KR101407033B1 - 변형 방출형의 활성 성분 및 양친매성 공중합체에 기초한 미립자 및 이를 함유하는 약학 제형 - Google Patents

변형 방출형의 활성 성분 및 양친매성 공중합체에 기초한 미립자 및 이를 함유하는 약학 제형 Download PDF

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Publication number
KR101407033B1
KR101407033B1 KR1020097004345A KR20097004345A KR101407033B1 KR 101407033 B1 KR101407033 B1 KR 101407033B1 KR 1020097004345 A KR1020097004345 A KR 1020097004345A KR 20097004345 A KR20097004345 A KR 20097004345A KR 101407033 B1 KR101407033 B1 KR 101407033B1
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KR
South Korea
Prior art keywords
microparticles
pharmaceutical formulation
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group
polymer
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KR1020097004345A
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English (en)
Korean (ko)
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KR20090054976A (ko
Inventor
알레인 콘스탄시스
유-핑 찬
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플라멜 테크놀로지스
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Publication of KR20090054976A publication Critical patent/KR20090054976A/ko
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Publication of KR101407033B1 publication Critical patent/KR101407033B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
KR1020097004345A 2006-07-28 2007-07-30 변형 방출형의 활성 성분 및 양친매성 공중합체에 기초한 미립자 및 이를 함유하는 약학 제형 KR101407033B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0653191A FR2904219B1 (fr) 2006-07-28 2006-07-28 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
FR0653191 2006-07-28
PCT/EP2007/006722 WO2008025425A1 (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
KR20090054976A KR20090054976A (ko) 2009-06-01
KR101407033B1 true KR101407033B1 (ko) 2014-06-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097004345A KR101407033B1 (ko) 2006-07-28 2007-07-30 변형 방출형의 활성 성분 및 양친매성 공중합체에 기초한 미립자 및 이를 함유하는 약학 제형

Country Status (11)

Country Link
EP (1) EP2049085A1 (zh)
JP (1) JP5302197B2 (zh)
KR (1) KR101407033B1 (zh)
CN (1) CN101568328B (zh)
BR (1) BRPI0714943A2 (zh)
CA (1) CA2661567C (zh)
FR (1) FR2904219B1 (zh)
IL (1) IL196426A (zh)
MX (1) MX2009000951A (zh)
WO (1) WO2008025425A1 (zh)
ZA (1) ZA200900929B (zh)

Families Citing this family (14)

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FR2934161B1 (fr) * 2008-07-28 2010-09-17 Flamel Tech Sa Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.
FR2940619B1 (fr) * 2008-12-31 2012-02-10 Flamel Technologies Sa Composition comprenant un actif de solubilite aqueuse faible ou moyenne
FR2954325B1 (fr) 2009-12-23 2012-02-03 Flamel Tech Sa Polymere amphiphile fonctionnalise par la methionine
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物
CN102232932B (zh) * 2010-04-27 2013-06-05 重庆莱美药业股份有限公司 果胶-阿霉素轭合物的冻干制剂及制备方法
CN102657843A (zh) * 2012-06-05 2012-09-12 云南民族大学 抗菌肽组合物及其制备方法
CN103483583B (zh) * 2013-09-24 2015-11-18 昆明理工大学 一种ε-聚赖氨酸的制备方法
WO2015151103A1 (en) * 2014-04-03 2015-10-08 Biondvax Pharmaceuticals Ltd. Compositions of multimeric-multiepitope influenza polypeptides and their production
AU2015338717B2 (en) 2014-10-31 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Powder formulation
KR101891715B1 (ko) * 2016-01-15 2018-08-27 연세대학교 산학협력단 바이러스 감염의 치료용 폴리아미노산 기반의 생체환경 감응형 나노입자
WO2018025699A1 (ja) * 2016-08-02 2018-02-08 日本化薬株式会社 アクティブターゲティング型高分子誘導体、その高分子誘導体を含む組成物、及びそれらの用途
CN110483785B (zh) * 2019-07-01 2020-05-19 中山大学 一种三嵌段聚合物、载药纳米胶束、纳米药物及其制备方法和应用
CN110343245B (zh) * 2019-07-16 2021-09-28 天津大学 一种ε-聚赖氨酸-接枝-疏水氨基酸-接枝-海藻糖的糖肽及制备方法
CN112553759A (zh) * 2020-11-30 2021-03-26 福建凤竹纺织科技股份有限公司 一种多功能海藻纤维针织面料

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051416A1 (fr) 2003-11-21 2005-06-09 Flamel Technologies Formulations pharmaceutiques pour la libération prolongée de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques

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DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5250293A (en) * 1991-04-22 1993-10-05 Gleich Gerald J Method for the treatment of hypersensitivity diseases by administration of anionic polymers
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DE4407898A1 (de) * 1994-03-09 1995-09-14 Hoechst Ag Nanopartikel, enthaltend einen Wirkstoff und ein Polyketalweinsäureamid, Verfahren zu ihrer Herstellung und Verwendung derselben
DK1071407T3 (da) * 1999-01-18 2014-10-20 Lg Life Sciences Ltd Lipofile mikropartikler indeholdende et proteinlægemiddel eller et antigen og formulering omhandlende samme
FR2814951B1 (fr) * 2000-10-06 2003-01-17 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
WO2003035051A2 (en) * 2001-10-19 2003-05-01 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
FR2862541B1 (fr) * 2003-11-21 2007-04-20 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051416A1 (fr) 2003-11-21 2005-06-09 Flamel Technologies Formulations pharmaceutiques pour la libération prolongée de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques

Also Published As

Publication number Publication date
IL196426A (en) 2014-07-31
CA2661567A1 (fr) 2008-03-06
CN101568328A (zh) 2009-10-28
CA2661567C (fr) 2016-09-20
WO2008025425A1 (fr) 2008-03-06
AU2007291577A1 (en) 2008-03-06
WO2008025425B1 (fr) 2008-05-02
MX2009000951A (es) 2009-02-04
FR2904219A1 (fr) 2008-02-01
WO2008025425A8 (fr) 2009-04-16
WO2008025425A9 (fr) 2008-06-12
ZA200900929B (en) 2010-06-30
EP2049085A1 (fr) 2009-04-22
CN101568328B (zh) 2012-09-05
KR20090054976A (ko) 2009-06-01
BRPI0714943A2 (pt) 2013-05-21
FR2904219B1 (fr) 2010-08-13
JP5302197B2 (ja) 2013-10-02
JP2009544759A (ja) 2009-12-17
IL196426A0 (en) 2009-09-22

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