KR101706519B1 - 레보캐리마이신, 약학 조성물, 제조방법 및 응용 - Google Patents

레보캐리마이신, 약학 조성물, 제조방법 및 응용 Download PDF

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KR101706519B1
KR101706519B1 KR1020167002375A KR20167002375A KR101706519B1 KR 101706519 B1 KR101706519 B1 KR 101706519B1 KR 1020167002375 A KR1020167002375 A KR 1020167002375A KR 20167002375 A KR20167002375 A KR 20167002375A KR 101706519 B1 KR101706519 B1 KR 101706519B1
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spiramycin
isovaler
iii
levocarimycin
crystalline compound
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KR20160019970A (ko
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양 지앙
유요우 하오
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쉔양 통리엔 그룹 컴패니, 리미티드
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Assigned to 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 reassignment 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 권리의 전부이전등록 Assignors: 쉔양 통리엔 그룹 컴패니, 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020167002375A 2010-05-25 2011-05-25 레보캐리마이신, 약학 조성물, 제조방법 및 응용 Active KR101706519B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201010182027.9 2010-05-25
CN201010182027 2010-05-25
PCT/CN2011/074658 WO2011147316A1 (zh) 2010-05-25 2011-05-25 左旋可利霉素、其药物组合物、制备方法及应用

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KR1020127033722A Division KR101625262B1 (ko) 2010-05-25 2011-05-25 레보캐리마이신, 약학 조성물, 제조방법 및 응용

Publications (2)

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KR20160019970A KR20160019970A (ko) 2016-02-22
KR101706519B1 true KR101706519B1 (ko) 2017-02-14

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KR1020167002375A Active KR101706519B1 (ko) 2010-05-25 2011-05-25 레보캐리마이신, 약학 조성물, 제조방법 및 응용
KR1020127033722A Active KR101625262B1 (ko) 2010-05-25 2011-05-25 레보캐리마이신, 약학 조성물, 제조방법 및 응용

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US (1) US9089586B2 (https=)
EP (1) EP2578596B1 (https=)
JP (1) JP5866737B2 (https=)
KR (2) KR101706519B1 (https=)
CN (1) CN102247396B (https=)
BR (1) BR112012029905B1 (https=)
CA (1) CA2800019C (https=)
DK (1) DK2578596T3 (https=)
ES (1) ES2633737T3 (https=)
IN (1) IN2012MN02623A (https=)
MX (1) MX346873B (https=)
MY (1) MY164230A (https=)
PH (1) PH12012502329A1 (https=)
PL (1) PL2578596T3 (https=)
RU (1) RU2593499C2 (https=)
WO (1) WO2011147316A1 (https=)
ZA (1) ZA201209739B (https=)

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EP2578595B1 (en) * 2010-05-25 2017-04-19 Shenyang Fuyang Pharmaceutical Technology Co., Ltd. Crystalline levoisovalerylspiramycin i
US9945611B2 (en) 2010-08-04 2018-04-17 Ima Life North America Inc. Bulk freeze drying using spray freezing and agitated drying
ES2649045T3 (es) * 2010-08-04 2018-01-09 Ima Life North America Inc. Liofilización a granel mediante congelación por pulverización y secado agitado
CN103694295B (zh) * 2014-01-08 2016-01-20 华东理工大学 一种优化可利霉素组分的方法
CN105497053B (zh) * 2015-12-31 2018-02-13 沈阳福洋医药科技有限公司 可利霉素在抗结核分枝杆菌感染中的应用
RU2746047C1 (ru) * 2017-04-06 2021-04-06 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Применение карримицина и его фармацевтически приемлемой соли для производства медикаментов для лечения и/или профилактики опухоли
RU2766176C2 (ru) * 2017-07-04 2022-02-08 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Применение изовалерил-спирамицина i, ii и/или iii при изготовлении препарата для лечения и/или профилактики опухоли и получения лекарственного препарата
CN110051845A (zh) * 2018-01-19 2019-07-26 沈阳福洋医药科技有限公司 一种mTOR抑制剂、药物组合物及其应用
MX2020007627A (es) * 2018-01-19 2020-11-24 Shenyang Fuyang Pharmaceutical Tech Co Ltd Uso de la carrimicina o de sus ingredientes activos.
KR20200144568A (ko) * 2018-04-17 2020-12-29 상하이 통리엔 파마슈티컬 컴퍼니 리미티드 통증 및/또는 발열을 예방 및/또는 치료하는 의약품, 조합 산물 및 그 응용
CN110384802B (zh) * 2018-04-17 2021-09-17 沈阳福洋医药科技有限公司 一种用于预防和/或治疗发热的药物、组合产品及其应用
CN110384710B (zh) * 2018-04-17 2023-01-10 沈阳福洋医药科技有限公司 一种用于预防和/或治疗疼痛的药物、组合产品及其应用
CN108992416A (zh) * 2018-09-27 2018-12-14 上海同联制药有限公司 一种可利霉素肠溶片及其制备方法
KR20220008895A (ko) * 2019-05-16 2022-01-21 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 섬유증을 예방, 완화 및/또는 치료하는 약물, 복합 제품 및 이의 응용
CN112239483B (zh) * 2019-07-18 2023-10-27 沈阳福洋医药科技有限公司 一种化合物及药物组合物
CN111450066B (zh) * 2020-04-24 2022-06-21 沈阳信达泰康医药科技有限公司 一种可利霉素冻干粉针制剂及其制备方法
WO2021219112A1 (zh) * 2020-04-30 2021-11-04 沈阳福洋医药科技有限公司 异戊酰螺旋霉素类化合物或其组合物在制备治疗脓毒症疾病药物中的应用

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Also Published As

Publication number Publication date
MX2012013469A (es) 2013-04-03
DK2578596T3 (en) 2017-07-17
KR20130020906A (ko) 2013-03-04
EP2578596B1 (en) 2017-04-19
IN2012MN02623A (https=) 2015-06-12
BR112012029905A2 (pt) 2019-08-06
US9089586B2 (en) 2015-07-28
PL2578596T3 (pl) 2017-09-29
PH12012502329A1 (en) 2013-02-11
KR20160019970A (ko) 2016-02-22
EP2578596A4 (en) 2013-11-06
CA2800019C (en) 2015-05-26
MX346873B (es) 2017-03-30
CN102247396B (zh) 2014-05-28
CN102247396A (zh) 2011-11-23
ZA201209739B (en) 2014-03-26
JP5866737B2 (ja) 2016-02-17
WO2011147316A1 (zh) 2011-12-01
RU2012156419A (ru) 2014-06-27
KR101625262B1 (ko) 2016-05-27
RU2593499C2 (ru) 2016-08-10
CA2800019A1 (en) 2011-12-01
US20130150316A1 (en) 2013-06-13
EP2578596A1 (en) 2013-04-10
MY164230A (en) 2017-11-30
ES2633737T3 (es) 2017-09-25
JP2013528167A (ja) 2013-07-08
BR112012029905B1 (pt) 2022-01-11

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