IL261781A - Combinations of anti-gpc3 antibodies and antagonists that bind to the pd-1 axis for use in the treatment of cancers - Google Patents

Combinations of anti-gpc3 antibodies and antagonists that bind to the pd-1 axis for use in the treatment of cancers

Info

Publication number
IL261781A
IL261781A IL261781A IL26178118A IL261781A IL 261781 A IL261781 A IL 261781A IL 261781 A IL261781 A IL 261781A IL 26178118 A IL26178118 A IL 26178118A IL 261781 A IL261781 A IL 261781A
Authority
IL
Israel
Prior art keywords
axis binding
treating cancers
binding antagonists
gpc3 antibodies
combinations
Prior art date
Application number
IL261781A
Other languages
English (en)
Hebrew (he)
Original Assignee
Genentech Inc
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Chugai Pharmaceutical Co Ltd filed Critical Genentech Inc
Publication of IL261781A publication Critical patent/IL261781A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL261781A 2016-03-15 2018-09-13 Combinations of anti-gpc3 antibodies and antagonists that bind to the pd-1 axis for use in the treatment of cancers IL261781A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016051424 2016-03-15
PCT/JP2017/010267 WO2017159699A1 (en) 2016-03-15 2017-03-14 Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies

Publications (1)

Publication Number Publication Date
IL261781A true IL261781A (en) 2018-10-31

Family

ID=58489041

Family Applications (1)

Application Number Title Priority Date Filing Date
IL261781A IL261781A (en) 2016-03-15 2018-09-13 Combinations of anti-gpc3 antibodies and antagonists that bind to the pd-1 axis for use in the treatment of cancers

Country Status (14)

Country Link
US (1) US11767362B1 (enExample)
EP (2) EP4112641A1 (enExample)
JP (3) JP6430025B2 (enExample)
KR (1) KR102046235B1 (enExample)
CN (2) CN109153719B (enExample)
AU (1) AU2017235097B2 (enExample)
BR (1) BR112018067923A2 (enExample)
CA (1) CA3016552A1 (enExample)
ES (1) ES2904286T3 (enExample)
IL (1) IL261781A (enExample)
MX (1) MX2018010546A (enExample)
PL (1) PL3430054T3 (enExample)
TW (2) TW202248213A (enExample)
WO (1) WO2017159699A1 (enExample)

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MX2018010546A (es) 2016-03-15 2019-02-20 Chugai Pharmaceutical Co Ltd Metodos de tratamiento de cancer que usan antagonistas de union al eje de muerte programada 1 (pd-1) y anticuerpos anti glipicano 3 (gpc3).
EP3684413A1 (en) * 2017-09-20 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent
CN111278497B (zh) 2017-11-28 2024-01-12 圣犹达医疗用品心脏病学部门有限公司 管腔控制导管
WO2019226640A1 (en) 2018-05-21 2019-11-28 St. Jude Medical, Cardiology Division, Inc. Radio-frequency ablation and direct current electroporation catheters
AU2020271352A1 (en) * 2019-04-11 2021-10-07 Bayer Aktiengesellschaft Combinations of anti-ILDR2 antibodies and PD-1 antagonists
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
CN115038466A (zh) * 2020-01-28 2022-09-09 葛兰素史密斯克莱知识产权发展有限公司 联合治疗及其用途和方法
WO2021213245A1 (zh) * 2020-04-20 2021-10-28 上海翰森生物医药科技有限公司 抗体或其抗原结合片段、其制备方法及医药用途
BR112022020716A2 (pt) * 2020-05-07 2022-11-29 Phanes Therapeutics Inc Anticorpos anti-tumor associados ao antígeno e usos dos mesmos
WO2022038546A1 (en) 2020-08-18 2022-02-24 St. Jude Medical, Cardiology Division, Inc. High-density electrode catheters with magnetic position tracking
MX2023010916A (es) 2021-03-17 2023-12-14 Myeloid Therapeutics Inc Composiciones de proteinas de fusion quimericas modificadas por ingenieria y metodos de uso de las mismas.
US20250002553A1 (en) * 2021-08-12 2025-01-02 Shanghai Jmt-Bio Technology Co., Ltd. A GPC3-targeting antibody-interferon a fusion protein and a use thereof
US20240409663A1 (en) * 2021-10-15 2024-12-12 Concept To Medicine Biotech Co., Ltd. Anti-glypican 3 antibodies
JP2024540536A (ja) * 2021-11-19 2024-10-31 アーディアジェン コーポレーション Ｇｐｃ３結合剤、そのコンジュゲートおよびその使用方法
WO2025103451A1 (zh) * 2023-11-15 2025-05-22 上海盛迪医药有限公司 Trgv9结合蛋白及其医药用途

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