AU2005258385B2 - Crystal of 1,2-dihydropyridine compound and method for producing same - Google Patents

Crystal of 1,2-dihydropyridine compound and method for producing same Download PDF

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Publication number
AU2005258385B2
AU2005258385B2 AU2005258385A AU2005258385A AU2005258385B2 AU 2005258385 B2 AU2005258385 B2 AU 2005258385B2 AU 2005258385 A AU2005258385 A AU 2005258385A AU 2005258385 A AU2005258385 A AU 2005258385A AU 2005258385 B2 AU2005258385 B2 AU 2005258385B2
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AU
Australia
Prior art keywords
crystal
diffraction
dihydropyridin
phenyl
pyridyl
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AU2005258385A
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English (en)
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AU2005258385A1 (en
Inventor
Itaru Arimoto
Koichi Ito
Satoshi Nagato
Hiroyuki Naka
Takao Omae
Yukiko Sugaya
Yoshio Urawa
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Publication of AU2005258385A1 publication Critical patent/AU2005258385A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
AU2005258385A 2004-07-06 2005-07-05 Crystal of 1,2-dihydropyridine compound and method for producing same Active 2029-05-23 AU2005258385B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004198709 2004-07-06
JP2004-198709 2004-07-06
PCT/JP2005/012388 WO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン化合物の結晶およびその製造方法

Publications (2)

Publication Number Publication Date
AU2005258385A1 AU2005258385A1 (en) 2006-01-12
AU2005258385B2 true AU2005258385B2 (en) 2009-11-05

Family

ID=35782900

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2005258385A Active 2029-05-23 AU2005258385B2 (en) 2004-07-06 2005-07-05 Crystal of 1,2-dihydropyridine compound and method for producing same
AU2005258378A Expired AU2005258378B2 (en) 2004-07-06 2005-07-05 Method for producing 1,2-dihydropyridine-2-one compound

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2005258378A Expired AU2005258378B2 (en) 2004-07-06 2005-07-05 Method for producing 1,2-dihydropyridine-2-one compound

Country Status (28)

Country Link
US (3) US8304548B2 (https=)
EP (3) EP1772450B1 (https=)
JP (3) JP5030206B2 (https=)
KR (2) KR101187218B1 (https=)
CN (7) CN101914057B (https=)
AT (1) ATE547405T1 (https=)
AU (2) AU2005258385B2 (https=)
BR (1) BRPI0510254B8 (https=)
CA (2) CA2561829C (https=)
CY (1) CY1114313T1 (https=)
DK (1) DK1764361T3 (https=)
ES (1) ES2404697T3 (https=)
HR (1) HRP20130363T1 (https=)
IL (2) IL180024A (https=)
JO (1) JO2832B1 (https=)
ME (1) ME01520B (https=)
MX (1) MXPA06014458A (https=)
MY (1) MY148809A (https=)
NO (1) NO339101B1 (https=)
NZ (1) NZ550720A (https=)
PL (2) PL1772450T3 (https=)
PT (1) PT1764361E (https=)
RS (1) RS52752B (https=)
RU (1) RU2323930C1 (https=)
SI (2) SI1764361T1 (https=)
TW (1) TW200606144A (https=)
WO (2) WO2006004100A1 (https=)
ZA (1) ZA200609274B (https=)

