JP5030206B2 - １，２−ジヒドロピリジン−２−オン化合物の製造方法 - Google Patents

１，２−ジヒドロピリジン−２−オン化合物の製造方法 Download PDF

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Publication number
JP5030206B2
JP5030206B2 JP2006528897A JP2006528897A JP5030206B2 JP 5030206 B2 JP5030206 B2 JP 5030206B2 JP 2006528897 A JP2006528897 A JP 2006528897A JP 2006528897 A JP2006528897 A JP 2006528897A JP 5030206 B2 JP5030206 B2 JP 5030206B2
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group
compound
formula
palladium
cuprous
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Japanese (ja)
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JPWO2006004100A1 (ja
Inventor
明生 栢野
克智 西浦
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
JP2006528897A 2004-07-06 2005-07-05 １，２−ジヒドロピリジン−２−オン化合物の製造方法 Expired - Lifetime JP5030206B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006528897A JP5030206B2 (ja) 2004-07-06 2005-07-05 １，２−ジヒドロピリジン−２−オン化合物の製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004198709 2004-07-06
JP2004198709 2004-07-06
PCT/JP2005/012364 WO2006004100A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン－２－オン化合物の製造方法
JP2006528897A JP5030206B2 (ja) 2004-07-06 2005-07-05 １，２−ジヒドロピリジン−２−オン化合物の製造方法

Publications (2)

Publication Number Publication Date
JPWO2006004100A1 JPWO2006004100A1 (ja) 2008-04-24
JP5030206B2 true JP5030206B2 (ja) 2012-09-19

Family

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Family Applications (3)

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JP2006528897A Expired - Lifetime JP5030206B2 (ja) 2004-07-06 2005-07-05 １，２−ジヒドロピリジン−２−オン化合物の製造方法
JP2006528904A Pending JPWO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２−ジヒドロピリジン化合物の結晶およびその製造方法
JP2011224926A Expired - Lifetime JP5419944B2 (ja) 2004-07-06 2011-10-12 １，２−ジヒドロピリジン化合物の結晶

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2006528904A Pending JPWO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２−ジヒドロピリジン化合物の結晶およびその製造方法
JP2011224926A Expired - Lifetime JP5419944B2 (ja) 2004-07-06 2011-10-12 １，２−ジヒドロピリジン化合物の結晶

Country Status (28)

Country Link
US (3) US8304548B2 (https=)
EP (3) EP1772450B1 (https=)
JP (3) JP5030206B2 (https=)
KR (2) KR101187218B1 (https=)
CN (7) CN101914057B (https=)
AT (1) ATE547405T1 (https=)
AU (2) AU2005258385B2 (https=)
BR (1) BRPI0510254B8 (https=)
CA (2) CA2561829C (https=)
CY (1) CY1114313T1 (https=)
DK (1) DK1764361T3 (https=)
ES (1) ES2404697T3 (https=)
HR (1) HRP20130363T1 (https=)
IL (2) IL180024A (https=)
JO (1) JO2832B1 (https=)
ME (1) ME01520B (https=)
MX (1) MXPA06014458A (https=)
MY (1) MY148809A (https=)
NO (1) NO339101B1 (https=)
NZ (1) NZ550720A (https=)
PL (2) PL1772450T3 (https=)
PT (1) PT1764361E (https=)
RS (1) RS52752B (https=)
RU (1) RU2323930C1 (https=)
SI (2) SI1764361T1 (https=)
TW (1) TW200606144A (https=)
WO (2) WO2006004100A1 (https=)
ZA (1) ZA200609274B (https=)

