KR101745029B1 - 재조합 조류 파라믹소바이러스 백신 및 이의 제조 및 사용 방법 - Google Patents

재조합 조류 파라믹소바이러스 백신 및 이의 제조 및 사용 방법 Download PDF

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KR101745029B1
KR101745029B1 KR1020127007373A KR20127007373A KR101745029B1 KR 101745029 B1 KR101745029 B1 KR 101745029B1 KR 1020127007373 A KR1020127007373 A KR 1020127007373A KR 20127007373 A KR20127007373 A KR 20127007373A KR 101745029 B1 KR101745029 B1 KR 101745029B1
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미셸 부블로
테쇼메 메바트시온
조이스 프리차드
에그베르트 문트
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메리얼 인코포레이티드
유니버시티 오브 조지아 리서치 파운데이션 인코퍼레이티드
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KR1020127007373A 2009-08-21 2010-08-20 재조합 조류 파라믹소바이러스 백신 및 이의 제조 및 사용 방법 Active KR101745029B1 (ko)

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US23591209P 2009-08-21 2009-08-21
US61/235,912 2009-08-21
PCT/US2010/046179 WO2011022656A2 (en) 2009-08-21 2010-08-20 Recombinant avian paramyxovirus vaccine and method for making and using thereof

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KR20120059570A KR20120059570A (ko) 2012-06-08
KR101745029B1 true KR101745029B1 (ko) 2017-06-08

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ711946A (en) 2013-03-14 2020-05-29 Icahn School Med Mount Sinai Newcastle disease viruses and uses thereof
US20140341950A1 (en) * 2013-05-15 2014-11-20 University Of Georgia Research Foundation, Inc. Recombinant avian paramyxovirus vaccine and method for making and using thereof
CA2940570A1 (en) 2014-02-27 2015-09-03 Viralytics Limited Combination method for treatment of cancer
CN104195116B (zh) * 2014-08-13 2018-03-06 吉林大学 一种表达鹅细小病毒vp3基因的重组新城疫病毒及其构建方法
CA2956291A1 (en) * 2014-08-22 2016-02-25 Investigacion Aplicada, S.A. De C.V. Emulsified vaccine to obtain formulations of concentrated igy immunoglobulins; processes and uses for the same
WO2016073410A1 (en) 2014-11-03 2016-05-12 Merial, Inc. Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
JOP20190256A1 (ar) * 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
CN107254450A (zh) * 2017-07-20 2017-10-17 扬州大学 克服鸡新城疫母源抗体影响的嵌合新城疫病毒疫苗载体候选株及构建方法
EP4397757A3 (en) 2017-08-18 2024-10-23 ModernaTX, Inc. Rna polymerase variants
CN108315486A (zh) * 2018-04-11 2018-07-24 张薇 一种用于检测罗湖病毒的环介导等温扩增引物组及试剂盒
WO2020014591A1 (en) * 2018-07-13 2020-01-16 Icahn School Of Medicine At Mount Sinai Apmv and uses thereof for the treatment of cancer
WO2020037215A1 (en) 2018-08-17 2020-02-20 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease
MA55037A (fr) 2019-02-20 2021-12-29 Modernatx Inc Variants d'arn polymérase pour le coiffage co-transcriptionnel
CN114390946A (zh) 2019-11-13 2022-04-22 株式会社Ihi 将填充部件插入反应装置中的夹具
CN112111467B (zh) * 2020-09-27 2021-06-22 湖北省农业科学院畜牧兽医研究所 一种基因vii型新城疫标记疫苗株及其制备方法与应用
CN116068196A (zh) * 2022-10-26 2023-05-05 新疆农业大学 一种检测禽副黏病毒4型血清抗体的elisa方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036617A2 (en) * 2000-11-02 2002-05-10 Akzo Nobel N.V. A recombinant newcastle disease virus nucleoprotein mutant as a marker vaccine
WO2009101149A2 (en) 2008-02-14 2009-08-20 Bayer Schering Pharma Aktiengesellschaft Anti-tumour effective paramyxovirus

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
AU672359B2 (en) 1991-03-07 1996-10-03 Virogenetics Corporation Genetically engineered vaccine strain
US6610661B1 (en) 1996-10-11 2003-08-26 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
FR2778858B1 (fr) 1998-05-20 2000-06-16 Oreal Emulsion e/h/e stable et son utilisation comme composition cosmetique et/ou dermatologique
EP0974660A1 (en) 1998-06-19 2000-01-26 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Newcastle disease virus infectious clones, vaccines and diagnostic assays
FR2801607B1 (fr) 1999-11-26 2001-12-28 Merial Sas Pneumovirus du canard et vaccins correspondants
RU2162341C1 (ru) * 2000-03-06 2001-01-27 Открытое акционерное общество "ВЫМПЕЛ КОМПЛЕКС" Сухая живая вакцина против ньюкаслской болезни и способ ее получения
JP4791651B2 (ja) * 2000-05-18 2011-10-12 株式会社ディナベック研究所 外来遺伝子導入用パラミクソウイルスベクター
UA84024C2 (ru) 2003-07-24 2008-09-10 Мериал Лимитед Новые вакцинные композиции, которые содержат эмульсию типа "масло в воде"
EP1996610A1 (en) * 2006-03-15 2008-12-03 Intervet International BV Recombinant newcastle disease virus expressing h5 hemagglutinin of avian influenza virus
RU2441070C2 (ru) * 2006-03-15 2012-01-27 Интервет Интернэшнл Б.В. Рекомбинантный вирус болезни ньюкастла, экспрессирующий н5 гемаглютинин вируса птичьего гриппа (avian ineluenza)
EP1834651A1 (en) * 2006-03-15 2007-09-19 Universiteit Gent Compositions and methods for veterinary vaccination
US20090175826A1 (en) * 2006-06-05 2009-07-09 Elankumaran Subbiah Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
JP5797636B2 (ja) * 2009-04-03 2015-10-21 メリアル リミテッド ニューカッスル病ウイルスをベクターとするトリワクチン

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036617A2 (en) * 2000-11-02 2002-05-10 Akzo Nobel N.V. A recombinant newcastle disease virus nucleoprotein mutant as a marker vaccine
WO2009101149A2 (en) 2008-02-14 2009-08-20 Bayer Schering Pharma Aktiengesellschaft Anti-tumour effective paramyxovirus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NCBI GenBank Accession No. FJ215863(2009.07.22.)
Virus Res. 142: 144-153(2009)

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CN102573901A (zh) 2012-07-11
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