KR101187218B1 - 1,2-디하이드로피리딘-2-온 화합물의 제조 방법 - Google Patents

1,2-디하이드로피리딘-2-온 화합물의 제조 방법 Download PDF

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Publication number
KR101187218B1
KR101187218B1 KR1020067027447A KR20067027447A KR101187218B1 KR 101187218 B1 KR101187218 B1 KR 101187218B1 KR 1020067027447 A KR1020067027447 A KR 1020067027447A KR 20067027447 A KR20067027447 A KR 20067027447A KR 101187218 B1 KR101187218 B1 KR 101187218B1
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South Korea
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group
formula
compound
palladium
substituted
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Korean (ko)
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KR20070028459A (ko
Inventor
아키오 가야노
가쓰토시 니시우라
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에자이 알앤드디 매니지먼트 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020067027447A 2004-07-06 2005-07-05 1,2-디하이드로피리딘-2-온 화합물의 제조 방법 Expired - Lifetime KR101187218B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2004-00198709 2004-07-06
JP2004198709 2004-07-06
PCT/JP2005/012364 WO2006004100A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン－２－オン化合物の製造方法

Publications (2)

Publication Number Publication Date
KR20070028459A KR20070028459A (ko) 2007-03-12
KR101187218B1 true KR101187218B1 (ko) 2012-10-02

Family

ID=35782900

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067027447A Expired - Lifetime KR101187218B1 (ko) 2004-07-06 2005-07-05 1,2-디하이드로피리딘-2-온 화합물의 제조 방법
KR1020067020395A Expired - Lifetime KR100939743B1 (ko) 2004-07-06 2005-07-05 1,2-디히드로피리딘 화합물의 결정 및 그 제조 방법

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KR1020067020395A Expired - Lifetime KR100939743B1 (ko) 2004-07-06 2005-07-05 1,2-디히드로피리딘 화합물의 결정 및 그 제조 방법

Country Status (28)

Country Link
US (3) US8304548B2 (https=)
EP (3) EP1772450B1 (https=)
JP (3) JP5030206B2 (https=)
KR (2) KR101187218B1 (https=)
CN (7) CN101914057B (https=)
AT (1) ATE547405T1 (https=)
AU (2) AU2005258385B2 (https=)
BR (1) BRPI0510254B8 (https=)
CA (2) CA2561829C (https=)
CY (1) CY1114313T1 (https=)
DK (1) DK1764361T3 (https=)
ES (1) ES2404697T3 (https=)
HR (1) HRP20130363T1 (https=)
IL (2) IL180024A (https=)
JO (1) JO2832B1 (https=)
ME (1) ME01520B (https=)
MX (1) MXPA06014458A (https=)
MY (1) MY148809A (https=)
NO (1) NO339101B1 (https=)
NZ (1) NZ550720A (https=)
PL (2) PL1772450T3 (https=)
PT (1) PT1764361E (https=)
RS (1) RS52752B (https=)
RU (1) RU2323930C1 (https=)
SI (2) SI1764361T1 (https=)
TW (1) TW200606144A (https=)
WO (2) WO2006004100A1 (https=)
ZA (1) ZA200609274B (https=)

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CN100358872C (zh) 2003-11-14 2008-01-02 上海睿星基因技术有限公司 吡啶酮衍生物及其应用
AU2006232517A1 (en) * 2005-04-04 2006-10-12 Eisai R&D Management Co., Ltd. Dihydropyridine compounds and compositions for headaches
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
US20090088574A1 (en) * 2005-12-21 2009-04-02 Eisai R&D Management Co., Ltd. Crystal of 1,2-dihydropyridine compound (type iv)
US7803818B2 (en) 2005-12-21 2010-09-28 Eisai R&D Management Co., Ltd. Amorphous form of 1,2-dihydropyridine compound
US7718807B2 (en) 2006-04-28 2010-05-18 Eisai R&D Management Co., Ltd. Salt of 1,2-dihydropyridine compound
CA2656057C (en) 2006-06-16 2012-10-02 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
WO2008111590A2 (en) * 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. Ampa and nmda receptor antagonists for neurodegenerative diseases
WO2008121074A1 (en) * 2007-03-29 2008-10-09 Agency For Science, Technology And Research Method of producing an optically active cyanohydrin derivative
WO2008139984A1 (en) * 2007-04-26 2008-11-20 Eisai R & D Management Co., Ltd. Cinnamide compounds for dementia
US20100179193A1 (en) * 2007-07-13 2010-07-15 Eisai R&D Management Co., Ltd AMPA Receptor Antagonists and Zonisamide for Neuropathic Pain
CA2690110A1 (en) * 2007-07-13 2009-01-22 Eisai R&D Management Co., Ltd. Ampa receptor antagonists for neuropathic pain
US20100222354A1 (en) * 2007-07-13 2010-09-02 Eisai R & D Management Co., Ltd. AMPA Receptor Antagonists and Aldose Reductase Inhibitors for Neuropathic Pain
WO2009054544A1 (en) * 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
SG174214A1 (en) 2009-03-25 2011-10-28 Abbott Lab Antiviral compounds and uses thereof
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US9096574B2 (en) 2012-01-03 2015-08-04 Mapi Pharma Ltd. Polymorphs of perampanel
ITMI20121390A1 (it) * 2012-08-06 2014-02-07 F I S Fabbrica Italiana Sint P A Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US9695147B2 (en) 2013-07-25 2017-07-04 Teva Pharmaceuticals International Gmbh Process for the preparation of perampanel
CN104649962A (zh) * 2013-11-25 2015-05-27 天津市汉康医药生物技术有限公司 吡仑帕奈倍半水合物化合物
CN103664756A (zh) * 2013-11-26 2014-03-26 苏州晶云药物科技有限公司 吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) * 2013-12-12 2015-06-17 北京星昊医药股份有限公司 一种吡仑帕奈冻干口崩片及其制备方法
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
CN105085382B (zh) * 2014-05-14 2019-10-18 江苏豪森药业集团有限公司 吡仑帕奈异构体晶型及其制备方法和用途
CN103980188B (zh) * 2014-05-30 2016-01-27 浙江永宁药业股份有限公司 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
WO2016132343A1 (en) 2015-02-17 2016-08-25 Mapi Pharma Ltd. Process and intermediates for the preparation of perampanel
WO2016147104A1 (en) * 2015-03-14 2016-09-22 Intas Pharmaceuticals Ltd. Novel process for the preparation of perampanel and its intermediates thereof
WO2016172333A1 (en) 2015-04-21 2016-10-27 Teva Pharmaceuticals International Gmbh A solid state form of perampanel
CN105287411A (zh) * 2015-09-22 2016-02-03 美吉斯制药（厦门）有限公司 一种吡仑帕奈分散片及其制备方法
CN105906557A (zh) * 2016-03-30 2016-08-31 北京万全德众医药生物技术有限公司 2-甲氧基-5-（吡啶-2-基）吡啶的一种合成方法
CN106389367B (zh) * 2016-11-16 2020-12-18 杭州朱养心药业有限公司 吡仑帕奈包衣片剂药物组合物
CN110028442B (zh) * 2018-01-11 2020-07-17 新发药业有限公司 一种吡仑帕奈的简便制备方法
KR20200132858A (ko) 2018-03-20 2020-11-25 에자이 알앤드디 매니지먼트 가부시키가이샤 간질 치료제
EP3560934A1 (en) 2018-04-26 2019-10-30 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040
MA54460A (fr) 2018-12-14 2021-10-20 Eisai R&D Man Co Ltd Formulations pharmaceutiques à base d'eau de composés de 1,2-dihydropyridine
KR102392825B1 (ko) 2020-02-18 2022-04-29 명인제약주식회사 2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 ｌ-말릭산의 공결정 화합물 및 이의 제조 방법
WO2021240540A1 (en) 2020-05-26 2021-12-02 Celagenex Research (India) Pvt. Ltd. Novel synergistic nutritional compositions for treating seizures and chronic inflammatory diseases
CN114853666A (zh) * 2021-02-03 2022-08-05 北京万全德众医药生物技术有限公司 一种制备高纯度吡仑帕奈中间体的纯化方法
GR1010285B (el) * 2021-05-31 2022-08-24 Elpen Αε Φαρμακευτικη Βιομηχανια, Στερεες φαρμακοτεχνικες μορφες περαμπανελης
KR102768044B1 (ko) * 2022-07-12 2025-02-17 이화여자대학교 산학협력단 연속 흐름 공정을 포함하는 페람파넬 유도체의 제조 방법
CN115745876B (zh) * 2022-11-01 2025-03-04 南京海纳医药科技股份有限公司 一种吡仑帕奈的制备方法
CN118415997B (zh) * 2024-07-04 2024-10-18 山东则正医药技术有限公司 一种吡仑帕奈细粒剂的制备方法

