IN2012DN03043A - - Google Patents
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- Publication number
- IN2012DN03043A IN2012DN03043A IN3043DEN2012A IN2012DN03043A IN 2012DN03043 A IN2012DN03043 A IN 2012DN03043A IN 3043DEN2012 A IN3043DEN2012 A IN 3043DEN2012A IN 2012DN03043 A IN2012DN03043 A IN 2012DN03043A
- Authority
- IN
- India
- Prior art keywords
- present
- bace1
- oxazin
- difluoro
- alzheimer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[l,3]oxazin-4-yl)-phenyl]-amide derivatives of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09178983 | 2009-12-11 | ||
PCT/EP2010/068912 WO2011069934A1 (en) | 2009-12-11 | 2010-12-06 | 2-amino-5, 5-difluoro-5, 6-dihydro-4h-oxazines as bace 1 and/or bace 2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN03043A true IN2012DN03043A (en) | 2015-07-31 |
Family
ID=43585547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN3043DEN2012 IN2012DN03043A (en) | 2009-12-11 | 2010-12-06 |
Country Status (25)
Country | Link |
---|---|
US (1) | US8389513B2 (en) |
EP (1) | EP2509965A1 (en) |
JP (1) | JP5584778B2 (en) |
KR (1) | KR101506773B1 (en) |
CN (1) | CN102712609A (en) |
AR (1) | AR079327A1 (en) |
AU (1) | AU2010330031B2 (en) |
BR (1) | BR112012013175A2 (en) |
CA (1) | CA2776727C (en) |
CL (1) | CL2012001464A1 (en) |
CO (1) | CO6541656A2 (en) |
CR (1) | CR20120262A (en) |
EC (1) | ECSP12011961A (en) |
IL (1) | IL219107A (en) |
IN (1) | IN2012DN03043A (en) |
MA (1) | MA34779B1 (en) |
MX (1) | MX2012006493A (en) |
MY (1) | MY169962A (en) |
NZ (1) | NZ599008A (en) |
PE (1) | PE20121500A1 (en) |
RU (1) | RU2515221C2 (en) |
SG (1) | SG181610A1 (en) |
TW (1) | TWI487704B (en) |
UA (1) | UA103272C2 (en) |
WO (1) | WO2011069934A1 (en) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1942105B8 (en) | 2005-10-25 | 2014-08-13 | Shionogi&Co., Ltd. | Aminodihydrothiazine derivative |
KR20100017255A (en) | 2007-04-24 | 2010-02-16 | 시오노기 앤드 컴파니, 리미티드 | Aminodihydrothiazine derivatives substituted with cyclic groups |
US8653067B2 (en) | 2007-04-24 | 2014-02-18 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating Alzheimer's disease |
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-aminopyridin-4-one and 2-aminopyridine derivative both having bace1-inhibiting activity |
AR077328A1 (en) | 2009-07-24 | 2011-08-17 | Novartis Ag | DERIVATIVES OF OXAZINE AND ITS USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS |
WO2011044184A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
EP2485591B1 (en) | 2009-10-08 | 2016-03-23 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
UA108363C2 (en) | 2009-10-08 | 2015-04-27 | IMINOTIADIASIADIOXIDE OXIDES AS BACE INHIBITORS, COMPOSITIONS THEREOF AND THEIR APPLICATIONS | |
WO2011044185A2 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
RU2012129168A (en) * | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | OXASINE DERIVATIVES |
SG185651A1 (en) | 2010-06-09 | 2012-12-28 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
JP5766198B2 (en) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | Condensed aminodihydropyrimidine derivatives |
CA2816285A1 (en) | 2010-10-29 | 2012-05-03 | Shionogi & Co., Ltd. | Naphthyridine derivative |
US8957083B2 (en) | 2010-11-23 | 2015-02-17 | Amgen Inc. | Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use |
SG191097A1 (en) | 2010-12-22 | 2013-08-30 | Janssen Pharmaceutica Nv | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
US8524897B2 (en) | 2011-01-12 | 2013-09-03 | Novartis Ag | Crystalline oxazine derivative |
EP2663561B1 (en) | 2011-01-13 | 2016-03-16 | Novartis AG | Novel heterocyclic derivatives and their use in the treatment of neurological disorders |
TWI520943B (en) | 2011-01-25 | 2016-02-11 | 陶氏農業科學公司 | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates |
US8404680B2 (en) | 2011-02-08 | 2013-03-26 | Hoffmann-La Roche Inc. | N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors |
US8815841B2 (en) * | 2011-02-18 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors |
