KR101640698B1 - 옥사졸리딘-2-온 화합물 및 pi3k 억제제로서의 그의 용도 - Google Patents

옥사졸리딘-2-온 화합물 및 pi3k 억제제로서의 그의 용도 Download PDF

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KR101640698B1
KR101640698B1 KR1020147023243A KR20147023243A KR101640698B1 KR 101640698 B1 KR101640698 B1 KR 101640698B1 KR 1020147023243 A KR1020147023243 A KR 1020147023243A KR 20147023243 A KR20147023243 A KR 20147023243A KR 101640698 B1 KR101640698 B1 KR 101640698B1
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amino
trifluoromethyl
oxazolidin
morpholin
bipyrimidinyl
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KR20140117581A (ko
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조르지오 카라바티
로빈 알렉 페어허스트
파스칼 피레
프레데릭 스타우퍼
프랑크 한스 사일러
하인리히 뤼거
클리브 맥카시
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노파르티스 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020147023243A 2012-02-24 2013-02-22 옥사졸리딘-2-온 화합물 및 pi3k 억제제로서의 그의 용도 Active KR101640698B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261602954P 2012-02-24 2012-02-24
US61/602,954 2012-02-24
US201261736707P 2012-12-13 2012-12-13
US61/736,707 2012-12-13
PCT/IB2013/051443 WO2013124826A1 (en) 2012-02-24 2013-02-22 Oxazolidin- 2 -one compounds and uses thereof as pi3ks inhibitors

Publications (2)

Publication Number Publication Date
KR20140117581A KR20140117581A (ko) 2014-10-07
KR101640698B1 true KR101640698B1 (ko) 2016-07-18

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KR1020147023243A Active KR101640698B1 (ko) 2012-02-24 2013-02-22 옥사졸리딘-2-온 화합물 및 pi3k 억제제로서의 그의 용도

Country Status (31)

Country Link
US (2) US8865894B2 (https=)
EP (1) EP2817307B1 (https=)
JP (1) JP6154404B2 (https=)
KR (1) KR101640698B1 (https=)
CN (1) CN104144926B (https=)
AP (1) AP2014007835A0 (https=)
AR (1) AR090121A1 (https=)
AU (1) AU2013223713C1 (https=)
BR (1) BR112014020672B1 (https=)
CA (1) CA2865372A1 (https=)
CO (1) CO7051028A2 (https=)
CR (1) CR20140397A (https=)
DO (1) DOP2014000194A (https=)
EA (1) EA026031B1 (https=)
ES (1) ES2598118T3 (https=)
GE (1) GEP20156389B (https=)
GT (1) GT201400178A (https=)
HK (1) HK1199643A1 (https=)
IL (1) IL233936A (https=)
MX (1) MX353341B (https=)
NI (1) NI201400089A (https=)
NZ (1) NZ629198A (https=)
PE (1) PE20142456A1 (https=)
PH (1) PH12014501900A1 (https=)
PL (1) PL2817307T3 (https=)
PT (1) PT2817307T (https=)
SG (1) SG11201404794XA (https=)
TW (1) TW201339155A (https=)
UY (1) UY34632A (https=)
WO (1) WO2013124826A1 (https=)
ZA (1) ZA201405446B (https=)

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UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
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TWI716362B (zh) 2014-10-14 2021-01-21 瑞士商諾華公司 針對ｐｄ－ｌ１之抗體分子及其用途
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