AU2006258116B2 - Process for the synthesis of 5- (methyl- 1H-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine - Google Patents

Process for the synthesis of 5- (methyl- 1H-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine Download PDF

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Publication number
AU2006258116B2
AU2006258116B2 AU2006258116A AU2006258116A AU2006258116B2 AU 2006258116 B2 AU2006258116 B2 AU 2006258116B2 AU 2006258116 A AU2006258116 A AU 2006258116A AU 2006258116 A AU2006258116 A AU 2006258116A AU 2006258116 B2 AU2006258116 B2 AU 2006258116B2
Authority
AU
Australia
Prior art keywords
methyl
trifluoromethyl
process according
imidazole
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006258116A
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English (en)
Other versions
AU2006258116A1 (en
Inventor
Murat Acemoglu
Pedro Garcia Fuentes
Jose Martin Medina
Berthold Schenkel
Wen-Chung Shieh
Francisco Vicente Banos
Erich Widmer
Song Xue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2006258116A1 publication Critical patent/AU2006258116A1/en
Application granted granted Critical
Publication of AU2006258116B2 publication Critical patent/AU2006258116B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2006258116A 2005-06-09 2006-06-07 Process for the synthesis of 5- (methyl- 1H-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine Ceased AU2006258116B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68892005P 2005-06-09 2005-06-09
US60/688,920 2005-06-09
PCT/US2006/022026 WO2006135619A1 (en) 2005-06-09 2006-06-07 Process for the synthesis of 5- (methyl- 1h-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine

Publications (2)

Publication Number Publication Date
AU2006258116A1 AU2006258116A1 (en) 2006-12-21
AU2006258116B2 true AU2006258116B2 (en) 2010-11-25

Family

ID=37085334

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006258116A Ceased AU2006258116B2 (en) 2005-06-09 2006-06-07 Process for the synthesis of 5- (methyl- 1H-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine

Country Status (20)

Country Link
US (1) US7709657B2 (enExample)
EP (1) EP1896425B1 (enExample)
JP (1) JP5139273B2 (enExample)
KR (1) KR101319071B1 (enExample)
CN (1) CN101193866B (enExample)
AR (1) AR057351A1 (enExample)
AT (1) ATE483690T1 (enExample)
AU (1) AU2006258116B2 (enExample)
BR (1) BRPI0611924A2 (enExample)
CA (1) CA2610402C (enExample)
DE (1) DE602006017369D1 (enExample)
ES (1) ES2354115T3 (enExample)
GT (1) GT200600207A (enExample)
MX (1) MX2007015420A (enExample)
PE (1) PE20070084A1 (enExample)
PL (1) PL1896425T3 (enExample)
PT (1) PT1896425E (enExample)
RU (1) RU2404167C2 (enExample)
TW (1) TW200710084A (enExample)
WO (1) WO2006135619A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
GB0618832D0 (en) * 2006-09-25 2006-11-01 Phoenix Chemicals Ltd Chemical process
US20110053968A1 (en) * 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
EP3144194B1 (en) 2014-05-16 2018-05-09 Robert Bosch GmbH Abs hydraulic unit
KR102335216B1 (ko) 2017-04-26 2021-12-03 삼성전자 주식회사 발광소자 패키지
CN107235910B (zh) * 2017-07-31 2020-04-24 安礼特（上海）医药科技有限公司 一种尼洛胺的合成方法
CN108530364B (zh) 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
CN1047776C (zh) * 1993-10-01 1999-12-29 诺瓦蒂斯有限公司 具有药理学活性的吡啶类衍生物及其制备方法
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
PE20040522A1 (es) * 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
US7202367B2 (en) 2002-05-31 2007-04-10 Rhodia Chimie Process for arylating or vinylating or alkynating a nucleophilic compound
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
AR057351A1 (es) 2007-11-28
PL1896425T3 (pl) 2011-04-29
WO2006135619A1 (en) 2006-12-21
US20080200691A1 (en) 2008-08-21
BRPI0611924A2 (pt) 2010-10-05
CN101193866B (zh) 2011-01-19
DE602006017369D1 (de) 2010-11-18
TW200710084A (en) 2007-03-16
JP2008545782A (ja) 2008-12-18
RU2404167C2 (ru) 2010-11-20
MX2007015420A (es) 2008-02-21
KR101319071B1 (ko) 2013-10-17
JP5139273B2 (ja) 2013-02-06
RU2007147927A (ru) 2009-07-20
CA2610402A1 (en) 2006-12-21
ATE483690T1 (de) 2010-10-15
EP1896425B1 (en) 2010-10-06
EP1896425A1 (en) 2008-03-12
US7709657B2 (en) 2010-05-04
PT1896425E (pt) 2010-11-30
ES2354115T3 (es) 2011-03-10
PE20070084A1 (es) 2007-03-09
AU2006258116A1 (en) 2006-12-21
CA2610402C (en) 2014-09-16
GT200600207A (es) 2007-01-15
CN101193866A (zh) 2008-06-04
KR20080016618A (ko) 2008-02-21

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired