DE60335708D1 - E exprimieren - Google Patents
E exprimierenInfo
- Publication number
- DE60335708D1 DE60335708D1 DE60335708T DE60335708T DE60335708D1 DE 60335708 D1 DE60335708 D1 DE 60335708D1 DE 60335708 T DE60335708 T DE 60335708T DE 60335708 T DE60335708 T DE 60335708T DE 60335708 D1 DE60335708 D1 DE 60335708D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- acid sequences
- polypeptides
- cells
- express
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0206308A GB0206308D0 (en) | 2002-03-16 | 2002-03-16 | Enzymes |
GB0212133A GB0212133D0 (en) | 2002-05-25 | 2002-05-25 | Enzymes |
GB0216013A GB0216013D0 (en) | 2002-07-11 | 2002-07-11 | Enzymes |
GB0225489A GB0225489D0 (en) | 2002-11-01 | 2002-11-01 | Enzymes |
PCT/GB2003/001099 WO2003078639A2 (en) | 2002-03-16 | 2003-03-17 | Transgenic plants expressing enzymes involved in fatty acid biosynthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60335708D1 true DE60335708D1 (de) | 2011-02-24 |
Family
ID=28046602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60335708T Expired - Lifetime DE60335708D1 (de) | 2002-03-16 | 2003-03-17 | E exprimieren |
Country Status (8)
Country | Link |
---|---|
US (1) | US7705202B2 (de) |
EP (2) | EP1487985B1 (de) |
AT (1) | ATE495263T1 (de) |
AU (1) | AU2003224236A1 (de) |
CA (1) | CA2519169C (de) |
DE (1) | DE60335708D1 (de) |
ES (1) | ES2388490T3 (de) |
WO (1) | WO2003078639A2 (de) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
GB0316629D0 (en) * | 2003-07-16 | 2003-08-20 | Univ York | Transgenic cell |
PT1322752E (pt) | 2000-09-28 | 2010-05-06 | Bioriginal Food & Science Corp | Fad4, fad5, fad5-2 e fad6, novos membros da família de dessaturases de ácidos gordos e susas utilizações |
US7626079B2 (en) * | 2001-07-20 | 2009-12-01 | The University Of Leeds | Regulation of peroxisomal fatty acid transport in plants |
BR122019013214B1 (pt) | 2004-04-22 | 2022-04-12 | Commonwealth Scientific And Industrial Research Organisation | Polinucleotídeo isolado, vetor, célula recombinante, método para produzir uma célula recombinante, método para produzir um ou mais ácido graxo(s) poliinsaturado de cadeia longa, método para produzir uma semente transgênica, método para produzir óleo, método para produzir uma semente oleaginosa, extrato da semente transgênica, composição compreendendo o referido extrato, ração e uso da referida célula recombinante ou extrato |
US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
AU2011232757B2 (en) * | 2004-04-22 | 2013-10-03 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
GB0421937D0 (en) * | 2004-10-02 | 2004-11-03 | Univ York | Acyl CoA synthetases |
JP2009529891A (ja) * | 2006-03-15 | 2009-08-27 | マーテック バイオサイエンシーズ コーポレーション | 多価不飽和脂肪酸を含む植物種子油 |
CA2693630C (en) | 2006-07-14 | 2021-08-31 | Commonwealth Scientific And Industrial Research Organisation | Altering the fatty acid composition of rice |
WO2008025068A1 (en) | 2006-08-29 | 2008-03-06 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of fatty acids |
WO2008060571A2 (en) * | 2006-11-13 | 2008-05-22 | Aurora Biofuels, Inc. | Methods and compositions for production and purification of biofuel from plants and microalgae |
JP2010533003A (ja) | 2007-07-13 | 2010-10-21 | オーシャン ニュートリッション カナダ リミテッド | D4デサチュラーゼ及びd5エロンガーゼ |