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AU2006232517A1 (en) * 2005-04-04 2006-10-12 Eisai R&D Management Co., Ltd. Dihydropyridine compounds and compositions for headaches
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
US20090088574A1 (en) * 2005-12-21 2009-04-02 Eisai R&D Management Co., Ltd. Crystal of 1,2-dihydropyridine compound (type iv)
US7803818B2 (en) 2005-12-21 2010-09-28 Eisai R&D Management Co., Ltd. Amorphous form of 1,2-dihydropyridine compound
US7718807B2 (en) 2006-04-28 2010-05-18 Eisai R&D Management Co., Ltd. Salt of 1,2-dihydropyridine compound
CA2656057C (en) 2006-06-16 2012-10-02 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
WO2008111590A2 (en) * 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. Ampa and nmda receptor antagonists for neurodegenerative diseases
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WO2008139984A1 (en) * 2007-04-26 2008-11-20 Eisai R & D Management Co., Ltd. Cinnamide compounds for dementia
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US20100222354A1 (en) * 2007-07-13 2010-09-02 Eisai R & D Management Co., Ltd. AMPA Receptor Antagonists and Aldose Reductase Inhibitors for Neuropathic Pain
WO2009054544A1 (en) * 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
SG174214A1 (en) 2009-03-25 2011-10-28 Abbott Lab Antiviral compounds and uses thereof
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US9096574B2 (en) 2012-01-03 2015-08-04 Mapi Pharma Ltd. Polymorphs of perampanel
ITMI20121390A1 (it) * 2012-08-06 2014-02-07 F I S Fabbrica Italiana Sint P A Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US9695147B2 (en) 2013-07-25 2017-07-04 Teva Pharmaceuticals International Gmbh Process for the preparation of perampanel
CN104649962A (zh) * 2013-11-25 2015-05-27 天津市汉康医药生物技术有限公司 吡仑帕奈倍半水合物化合物
CN103664756A (zh) * 2013-11-26 2014-03-26 苏州晶云药物科技有限公司 吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) * 2013-12-12 2015-06-17 北京星昊医药股份有限公司 一种吡仑帕奈冻干口崩片及其制备方法
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
CN105085382B (zh) * 2014-05-14 2019-10-18 江苏豪森药业集团有限公司 吡仑帕奈异构体晶型及其制备方法和用途
CN103980188B (zh) * 2014-05-30 2016-01-27 浙江永宁药业股份有限公司 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
WO2016132343A1 (en) 2015-02-17 2016-08-25 Mapi Pharma Ltd. Process and intermediates for the preparation of perampanel
WO2016147104A1 (en) * 2015-03-14 2016-09-22 Intas Pharmaceuticals Ltd. Novel process for the preparation of perampanel and its intermediates thereof
WO2016172333A1 (en) 2015-04-21 2016-10-27 Teva Pharmaceuticals International Gmbh A solid state form of perampanel
CN105287411A (zh) * 2015-09-22 2016-02-03 美吉斯制药（厦门）有限公司 一种吡仑帕奈分散片及其制备方法
CN105906557A (zh) * 2016-03-30 2016-08-31 北京万全德众医药生物技术有限公司 2-甲氧基-5-（吡啶-2-基）吡啶的一种合成方法
CN106389367B (zh) * 2016-11-16 2020-12-18 杭州朱养心药业有限公司 吡仑帕奈包衣片剂药物组合物
CN110028442B (zh) * 2018-01-11 2020-07-17 新发药业有限公司 一种吡仑帕奈的简便制备方法
KR20200132858A (ko) 2018-03-20 2020-11-25 에자이 알앤드디 매니지먼트 가부시키가이샤 간질 치료제
EP3560934A1 (en) 2018-04-26 2019-10-30 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040
MA54460A (fr) 2018-12-14 2021-10-20 Eisai R&D Man Co Ltd Formulations pharmaceutiques à base d'eau de composés de 1,2-dihydropyridine
KR102392825B1 (ko) 2020-02-18 2022-04-29 명인제약주식회사 2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 ｌ-말릭산의 공결정 화합물 및 이의 제조 방법
WO2021240540A1 (en) 2020-05-26 2021-12-02 Celagenex Research (India) Pvt. Ltd. Novel synergistic nutritional compositions for treating seizures and chronic inflammatory diseases
CN114853666A (zh) * 2021-02-03 2022-08-05 北京万全德众医药生物技术有限公司 一种制备高纯度吡仑帕奈中间体的纯化方法
GR1010285B (el) * 2021-05-31 2022-08-24 Elpen Αε Φαρμακευτικη Βιομηχανια, Στερεες φαρμακοτεχνικες μορφες περαμπανελης
KR102768044B1 (ko) * 2022-07-12 2025-02-17 이화여자대학교 산학협력단 연속 흐름 공정을 포함하는 페람파넬 유도체의 제조 방법
CN115745876B (zh) * 2022-11-01 2025-03-04 南京海纳医药科技股份有限公司 一种吡仑帕奈的制备方法
CN118415997B (zh) * 2024-07-04 2024-10-18 山东则正医药技术有限公司 一种吡仑帕奈细粒剂的制备方法