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Also Published As

Publication number Publication date
SI1764361T1 (sl) 2013-07-31
DK1764361T3 (da) 2013-05-06
JPWO2006004107A1 (ja) 2008-04-24
CA2570177A1 (en) 2006-01-12
KR20070028459A (ko) 2007-03-12
ATE547405T1 (de) 2012-03-15
NO20065754L (no) 2007-04-04
JP2012021029A (ja) 2012-02-02
TW200606144A (en) 2006-02-16
CA2561829A1 (en) 2006-01-12
IL180151A0 (en) 2007-06-03
CN104402807A (zh) 2015-03-11
CN101914057B (zh) 2012-07-04
MY148809A (en) 2013-05-31
AU2005258378B2 (en) 2011-04-28
IL180151A (en) 2012-01-31
US20100324297A1 (en) 2010-12-23
CN104402808A (zh) 2015-03-11
RU2323930C1 (ru) 2008-05-10
EP1772450A1 (en) 2007-04-11
EP1764361A1 (en) 2007-03-21
CN102382047A (zh) 2012-03-21
JO2832B1 (en) 2014-09-15
HK1104999A1 (en) 2008-02-01
CN101544599B (zh) 2012-06-06
BRPI0510254A (pt) 2007-10-23
AU2005258385B2 (en) 2009-11-05
TWI346660B (https=) 2011-08-11
US8304548B2 (en) 2012-11-06
MXPA06014458A (es) 2007-03-01
US9045426B2 (en) 2015-06-02
ME01520B (me) 2014-04-20
CY1114313T1 (el) 2016-08-31
US8772497B2 (en) 2014-07-08
CN101914057A (zh) 2010-12-15
US20070142640A1 (en) 2007-06-21
WO2006004100A1 (ja) 2006-01-12
EP1772450A4 (en) 2009-06-10
CA2570177C (en) 2012-11-20
IL180024A0 (en) 2007-05-15
PT1764361E (pt) 2013-04-23
IL180024A (en) 2011-09-27
NO339101B1 (no) 2016-11-14
BRPI0510254B1 (pt) 2019-10-29
JPWO2006004100A1 (ja) 2008-04-24
CN102382047B (zh) 2014-04-23
AU2005258385A1 (en) 2006-01-12
CN101544599A (zh) 2009-09-30
WO2006004100A8 (ja) 2006-02-23
EP2586771A3 (en) 2013-07-31
ZA200609274B (en) 2008-06-25
JP5030206B2 (ja) 2012-09-19
CN1942443B (zh) 2012-05-09
HRP20130363T1 (en) 2013-05-31
CN1984890A (zh) 2007-06-20
KR20070008617A (ko) 2007-01-17
BRPI0510254B8 (pt) 2021-05-25
EP2586771A2 (en) 2013-05-01
JP5419944B2 (ja) 2014-02-19
PL1764361T3 (pl) 2013-06-28
PL1772450T3 (pl) 2012-07-31
US20140142315A1 (en) 2014-05-22
EP1764361A4 (en) 2012-05-30
WO2006004107A1 (ja) 2006-01-12
EP1772450B1 (en) 2012-02-29
SI1772450T1 (sl) 2012-06-29
ES2404697T3 (es) 2013-05-28
EP1764361B1 (en) 2013-01-30
RS52752B (sr) 2013-08-30
CA2561829C (en) 2009-11-24
HK1102127A1 (en) 2007-11-09
KR100939743B1 (ko) 2010-02-04
AU2005258378A1 (en) 2006-01-12
NZ550720A (en) 2009-10-30
CN1942443A (zh) 2007-04-04

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