic acid is metabolized to prostaglandin and leukotriene, which are inflammatory mediators, through two pathways: cyclooxygenase or lipooxygenase.

The anti-inflammatory agent that acts to remove inflammation and reduce bioreactions and symptoms is a non-steroidal substance that has been used for anti-inflammatory purposes so far, such as flufenamic acid, ibuprofen, and benzine. There are benzydamine, indomethacin, and prednisolone and dexamethasone as steroid systems.

In addition, allantoin, azene, hydrocortisone, etc. are known to be effective in anti-inflammatory, but these substances have limitations in the amount of use due to safety problems for the skin, or the effect is insignificant, so that it is not possible to expect an anti-inflammatory effect. There is this.

Accordingly, in order to secure skin safety, recently, skin antioxidant and anti-inflammatory cosmetic compositions containing natural substances have been actively developed. Representatively, the peel was removed in Korean Patent Registration No. 10-1490762 (Registration Date 02/02/2015) Antioxidant cosmetic compositions containing an okra polysaccharide extracted from mature okra (Hibiscus esculentus) fruit as an active ingredient are known.

In addition, in Korean Patent Publication No. 10-2015-0118293 (published on October 22, 2015), cosmetic compositions for antioxidant, anti-wrinkle, anti-inflammatory and whitening consisting of mixed extracts of licorice, Angelica, and ginseng are known.

In addition, in the Korean Patent Registration No. 10-1848250 (date of registration April 6, 2018) (a) drying and crushing the bamboo leaves to prepare a bamboo leaf powder; (B) dissolving the bamboo leaf powder prepared in step (a) in water, and adding a carbohydrate hydrolase or pectin hydrolase to hydrolyze; (c) treating 100% ethanol to the hydrolyzate of step (b); And (d) homogenizing the hydrolyzate treated with ethanol in the step (c) under a high pressure of 100 to 120 MPa; an anti-inflammatory and skin whitening cosmetic comprising the bamboo leaf extract prepared by the method as an active ingredient. Compositions are known.

In addition, Korean Registered Patent 10-1758338 (Registration Date July 10, 2017) eliminates reactive oxygen species (ROS) and contains 1-4 mg/mL of aloe flower extract as an active ingredient, dermatitis, atopy , Hepatitis, diabetes, skin sclerosis, degenerative neurological diseases, atherosclerosis and ischemia is known to prevent or treat at least one disease selected from the group consisting of active oxygen suppression composition.

However, although the skin cosmetic compositions contain natural substances and exhibit anti-oxidative or anti-inflammatory effects, most of them use a single natural substance or some auxiliary natural substances, and thus there are problems in that the antioxidant and anti-inflammatory effects are uniform and unsatisfactory.

As a result, the present inventors tried to solve the above problems, as a result of extracting from the extracts of jachom, gardenia, kyokyo, baekjak, gosam, hyeonsam, machihyeon, and licorice, medicinal mushrooms, yeongji mushrooms, chaga mushrooms, leaf mushrooms, flower mushrooms A natural skin extract formulated by mixing has an antioxidant effect, has excellent anti-inflammatory effect, has developed a new skin cosmetic composition with less human side effects and completed the present invention.

[Patent Document 1] Korean Registered Patent 10-1490762 (Registration Date 02/02/2015) [Patent Document 2] Korean Patent Publication No. 10-2015-0118293 (published on October 22, 2015) [Patent Document 3] Korean Registered Patent 10-1848250 (Registration Date April 6, 2018) [Patent Document 4] Korean Patent Registration No. 10-1758338 (Registration Date July 10, 2017)

In order to solve the above problems, the present invention is a mixture of Jachu, gardenia, yeonkyo, baekjak, gosam, hyeonsam, machihyeon and licorice, mixed with medicinal mushrooms, ganoderma mushrooms, chaga mushrooms, leafy mushrooms, blossom mushrooms It is an object to solve the problem of providing a skin cosmetic composition for skin anti-oxidation and anti-inflammatory that contains a natural complex extract having an anti-oxidant effect and having excellent anti-inflammatory effect and less human side effects.

