KR101506773B1 - Ｂａｃｅ 1 및/또는 ｂａｃｅ 2 억제제로서의 2-아미노-5,5-다이플루오로-5,6-다이하이드로-4ｈ-옥사진 - Google Patents

Ｂａｃｅ 1 및/또는 ｂａｃｅ 2 억제제로서의 2-아미노-5,5-다이플루오로-5,6-다이하이드로-4ｈ-옥사진 Download PDF

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KR101506773B1
KR101506773B1 KR1020127017919A KR20127017919A KR101506773B1 KR 101506773 B1 KR101506773 B1 KR 101506773B1 KR 1020127017919 A KR1020127017919 A KR 1020127017919A KR 20127017919 A KR20127017919 A KR 20127017919A KR 101506773 B1 KR101506773 B1 KR 101506773B1
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difluoro
amino
phenyl
dihydro
methyl
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KR20120104598A (ko
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데이빗 배너
볼프강 구바
한스 힐페르트
하랄트 마우저
알렉산더 브이 마이베크
로베르트 나르퀴지안
엠마누엘 피나르드
어인 파워
마크 로저스-에반스
토마스 볼테링
볼프강 보스틀
Original Assignee
에프. 호프만-라 로슈 아게
시에나 바이오테크 에스.피.에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020127017919A 2009-12-11 2010-12-06 Ｂａｃｅ 1 및/또는 ｂａｃｅ 2 억제제로서의 2-아미노-5,5-다이플루오로-5,6-다이하이드로-4ｈ-옥사진 Expired - Fee Related KR101506773B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09178983.4 2009-12-11
EP09178983 2009-12-11
PCT/EP2010/068912 WO2011069934A1 (en) 2009-12-11 2010-12-06 2-amino-5, 5-difluoro-5, 6-dihydro-4h-oxazines as bace 1 and/or bace 2 inhibitors

Publications (2)

Publication Number Publication Date
KR20120104598A KR20120104598A (ko) 2012-09-21
KR101506773B1 true KR101506773B1 (ko) 2015-03-27

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ID=43585547

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KR1020127017919A Expired - Fee Related KR101506773B1 (ko) 2009-12-11 2010-12-06 Ｂａｃｅ 1 및/또는 ｂａｃｅ 2 억제제로서의 2-아미노-5,5-다이플루오로-5,6-다이하이드로-4ｈ-옥사진

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Country Link
US (1) US8389513B2 (https=)
EP (1) EP2509965A1 (https=)
JP (1) JP5584778B2 (https=)
KR (1) KR101506773B1 (https=)
CN (1) CN102712609A (https=)
AR (1) AR079327A1 (https=)
AU (1) AU2010330031B2 (https=)
BR (1) BR112012013175A2 (https=)
CA (1) CA2776727C (https=)
CL (1) CL2012001464A1 (https=)
CO (1) CO6541656A2 (https=)
CR (1) CR20120262A (https=)
EC (1) ECSP12011961A (https=)
IL (1) IL219107A (https=)
IN (1) IN2012DN03043A (https=)
MA (1) MA34779B1 (https=)
MX (1) MX2012006493A (https=)
MY (1) MY169962A (https=)
NZ (1) NZ599008A (https=)
PE (1) PE20121500A1 (https=)
PH (1) PH12012500619A1 (https=)
RU (1) RU2515221C2 (https=)
SG (1) SG181610A1 (https=)
TW (1) TWI487704B (https=)
UA (1) UA103272C2 (https=)
WO (1) WO2011069934A1 (https=)

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