KR101506347B1 - 다불포화 지방산을 함유하는 식물 종자 오일 - Google Patents

다불포화 지방산을 함유하는 식물 종자 오일 Download PDF

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KR101506347B1
KR101506347B1 KR1020087025101A KR20087025101A KR101506347B1 KR 101506347 B1 KR101506347 B1 KR 101506347B1 KR 1020087025101 A KR1020087025101 A KR 1020087025101A KR 20087025101 A KR20087025101 A KR 20087025101A KR 101506347 B1 KR101506347 B1 KR 101506347B1
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KR20080104374A (ko
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제임스 지. 메츠
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디에스엠 아이피 어셋츠 비.브이.
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KR1020087025101A 2006-03-15 2007-03-15 다불포화 지방산을 함유하는 식물 종자 오일 Expired - Fee Related KR101506347B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78320506P 2006-03-15 2006-03-15
US60/783,205 2006-03-15
US78461606P 2006-03-21 2006-03-21
US60/784,616 2006-03-21
PCT/US2007/064105 WO2007106904A2 (en) 2006-03-15 2007-03-15 Plant seed oils containing polyunsaturated fatty acids

Publications (2)

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KR20080104374A KR20080104374A (ko) 2008-12-02
KR101506347B1 true KR101506347B1 (ko) 2015-03-26

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KR1020087025101A Expired - Fee Related KR101506347B1 (ko) 2006-03-15 2007-03-15 다불포화 지방산을 함유하는 식물 종자 오일
KR1020137023972A Expired - Fee Related KR101524398B1 (ko) 2006-03-15 2007-03-15 Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조
KR1020087025100A Expired - Fee Related KR101517243B1 (ko) 2006-03-15 2007-03-15 Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조

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KR1020137023972A Expired - Fee Related KR101524398B1 (ko) 2006-03-15 2007-03-15 Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조
KR1020087025100A Expired - Fee Related KR101517243B1 (ko) 2006-03-15 2007-03-15 Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조