In order to solve the above problems, the present invention is a mixture of Jachu, gardenia, kyokyo, baekjak, gosam, hyeonsam, machihyeon and licorice, mixed with medicinal mushrooms, yeongji mushrooms, chaga mushrooms, leafy mushrooms, blossom mushrooms A skin cosmetic composition for skin anti-oxidation and skin anti-inflammatory, which contains the composition of the natural complex extract, is used as a solution to the problem.

The anti-inflammatory extracts extracted from the self-grown, gardenia, kyokyo, county medicinal, high ginseng, hyeonsam, marchi and licorice crush each material finely, and then mix each crushed material in the same weight ratio, and 5 times the volume ratio of ethanol aqueous solution compared to the mixture (Ethanol: water = 7: 3 volume ratio) was added and extracted for 8 hours at 40°C using a cryogenic pressure extractor, and then filtered to recover the extract.

The above situation mushrooms, youngji mushrooms, chaga mushrooms, leafy mushrooms, and oyster mushroom extracts, after crushing each material finely, add ethanol to the crushed material and extract for 4 hours at 40°C using a cryogenic pressure extractor, then filter and extract. To recover, and obtained by distillation under reduced pressure using a ratary evaporator as a solution to the problem.

The skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract is a lotion, gel, water-soluble liquid, cream, essence, oil-in-water or water-in-oil makeup base, foundation, skin cover, face powder, and two-way cake One formulation selected from the group consisting is used as a solution to the problem.

The skin cosmetic composition for skin antioxidant and skin anti-inflammatory, which contains the natural complex extract of the present invention, is a compound extract extracted from self-grown, gardenia, yeongyo, county medicinal, red ginseng, hyeonsam, marchi and licorice mushrooms, oyster mushroom, chaga mushroom, It is composed of a mixture of leaf mushrooms and zinnia mushroom extracts, has an antioxidant effect, has excellent anti-inflammatory effects, and has excellent human side effects.

The present invention, natural complex extracts prepared by mixing a mixture of medicinal mushrooms, young mushrooms, chaga mushrooms, leafy mushrooms, matsutake mushrooms, and mixed extracts extracted from self-grown, gardenia, lotus, county medicinal, high ginseng, hyeonsam, and licorice The skin cosmetic composition for skin anti-oxidation and skin anti-inflammatory containing is characterized by the technical composition.

The anti-inflammatory extracts extracted from the self-grown, gardenia, kyokyo, county medicinal, high ginseng, hyeonsam, marchi and licorice crush each material finely, and then mix each crushed material in the same weight ratio, and 5 times the volume ratio of ethanol aqueous solution compared to the mixture (Ethanol: water = 7: 3 volume ratio) was added and extracted for 8 hours at 40°C using a cryogenic pressure extractor, and then filtered to recover the extract.

The above situation mushrooms, youngji mushrooms, chaga mushrooms, leafy mushrooms, and oyster mushroom extracts, after crushing each material finely, add ethanol to the crushed material and extract for 4 hours at 40°C using a cryogenic pressure extractor, then filter and extract. It is recovered, and obtained by distillation under reduced pressure using a ratary evaporator is characterized by a technical configuration.

The skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract is a lotion, gel, water-soluble liquid, cream, essence, oil-in-water or water-in-oil makeup base, foundation, skin cover, face powder, and two-way cake One formulation selected from the group consisting of features of the technical configuration.

Hereinafter, it will be described in detail through the embodiments of the present invention so that those skilled in the art to which the present invention pertains can easily practice. However, the present invention may be implemented in various different forms, and is not limited to the embodiments and drawings described herein.

First, the skin cosmetic composition for skin antioxidant and skin anti-inflammatory, which contains the natural complex extract of the present invention, is a situation extract, ginji mushroom, chaga on a complex extract extracted from self-grown, gardenia, yeonkyo, county medicinal, ginseng, hyeonsam, marchi and licorice It is composed by mixing mushrooms, leafy mushrooms, and mushrooms.

