PL3535388T3 - Sposoby oczyszczania wirusów związanych z adenowirusami - Google Patents
Sposoby oczyszczania wirusów związanych z adenowirusamiInfo
- Publication number
- PL3535388T3 PL3535388T3 PL17866365.4T PL17866365T PL3535388T3 PL 3535388 T3 PL3535388 T3 PL 3535388T3 PL 17866365 T PL17866365 T PL 17866365T PL 3535388 T3 PL3535388 T3 PL 3535388T3
- Authority
- PL
- Poland
- Prior art keywords
- adeno
- associated virus
- purification methods
- virus purification
- methods
- Prior art date
Links
- 241000702421 Dependoparvovirus Species 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417775P | 2016-11-04 | 2016-11-04 | |
| PCT/US2017/059967 WO2018128688A1 (en) | 2016-11-04 | 2017-11-03 | Adeno-associated virus purification methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3535388T3 true PL3535388T3 (pl) | 2023-08-14 |
Family
ID=62044944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17866365.4T PL3535388T3 (pl) | 2016-11-04 | 2017-11-03 | Sposoby oczyszczania wirusów związanych z adenowirusami |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11000561B2 (pl) |
| EP (2) | EP3535388B1 (pl) |
| JP (1) | JP7071348B2 (pl) |
| KR (1) | KR102482744B1 (pl) |
| CN (1) | CN110168081A (pl) |
| AU (1) | AU2017391164B2 (pl) |
| BR (1) | BR112019009033A2 (pl) |
| CA (1) | CA3040288A1 (pl) |
| ES (1) | ES2948849T3 (pl) |
| FI (1) | FI3535388T3 (pl) |
| IL (1) | IL266162B2 (pl) |
| MX (1) | MX2019004784A (pl) |
| PL (1) | PL3535388T3 (pl) |
| PT (1) | PT3535388T (pl) |
| SG (1) | SG11201903890QA (pl) |
| WO (1) | WO2018128688A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3034527A1 (en) | 2016-08-23 | 2018-03-01 | Emmanuel John Simons | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| WO2020014479A1 (en) * | 2018-07-11 | 2020-01-16 | Baxalta Incorporated | Aav compositions |
| WO2021153659A1 (ja) * | 2020-01-31 | 2021-08-05 | Ａｇｃ株式会社 | アデノ随伴ウイルス（ａａｖ）の定量方法 |
| CN116096905A (zh) | 2020-02-21 | 2023-05-09 | 阿库斯股份有限公司 | 用于治疗人受试者的非年龄相关性听力损伤的组合物和方法 |
| EP3868886A1 (en) * | 2020-02-21 | 2021-08-25 | Bia Separations D.O.O. | A method for separation or depletion of empty aav capsids from full aav capsids |
| CN111808828B (zh) * | 2020-09-14 | 2020-11-17 | 和元生物技术（上海）股份有限公司 | 腺相关病毒的分离纯化方法 |
| WO2022081857A1 (en) * | 2020-10-14 | 2022-04-21 | Avantor Performance Materials, Llc | Membrane rupture compositions and methods of making and using same |
| JPWO2022220273A1 (pl) * | 2021-04-15 | 2022-10-20 | ||
| WO2022229703A2 (en) | 2021-04-30 | 2022-11-03 | Takeda Pharmaceutical Company, Ltd. | New aav8 based immune escaping variants |
| WO2022229702A2 (en) | 2021-04-30 | 2022-11-03 | Takeda Pharmaceutical Company, Ltd. | Aav8 capsid variants with enhanced liver targeting |
| WO2023028035A1 (en) * | 2021-08-23 | 2023-03-02 | University Of Florida Research Foundation, Incorporated | Lipid enveloped recombinant aav particles for gene therapy use |
| GB202206123D0 (en) * | 2022-04-27 | 2022-06-08 | Cytiva Bioprocess R & D Ab | A pre-screening method and a method for separating adeno-associated virus capsids |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158054A (en) | 1973-10-18 | 1979-06-12 | Duncan Flockhart & Co. Ltd. | Preparation of virus sub-unit vaccines |
| DK187679A (da) | 1978-05-08 | 1979-11-09 | Merck & Co Inc | Fremgangsmaade til direkte ekstraktion af smaa partikler fra en proteinholdig vaeske |
| US4217418A (en) | 1978-05-08 | 1980-08-12 | Merck & Co., Inc. | Recovery of small particles by flow centrifugation |
| JPH06247995A (ja) | 1991-06-24 | 1994-09-06 | Asahi Chem Ind Co Ltd | 新規なシアリル（α２−６）ラクトテトラオシルセラミド |
| US5688675A (en) * | 1995-06-07 | 1997-11-18 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| EP1080218A1 (en) * | 1998-05-27 | 2001-03-07 | University of Florida | Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient |
| EP1104767A1 (en) * | 1999-11-30 | 2001-06-06 | Stichting Dienst Landbouwkundig Onderzoek | Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups |
