KR101319071B1 - 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법 - Google Patents

5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법 Download PDF

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Publication number
KR101319071B1
KR101319071B1 KR1020077028640A KR20077028640A KR101319071B1 KR 101319071 B1 KR101319071 B1 KR 101319071B1 KR 1020077028640 A KR1020077028640 A KR 1020077028640A KR 20077028640 A KR20077028640 A KR 20077028640A KR 101319071 B1 KR101319071 B1 KR 101319071B1
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KR
South Korea
Prior art keywords
methyl
trifluoromethyl
imidazole
imidazol
benzeneamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020077028640A
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English (en)
Korean (ko)
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KR20080016618A (ko
Inventor
무라트 아체모글루
베르톨트 쉔켈
웬-충 시에
송 쉬에
에리히 위드머
페드로 가르시아 푸엔테스
호세 마틴 메디나
프란시스코 빈센테 바뇨스
Original Assignee
노파르티스 아게
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Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20080016618A publication Critical patent/KR20080016618A/ko
Application granted granted Critical
Publication of KR101319071B1 publication Critical patent/KR101319071B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020077028640A 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법 Expired - Fee Related KR101319071B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68892005P 2005-06-09 2005-06-09
US60/688,920 2005-06-09
PCT/US2006/022026 WO2006135619A1 (en) 2005-06-09 2006-06-07 Process for the synthesis of 5- (methyl- 1h-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine

Publications (2)

Publication Number Publication Date
KR20080016618A KR20080016618A (ko) 2008-02-21
KR101319071B1 true KR101319071B1 (ko) 2013-10-17

Family

ID=37085334

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077028640A Expired - Fee Related KR101319071B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법

Country Status (20)

Country Link
US (1) US7709657B2 (enExample)
EP (1) EP1896425B1 (enExample)
JP (1) JP5139273B2 (enExample)
KR (1) KR101319071B1 (enExample)
CN (1) CN101193866B (enExample)
AR (1) AR057351A1 (enExample)
AT (1) ATE483690T1 (enExample)
AU (1) AU2006258116B2 (enExample)
BR (1) BRPI0611924A2 (enExample)
CA (1) CA2610402C (enExample)
DE (1) DE602006017369D1 (enExample)
ES (1) ES2354115T3 (enExample)
GT (1) GT200600207A (enExample)
MX (1) MX2007015420A (enExample)
PE (1) PE20070084A1 (enExample)
PL (1) PL1896425T3 (enExample)
PT (1) PT1896425E (enExample)
RU (1) RU2404167C2 (enExample)
TW (1) TW200710084A (enExample)
WO (1) WO2006135619A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
GB0618832D0 (en) * 2006-09-25 2006-11-01 Phoenix Chemicals Ltd Chemical process
US20110053968A1 (en) * 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
US10005439B2 (en) 2014-05-16 2018-06-26 Robert Bosch Gmbh ABS hydraulic unit
KR102335216B1 (ko) 2017-04-26 2021-12-03 삼성전자 주식회사 발광소자 패키지
CN107235910B (zh) * 2017-07-31 2020-04-24 安礼特（上海）医药科技有限公司 一种尼洛胺的合成方法
CN108530364B (zh) 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005281A1 (en) 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
ES2167377T3 (es) * 1993-10-01 2002-05-16 Novartis Ag Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
AR037647A1 (es) * 2002-05-29 2004-12-01 Novartis Ag Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina
US7202367B2 (en) 2002-05-31 2007-04-10 Rhodia Chimie Process for arylating or vinylating or alkynating a nucleophilic compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005281A1 (en) 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases

Also Published As

Publication number Publication date
GT200600207A (es) 2007-01-15
ES2354115T3 (es) 2011-03-10
AU2006258116B2 (en) 2010-11-25
DE602006017369D1 (de) 2010-11-18
PE20070084A1 (es) 2007-03-09
CA2610402C (en) 2014-09-16
US20080200691A1 (en) 2008-08-21
CN101193866B (zh) 2011-01-19
JP5139273B2 (ja) 2013-02-06
CA2610402A1 (en) 2006-12-21
EP1896425A1 (en) 2008-03-12
BRPI0611924A2 (pt) 2010-10-05
AU2006258116A1 (en) 2006-12-21
ATE483690T1 (de) 2010-10-15
PL1896425T3 (pl) 2011-04-29
MX2007015420A (es) 2008-02-21
PT1896425E (pt) 2010-11-30
AR057351A1 (es) 2007-11-28
EP1896425B1 (en) 2010-10-06
JP2008545782A (ja) 2008-12-18
US7709657B2 (en) 2010-05-04
TW200710084A (en) 2007-03-16
CN101193866A (zh) 2008-06-04
WO2006135619A1 (en) 2006-12-21
RU2404167C2 (ru) 2010-11-20
KR20080016618A (ko) 2008-02-21
RU2007147927A (ru) 2009-07-20

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