Jacho (scientific name: Lithospermum erythrorhizon) is a perennial plant of the branch of the Mole family of calliflora, also known as Jicho. It is 30~70cm high, and the roots are deep in the ground and are thick and purple. Stems or leaves have coarse hair. The leaves are alternately without peduncles and are lanceolate, 3~7cm long, 1~2cm wide, with 2~3 side veins distinct. Flowers bloom white in May-June and run in water. The bract is leaf-shaped, and the calyx fragment is 5, wide and linear, longer than the corolla. The corolla has 5 ends, which are shallowly split and spread almost horizontally. There are 5 stamens and 1 pistil, and the ovary has a cross-shaped groove. The fruit is a grayish-white branch and glossy. Dried roots of Chichi are called Jageun, and they are used in Chinese medicine for detoxification, fever, swelling, burns, frostbite, eczema, and blisters. In the private sector, it is used as a fire medicine. In the old days, it was used as a purple dye or food coloring. It grows on dry grass or in mountainous areas. It is known to be distributed across Korea, Japan and China's Dongbei region. In particular, the self-growth contains ingredients such as shikonin and acetyl shikonin, which are polysaccharides, resource permanents, and has various functions such as promoting blood circulation, detoxification, antibacterial and anti-inflammatory properties, resulting in boils and burns. , It is known as an herbal medicine used to treat eczema. In addition, it has a very strong collagen synthesis promoting effect, so the skin wrinkle improvement effect is excellent.

In addition, Gardenia (Gardenia jasminoides) is a tropical plant and subtropical plant that is also grown in Okinawa, China, and Taiwan, Japan. It is a broad-leaved broad-leaved shrub of the family Rubiaceae. It blooms and smells white in summer. Its fruit is an oval with an angled shape, and has the shape of an old liquor complex. The name gardenia comes from the shape of the liquor complex. In addition, gardenia is also used as a medicinal herb, the main component is genipin, and the yellow component of the fruit is crocin. Gardenia fruit contains saponin and crosine, and is known to have an effect of promoting appetite as well as fatigue recovery, dry stomach, diuresis, formal wear, and antipyretic. When a nosebleed is burned, it is effective for hemostasis by burning a gardenia fruit, and it has an effect of biliary tract, sedation, blood pressure control, and cancer cell suppression. In particular, gardenia contains iridoid glycosides such as genipin, geniposide, and gardenoside, components such as crocin, crocetin, and gardanine ( It contains flavonoids of gardanin and choline, ursolic acid, etc., which is effective for heat and detoxification.

Lotus (Forsythia viridissima) is a fruit of the Forsythia viridissima L belonging to the family Oleaceae, and is used as an anti-inflammatory and drainage skin disease agent in oriental medicine. The medicinal ingredients of yeonkyo are known as actininin as lignan, actinin as lignan glycoside, and caffeic acid glycoside, and swelling, gonorrhea, tuberculosis, diuresis, hemorrhoids, tuberculosis, and dysfunction in oriental medicine and the private sector. , Scabies, is widely used as a detoxification treatment. The effect of yeonkyo is to detoxify and detoxify heat, to remove wind fever, to make boils or wounds swollen, or to boil or clump, so it has the effect of boil-off. Therefore, by lowering the heat in the early stage of fever, it can be used to calm down high fever and mental confusion, or to be used for boils, lymphadenitis, and sore throat. It is a medicine that can be used in Soyangin in thought medicine.

In particular, yeonkyo has been used as an anti-inflammatory and drainage skin disease agent in oriental medicine, and as an inhibitor of tyrosinase, it has the effect of inhibiting melanin synthesis and the melanin metabolic pathway caused by α-melanosite stimulating hormone (α-MSH). It has attracted attention as a whitening cosmetic material because it has the effect of controlling the production of melanin by acting. In addition, the bridge contains matairesinol, actigenin, or a mixture thereof, and matairesinol is known to have a collagen synthesis effect. In the present invention, an antioxidant, skin cell proliferation related to skin wrinkle improvement of the bridge extract, Used to take advantage of collagen synthesis and collagenase inhibitory effects.

