KR101218213B1 - 카스파제의 활성인자 및 세포자멸사의 유도인자로서의4-아릴아미노-퀴나졸린 - Google Patents
카스파제의 활성인자 및 세포자멸사의 유도인자로서의4-아릴아미노-퀴나졸린 Download PDFInfo
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- KR101218213B1 KR101218213B1 KR1020067000187A KR20067000187A KR101218213B1 KR 101218213 B1 KR101218213 B1 KR 101218213B1 KR 1020067000187 A KR1020067000187 A KR 1020067000187A KR 20067000187 A KR20067000187 A KR 20067000187A KR 101218213 B1 KR101218213 B1 KR 101218213B1
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- 0 Cc(c(N(*)c(c([U]([Rn]=I)=*(*)[U](C)=C**)c1C)pc(*)*1P)c1*=C)c(*)c(*)c1[Re] Chemical compound Cc(c(N(*)c(c([U]([Rn]=I)=*(*)[U](C)=C**)c1C)pc(*)*1P)c1*=C)c(*)c(*)c1[Re] 0.000 description 6
- HWSLPYIZURSBDY-UHFFFAOYSA-N CC(CC(C)=CC1)C1OC Chemical compound CC(CC(C)=CC1)C1OC HWSLPYIZURSBDY-UHFFFAOYSA-N 0.000 description 1
- FIXBWSNMTCVMDA-UHFFFAOYSA-N CCCC(C)OCc1ccc(C)cc1 Chemical compound CCCC(C)OCc1ccc(C)cc1 FIXBWSNMTCVMDA-UHFFFAOYSA-N 0.000 description 1
- NHSXPANLTGKJRK-UHFFFAOYSA-N CCCOc(cc1)ccc1N(CC)c1nc(Cl)nc2ccccc12 Chemical compound CCCOc(cc1)ccc1N(CC)c1nc(Cl)nc2ccccc12 NHSXPANLTGKJRK-UHFFFAOYSA-N 0.000 description 1
- MSJDZQAPAIGAFY-UHFFFAOYSA-N CCc(cc1)ccc1Nc1nc(C)nc2c1cccc2 Chemical compound CCc(cc1)ccc1Nc1nc(C)nc2c1cccc2 MSJDZQAPAIGAFY-UHFFFAOYSA-N 0.000 description 1
- ODIKAAXWUXCNCY-UHFFFAOYSA-N CN(Cc(cc1)ccc1OC)c1nc(Cl)nc2ccccc12 Chemical compound CN(Cc(cc1)ccc1OC)c1nc(Cl)nc2ccccc12 ODIKAAXWUXCNCY-UHFFFAOYSA-N 0.000 description 1
- YZVNXLGRTUNMJP-UHFFFAOYSA-N CN(c(cc1)ccc1OC)C1=C2N=CNC2=NC(N)N1C Chemical compound CN(c(cc1)ccc1OC)C1=C2N=CNC2=NC(N)N1C YZVNXLGRTUNMJP-UHFFFAOYSA-N 0.000 description 1
- KELXSRIJIVMIEF-UHFFFAOYSA-N CN(c(cc1)ccc1OC)c1nc(C(O)=O)nc2c1cccc2 Chemical compound CN(c(cc1)ccc1OC)c1nc(C(O)=O)nc2c1cccc2 KELXSRIJIVMIEF-UHFFFAOYSA-N 0.000 description 1
- CRJNFYARUGUOJP-UHFFFAOYSA-N CN(c(cc1)ccc1OC)c1nc(C[ClH]I)nc2c1cccc2 Chemical compound CN(c(cc1)ccc1OC)c1nc(C[ClH]I)nc2c1cccc2 CRJNFYARUGUOJP-UHFFFAOYSA-N 0.000 description 1
- FPYMICFLRIEXEX-UHFFFAOYSA-N CN(c1ccccc1)c1c(cc(c(OC)c2)OC)c2ncn1 Chemical compound CN(c1ccccc1)c1c(cc(c(OC)c2)OC)c2ncn1 FPYMICFLRIEXEX-UHFFFAOYSA-N 0.000 description 1
- FHQAWLQDAZMCOP-UHFFFAOYSA-N Cc1nc2ccccc2c(N(C)c(cc2)nnc2OC)n1 Chemical compound Cc1nc2ccccc2c(N(C)c(cc2)nnc2OC)n1 FHQAWLQDAZMCOP-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48432503P | 2003-07-03 | 2003-07-03 | |
US60/484,325 | 2003-07-03 | ||
US49300603P | 2003-08-07 | 2003-08-07 | |
US60/493,006 | 2003-08-07 | ||
US55755604P | 2004-03-29 | 2004-03-29 | |
US60/557,556 | 2004-03-29 | ||
US57128804P | 2004-05-14 | 2004-05-14 | |
US60/571,288 | 2004-05-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20060052775A KR20060052775A (ko) | 2006-05-19 |
KR101218213B1 true KR101218213B1 (ko) | 2013-01-04 |
Family
ID=33568832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067000187A KR101218213B1 (ko) | 2003-07-03 | 2004-07-06 | 카스파제의 활성인자 및 세포자멸사의 유도인자로서의4-아릴아미노-퀴나졸린 |
Country Status (9)
Families Citing this family (82)
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US7618975B2 (en) | 2009-11-17 |
US20080039479A1 (en) | 2008-02-14 |
JP2007524637A (ja) | 2007-08-30 |
WO2005003100A3 (en) | 2005-05-12 |
NZ544472A (en) | 2009-04-30 |
AU2004253967A1 (en) | 2005-01-13 |
US20050137213A1 (en) | 2005-06-23 |
AU2004253967A8 (en) | 2010-02-04 |
JP5129957B2 (ja) | 2013-01-30 |
CN1984660B (zh) | 2010-12-15 |
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