CA2695112A1 (en) | 2007-07-31 | 2009-02-05 | Basf Plant Science Gmbh | Elongases and processes for the production of polyunsaturated fatty acids in transgenic organisms |
BRPI0909611B8 (pt) | 2008-05-23 | 2022-12-06 | Pioneer Hi Bred Int | Método de aumento do teor total de ácido graxo de uma célula de oleaginosa, ácido nucleico recombinante, construção de dna recombinante e método de produção de uma semente oleaginosa |
EP2620500A3 (de) | 2008-05-23 | 2014-01-08 | E. I. du Pont de Nemours and Company | DGAT-Gene aus ölhaltigen Organismen für erhöhte Samenfettproduktion sowie veränderte Fettsäureprofile bei Ölsamenpflanzen |
AU2009273755A1 (en) | 2008-07-21 | 2010-01-28 | Commonwealth Scientific And Industrial Research Organisation | Improved vegetable oils and uses therefor |
CN102202498B (zh) | 2008-07-21 | 2016-09-07 | 澳大利亚联邦科学与工业研究组织 | 改良的棉籽油及应用 |
US20100022393A1 (en) * | 2008-07-24 | 2010-01-28 | Bertrand Vick | Glyphosate applications in aquaculture |
CA2743880C (en) | 2008-11-18 | 2020-08-18 | James Robertson Petrie | Recombinant cells comprising exogenous a5 elongase and methods for producing docosapentaenoic acid |
US8431772B1 (en) | 2008-11-19 | 2013-04-30 | University Of Kentucky Research Foundation | Diacylglycerol acyltransferase sequences and related methods |
US8940340B2 (en) * | 2009-01-22 | 2015-01-27 | Aurora Algae, Inc. | Systems and methods for maintaining the dominance of Nannochloropsis in an algae cultivation system |
US8143051B2 (en) * | 2009-02-04 | 2012-03-27 | Aurora Algae, Inc. | Systems and methods for maintaining the dominance and increasing the biomass production of nannochloropsis in an algae cultivation system |
TWI600762B (zh) * | 2009-03-19 | 2017-10-01 | Dsm智慧財產有限公司 | 多不飽和脂肪酸合成酶核酸分子及多肽,組成物,以及其製造方法與用途 |
US9187778B2 (en) * | 2009-05-04 | 2015-11-17 | Aurora Algae, Inc. | Efficient light harvesting |
US8865452B2 (en) * | 2009-06-15 | 2014-10-21 | Aurora Algae, Inc. | Systems and methods for extracting lipids from wet algal biomass |
US8769867B2 (en) * | 2009-06-16 | 2014-07-08 | Aurora Algae, Inc. | Systems, methods, and media for circulating fluid in an algae cultivation pond |
US9101942B2 (en) * | 2009-06-16 | 2015-08-11 | Aurora Algae, Inc. | Clarification of suspensions |
US8747930B2 (en) * | 2009-06-29 | 2014-06-10 | Aurora Algae, Inc. | Siliceous particles |
US20100325948A1 (en) * | 2009-06-29 | 2010-12-30 | Mehran Parsheh | Systems, methods, and media for circulating and carbonating fluid in an algae cultivation pond |
US8765983B2 (en) * | 2009-10-30 | 2014-07-01 | Aurora Algae, Inc. | Systems and methods for extracting lipids from and dehydrating wet algal biomass |
US8748160B2 (en) * | 2009-12-04 | 2014-06-10 | Aurora Alage, Inc. | Backward-facing step |
US8202425B2 (en) | 2010-04-06 | 2012-06-19 | Heliae Development, Llc | Extraction of neutral lipids by a two solvent method |
US8273248B1 (en) | 2010-04-06 | 2012-09-25 | Heliae Development, Llc | Extraction of neutral lipids by a two solvent method |
WO2011127127A2 (en) | 2010-04-06 | 2011-10-13 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Extraction with fractionation of oil and co-products from oleaginous material |
