MX339812B - Produccion de acido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policetido pufa. - Google Patents
Produccion de acido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policetido pufa.Info
- Publication number
- MX339812B MX339812B MX2012003219A MX2012003219A MX339812B MX 339812 B MX339812 B MX 339812B MX 2012003219 A MX2012003219 A MX 2012003219A MX 2012003219 A MX2012003219 A MX 2012003219A MX 339812 B MX339812 B MX 339812B
- Authority
- MX
- Mexico
- Prior art keywords
- organisms
- pufas
- fatty acid
- express
- nucleic acid
- Prior art date
Links
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title abstract 7
- 108010030975 Polyketide Synthases Proteins 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000057234 Acyl transferases Human genes 0.000 abstract 2
- 108700016155 Acyl transferases Proteins 0.000 abstract 2
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 abstract 2
- 102000005870 Coenzyme A Ligases Human genes 0.000 abstract 2
- 108010039731 Fatty Acid Synthases Proteins 0.000 abstract 2
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 abstract 2
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 2
- 235000003869 genetically modified organism Nutrition 0.000 abstract 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 108700014220 acyltransferase activity proteins Proteins 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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Abstract
La presente invención se refiere a novedosas acil-CoA sintetasas y novedosas aciltransferasas, moléculas de ácido nucleico que las codifican, moléculas de ácido nucleico recombinante y células huésped recombinantes que contienen estas moléculas de ácido nucleico, organismos modificados genéticamente (por ejemplo, plantas, microorganismos) que han sido modificados genéticamente para que expresen un sistema del tipo policétido sintasa (PKS) para la producción de ácidos grasos poli insaturados (PUFA) (un sistema PKS de PUFA o de sintasa de PUFA), en donde los organismos han sido modificados para que expresen una acil-CoA sintetasa, para que expresen una acil transferasa, para que eliminen o inactiven una sintasa de ácido graso (FAS) expresada por el organismo, para reducir la competencia por malonil CoA con la sintasa de PUFA o para aumentar el nivel de malonil CoA en el organismo, y en un aspecto, para inhibir KASII o KASlll. Se describen otras modificaciones y métodos para hacer uso de estos organismos, además de las PUFA y los aceites obtenidos de estos organismos, solos con diversos productos incluyendo estos PUFA y aceites.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78320506P | 2006-03-15 | 2006-03-15 | |
| US78461606P | 2006-03-21 | 2006-03-21 | |
| PCT/US2007/064104 WO2007106903A2 (en) | 2006-03-15 | 2007-03-15 | Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX339812B true MX339812B (es) | 2016-06-08 |
Family
ID=38510298
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008011784A MX2008011784A (es) | 2006-03-15 | 2007-03-15 | Produccion de ácido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policétido pufa. |
| MX2012003219A MX339812B (es) | 2006-03-15 | 2007-03-15 | Produccion de acido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policetido pufa. |
| MX2008011783A MX340759B (es) | 2006-03-15 | 2007-03-15 | Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008011784A MX2008011784A (es) | 2006-03-15 | 2007-03-15 | Produccion de ácido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policétido pufa. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008011783A MX340759B (es) | 2006-03-15 | 2007-03-15 | Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados. |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US7759548B2 (es) |
| EP (3) | EP2653557A1 (es) |
| JP (4) | JP5227302B2 (es) |
| KR (3) | KR101524398B1 (es) |
| CN (1) | CN104073505A (es) |
| AU (2) | AU2007226511A1 (es) |
| BR (1) | BRPI0709317A2 (es) |
| CA (2) | CA2646317A1 (es) |
| ES (1) | ES2527875T3 (es) |
| HK (1) | HK1126253A1 (es) |
| IL (2) | IL194077A (es) |
| MX (3) | MX2008011784A (es) |
| TW (2) | TW200813222A (es) |
| WO (3) | WO2007106904A2 (es) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| TWI377253B (en) | 2001-04-16 | 2012-11-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| EP2357243B1 (en) | 2004-04-22 | 2018-12-12 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| CA2646317A1 (en) | 2006-03-15 | 2007-09-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems |
| EP2059588A4 (en) | 2006-08-29 | 2010-07-28 | Commw Scient Ind Res Org | FATTY ACID SYNTHESIS |
| US20100210017A1 (en) * | 2007-01-12 | 2010-08-19 | Gill Ryan T | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
| MY154965A (en) | 2007-06-01 | 2015-08-28 | Solazyme Inc | Production of oil in microorganisms |
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2008
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- 2008-09-14 IL IL194078A patent/IL194078A/en not_active IP Right Cessation
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2009
- 2009-05-27 HK HK09104827.2A patent/HK1126253A1/xx not_active IP Right Cessation
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2010
- 2010-06-08 US US12/796,100 patent/US8426686B2/en active Active
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2012
- 2012-11-28 JP JP2012259228A patent/JP2013116104A/ja active Pending
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2013
- 2013-03-21 US US13/848,070 patent/US9382521B2/en active Active - Reinstated
- 2013-10-22 JP JP2013219079A patent/JP2014087338A/ja not_active Withdrawn
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