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CN103664756A (zh) * 2013-11-26 2014-03-26 苏州晶云药物科技有限公司 吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) * 2013-12-12 2015-06-17 北京星昊医药股份有限公司 一种吡仑帕奈冻干口崩片及其制备方法
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CN105085382B (zh) * 2014-05-14 2019-10-18 江苏豪森药业集团有限公司 吡仑帕奈异构体晶型及其制备方法和用途
CN103980188B (zh) * 2014-05-30 2016-01-27 浙江永宁药业股份有限公司 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
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WO2016147104A1 (en) * 2015-03-14 2016-09-22 Intas Pharmaceuticals Ltd. Novel process for the preparation of perampanel and its intermediates thereof
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CN105287411A (zh) * 2015-09-22 2016-02-03 美吉斯制药（厦门）有限公司 一种吡仑帕奈分散片及其制备方法
CN105906557A (zh) * 2016-03-30 2016-08-31 北京万全德众医药生物技术有限公司 2-甲氧基-5-（吡啶-2-基）吡啶的一种合成方法
CN106389367B (zh) * 2016-11-16 2020-12-18 杭州朱养心药业有限公司 吡仑帕奈包衣片剂药物组合物
CN110028442B (zh) * 2018-01-11 2020-07-17 新发药业有限公司 一种吡仑帕奈的简便制备方法
KR20200132858A (ko) 2018-03-20 2020-11-25 에자이 알앤드디 매니지먼트 가부시키가이샤 간질 치료제
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MA54460A (fr) 2018-12-14 2021-10-20 Eisai R&D Man Co Ltd Formulations pharmaceutiques à base d'eau de composés de 1,2-dihydropyridine
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CN114853666A (zh) * 2021-02-03 2022-08-05 北京万全德众医药生物技术有限公司 一种制备高纯度吡仑帕奈中间体的纯化方法
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SI1764361T1 (sl) 2013-07-31
DK1764361T3 (da) 2013-05-06
JPWO2006004107A1 (ja) 2008-04-24
CA2570177A1 (en) 2006-01-12
KR20070028459A (ko) 2007-03-12
ATE547405T1 (de) 2012-03-15
KR101187218B1 (ko) 2012-10-02
NO20065754L (no) 2007-04-04
JP2012021029A (ja) 2012-02-02
TW200606144A (en) 2006-02-16
CA2561829A1 (en) 2006-01-12
IL180151A0 (en) 2007-06-03
CN104402807A (zh) 2015-03-11
CN101914057B (zh) 2012-07-04
MY148809A (en) 2013-05-31
AU2005258378B2 (en) 2011-04-28
IL180151A (en) 2012-01-31
US20100324297A1 (en) 2010-12-23
CN104402808A (zh) 2015-03-11
RU2323930C1 (ru) 2008-05-10
EP1772450A1 (en) 2007-04-11
EP1764361A1 (en) 2007-03-21
CN102382047A (zh) 2012-03-21
JO2832B1 (en) 2014-09-15
HK1104999A1 (en) 2008-02-01
CN101544599B (zh) 2012-06-06
BRPI0510254A (pt) 2007-10-23
AU2005258385B2 (en) 2009-11-05
TWI346660B (https=) 2011-08-11
US8304548B2 (en) 2012-11-06
MXPA06014458A (es) 2007-03-01
US9045426B2 (en) 2015-06-02
ME01520B (me) 2014-04-20
CY1114313T1 (el) 2016-08-31
US8772497B2 (en) 2014-07-08
CN101914057A (zh) 2010-12-15
US20070142640A1 (en) 2007-06-21
WO2006004100A1 (ja) 2006-01-12
EP1772450A4 (en) 2009-06-10
CA2570177C (en) 2012-11-20
IL180024A0 (en) 2007-05-15
PT1764361E (pt) 2013-04-23
IL180024A (en) 2011-09-27
NO339101B1 (no) 2016-11-14
BRPI0510254B1 (pt) 2019-10-29
JPWO2006004100A1 (ja) 2008-04-24
CN102382047B (zh) 2014-04-23
AU2005258385A1 (en) 2006-01-12
CN101544599A (zh) 2009-09-30
WO2006004100A8 (ja) 2006-02-23
EP2586771A3 (en) 2013-07-31
ZA200609274B (en) 2008-06-25
CN1942443B (zh) 2012-05-09
HRP20130363T1 (en) 2013-05-31
CN1984890A (zh) 2007-06-20
KR20070008617A (ko) 2007-01-17
BRPI0510254B8 (pt) 2021-05-25
EP2586771A2 (en) 2013-05-01
JP5419944B2 (ja) 2014-02-19
PL1764361T3 (pl) 2013-06-28
PL1772450T3 (pl) 2012-07-31
US20140142315A1 (en) 2014-05-22
EP1764361A4 (en) 2012-05-30
WO2006004107A1 (ja) 2006-01-12
EP1772450B1 (en) 2012-02-29
SI1772450T1 (sl) 2012-06-29
ES2404697T3 (es) 2013-05-28
EP1764361B1 (en) 2013-01-30
RS52752B (sr) 2013-08-30
CA2561829C (en) 2009-11-24
HK1102127A1 (en) 2007-11-09
KR100939743B1 (ko) 2010-02-04
AU2005258378A1 (en) 2006-01-12
NZ550720A (en) 2009-10-30
CN1942443A (zh) 2007-04-04

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