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Country Link
US (5) US20070220634A1 (https=)
EP (3) EP2001277B9 (https=)
JP (4) JP2009529891A (https=)
KR (3) KR101506347B1 (https=)
CN (1) CN104073505A (https=)
AU (2) AU2007226511A1 (https=)
BR (1) BRPI0709317A2 (https=)
CA (2) CA2646317A1 (https=)
ES (1) ES2527875T3 (https=)
IL (2) IL194077A (https=)
MX (3) MX2008011784A (https=)
TW (2) TWI504748B (https=)
WO (3) WO2007106905A2 (https=)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
TWI377253B (en) 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
CN103451246B (zh) 2004-04-22 2018-02-16 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
EP2357244A3 (en) 2004-04-22 2011-11-23 Commonwealth Scientific and Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells.
WO2007106905A2 (en) * 2006-03-15 2007-09-20 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
RU2009111266A (ru) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
BRPI0806695A2 (pt) * 2007-01-12 2014-06-03 Univ Colorado Composições e métodos para aumentar a tolerância à produção de produtos químicos produzidos por microorganismos
US20090004715A1 (en) 2007-06-01 2009-01-01 Solazyme, Inc. Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
WO2009097331A1 (en) * 2008-01-28 2009-08-06 The Board Of Regents Of The University Of Oklahoma Very long chain polyunsaturated fatty acids, methods of production, and uses
WO2010019813A2 (en) * 2008-08-13 2010-02-18 Sapphire Energy, Inc. Production of fatty actds by genetically modified photosynthetic organisms
US20110218354A1 (en) * 2008-09-19 2011-09-08 President And Fellows Of Harvard College Photoautotrophic Adipogenesis Technology (Phat)
BRPI0921467B1 (pt) 2008-11-18 2021-12-14 Commonwealth Scientific And Industrial Research Organisation Processo para a produção de óleo compreendendo ácido eicosapentaenóico (epa), ácido docosapentaenóico (dpa) e ácido docosahexaenóico (dha)
MY182693A (en) * 2008-11-28 2021-01-29 Terravia Holdings Inc Production of tailored oils in heterotrophic microorganisms
EP2379703A4 (en) * 2008-12-19 2013-01-23 Alpha J Res Ltd Partnership OPTIMIZED PREPARATION OF ALGAE PRODUCTS BY DECONTROLLING CELL PROLIFERATION AND PRODUCTION OF ALGAE PRODUCT
TW201028472A (en) * 2009-01-13 2010-08-01 Alpha J Res Ltd Partnership Use of plant growth regulators to enhance algae growth for the production of added value products
ES2752196T3 (es) * 2009-03-16 2020-04-03 Dsm Ip Assets Bv Producción de proteínas en microorganismos del filo Labyrinthulomycota
US8940884B2 (en) 2009-03-19 2015-01-27 Dsm Ip Assets B.V. Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof
EP2440662B1 (en) * 2009-06-08 2018-08-01 BASF Plant Science Company GmbH Novel fatty acid elongation components and uses thereof
JP2012531914A (ja) * 2009-06-30 2012-12-13 ソレイ リミテッド ライアビリティ カンパニー ω−３脂肪酸富化ベイクド食品およびバー組成物
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
GB2487866A (en) * 2009-09-27 2012-08-08 Opx Biotechnologies Inc Method for producing 3-Hydroxypropionic acid and other products
IN2012DN06277A (https=) * 2009-12-28 2015-09-25 Dsm Ip Assets Bv
EP2519636B8 (en) * 2009-12-28 2017-08-09 DSM IP Assets B.V. Production of hemagglutinin-neuraminidase protein in microalgae
EP2519332B1 (en) 2009-12-30 2014-03-05 BASF Pharma (Callanish) Limited Simulated moving bed chromatographic separation process for the purification of polyunsaturated fatty acids
EP2521441A4 (en) * 2010-01-07 2013-10-23 Basf Agro B V Arnhem Nl Zuerich Branch HERBICID TOLERANT PLANTS
CA2788045A1 (en) * 2010-01-27 2011-08-04 Opx Biotechnologies, Inc. Microorganism production of high-valve chemical products, and related compositions, methods and systems
DK2772538T3 (da) * 2010-02-01 2016-03-07 Suntory Holdings Ltd Polynukleotid, som koder for en acyl-CoA-syntetasehomolog og fremgangsmåde til anvendelse heraf
US8372465B2 (en) 2010-02-17 2013-02-12 Bunge Oils, Inc. Oil compositions of stearidonic acid
TW201144442A (en) * 2010-05-17 2011-12-16 Dow Agrosciences Llc Production of DHA and other LC-PUFAs in plants
US11236351B2 (en) * 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
SG10201504187YA (en) 2010-05-28 2015-06-29 Solazyme Inc Tailored oils produced from recombinant heterotrophic microorganisms
AU2013202057B2 (en) * 2010-06-25 2016-01-28 Basf Plant Science Company Gmbh Acyltransferases and uses therof in fatty acid production
NO2585603T3 (https=) 2010-06-25 2018-05-19
CN108823254A (zh) 2010-11-03 2018-11-16 柯碧恩生物技术公司 具有降低倾点的微生物油、从其中产生的介电流体、以及相关方法
MX344012B (es) 2011-02-02 2016-12-02 Terravia Holdings Inc Aceites adaptados producidos a partir de microorganismos oleaginosos recombinantes.
CN102250864B (zh) * 2011-05-03 2013-03-20 中国农业大学 亚油酸异构酶在脱氢和异构方面的双重用途