Peony (Paeonia japonica (Makino) Miyabe & Takeda) is a perennial perennial plant belonging to the family Ranunculaceae, also known as the hammock flower, and its scientific name is Paeonia lactiflora Pall. It is the most widely used medicinal crop after ginseng and Angelica in Korea, and is widely used as a raw material for herbal medicines such as saffron, ssanghwatang, and samultang. Roots have been prescribed for the purpose of inflammation, analgesic and antispasmodic in the oriental medicine, mainly for the control of amenorrhea, trauma treatment, non-bleeding, inflammation, boils and wounds, and pain relief for chest and ribs. The physiologically active components of the roots were separated from mototerpine glucoside compounds, including pheoniflorin and albiflorin, and several phenolic compounds, and the chemical structure was reported.( Sejong Kim et al., Separation and identification of physiologically active substances from peony leaves and stems, Korean Society of Medicinal Crop Science 15(1), 6-11, 2007)

In addition, ginseng is a perennial plant belonging to the family Rosaceae, and is widely distributed in Asia and has been widely used in various medicines. Gosam has a very bitter taste, and it is known that it is rich in natural antibiotic ingredients that are harmless to the human body and has considerable efficacy in treating indigestion and pain caused by bacterial infection. In addition, in addition to the effect of lowering blood sugar, high ginseng has the effect of increasing coronary blood flow and strengthening the heart muscle, and it has a good effect of healing dermatitis of the scalp, and shampoo products using high ginseng ingredients are also being released.

According to reports related to the mechanism of inhibition of inflammatory response by ginseng, it is known that HMC-1 cells inhibit the production of inflammatory cytokines through inhibition of NF-κB/IκB mechanism (Toxicology in Vitro 23:251-258, 2009), B In the present invention, since it is known that the NF-κB/I κB mechanism inhibits inflammation and inhibits inflammation (International Immunopharmacology 15:467-473, 2013), it can be seen that high ginseng is involved in the anti-inflammatory reaction. Used as a powerful anti-inflammatory extract raw material.

Hyeonsam is a perennial herb with Hyeonsam, the stem of which is hairy, and the leaves are narrow and long. The flowers are light yellow-green, bloom in August-September, and the roots are lumps that turn white or black when cut. Hyunsam is a succinct herb that dries up the stems on the ground during the winter, lives only on the roots, and then sprouts again in the following spring. In oriental medicine, the root is used as a medicine. Hyunsam loves humid places with a mild climate and is resistant to cold. It is distributed in Korea, China, and Japan, and is produced a lot in Gyeongbuk Province in Korea. It is also referred to as jungtai, heavy horse, hyeontai, ear, ox horse, raw ginseng, polish, or black ginseng. The main ingredients include scoroladine, phytosterol, phytosterine, and other sugars, essential oils, and fatty acids. Hyunsam ginseng reduces heat, strengthens heart function, and prevents inflammation. It is used for sore throat, tonsillitis, conjunctivitis, lymphadenitis, and is effective in various high fever diseases. The main effects in oriental medicine include consonants, fortification, burnout, detoxification, yanghyeol, saengjin, sewage, and nominal ), noonjang (定五臟), bosimshim (이心血), inhu (후), Tongsobyeon (通小便), bovine poison (消腫毒), longevity shoes (壯水制火), bokbok (久)服), Bohe (등), etc.

Machi Prefecture is an annual weed, hairless, 30 centimeters high, brownish red, with many branches, spreading obliquely to the side, and the roots are white, but when peeled by hand, they become red like a main stem. The leaves are coarse or coarse, but at the end, they appear to be aquatic. They are metrological beans and narrow at the bottom, forming short leaves, 15 to 25 millimeters long and 5 to 15 millimeters long, with a flat edge. The flowers are positive and continue to bloom from June to autumn and are yellow and hang at the ends of branches. There are 2 calyxes, oval, 5 petals, and omelet. There are 7 to 12 stamens, one pistil, neutral torso and 5 pistils. The fruit is oval and the central part is split sideways, resulting in many seeds with long stems. Seeds are crushed, round, black in color, slightly rounded at the edges. In the West, salads are made with lettuce, and in Korea, the soft parts are used as herbs, and the outpost is used to relieve toxins of insects and snakes, or as a disease and diuretic (Korean Plant Book, Lee Chang-bok, p324, 1993). In particular, since the anti-inflammatory effect on Machihyeon is described as having an excellent effect on anti-inflammatory and anti-irritant properties when it contains 0.001 to 30.0 wt% in Korean Patent Application Publication No. 2000-0032674, the present invention has anti-inflammatory and anti-irritant effects on skin. It is used as a raw material.

