KR101808496B1 - Adamts 단백질 발현을 위한 세포 배양 배지 - Google Patents

Adamts 단백질 발현을 위한 세포 배양 배지 Download PDF

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KR101808496B1
KR101808496B1 KR1020177018298A KR20177018298A KR101808496B1 KR 101808496 B1 KR101808496 B1 KR 101808496B1 KR 1020177018298 A KR1020177018298 A KR 1020177018298A KR 20177018298 A KR20177018298 A KR 20177018298A KR 101808496 B1 KR101808496 B1 KR 101808496B1
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adamts13
protein
culture medium
cell
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KR20170081747A (ko
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레오폴트 그릴베르거
알렉산드라 스펜거
마인하르트 하슬라허
라나 그릴베르거
만프레트 라이터
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백스터 인터내셔널 인코포레이티드
박스터 헬쓰케어 에스에이
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Assigned to 박스앨타 게엠베하, 박스알타 인코퍼레이티드 reassignment 박스앨타 게엠베하 권리의 전부이전등록 Assignors: 박스터 헬쓰케어 에스에이, 백스터 인터내셔널 인코포레이티드
Assigned to 다케다 야쿠힌 고교 가부시키가이샤 reassignment 다케다 야쿠힌 고교 가부시키가이샤 권리의 전부이전등록 Assignors: 박스알타 인코퍼레이티드, 박스앨타 게엠베하
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    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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KR1020177018298A 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지 Active KR101808496B1 (ko)

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US23047709P 2009-07-31 2009-07-31
US61/230,477 2009-07-31
PCT/US2010/044020 WO2011014838A1 (en) 2009-07-31 2010-07-30 Cell culture medium for adamts protein expression

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KR1020157033595A Division KR101756354B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지

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KR101808496B1 true KR101808496B1 (ko) 2017-12-12

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KR1020177018298A Active KR101808496B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020127005425A Active KR101573972B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020157033595A Active KR101756354B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020157009715A Active KR101574056B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020177035177A Active KR101912552B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지

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KR1020127005425A Active KR101573972B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020157033595A Active KR101756354B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020157009715A Active KR101574056B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지
KR1020177035177A Active KR101912552B1 (ko) 2009-07-31 2010-07-30 Adamts 단백질 발현을 위한 세포 배양 배지