CA2825620C (en) | 2011-03-09 | 2019-04-23 | Janssen Pharmaceutica Nv | 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) |
US9221839B2 (en) | 2011-04-07 | 2015-12-29 | Merck Sharp & Dohme Corp. | C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
US8754075B2 (en) * | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
US9499502B2 (en) | 2011-04-13 | 2016-11-22 | Merck Sharp & Dohme Corp. | 5-substituted iminothiazines and their mono- and dioxides as BACE inhibitors, compositions, and their use |
CN103608345A (en) * | 2011-04-26 | 2014-02-26 | 盐野义制药株式会社 | Oxazine derivative and BACE 1 inhibitor containing same |
US8785436B2 (en) | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
US9079919B2 (en) * | 2011-05-27 | 2015-07-14 | Hoffmann-La Roche Inc. | Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors |
KR20140041590A (en) * | 2011-06-07 | 2014-04-04 | 에프. 호프만-라 로슈 아게 | [1,3]oxazines |
WO2012168164A1 (en) * | 2011-06-07 | 2012-12-13 | F. Hoffmann-La Roche Ag | Halogen-alkyl-1,3 oxazines as bace1 and/or bace2 inhibitors |
CA2844988A1 (en) | 2011-08-22 | 2013-02-28 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono- and dioxides as bace inhibitors, compositions, and their use |
UY34278A (en) | 2011-08-25 | 2013-04-05 | Novartis Ag | NEW NOXEDINE DERIVATIVES OF OXAZINE AND ITS USE IN THE TREATMENT OF DISEASES |
US8476264B2 (en) | 2011-09-21 | 2013-07-02 | Hoffmann-La Roche Inc. | N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors |
UA111749C2 (en) * | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | 6-difluoromethyl-5,6-dihydro-2H- [1,4] OXASINE-3-AMINE DERIVATIVES |
CN104066727B (en) * | 2012-01-26 | 2019-04-26 | 霍夫曼-拉罗奇有限公司 | Methyl fluoride -5,6- dihydro -4H- [1,3] oxazines class |
US8338413B1 (en) | 2012-03-07 | 2012-12-25 | Novartis Ag | Oxazine derivatives and their use in the treatment of neurological disorders |
EP2827857A4 (en) | 2012-03-20 | 2016-03-30 | Elan Pharm Inc | Spirocyclic dihydro-thiazine and dihydro-oxazine bace inhibitors, and compositions and uses thereof |
US9273042B2 (en) | 2012-05-24 | 2016-03-01 | Hoffmann-La Roche Inc. | 5-amino[1,4]thiazines as BACE 1 inhibitors |
CN104470915B (en) * | 2012-06-26 | 2019-07-26 | 霍夫曼-拉罗奇有限公司 | Two fluoro- hexahydros-cyclopenta oxazines base class and two fluoro- hexahydros-benzoxazine base class as BACE1 inhibitor |
WO2014056816A1 (en) | 2012-10-10 | 2014-04-17 | F. Hoffmann-La Roche Ag | COMBINATION OF AN Aβ ANTIBODY AND A BACE INHIBITOR |
WO2014059185A1 (en) | 2012-10-12 | 2014-04-17 | Amgen Inc. | Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use |
WO2014065434A1 (en) * | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
WO2014120658A1 (en) | 2013-01-29 | 2014-08-07 | Amgen Inc. | Fused multicyclic 3-amino-5,6-dihydro-2h-1,4-thiazine derivatives and their use as beta-secretase inhibitors |
EP2961749B1 (en) * | 2013-03-01 | 2019-10-09 | Amgen Inc. | Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
CA2903215C (en) | 2013-03-08 | 2021-07-20 | Amgen Inc. | Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
MA38556A1 (en) | 2013-04-11 | 2017-09-29 | Hoffmann La Roche | Inhibitors of bace1 |
JP2016517858A (en) * | 2013-04-26 | 2016-06-20 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Synthesis of BACE inhibitors |
BR112015030597A2 (en) | 2013-06-12 | 2017-07-25 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro [1,2,3] triazolo [1,5-a] pyrazine derivatives as beta-secretase (bace) inhibitors |
US9834559B2 (en) | 2013-06-12 | 2017-12-05 | Janssen Pharmaceutica Nv | 4-Amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2H)-one derivatives as inhibitors of beta-secretase (BACE) |
JO3318B1 (en) | 2013-06-18 | 2019-03-13 | Lilly Co Eli | Bace inhibitors |
US9096615B2 (en) | 2013-07-30 | 2015-08-04 | Amgen Inc. | Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof |
TW201623295A (en) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | Dihydrothiazine and dihydrooxazine derivatives having BACE1 inhibitory activity |
US9550762B2 (en) | 2014-08-08 | 2017-01-24 | Amgen, Inc. | Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use |