Licorice is a perennial herb belonging to the family Leguminosae, and its scientific name is Glycyrrhiza uralensis Fisch. It contains glycyrrhizin, a sweet ingredient, and is used as a sweetener, and is known for its therapeutic effect, antibacterial action, and excellent antioxidant ability against various diseases. It uses root as a medicine, and is known to act on the heart, lungs, and gastric veins, and is known to be effective for masturbation, wetness, and swelling. It is also known for pain relief, weight gain, white blood cell increase, diuretic action, and anti-inflammatory action due to sudden tension of muscles and tissues.(Bacchuza, antibacterial and antioxidant activity of licorice and spice water extracts, Korean Journal of Food and Cookery Science 23(6 ),793-799, 2007). In particular, licorice facilitates the regeneration and metabolism of cells, so it has the effect of refreshing and brightening the tired and dull skin caused by trouble.

As described above, anti-inflammatory extracts extracted from self-grown, gardenia, yeonkyo, county medicinal, high ginseng, hyeonsam, marchi and licorice are finely crushed for each material, and then mixed with each crushed material in the same weight ratio, 5 times the volume ratio of the mixture The ethanol aqueous solution of (ethanol: water = 7: 3 volume ratio) was added to the extract for 8 hours at 40°C using a cryogenic pressure extractor, and then the filter was used to recover the extract. The reason for using each material in the same weight ratio It is to evenly show the efficacy of the ingredients of each material.

On the other hand, in general, mushrooms have more than 90% moisture, and the remaining 10% are composed of protein (2-3%), fat, sugar, and minerals. It is considered as a very good food for diet and prevention of adult diseases because it has little calories and is high in protein.

Mushrooms are rich in vitamins and minerals, and vitamins B2, niacin, and provitamin D are many. Vitamin B2 is an important substance for metabolism of fat, protein, and sugar, and is an essential substance for promoting growth. On the dermatological side, niacin prevents dermatitis, and provitamin D changes its intake to vitamin D in the body. Vitamin D is essential for preventing skin cancer, making bone tissue, preventing osteoporosis, and is essential for the development of bones and teeth in infants.

Potassium is the most mineral, and potassium is excellent in preventing hypertension because sodium, which causes blood pressure to rise, falls out of the body. In addition, there are a lot of phosphorus in minerals, which act as an important component of bones and teeth.

Among the above mushrooms, Phellinus linteus (Ikekawa, T,: Antitumor action of some basidiemycetes, especially Phellinus Linteus GANN, 59: 155,l968)] has been introduced to parasites on mulberry trees in China since ancient times, but has been investigated in Korea. According to them, wild can also be seen in broad-leaved trees (Cha Dong-ryul, monthly jam p34-37,9512). In Korea, the situation mushroom refers to the phellinus linteus and belongs to the pine scales (Hymenochaetaceae).

About 48 species are reported worldwide in the mud mushrooms belonging to the genus Mushroom, but rusty mud mushrooms (P. ferruginosus), dried mud mushrooms (P. gilvus), horseshit mud mushrooms (P. igniarius), eggplant mud mushrooms Eight species were collected from P. laevigatus, P. pomaceus, P. robustus, fir mud, and deciduous mud (P. pini).

Mushrooms belonging to these mud mushrooms have been used as treatments for women's diseases such as uterine bleeding and dysmenorrhea, under the names of differentiation, streptococcus, and hawthorn. According to various researchers, it is known that the tumor inhibition rate in animal experiments is 60-97%, which is excellent. Cancer treatment effect Adult disease treatment Immune function enhancement Long-term activity Active anti-cancer effect is excellent, vitamin C is abundant, and whitening efficacy This is excellent and has the effect of suppressing the generation of blemishes, so the present invention uses a mixture of shiitake mushrooms for this purpose.

Yeongji mushroom (scientific name Ganodema lucidum (Fr) Karst) is a perennial mushroom belonging to the polyporaceae family.It is a medicine on the main tree and the new plant of Yi Shijin, the best herb in China more than 2,000 years ago. It is said to be effective in treating arthritis, relieving, and bronchitis. Since oriental medicine exhibits pharmacological effects such as nourishment tonicity, detoxification, droplets, and reduction of blood lipids, it has been used in combination with other herbal medicines such as atherosclerosis, hypertension, stroke, angina, various cancers, myasthenia gravis, and chronic bronchitis.

