KR101703299B1 - 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 - Google Patents

내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 Download PDF

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KR101703299B1
KR101703299B1 KR1020157022196A KR20157022196A KR101703299B1 KR 101703299 B1 KR101703299 B1 KR 101703299B1 KR 1020157022196 A KR1020157022196 A KR 1020157022196A KR 20157022196 A KR20157022196 A KR 20157022196A KR 101703299 B1 KR101703299 B1 KR 101703299B1
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로날드 뷔로
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오픈 모노클로날 테크놀로지, 인코포레이티드
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KR1020157022196A 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 Active KR101703299B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60/044,324 1997-04-25
US94161907P 2007-06-01 2007-06-01
US60/914,619 2007-06-01
US4432408P 2008-04-11 2008-04-11
PCT/US2008/065419 WO2008151081A1 (en) 2007-06-01 2008-05-30 Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies

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KR1020097024974A Division KR101661357B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물

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KR1020177002729A Division KR101886610B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물

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KR20150101475A KR20150101475A (ko) 2015-09-03
KR101703299B1 true KR101703299B1 (ko) 2017-02-06

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KR1020157022196A Active KR101703299B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
KR1020187022408A Active KR102096731B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
KR1020097024974A Active KR101661357B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
KR1020177002729A Active KR101886610B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물

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KR1020187022408A Active KR102096731B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
KR1020097024974A Active KR101661357B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
KR1020177002729A Active KR101886610B1 (ko) 2007-06-01 2008-05-30 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물

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US (6) US8703485B2 (https=)
EP (4) EP3382022A1 (https=)
JP (6) JP5823690B2 (https=)
KR (4) KR101703299B1 (https=)
CN (1) CN101784664B (https=)
AT (1) ATE522611T1 (https=)
AU (1) AU2008259939B2 (https=)
CA (2) CA3054224C (https=)
CY (1) CY1120383T1 (https=)
DK (3) DK2602323T3 (https=)
ES (3) ES2393826T3 (https=)
HR (1) HRP20180506T1 (https=)
HU (1) HUE037302T2 (https=)
IL (2) IL202302A (https=)
LT (1) LT2602323T (https=)
NZ (1) NZ581396A (https=)
PL (3) PL2602323T3 (https=)
PT (3) PT2336329E (https=)
SG (2) SG10201509853UA (https=)
SI (1) SI2602323T1 (https=)
WO (1) WO2008151081A1 (https=)

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US12016313B2 (en) 2017-01-19 2024-06-25 Omniab Operations, Inc. Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci

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SI2311874T1 (sl) 2004-07-22 2017-12-29 Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics Vezavne molekule
DK2602323T3 (en) * 2007-06-01 2018-04-16 Open Monoclonal Tech Inc Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies
JP2012501641A (ja) * 2008-09-08 2012-01-26 セレクティス グルタミンシンセターゼ遺伝子からのｄｎａ標的配列を切断するメガヌクレアーゼ変異型及びその使用
EP2346994B1 (en) * 2008-09-30 2022-02-16 Ablexis, LLC Knock-in mice for the production of chimeric antibodies
EP3156494B8 (en) * 2008-12-04 2018-09-19 Sangamo Therapeutics, Inc. Genome editing in rats using zinc-finger nucleases
JP5827127B2 (ja) * 2008-12-18 2015-12-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
GB0905023D0 (en) * 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
BR112012000536A2 (pt) 2009-07-08 2020-08-11 Kymab Limited métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
US8754287B2 (en) 2009-12-10 2014-06-17 Regeneron Pharmaceuticals, Inc. Mice that make heavy chain antibodies
SI2501817T2 (sl) 2010-02-08 2021-09-30 Regeneron Pharmaceuticals, Inc. Miš z navadno lahko verigo
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PT2152880E (pt) 2011-12-15
CN102850452A (zh) 2013-01-02
KR20100037027A (ko) 2010-04-08
AU2008259939B2 (en) 2014-03-13
DK2152880T3 (da) 2011-11-28
EP2336329A1 (en) 2011-06-22
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ES2372718T3 (es) 2012-01-25
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US20160311888A1 (en) 2016-10-27
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KR101886610B1 (ko) 2018-08-09
PL2336329T3 (pl) 2013-04-30
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CA3054224A1 (en) 2008-12-11
JP2020125360A (ja) 2020-08-20
PT2602323T (pt) 2018-04-02
US9388233B2 (en) 2016-07-12
EP3382022A1 (en) 2018-10-03
IL202302A0 (en) 2011-08-01
US20090098134A1 (en) 2009-04-16
JP6712254B2 (ja) 2020-06-17
US10072069B2 (en) 2018-09-11
US8907157B2 (en) 2014-12-09
PL2152880T3 (pl) 2012-03-30
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ATE522611T1 (de) 2011-09-15
US20100212035A1 (en) 2010-08-19
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US20190169270A1 (en) 2019-06-06
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HUE037302T2 (hu) 2018-08-28
NZ581396A (en) 2012-07-27
KR20170016518A (ko) 2017-02-13
WO2008151081A8 (en) 2010-02-04
HRP20180506T1 (hr) 2018-05-04
KR102096731B1 (ko) 2020-04-02
JP2014027947A (ja) 2014-02-13
EP2152880A4 (en) 2010-06-16
PL2602323T3 (pl) 2018-06-29
JP2010529042A (ja) 2010-08-26
ES2393826T3 (es) 2012-12-28
LT2602323T (lt) 2018-04-10
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IL220209A (en) 2013-11-28
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