IN2012MN02623A - - Google Patents

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Publication number
IN2012MN02623A
IN2012MN02623A IN2623MUN2012A IN2012MN02623A IN 2012MN02623 A IN2012MN02623 A IN 2012MN02623A IN 2623MUN2012 A IN2623MUN2012 A IN 2623MUN2012A IN 2012MN02623 A IN2012MN02623 A IN 2012MN02623A
Authority
IN
India
Prior art keywords
iii
levocarrimycin
content
isovalerylspiramycin
pharmaceutical compositions
Prior art date
Application number
Inventor
Yang Jiang
Yuyou Hao
Original Assignee
Shenyang tonglian group co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenyang tonglian group co ltd filed Critical Shenyang tonglian group co ltd
Publication of IN2012MN02623A publication Critical patent/IN2012MN02623A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Abstract

DDisclosed are levocarrimycin pharmaceutical compositions preparation methods and uses thereof. Levocarrimycin is a mixture of isovalerylspiramycin III II and I as main components and contains certain content of isobutyrylspiramycin III and II butyrylspiramycin III and II propionylspiramycin III and II as well as acetylspiramycin III and II wherein the content of isovalerylspiramycin III is not less than 30 wt% the total content of isovalerylspiramycin III II and I is not less than 60 wt% and the content of acylspiramycin is 80 98 wt%. Specific optical rotation of said levocarrimycin is [a] = 52° ~ 57° in the solution of 0.02g/ml chloroform at temperature of 25°C. Also disclosed are levocarrimycin comprising the crystal of isovalerylspiramycin III II or I and pharmaceutical compositions containing said levocarrimycin. The active components in levocarrimycin or its pharmaceutical compositions has optical activity and excellent anti infective effect.
IN2623MUN2012 2010-05-25 2011-05-25 IN2012MN02623A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010182027 2010-05-25
PCT/CN2011/074658 WO2011147316A1 (en) 2010-05-25 2011-05-25 Levocarrimycin, pharmaceutical compositions, preparation methods and uses thereof

Publications (1)

Publication Number Publication Date
IN2012MN02623A true IN2012MN02623A (en) 2015-06-12

Family

ID=44975203

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2623MUN2012 IN2012MN02623A (en) 2010-05-25 2011-05-25

Country Status (16)