US8846352B2 (en) 2011-05-06 2014-09-30 Solazyme, Inc. Genetically engineered microorganisms that metabolize xylose
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
TW201307553A (zh) * 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術
BR112014002418A2 (pt) * 2011-08-04 2017-03-14 Suntory Holdings Ltd proteína tendo atividade para promover alongamento da cadeia de ácido graxo, gene que codifica a mesma e seu uso
EP2784158A4 (en) * 2011-11-25 2015-08-05 Nat Inst Of Agrobio Sciences PLANT TRANSFORMANT, TRANSFORMATION PROCESS FOR PLANTS AND VECTOR USED IN THIS PROCEDURE
KR20150001830A (ko) 2012-04-18 2015-01-06 솔라짐, 인코포레이티드 맞춤 오일
US9719114B2 (en) 2012-04-18 2017-08-01 Terravia Holdings, Inc. Tailored oils
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
WO2013185184A2 (en) 2012-06-15 2013-12-19 Commonwealth Scientific And Industrial Research Organisation Production of long chain polyunsaturated fatty acids in plant cells
SG11201501013PA (en) * 2012-08-10 2015-04-29 Opx Biotechnologies Inc Microorganisms and methods for the production of fatty acids and fatty acid derived products
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9809804B2 (en) 2013-01-23 2017-11-07 Iowa State University Research Foundation, Inc. Materials and methods for characterizing and using KASIII for production of bi-functional fatty acids
US10184140B2 (en) 2013-01-23 2019-01-22 Iowa State University Research Foundation, Inc. Materials and methods for production of bi-functional fatty acids in recombinant bacteria
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
CA2905602A1 (en) 2013-03-15 2014-09-18 Sarah M. Hoyt Flash evaporation for product purification and recovery
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
CN106795483A (zh) 2013-07-19 2017-05-31 嘉吉公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
SG11201602638SA (en) 2013-10-04 2016-05-30 Solazyme Inc Tailored oils
CA2962266A1 (en) 2013-11-01 2015-05-07 Conagen Inc. Methods of using acyl-coa synthetase for biosynthetic production of acyl-coas
TW201525136A (zh) 2013-11-26 2015-07-01 Dow Agrosciences Llc 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸
CA3114049C (en) * 2013-12-05 2023-06-13 REG Life Sciences, LLC Microbial production of fatty amines
EP3082405A4 (en) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
ES2721269T3 (es) 2014-01-28 2019-07-30 Dsm Ip Assets Bv Factores para la producción y acumulación de ácidos grasos poliinsaturados (PUFA) obtenidos con PUFA sintasas
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
CN106574255A (zh) 2014-07-10 2017-04-19 泰拉瑞亚控股公司 酮脂酰acp合酶基因及其用途
EP3172320B1 (en) 2014-07-24 2019-11-20 Corbion Biotech, Inc. Variant thioesterases and methods of use
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN107208103A (zh) 2014-09-18 2017-09-26 泰拉瑞亚控股公司 酰基‑acp硫酯酶及其突变体
US10570427B2 (en) * 2014-10-31 2020-02-25 Lanzatech New Zealand Limited Fermentation process for the production of lipids
WO2016137897A1 (en) * 2015-02-24 2016-09-01 William Marsh Rice University Kasiii-free fa synthesis
CN107846857B (zh) 2015-06-06 2021-07-02 帝斯曼知识产权资产管理有限公司 使用新模块二十二碳六烯酸(dha)合酶生成多不饱和脂肪酸(pufas)
WO2017117425A1 (en) * 2015-12-31 2017-07-06 Synthetic Genomics, Inc. Expression of type i fatty acid synthase genes in eukaryotic algae
MX2018008351A (es) 2016-01-07 2018-12-06 Conagen Inc Metodos para preparar capsinoides por procesos biosinteticos.
CN109790513B (zh) 2016-07-19 2023-04-18 科纳根公司 用于特定天然辣椒素的微生物产生的方法
EP3577227A4 (en) 2017-02-02 2020-12-30 Cargill Inc. GENETICALLY MODIFIED CELLS PRODUCING C6-C10 FATTY ACID DERIVATIVES
US11352601B2 (en) 2017-07-27 2022-06-07 University Of Florida Research Foundation, Incorporated Cyanobacterial hosts and methods for producing chemicals
WO2019164294A1 (ko) * 2018-02-21 2019-08-29 경상북도 신규한 1-octen-3-ol을 생산하는 형질전환 효모 및 그 제조방법
KR102318983B1 (ko) * 2018-02-21 2021-11-01 경상북도 신규한 1-octen-3-ol을 생산하는 형질전환 효모 및 그 제조방법
CN112661821B (zh) * 2021-01-21 2022-04-12 江南大学 一种柠檬酸转运蛋白及其在脂质合成中的应用
US20250034601A1 (en) * 2021-10-25 2025-01-30 Purdue Research Foundation Heterodimeric benzaldehyde synthase, methods of producing, and uses thereof
US20250129395A1 (en) 2022-01-25 2025-04-24 Dsm Ip Assets B.V. Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production
WO2025238190A1 (en) 2024-05-15 2025-11-20 Dsm Ip Assets B.V. Spray-dried powders having high pufa content
US20250388920A1 (en) * 2024-06-21 2025-12-25 East Tennessee State University Research Foundation Genetically modified plants having increased oil and oleic acid content and methods of producing same
CN119193346A (zh) * 2024-11-26 2024-12-27 南京师范大学 一种过表达溶血磷脂酸酰基转移酶基因的裂殖壶菌基因工程菌株及其构建方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050100995A1 (en) * 1999-01-14 2005-05-12 Weaver Craig A. PUFA polyketide synthase systems and uses thereof

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317248D0 (en) 1983-06-24 1983-07-27 Wyeth John & Brother Ltd Fat compositions
US5246841A (en) 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5601860A (en) 1990-11-30 1997-02-11 American Home Products Corporation Corandomized fat compositions for infant formulas
US5639790A (en) * 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
JPH07501701A (ja) 1991-12-04 1995-02-23 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 植物由来の脂肪酸不飽和化酵素遺伝子
US5683898A (en) 1992-05-15 1997-11-04 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
US5798259A (en) 1992-05-15 1998-08-25 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
EP0594868A4 (en) 1992-05-15 1997-01-02 Sagami Chem Res Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid
US5310242A (en) * 1992-09-28 1994-05-10 Golder Kimberly A Portable infant seat
US6372965B1 (en) 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
DE4323727A1 (de) * 1993-07-15 1995-03-09 Boehringer Mannheim Gmbh Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
EP0831149A4 (en) 1995-01-13 2000-12-06 Sagami Chem Res GENES CODING FOR THE GROUP OF ENZYMES FOR BIOSYNTHESIS OF EICOSAPENTIC ACID AND METHOD FOR PRODUCING EICOSAPENTIC ACID
US6582941B1 (en) 1995-04-17 2003-06-24 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
AR006830A1 (es) 1996-04-26 1999-09-29 Du Pont Aceite de soja con alta estabilidad oxidativa
EP0913473A4 (en) 1996-07-10 2000-12-06 Sagami Chem Res METHOD FOR PRODUCING EICOSAPENTIC ACID BY GENETIC RECOMBINATION
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
SA98190002B1 (ar) 1997-03-28 2006-06-20 ذي يونيفيرسيتي اوف تننيسي ريسيرش كوربوريشن استخدام أحماض دهنية تحتوي على عدة روابط غير مشبعة polyunsaturated fatty acids لتقليل حدوث الالتهاب المعوي القولوني الناخر incidence of necrotizing enterocolitis
US6051754A (en) 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US6432684B1 (en) 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
BR9808506A (pt) 1997-04-11 2000-05-23 Calgene Llc Métodos e composições para sìntese de ácidos graxos poliinsaturados de cadeia longa em plantas
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
CA2283422A1 (en) 1997-06-04 1998-12-10 Calgene, Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
US6013665A (en) 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US7271315B2 (en) * 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
AU2001268296B2 (en) * 2000-06-08 2006-05-25 Miami University Fatty acid elongase 3-ketoacyl coa synthase polypeptides
US20040010817A1 (en) * 2000-07-21 2004-01-15 Washington State University Research Foundation Plant acyl-CoA synthetases
EP1911837B1 (en) 2000-09-28 2011-05-25 Bioriginal Food & Science Corp. FAD5-2 fatty acid desaturase family member and uses thereof
US6912470B2 (en) 2001-05-21 2005-06-28 Ecopia Biosciences, Inc. Genes and proteins involved in the biosynthesis of enediyne ring structures
TWI337619B (en) 2001-04-16 2011-02-21 Martek Biosciences Corp Pufa polyketide synthase systems and uses thereof
TWI377253B (en) 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US20040005672A1 (en) 2002-02-22 2004-01-08 Santi Daniel V. Heterologous production of polyketides
GB2385852A (en) * 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
EP1487985B1 (en) * 2002-03-16 2011-01-12 The University Of York Transgenic plants expressing enzymes involved in fatty acid biosynthesis
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
CN101389213B (zh) 2003-03-26 2014-05-28 Dsmip资产公司 Pufa聚酮化合物合酶系统及其用途
EP1613746B1 (de) 2003-03-31 2013-03-06 University Of Bristol Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7208590B2 (en) 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
DE102004017370A1 (de) * 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
DE102004060340A1 (de) 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
AR050881A1 (es) 2004-09-20 2006-11-29 Basf Plant Science Gmbh Genes de arabidopsis que codifican proteinas que participan en el metabolismo de azucares y lipidos y metodos de uso
GB0421937D0 (en) * 2004-10-02 2004-11-03 Univ York Acyl CoA synthetases
WO2006135866A2 (en) * 2005-06-10 2006-12-21 Martek Biosciences Corporation Pufa polyketide synthase systems and uses thereof
WO2007106905A2 (en) 2006-03-15 2007-09-20 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
FR2904328B1 (fr) * 2006-07-27 2008-10-24 St Microelectronics Sa Depot par adsorption sous un champ electrique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050100995A1 (en) * 1999-01-14 2005-05-12 Weaver Craig A. PUFA polyketide synthase systems and uses thereof

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