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WO2003047577A2 (en) * 2001-12-06 2003-06-12 Eisai Co Ltd Pharmaceutical compositions comprising dihydropyridinone compounds and an immunoregulatory or an antiinflammatory agent and their uses

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WO2003047577A2 (en) * 2001-12-06 2003-06-12 Eisai Co Ltd Pharmaceutical compositions comprising dihydropyridinone compounds and an immunoregulatory or an antiinflammatory agent and their uses

Also Published As

Publication number Publication date
SI1764361T1 (sl) 2013-07-31
DK1764361T3 (da) 2013-05-06
JPWO2006004107A1 (ja) 2008-04-24
CA2570177A1 (en) 2006-01-12
KR20070028459A (ko) 2007-03-12
ATE547405T1 (de) 2012-03-15
KR101187218B1 (ko) 2012-10-02
NO20065754L (no) 2007-04-04
JP2012021029A (ja) 2012-02-02
TW200606144A (en) 2006-02-16
CA2561829A1 (en) 2006-01-12
IL180151A0 (en) 2007-06-03
CN104402807A (zh) 2015-03-11
CN101914057B (zh) 2012-07-04
MY148809A (en) 2013-05-31
AU2005258378B2 (en) 2011-04-28
IL180151A (en) 2012-01-31
US20100324297A1 (en) 2010-12-23
CN104402808A (zh) 2015-03-11
RU2323930C1 (ru) 2008-05-10
EP1772450A1 (en) 2007-04-11
EP1764361A1 (en) 2007-03-21
CN102382047A (zh) 2012-03-21
JO2832B1 (en) 2014-09-15
HK1104999A1 (en) 2008-02-01
CN101544599B (zh) 2012-06-06
BRPI0510254A (pt) 2007-10-23
TWI346660B (https=) 2011-08-11
US8304548B2 (en) 2012-11-06
MXPA06014458A (es) 2007-03-01
US9045426B2 (en) 2015-06-02
ME01520B (me) 2014-04-20
CY1114313T1 (el) 2016-08-31
US8772497B2 (en) 2014-07-08
CN101914057A (zh) 2010-12-15
US20070142640A1 (en) 2007-06-21
WO2006004100A1 (ja) 2006-01-12
EP1772450A4 (en) 2009-06-10
CA2570177C (en) 2012-11-20
IL180024A0 (en) 2007-05-15
PT1764361E (pt) 2013-04-23
IL180024A (en) 2011-09-27
NO339101B1 (no) 2016-11-14
BRPI0510254B1 (pt) 2019-10-29
JPWO2006004100A1 (ja) 2008-04-24
CN102382047B (zh) 2014-04-23
AU2005258385A1 (en) 2006-01-12
CN101544599A (zh) 2009-09-30
WO2006004100A8 (ja) 2006-02-23
EP2586771A3 (en) 2013-07-31
ZA200609274B (en) 2008-06-25
JP5030206B2 (ja) 2012-09-19
CN1942443B (zh) 2012-05-09
HRP20130363T1 (en) 2013-05-31
CN1984890A (zh) 2007-06-20
KR20070008617A (ko) 2007-01-17
BRPI0510254B8 (pt) 2021-05-25
EP2586771A2 (en) 2013-05-01
JP5419944B2 (ja) 2014-02-19
PL1764361T3 (pl) 2013-06-28
PL1772450T3 (pl) 2012-07-31
US20140142315A1 (en) 2014-05-22
EP1764361A4 (en) 2012-05-30
WO2006004107A1 (ja) 2006-01-12
EP1772450B1 (en) 2012-02-29
SI1772450T1 (sl) 2012-06-29
ES2404697T3 (es) 2013-05-28
EP1764361B1 (en) 2013-01-30
RS52752B (sr) 2013-08-30
CA2561829C (en) 2009-11-24
HK1102127A1 (en) 2007-11-09
KR100939743B1 (ko) 2010-02-04
AU2005258378A1 (en) 2006-01-12
NZ550720A (en) 2009-10-30
CN1942443A (zh) 2007-04-04

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