US8211308B2 (en) | 2010-04-06 | 2012-07-03 | Heliae Development, Llc | Extraction of polar lipids by a two solvent method |
MX2012011558A (es) | 2010-04-06 | 2013-02-21 | Heliae Dev Llc | Metodos y sistemas para producir biocombustible. |
US8313648B2 (en) | 2010-04-06 | 2012-11-20 | Heliae Development, Llc | Methods of and systems for producing biofuels from algal oil |
US8308951B1 (en) | 2010-04-06 | 2012-11-13 | Heliae Development, Llc | Extraction of proteins by a two solvent method |
US8115022B2 (en) | 2010-04-06 | 2012-02-14 | Heliae Development, Llc | Methods of producing biofuels, chlorophylls and carotenoids |
US8475660B2 (en) | 2010-04-06 | 2013-07-02 | Heliae Development, Llc | Extraction of polar lipids by a two solvent method |
US8211309B2 (en) | 2010-04-06 | 2012-07-03 | Heliae Development, Llc | Extraction of proteins by a two solvent method |
RU2636344C2 (ru) | 2010-06-28 | 2017-11-22 | Коммонуэлт Сайентифик энд Индастриал Рисерч Организейшн | Способы получения липидов |
US8926844B2 (en) | 2011-03-29 | 2015-01-06 | Aurora Algae, Inc. | Systems and methods for processing algae cultivation fluid |
US8569530B2 (en) | 2011-04-01 | 2013-10-29 | Aurora Algae, Inc. | Conversion of saponifiable lipids into fatty esters |
US8752329B2 (en) | 2011-04-29 | 2014-06-17 | Aurora Algae, Inc. | Optimization of circulation of fluid in an algae cultivation pond |
US8365462B2 (en) | 2011-05-31 | 2013-02-05 | Heliae Development, Llc | V-Trough photobioreactor systems |
USD682637S1 (en) | 2011-06-10 | 2013-05-21 | Heliae Development, Llc | Aquaculture vessel |
USD679965S1 (en) | 2011-06-10 | 2013-04-16 | Heliae Development, Llc | Aquaculture vessel |
USD661164S1 (en) | 2011-06-10 | 2012-06-05 | Heliae Development, Llc | Aquaculture vessel |
WO2013075116A2 (en) | 2011-11-17 | 2013-05-23 | Heliae Development, Llc | Omega 7 rich compositions and methods of isolating omega 7 fatty acids |
BR112014015921A2 (pt) | 2011-12-27 | 2021-05-25 | Commonwealth Scientific And Industrial Research Organisation | processos para produzir lipídeos |
US11639507B2 (en) | 2011-12-27 | 2023-05-02 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
US8809026B2 (en) | 2011-12-27 | 2014-08-19 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
US10323209B2 (en) | 2012-04-25 | 2019-06-18 | Commonwealth Scientific And Industrial Research Organisation | High oleic acid oils |
MY187101A (en) | 2012-06-15 | 2021-08-31 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
US9266973B2 (en) | 2013-03-15 | 2016-02-23 | Aurora Algae, Inc. | Systems and methods for utilizing and recovering chitosan to process biological material |
UA122768C2 (uk) | 2013-12-18 | 2021-01-06 | Коммонвелз Сайнтіфік Енд Індастріал Рисерч Организейшн | Екстрагований рослинний ліпід, що містить довголанцюгові поліненасичені жирні кислоти |
AU2015281791A1 (en) | 2014-06-27 | 2017-01-12 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising docosapentaenoic acid |
JP6882160B2 (ja) | 2014-07-07 | 2021-06-02 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション | 植物脂質から工業製品を製造する工程 |
JP7423177B2 (ja) | 2014-11-14 | 2024-01-29 | ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー | Pufaを含有する植物性脂質の改質 |
BR112019004530A2 (pt) | 2016-09-02 | 2019-10-22 | Commw Scient Ind Res Org | plantas com traços modificados |