| ES2267724T3 (es) | 2000-02-15 | 2007-03-16 | Id Biomedical Corporation Of Quebec | Vacuna antigripal basada en proteosomas. |
| AU2002348151A1 (en) * | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| ATE494362T1 (de) * | 2002-05-14 | 2011-01-15 | Merck Sharp & Dohme | Verfahren zur reinigung von adenovirus |
| JP4571620B2 (ja) | 2003-04-01 | 2010-10-27 | インセルム（アンスティチュ・ナショナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | 肝炎ｃウイルスｅ１ｅ２複合体に対する抗体、ｈｃｖ粒子の組成物及び医薬組成物 |
| US7261544B2 (en) * | 2003-05-21 | 2007-08-28 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
| JP2007068401A (ja) | 2003-08-07 | 2007-03-22 | Chemo Sero Therapeut Res Inst | 西ナイルウイルスワクチン |
| CN1739801A (zh) | 2004-08-27 | 2006-03-01 | 上海生物制品研究所 | 一种流行性感冒病毒裂解疫苗及其制备方法 |
| CN104694489A (zh) * | 2007-05-04 | 2015-06-10 | 巴克斯特国际公司 | 用于病毒纯化用连续超速离心的糖溶液配方 |
| MX2011013613A (es) * | 2009-06-16 | 2012-01-19 | Genzyme Corp | Metodos mejorados para purificacion de vecotres de aav recombinantes. |
| CA2769361A1 (en) * | 2009-07-31 | 2011-02-03 | Baxter International Inc. | Cell culture medium for adamts protein expression |
| CA2787827C (en) * | 2010-01-28 | 2020-11-10 | The Children's Hospital Of Philadelphia | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
| WO2011097447A2 (en) * | 2010-02-04 | 2011-08-11 | Neurologix, Inc. | Production of recombinant virus |
| JP2016514152A (ja) * | 2013-03-13 | 2016-05-19 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | アデノ随伴ウイルスベクターおよびその使用の方法 |
| EP3054006A1 (en) * | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification with multiple-step anion exchange chromatography |
| EP3054007A1 (en) * | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| CN105396128A (zh) * | 2015-11-11 | 2016-03-16 | 北京科兴中维生物技术有限公司 | 一种纯化脊髓灰质炎病毒液的方法 |
-
2017
- 2017-11-03 AU AU2017391164A patent/AU2017391164B2/en active Active
- 2017-11-03 EP EP17866365.4A patent/EP3535388B1/en active Active
- 2017-11-03 PT PT178663654T patent/PT3535388T/pt unknown
- 2017-11-03 CA CA3040288A patent/CA3040288A1/en active Pending
- 2017-11-03 KR KR1020197015637A patent/KR102482744B1/ko active IP Right Grant
- 2017-11-03 JP JP2019520408A patent/JP7071348B2/ja active Active
- 2017-11-03 EP EP23175354.2A patent/EP4234688A3/en active Pending
- 2017-11-03 BR BR112019009033A patent/BR112019009033A2/pt unknown
- 2017-11-03 MX MX2019004784A patent/MX2019004784A/es unknown
- 2017-11-03 US US16/347,082 patent/US11000561B2/en active Active
- 2017-11-03 IL IL266162A patent/IL266162B2/en unknown
- 2017-11-03 FI FIEP17866365.4T patent/FI3535388T3/fi active
- 2017-11-03 CN CN201780082317.6A patent/CN110168081A/zh active Pending
- 2017-11-03 SG SG11201903890QA patent/SG11201903890QA/en unknown
- 2017-11-03 PL PL17866365.4T patent/PL3535388T3/pl unknown
- 2017-11-03 ES ES17866365T patent/ES2948849T3/es active Active
- 2017-11-03 WO PCT/US2017/059967 patent/WO2018128688A1/en unknown
-
2021
- 2021-04-12 US US17/227,527 patent/US20210338752A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017391164B2 (en) | 2024-01-04 |
| ES2948849T3 (es) | 2023-09-20 |
| EP3535388A1 (en) | 2019-09-11 |
| MX2019004784A (es) | 2019-08-12 |
| FI3535388T3 (fi) | 2023-06-14 |
| PT3535388T (pt) | 2023-06-27 |
| WO2018128688A1 (en) | 2018-07-12 |
| EP4234688A2 (en) | 2023-08-30 |
| JP7071348B2 (ja) | 2022-05-18 |
| KR102482744B1 (ko) | 2022-12-30 |
| IL266162B1 (en) | 2023-07-01 |
| KR20190073529A (ko) | 2019-06-26 |
| IL266162A (en) | 2019-06-30 |
| CA3040288A1 (en) | 2018-07-12 |
| US11000561B2 (en) | 2021-05-11 |
| US20210338752A1 (en) | 2021-11-04 |
| EP4234688A3 (en) | 2023-09-27 |
| US20190365835A1 (en) | 2019-12-05 |
| AU2017391164A1 (en) | 2019-05-02 |
| CN110168081A (zh) | 2019-08-23 |
| JP2020502997A (ja) | 2020-01-30 |
| RU2019113381A3 (pl) | 2021-04-06 |
| SG11201903890QA (en) | 2019-05-30 |
| IL266162B2 (en) | 2023-11-01 |
| EP3535388B1 (en) | 2023-05-31 |
| RU2019113381A (ru) | 2020-12-04 |
| BR112019009033A2 (pt) | 2019-07-09 |
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