According to the research paper on the medical efficacy of the ganoderma mushroom, the anti-cancer effect, immuno-promoting effect as well as the wound healing effect (Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes Tie L, Yang HQ, An Y , Liu SQ, Han J, Xu Y, Hu M, Li WD, Chen AF, Lin ZB, Li XJ Cell Physiol Biochem 2012;29(3-4):583-94 Epub 2012 Apr 3) It has also been reported to have a potentiating effect (Eur Rev Med Pharmacol Sci 2012 Feb;16(2):166-75 Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats Teng BS, Wang CD, Zhang D , Wu JS, Pan D, Pan LF, Yang HJ, Zhou P)

In particular, Youngji mushroom is high in amino acids, water-soluble proteins, steroids, alkaloids, and vitamins, so it does not age and is used for the treatment of central nervous system, hemolytic anemia, arteriosclerosis, thyroid gland, and improving the blood circulation of the skin. Since it has the effect of moisturizing the skin by supplying nutrition, in the present invention, the Youngji mushroom extract is used for this purpose.

Chaga (Scientific name: Inonotus-obliquus or Fuscoporia obliqua) is a cold-resistant mushroom of the genus Fuscoporia-SPP, the closest lineage of the Hymenochaetaceae family and the Mucropor eceae family. Acids, hormones, phenol groups, polyphenols, oxyphenol carboxylic acids, phenols, chaga acids (60%), 6-8 polysaccharides, lactic acid, lignin, magnesium, etc., other oxides of aluminum, iron, silicon, Contains calcium, cupric oxide, manganese, zinc and sodium.

The chaga mushroom has a black color, and it usually takes 10 to 15 years to be 40 cm long, 15 cm circumference, and 5 kg in weight. The junction of the chaga mushroom has a soft bright color and is a cold-resistant mushroom found mainly in cold and deep cold regions north of 45 degrees north latitude. It has been found on the planet in Ukraine, Siberia, Russia, and Kamchatka. It is known as a peninsula, a coastal region, some parts of Mongolia, some parts of Heilongjiang Province in China, Norway, Finland, Sweden, and the northern regions of Hokkaido in Japan, but is rarely found in Korea, and is also found in Canada, the United States, and the northeastern United States. Examples have been reported. In addition, chaga germinates when the spores penetrated through the wounded part of the living birch have the proper temperature, moisture, and acidity, and the mycelium grows. When the mycelium growing inside the birch grows to a certain size, it destroys the bark and goes out. It comes out, and this part is called a nucleus. The above-mentioned nucleus part is generally called chaga, and in the fruiting body of the bark part where the nucleus is formed, spores are formed and reproduce and grow until the tree dies.

Chaga mushroom has excellent anti-cancer effect, and has anti-HIV action by water-soluble lignin and inhibitory effect on influenza virus proliferation due to diabetes treatment, anti-oxidation, and immune-enhancing functions.

In particular, since chaga mushroom is known to have an effect of promoting the activity of fibroblasts and promotes the production of elastin, which is known to have an excellent effect on skin elasticity recovery, the present invention uses a mixture of chaga mushroom for this purpose.

Leafy mushrooms (Grifola frondosa Fr) are taxonomically belong to the genus Aphllophorales, Polyporaceae, and Grifola. Mycelia of leafy mushrooms include fever, edema, and antitumor. It has medicinal properties and is used as a medicinal herb. Among the edible mushrooms, leafy mushrooms are rich in flavor ingredients, as well as ingredients necessary for physiological control of the body, such as sugars, proteins, fatty acids, organic acids, amino acids, nucleic acids, enzymes, and inorganic salts. As it has excellent taste and form, it is regarded as one of the fine mushrooms useful as food.

In addition, the chemical structure of beta glucan, a major polysaccharide of leafy mushrooms, is reported to be the most potent component that stimulates the immune response of cells, unlike the structure of beta glucan found in other medicinal mushrooms (Chem Pharm Bull, 34(4), 1709-1715, Nippon Shokuhin Kogyo Gakkaishi, 41(10), 733-740)

In addition, leafy mushrooms are known to have anti-cancer effects, as well as blood pressure lowering, diabetes, obesity treatment, blood cholesterol reduction, antibacterial, diuretic, tonic, anti-anemia, and pulmonary tuberculosis treatments (Critical Review in Immunology, 19, 65-96)

In particular, leafy mushrooms are rich in heteroglucan, peptide glucan, and niacin, and thus have excellent effects on anti-diabetes, breast cancer, and lung cancer, and peptide glucan has the effect of inhibiting wrinkles by promoting collagen synthesis. Mix mushroom extracts.

