KR102046235B1 - Pd-1 축 결합 길항제 및 항-gpc3 항체를 사용하여 암을 치료하는 방법 - Google Patents

Pd-1 축 결합 길항제 및 항-gpc3 항체를 사용하여 암을 치료하는 방법 Download PDF

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KR102046235B1
KR102046235B1 KR1020177016450A KR20177016450A KR102046235B1 KR 102046235 B1 KR102046235 B1 KR 102046235B1 KR 1020177016450 A KR1020177016450 A KR 1020177016450A KR 20177016450 A KR20177016450 A KR 20177016450A KR 102046235 B1 KR102046235 B1 KR 102046235B1
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hvr
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미카 엔도
아쓰히코 가토
도시히코 오토모
겐지 아다치
야스코 기노시타
요시노리 나리타
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추가이 세이야쿠 가부시키가이샤
제넨테크, 인크.
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303Liver or Pancreas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
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    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020177016450A 2016-03-15 2017-03-14 Pd-1 축 결합 길항제 및 항-gpc3 항체를 사용하여 암을 치료하는 방법 Active KR102046235B1 (ko)

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JPJP-P-2016-051424 2016-03-15
JP2016051424 2016-03-15
PCT/JP2017/010267 WO2017159699A1 (en) 2016-03-15 2017-03-14 Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies

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KR20180120063A KR20180120063A (ko) 2018-11-05
KR102046235B1 true KR102046235B1 (ko) 2019-11-18

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US (1) US11767362B1 (enExample)
EP (2) EP3430054B1 (enExample)
JP (3) JP6430025B2 (enExample)
KR (1) KR102046235B1 (enExample)
CN (2) CN109153719B (enExample)
AU (1) AU2017235097B2 (enExample)
BR (1) BR112018067923A2 (enExample)
ES (1) ES2904286T3 (enExample)
IL (1) IL261781A (enExample)
MX (1) MX2018010546A (enExample)
PL (1) PL3430054T3 (enExample)
TW (2) TW202248213A (enExample)
WO (1) WO2017159699A1 (enExample)

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WO2017159699A1 (en) 2016-03-15 2017-09-21 Chugai Seiyaku Kabushiki Kaisha Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies
WO2019059411A1 (en) * 2017-09-20 2019-03-28 Chugai Seiyaku Kabushiki Kaisha DOSAGE FOR POLYTHERAPY USING PD-1 AXIS BINDING ANTAGONISTS AND GPC3 TARGETING AGENT
CN111278497B (zh) 2017-11-28 2024-01-12 圣犹达医疗用品心脏病学部门有限公司 管腔控制导管
EP4230165A1 (en) 2018-05-21 2023-08-23 St. Jude Medical, Cardiology Division, Inc. Radio-frequency ablation and direct current electroporation catheters
CA3136510A1 (en) * 2019-04-11 2020-10-15 Bayer Aktiengesellschaft Combinations of anti-ildr2 antibodies and pd-1 antagonists
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
WO2021152495A1 (en) * 2020-01-28 2021-08-05 Glaxosmithkline Intellectual Property Development Limited Combination treatments and uses and methods thereof
WO2021213245A1 (zh) * 2020-04-20 2021-10-28 上海翰森生物医药科技有限公司 抗体或其抗原结合片段、其制备方法及医药用途
EP4146702A4 (en) * 2020-05-07 2024-07-10 Phanes Therapeutics, Inc. Anti-tumor associated antigen antibodies and uses thereof
CN115942915B (zh) 2020-08-18 2025-11-28 圣犹达医疗用品心脏病学部门有限公司 具有磁性位置跟踪的高密度电极导管
AU2022237618A1 (en) 2021-03-17 2023-10-12 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
AU2022326107A1 (en) * 2021-08-12 2024-03-14 Shanghai Ttm-Bio Technology Co., Ltd. Bispecific recombinant protein and use thereof
CN118488970A (zh) * 2021-10-15 2024-08-13 乐普创一生物科技(上海)有限公司 抗磷脂酰肌醇蛋白聚糖3抗体
WO2023092099A1 (en) * 2021-11-19 2023-05-25 Ardeagen Corporation Gpc3 binding agents, conjugates thereof and methods of using the same
WO2025103451A1 (zh) * 2023-11-15 2025-05-22 上海盛迪医药有限公司 Trgv9结合蛋白及其医药用途

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