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CN (2) CN102549145B (cg-RX-API-DMAC10.html)
AU (1) AU2010278751B2 (cg-RX-API-DMAC10.html)
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CA (1) CA2769361A1 (cg-RX-API-DMAC10.html)
CO (1) CO6501191A2 (cg-RX-API-DMAC10.html)
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IN (1) IN2012DN00801A (cg-RX-API-DMAC10.html)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ597727A (en) * 2009-07-31 2013-08-30 Baxter Int Cell culture medium for adamts protein expression
EA202090067A3 (ru) * 2010-07-08 2020-07-31 Баксалта Инкорпорейтид Способ получения рекомбинантного adamts13 в культуре клеток
SI2726600T1 (sl) 2011-07-01 2017-07-31 Amgen Inc. Sesalska celična kultura
EP2906683B1 (en) 2012-10-15 2017-05-31 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
EP2970916B1 (en) 2013-03-13 2021-04-14 Merck Sharp & Dohme Corp. Adapted lepidopteran insect cells for the production of recombinant proteins
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
KR102418824B1 (ko) * 2013-10-14 2022-07-11 아레스 트레이딩 에스.아. 포유동물의 고성능 유가식 배양을 위한 신규 배지
KR102391259B1 (ko) 2014-06-04 2022-04-26 암젠 인크 포유류 세포 배양물을 회수하는 방법
KR101867134B1 (ko) * 2015-03-23 2018-06-12 한양대학교 산학협력단 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법
ES2929531T3 (es) * 2015-05-22 2022-11-30 Dupont Nutrition Biosci Aps Acetolactato descarboxilasa
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法(一)
US11191818B2 (en) 2016-08-04 2021-12-07 Takeda Pharmaceutical Company Limited Use of ADAMTS13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome
PL3535388T3 (pl) * 2016-11-04 2023-08-14 Takeda Pharmaceutical Company Limited Sposoby oczyszczania wirusów związanych z adenowirusami
KR20210084695A (ko) * 2017-07-06 2021-07-07 리제너론 파마슈티칼스 인코포레이티드 당단백질을 만들기 위한 세포 배양 과정
MA52007A (fr) * 2018-03-16 2021-01-20 Genzyme Corp Procédés d'amélioration de la viabilité cellulaire dans un bioréacteur de production
EP3807408A4 (en) * 2018-06-18 2022-03-30 Synthetic Biologics, Inc. METHODS OF MAKING ALKALINE PHOSPHATASE AGENTS
US12661390B2 (en) 2019-10-04 2026-06-23 The Children's Medical Center Corporation ADAMTS13 treatment to enhance graft survival
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
IL309560B2 (en) 2019-12-06 2025-05-01 Regeneron Pharma Anti-VEGF protein preparations and methods for their production
EP4127158A2 (en) 2020-04-02 2023-02-08 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof
MX2022013812A (es) 2020-05-08 2022-12-15 Regeneron Pharma Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer.
CN115835904A (zh) 2020-05-22 2023-03-21 武田药品工业有限公司 用于治疗和诊断冠状病毒疾病并发症的adamts13组合物和方法
WO2021246557A1 (ko) * 2020-06-05 2021-12-09 주식회사 프로앱텍 특정한 갯수의 알부민이 연결된 요산산화효소-알부민 복합체 및 이의 제조 방법
CN111808822B (zh) * 2020-07-02 2024-01-12 北京百普赛斯生物科技股份有限公司 细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
CZ280901B6 (cs) 1988-10-06 1996-05-15 Hideaki Yamada Způsob kultivace bakterií
JPH0753104B2 (ja) * 1989-02-28 1995-06-07 秀明 山田 細菌の培養法
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
ATE542891T1 (de) 1994-11-10 2012-02-15 Baxter Healthcare Sa Verfahren zur herstellung von biologischen produkten in protein-freier kultur
CA2211630A1 (en) 1995-02-23 1996-08-29 Quest International B.V. Peptides for tissue and cell culture media
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
EP2221361A3 (en) 1996-08-30 2011-02-09 Life Technologies Corporation Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium
IT1285158B1 (it) 1996-09-17 1998-06-03 Angeletti P Ist Richerche Bio Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il
UA59375C2 (uk) 1996-10-07 2003-09-15 Солюшіа Інк. Суміш для гідроксилювання, спосіб гідроксилювання ароматичних сполук та спосіб одержання фенолу
US6103529A (en) 1996-10-10 2000-08-15 Life Technologies, Inc. Animal cell culture media comprising peptides derived from rice
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6406909B1 (en) 1998-07-10 2002-06-18 Chugai Seiyaku Kabushiki Kaisha Serum-free medium for culturing animal cells
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
US6926894B2 (en) * 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
AU2003295270A1 (en) 2002-12-23 2004-07-14 Fuji Photo Film B.V. Process for coating cell-culture support
MXPA06011815A (es) * 2004-04-16 2006-12-15 Wyeth Corp Proteinas adamts-8 y usos de las mismas.
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
JP2007174948A (ja) * 2005-12-27 2007-07-12 Noritsu Koki Co Ltd 酵素水製造装置
JP4880997B2 (ja) * 2005-12-28 2012-02-22 アルフレッサファーマ株式会社 Adamts13の安定化方法
ES2474573T3 (es) * 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
BRPI0622214A2 (pt) * 2006-12-22 2012-01-03 Springer Carrier Ltda unidade de condicionamento de ar e mÉtodo de misturar ar em uma unidade de condicionamento de ar
US20090067805A1 (en) 2007-09-10 2009-03-12 Victor Company Of Japan, Limited Recording and reproducing device
SI2574677T1 (sl) * 2007-12-27 2017-11-30 Baxalta GmbH Procesi celične kulture
NZ597727A (en) * 2009-07-31 2013-08-30 Baxter Int Cell culture medium for adamts protein expression

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BLOOD. Vol. 100, No. 10, 페이지 3626-3632 (2002.11.15.)

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