Blossom Mushroom (Sparassis crispa) is a mushroom of the genus genus Dermatophyte, and the fruiting body of the mushroom has a size of 5~20cm or more, and each branch is fleshy and white with a wavy flower shape, between summer and autumn In the near roots of living trees, dead trunks, stumps, etc., come out and live a by-product.

Blossom mushroom is one of the parasitic mushrooms in coniferous forests in Korea, and is a high-temperature mushroom that grows mainly from pine trees, pine trees, larch trees, and fir trees between May and August. In the beginning, it was known as a fungus that grows on the roots of coniferous trees and decreases the value of wood, and in 1997, a Japanese high school teacher, Fukushima, developed a sawdust bottle cultivation method, and interest in medicinal value began to develop. The main production areas are Paju, Yeoncheon, and Uiwang, Gyeonggi-do in Korea, and Japan, China, Europe, and the Americas. It was confirmed that it contains a large amount of beta-glucan (β-glucan), which is a major ingredient, and has attracted attention worldwide, and also contains vitamin D and vitamin B2. Blossom mushrooms are used for food because they have a firm texture and a good texture, and are widely used for medicinal purposes because they are recognized for their various functions. Currently, most of them are produced indoors through artificial cultivation.

In particular, zinnia mushroom contains a large amount of beta-glucan, so it is regarded as the best luxury mushroom for health promotion and is known for its excellent moisturizing dermatological effect. Therefore, the present invention uses leaf mushroom extract for mixing.

After extracting the above-mentioned situational mushrooms, reishi mushrooms, chaga mushrooms, leafy mushrooms, and zinnia mushrooms, finely crush each material, add ethanol to the crushed material, extract for 4 hours at 40°C using a cryogenic pressure extractor, and then filter The extract was recovered by distillation under reduced pressure using a ratary evaporator.

The skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract is a lotion, gel, water-soluble liquid, cream, essence, oil-in-water or water-in-oil makeup base, foundation, skin cover, face powder, and two-way cake Of course, it can be prepared in one formulation selected from the group consisting of.

[Preparation of skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract of the present invention]

After washing self-grown, gardenia, yeonkyo, county medicinal, goinseng, hyeonsam, marchi and licorice, each weighed 50g, dried to less than 10% moisture content, and then shred the dried raw materials to the size of 1 to 3 cm, and mix them. Did. To the mixture, 5 times the volume of ethanol aqueous solution (ethanol: water = 7: 3 volume ratio) was added, and the mixture was extracted at 40°C for 8 hours using a cryogenic pressure extractor. The extract was passed through a filter paper (Adventec Noe) to remove the residue, and the extract was recovered to prepare a complex extract.

Next, after crushing each of 100g of situation mushrooms, 100g of ganoderma mushrooms, 100g of chaga mushrooms, 100g of leaf mushrooms, and 100g of mushrooms, respectively, add 1 liter of ethanol to the crushed material and use a cryogenic extractor for 4 hours at 40℃. After extraction, the extract was recovered by filtering, and distilled under reduced pressure using a ratary evaporator to prepare a complex extract.

The above-mentioned prepared self-extracting, gardenia, yeongyo, county medicinal, high ginseng, hyeonsam, marzipan and licorice extracts and circumference mushrooms, youngji mushrooms, chaga mushrooms, leafy mushrooms, oyster mushroom complex extracts are mixed in a 1:1 weight ratio and 5 times Diluted with purified water to prepare a cosmetic composition of the present invention.

[Measurement of antioxidant effect of skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract of the present invention]

In order to measure the antioxidant effect of the skin cosmetic composition prepared in [Example 1], a free radical scavenging activity test was performed. Specifically, three tubes containing 1 ml of 02 mM DPPH (1,1-diphenyl-2-picryhydrazyl, Sigma) solution were prepared. One tube was added with purified water as a control, and the other two tubes were each added with a situation mushroom extract prepared according to the above method and a skin cosmetic composition of the present invention as an experimental group. Then, after leaving the three tubes at room temperature for 10 minutes, the absorbance was measured at 525 nm with respect to the three tubes, and then the free radical elimination rate of the experimental group was calculated using the equation. The results are shown in the following [Table 1].