Country Link
US (1) US9089586B2 (en)
EP (1) EP2578596B1 (en)
JP (1) JP5866737B2 (en)
KR (2) KR101625262B1 (en)
CN (1) CN102247396B (en)
BR (1) BR112012029905B1 (en)
CA (1) CA2800019C (en)
DK (1) DK2578596T3 (en)
ES (1) ES2633737T3 (en)
IN (1) IN2012MN02623A (en)
MX (1) MX346873B (en)
MY (1) MY164230A (en)
PL (1) PL2578596T3 (en)
RU (1) RU2593499C2 (en)
WO (1) WO2011147316A1 (en)
ZA (1) ZA201209739B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130041829A (en) * 2010-05-25 2013-04-25 쉔양 통리엔 그룹 컴패니, 리미티드 Levoisovalerylspiramycin i, ii or iii, preparations, preparation methods and uses thereof
ES2649045T3 (en) * 2010-08-04 2018-01-09 Ima Life North America Inc. Bulk freeze-drying by spray freezing and agitated drying
US9945611B2 (en) 2010-08-04 2018-04-17 Ima Life North America Inc. Bulk freeze drying using spray freezing and agitated drying
CN103694295B (en) * 2014-01-08 2016-01-20 华东理工大学 A kind of method optimizing rokitamycin component
CN105497053B (en) * 2015-12-31 2018-02-13 沈阳福洋医药科技有限公司 Application of the rokitamycin in Killing Mycobacterium Tuberculosis infection
JP6959355B2 (en) * 2017-04-06 2021-11-02 沈陽福洋医薬科技有限公司Ｓｈｅｎｙａｎｇ Ｆｕｙａｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ Application of Calimycin and its pharmaceutically acceptable salts in the preparation of drugs to treat and / or prevent tumors
ES2912734T3 (en) * 2017-07-04 2022-05-27 Shenyang Fuyang Pharmaceutical Tech Co Ltd Use of isovaleryl spiramycin I or III in the preparation of drug to treat and/or prevent tumor and drug
KR20200112897A (en) * 2018-01-19 2020-10-05 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 mTOR inhibitor, drug composition and application thereof
RU2771046C2 (en) * 2018-01-19 2022-04-25 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Use of carrimycin or its active ingredients
CN110384802B (en) * 2018-04-17 2021-09-17 沈阳福洋医药科技有限公司 Medicine and combination product for preventing and/or treating fever and application thereof
EP3782627A4 (en) * 2018-04-17 2021-07-07 Shanghai Tonglian Pharmaceutical Co., Ltd. Drug used for preventing and/or treating pain and/or fever, combination product, and use thereof
CN110384710B (en) * 2018-04-17 2023-01-10 沈阳福洋医药科技有限公司 Medicine and combination product for preventing and/or treating pain and application thereof
CN108992416A (en) * 2018-09-27 2018-12-14 上海同联制药有限公司 A kind of rokitamycin enteric coatel tablets and preparation method thereof
KR20220008895A (en) * 2019-05-16 2022-01-21 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 Drugs, combination products and their applications for preventing, alleviating and/or treating fibrosis
CN112239483B (en) * 2019-07-18 2023-10-27 沈阳福洋医药科技有限公司 Compound and pharmaceutical composition
CN111450066B (en) * 2020-04-24 2022-06-21 沈阳信达泰康医药科技有限公司 Kelimycin freeze-dried powder injection and preparation method thereof
WO2021219112A1 (en) * 2020-04-30 2021-11-04 沈阳福洋医药科技有限公司 Isovaleryl spiramycin compound or application of isovaleryl spiramycin composition in preparation of drug for treating sepsis disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334788A (en) * 1976-09-11 1978-03-31 Sanraku Inc Antibiotics spiramycin derivatives
CN1169947C (en) * 2002-11-19 2004-10-06 中国医学科学院医药生物技术研究所 Genetically engineered bacterial strain spiramycin streptomycete WSJ-195 of bite spiramycin
CN1237976C (en) * 2003-12-23 2006-01-25 沈阳同联集团有限公司 Bite spiramycin and its use in anti inflammatory disease
BRPI0514254A (en) * 2004-08-12 2008-06-03 Glaxosmithkline Zagreb use of cell-specific conjugates for the treatment of inflammatory diseases of the gastrointestinal tract
KR100662363B1 (en) 2004-10-19 2007-01-02 엘지전자 주식회사 Apparatus and method for install of display device
CN101054553A (en) * 2007-04-09 2007-10-17 中国医学科学院医药生物技术研究所 Construction of isovalerylspiramycin I gene engineering strain
CN100554355C (en) 2007-04-11 2009-10-28 华南理工大学 A kind of thermal-insulating external-wall coating of nano-composite water and preparation method thereof
CN101649325B (en) * 2009-07-03 2011-09-07 中国医学科学院医药生物技术研究所 Gene series technology for increasing main component content of gene engineering isovaleryl selectomycin
KR20130041829A (en) * 2010-05-25 2013-04-25 쉔양 통리엔 그룹 컴패니, 리미티드 Levoisovalerylspiramycin i, ii or iii, preparations, preparation methods and uses thereof

Also Published As

Publication number Publication date
KR101706519B1 (en) 2017-02-14
JP2013528167A (en) 2013-07-08
CA2800019A1 (en) 2011-12-01
BR112012029905A2 (en) 2019-08-06
KR20130020906A (en) 2013-03-04
US20130150316A1 (en) 2013-06-13
EP2578596A1 (en) 2013-04-10
CN102247396A (en) 2011-11-23
BR112012029905B1 (en) 2022-01-11
KR20160019970A (en) 2016-02-22
KR101625262B1 (en) 2016-05-27
CN102247396B (en) 2014-05-28
CA2800019C (en) 2015-05-26
RU2593499C2 (en) 2016-08-10
MX2012013469A (en) 2013-04-03
ZA201209739B (en) 2014-03-26
EP2578596A4 (en) 2013-11-06
ES2633737T3 (en) 2017-09-25
RU2012156419A (en) 2014-06-27
PL2578596T3 (en) 2017-09-29
JP5866737B2 (en) 2016-02-17
MX346873B (en) 2017-03-30
DK2578596T3 (en) 2017-07-17
WO2011147316A1 (en) 2011-12-01
EP2578596B1 (en) 2017-04-19
US9089586B2 (en) 2015-07-28
MY164230A (en) 2017-11-30

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