KR101131684B1 - Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 - Google Patents

Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 Download PDF

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KR101131684B1
KR101131684B1 KR1020057001920A KR20057001920A KR101131684B1 KR 101131684 B1 KR101131684 B1 KR 101131684B1 KR 1020057001920 A KR1020057001920 A KR 1020057001920A KR 20057001920 A KR20057001920 A KR 20057001920A KR 101131684 B1 KR101131684 B1 KR 101131684B1
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formula
compound
alkoxy
fluorine
dione
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KR20050026568A (ko
Inventor
아르민 하첼만
요하네스 바르지히
데겐하르트 막스
한스-페터 클라이
아. 엠. 크리스티안스 요하네스
엠.페.베. 멩에 비로
얀 슈테르크 헤어트
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니코메드 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
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  • AIDS & HIV (AREA)
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  • Gynecology & Obstetrics (AREA)
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KR1020057001920A 2002-08-10 2003-08-06 Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 Expired - Fee Related KR101131684B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02017977 2002-08-10
EP02017977.6 2002-08-10
PCT/EP2003/008675 WO2004018457A1 (en) 2002-08-10 2003-08-06 Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors

Publications (2)

Publication Number Publication Date
KR20050026568A KR20050026568A (ko) 2005-03-15
KR101131684B1 true KR101131684B1 (ko) 2012-03-28

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KR1020057001920A Expired - Fee Related KR101131684B1 (ko) 2002-08-10 2003-08-06 Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존

Country Status (18)

Country Link
US (2) US7220746B2 (enExample)
EP (2) EP1556049A1 (enExample)
JP (2) JP4555684B2 (enExample)
KR (1) KR101131684B1 (enExample)
CN (1) CN1671695A (enExample)
AT (1) ATE360627T1 (enExample)
AU (2) AU2003260376A1 (enExample)
BR (1) BR0313330A (enExample)
CA (2) CA2494613C (enExample)
DE (1) DE60313472T2 (enExample)
ES (1) ES2286491T3 (enExample)
HR (1) HRP20050198A2 (enExample)
IL (1) IL166271A (enExample)
IS (2) IS2416B (enExample)
MX (1) MXPA05001354A (enExample)
PL (2) PL372926A1 (enExample)
RS (1) RS51445B (enExample)
WO (2) WO2004017974A1 (enExample)

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US20070254928A1 (en) * 2004-05-10 2007-11-01 Altana Pharma Ag Use of Roflumilast for the Prophylaxis or Treatment of Emphysema
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
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EP1861074B1 (en) 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
EP1957530A2 (en) 2005-10-21 2008-08-20 Novartis AG Human antibodies against il13 and therapeutic uses
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
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CN101522682A (zh) 2006-10-30 2009-09-02 诺瓦提斯公司 作为抗炎剂的杂环化合物
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WO2008127898A1 (en) * 2007-04-11 2008-10-23 Martinez Rodolfo A Single carbon precursor synthons
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PL2444120T3 (pl) 2007-12-10 2018-02-28 Novartis Ag Spirocyklicze analogi amiloridu jako blokery ENac
JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
KR20110040818A (ko) 2008-06-10 2011-04-20 노파르티스 아게 상피 나트륨 채널 차단제로서의 피라진 유도체
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
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