Free radical scavenging rate (%)=[100-{(absorbance of the experimental group-absorbance of the control group)/absorbance of the control group}×100]

Experimental group Free radical scavenging rate (%) Phellinus linteus extract 32.8 Skin cosmetic composition of the present invention 42.3

As shown in [Table 1], since the skin cosmetic composition of the present invention exhibits a free radical scavenging rate of about 30% or more than the situation mushroom extract, from this, the skin cosmetic composition of the present invention has much more antioxidant effect than the situation mushroom extract. Know the excellence

[Measurement of anti-inflammatory effect of skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract of the present invention]

In order to confirm the skin trouble relieving function of the anti-inflammatory effect of the skin cosmetic composition of the present invention prepared in [Example 1], a PGE2 production inhibitory effect test was performed. (Jeffrey, KH, Anglea, SW, Zoe, S, and Rhia CM, Intracellular Measurement of Prostaglandin E2: Effect of antiinflammatory drugs on cyclooxygenase activity and prostanoid expression, Analytical Biochemistry, 1999, 271, 18-28). After macrophages RAW 264.7 cells were passaged several times, 1 x 10 ⁵ cells were placed in 24-well plates and cultured for 24 hours in a 5% CO2 thermostat. Thereafter, the medium was removed and treated with a new medium containing 50 µg of the skin cosmetic composition of [Example 1] prepared at a 10-fold concentration (1 mg/ml) and 450 µg of LPS (1 µg/ml) at the same time. Cultured under the same conditions. After 24 hours, in order to measure PGE2, the culture medium was centrifuged (12,000 rpm, 3 min) to obtain a supernatant. The measurement of PGE2 was determined by enzymatic immunoassay (Enzyme-Linked Immunosorbent Assay, ELISA) to determine the prostaglandin inhibitory effect of herbal extracts and the results are shown in [Table 2].

sample Inhibition rate (%) Skin cosmetic composition of the present invention 80.2

As shown in [Table 1], it can be seen that the skin cosmetic composition of the present invention exhibits a very strong prostaglandin (PGE2) inhibition rate and thus has excellent anti-inflammatory efficacy.

The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and variations without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical spirit of the present invention, but to explain, and the scope of the technical spirit of the present invention is not limited by these embodiments. The scope of protection of the present invention should be interpreted by the claims below, and all technical spirits within the scope equivalent thereto should be interpreted as being included in the scope of the present invention.

Claims (4)

Contains natural extracts that are made by mixing the complex extracts extracted from Jacho, Gardenia, Lotus, Count, Orchid, Hyunsam, Machihyeon, and Licorice, mixed extracts from Phellinus linteus, Youngji mushroom, Chaga mushroom, Leafy mushroom and Blossom mushroom Ha,
The complex extracts extracted from the self-grown, gardenia, kyokyo, county medicinal, gosam, hyeonsam, machihyeon and licorice, finely pulverize each material, mix each crushed material in the same weight ratio, and 5 times the volume ratio of ethanol aqueous solution compared to the mixture (Ethanol: water = 7: 3 volume ratio) was added and extracted for 8 hours at 40°C using a cryogenic pressure extractor, and then the extract was recovered by filtering.
The composite extracts extracted from the above situation mushrooms, ganoderma mushrooms, chaga mushrooms, leafy mushrooms, and matsutake mushrooms are finely pulverized, then ethanol is added to the crushed materials and extracted for 4 hours at 40°C using an ultra-low temperature extractor. , Skin extract composition for skin antioxidant and skin anti-inflammatory containing natural extract, characterized in that obtained by distillation under reduced pressure using a rotary evaporator to recover the extract by filtering.
delete delete According to claim 1,
The skin cosmetic composition for skin antioxidant and skin anti-inflammatory containing the natural complex extract is a lotion, gel, water-soluble liquid, cream, essence, oil-in-water or water-in-oil makeup base, foundation, skin cover, face powder, and two-way cake A skin cosmetic composition for skin antioxidant and skin anti-inflammatory, containing a natural complex extract, characterized in that it is one formulation selected from the group consisting of.