CA2967164A1 (en) | 2014-12-18 | 2016-06-23 | Janssen Pharmaceutica Nv | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase |
RU2712272C2 (en) | 2015-03-20 | 2020-01-28 | Ф. Хоффманн-Ля Рош Аг | Beta-secretase inhibitors |
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US11021493B2 (en) | 2016-12-15 | 2021-06-01 | Amgen Inc. | 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use |
EP3555106B1 (en) | 2016-12-15 | 2022-03-09 | Amgen Inc. | Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use |
AU2019258575A1 (en) | 2018-04-27 | 2020-10-29 | Shionogi & Co., Ltd. | Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity |
CN110747276B (en) * | 2019-11-22 | 2020-06-30 | 山东大学齐鲁医院 | Application of BACE2 as glioma prognosis/diagnosis/treatment marker |
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EP1942105B8 (en) | 2005-10-25 | 2014-08-13 | Shionogi&Co., Ltd. | Aminodihydrothiazine derivative |
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US8653067B2 (en) | 2007-04-24 | 2014-02-18 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating Alzheimer's disease |
KR20100017255A (en) | 2007-04-24 | 2010-02-16 | 시오노기 앤드 컴파니, 리미티드 | Aminodihydrothiazine derivatives substituted with cyclic groups |
KR101564634B1 (en) | 2008-01-18 | 2015-10-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Condensed aminodihydrothiazine derivative |
KR101259240B1 (en) | 2008-02-18 | 2013-04-29 | 시에나 바이오테크 에스.피.에이. | 4,5-dihydro-oxazol-2-yl amine derivatives |
GB0912778D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
AR077328A1 (en) | 2009-07-24 | 2011-08-17 | Novartis Ag | DERIVATIVES OF OXAZINE AND ITS USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS |
WO2011071109A1 (en) * | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | Fused heterocyclic compound having amino group |
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- 2010-06-12 UA UAA201208098A patent/UA103272C2/en unknown
- 2010-12-03 US US12/959,412 patent/US8389513B2/en not_active Expired - Fee Related
- 2010-12-06 AU AU2010330031A patent/AU2010330031B2/en not_active Ceased
- 2010-12-06 RU RU2012126989/04A patent/RU2515221C2/en not_active IP Right Cessation
- 2010-12-06 WO PCT/EP2010/068912 patent/WO2011069934A1/en active Application Filing
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- 2010-12-06 PE PE2012000803A patent/PE20121500A1/en not_active Application Discontinuation
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- 2010-12-06 CN CN2010800561519A patent/CN102712609A/en active Pending
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- 2010-12-06 EP EP10785437A patent/EP2509965A1/en not_active Withdrawn
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- 2010-12-06 BR BR112012013175A patent/BR112012013175A2/en not_active IP Right Cessation
- 2010-12-06 MA MA34922A patent/MA34779B1/en unknown
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NZ599008A (en) | 2013-08-30 |
RU2012126989A (en) | 2014-01-20 |
CN102712609A (en) | 2012-10-03 |
PE20121500A1 (en) | 2012-11-05 |
TWI487704B (en) | 2015-06-11 |
JP2013513563A (en) | 2013-04-22 |
CO6541656A2 (en) | 2012-10-16 |
AU2010330031A1 (en) | 2012-06-07 |
AR079327A1 (en) | 2012-01-18 |
BR112012013175A2 (en) | 2019-09-24 |
CA2776727A1 (en) | 2011-06-16 |
WO2011069934A1 (en) | 2011-06-16 |
US8389513B2 (en) | 2013-03-05 |
UA103272C2 (en) | 2013-09-25 |
KR20120104598A (en) | 2012-09-21 |
CA2776727C (en) | 2016-05-31 |
SG181610A1 (en) | 2012-07-30 |
CR20120262A (en) | 2012-07-27 |
KR101506773B1 (en) | 2015-03-27 |
MX2012006493A (en) | 2012-07-03 |
IL219107A (en) | 2015-10-29 |
US20110144097A1 (en) | 2011-06-16 |
ECSP12011961A (en) | 2012-07-31 |
RU2515221C2 (en) | 2014-05-10 |
MA34779B1 (en) | 2014-01-02 |
TW201124408A (en) | 2011-07-16 |
JP5584778B2 (en) | 2014-09-03 |
EP2509965A1 (en) | 2012-10-17 |
CL2012001464A1 (en) | 2014-03-07 |
MY169962A (en) | 2019-06-19 |
AU2010330031B2 (en) | 2013-06-20 |
IL219107A0 (en) | 2012-06-28 |
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