CN109022284B (zh) * | 2018-09-03 | 2021-05-21 | 杭州园泰生物科技有限公司 | 提高球等鞭金藻生物量以及dha产量的方法 |
CA3129494A1 (en) | 2019-02-14 | 2020-08-20 | Cargill, Incorporated | Brassica plants producing elevated levels of polyunsaturated fatty acids |
WO2022098631A1 (en) | 2020-11-04 | 2022-05-12 | Cargill, Incorporated | Harvest management |
AU2022246152A1 (en) | 2021-03-25 | 2023-10-05 | Basf Plant Science Company Gmbh | Fertilizer management |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1288073C (en) | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
US5569597A (en) | 1985-05-13 | 1996-10-29 | Ciba Geigy Corp. | Methods of inserting viral DNA into plant material |
US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
US5608142A (en) | 1986-12-03 | 1997-03-04 | Agracetus, Inc. | Insecticidal cotton plants |
ATE225853T1 (de) | 1990-04-12 | 2002-10-15 | Syngenta Participations Ag | Gewebe-spezifische promotoren |
US5498830A (en) | 1990-06-18 | 1996-03-12 | Monsanto Company | Decreased oil content in plant seeds |
US5399680A (en) | 1991-05-22 | 1995-03-21 | The Salk Institute For Biological Studies | Rice chitinase promoter |
WO1993004177A1 (en) | 1991-08-27 | 1993-03-04 | Agricultural Genetics Company Limited | Proteins with insecticidal properties against homopteran insects and their use in plant protection |
US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
US5789156A (en) | 1993-06-14 | 1998-08-04 | Basf Ag | Tetracycline-regulated transcriptional inhibitors |
US5608144A (en) | 1994-08-12 | 1997-03-04 | Dna Plant Technology Corp. | Plant group 2 promoters and uses thereof |
US6307128B1 (en) | 1997-06-03 | 2001-10-23 | Miami University | Fatty acid elongases |
US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
CA2365096A1 (en) * | 1999-03-18 | 2000-09-21 | The University Of Bristol | Polyunsaturated fatty acid (pufa) elongase from caenorhabditis elegans |
IL150414A0 (en) | 2000-02-09 | 2002-12-01 | Basf Ag | Novel elongase gene and method for producing multiple-unsaturated fatty acid |
-
2003
- 2003-03-17 US US10/508,109 patent/US7705202B2/en active Active
- 2003-03-17 AT AT03720659T patent/ATE495263T1/de active
- 2003-03-17 CA CA2519169A patent/CA2519169C/en not_active Expired - Lifetime
- 2003-03-17 EP EP03720659A patent/EP1487985B1/de not_active Expired - Lifetime
- 2003-03-17 ES ES10009225T patent/ES2388490T3/es not_active Expired - Lifetime
- 2003-03-17 EP EP10009225A patent/EP2302060B1/de not_active Expired - Lifetime
- 2003-03-17 DE DE60335708T patent/DE60335708D1/de not_active Expired - Lifetime
- 2003-03-17 AU AU2003224236A patent/AU2003224236A1/en not_active Abandoned
- 2003-03-17 WO PCT/GB2003/001099 patent/WO2003078639A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1487985A2 (de) | 2004-12-22 |
US20050164192A1 (en) | 2005-07-28 |
US7705202B2 (en) | 2010-04-27 |
CA2519169A1 (en) | 2003-09-25 |
ATE495263T1 (de) | 2011-01-15 |
AU2003224236A8 (en) | 2003-09-29 |
EP2302060A1 (de) | 2011-03-30 |
WO2003078639A3 (en) | 2004-02-12 |
EP2302060B1 (de) | 2012-07-25 |
WO2003078639A2 (en) | 2003-09-25 |
AU2003224236A1 (en) | 2003-09-29 |
CA2519169C (en) | 2013-04-30 |
ES2388490T3 (es) | 2012-10-15 |
EP1487985B1 (de) | 2011-01-12 |
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