KR101088219B1 - Ｐ70 ｓ6 키나제 억제제 - Google Patents

Ｐ70 ｓ6 키나제 억제제 Download PDF

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Publication number
KR101088219B1
KR101088219B1 KR1020097023455A KR20097023455A KR101088219B1 KR 101088219 B1 KR101088219 B1 KR 101088219B1 KR 1020097023455 A KR1020097023455 A KR 1020097023455A KR 20097023455 A KR20097023455 A KR 20097023455A KR 101088219 B1 KR101088219 B1 KR 101088219B1
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KR
South Korea
Prior art keywords
phenyl
mmol
trifluoromethyl
equiv
added
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020097023455A
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English (en)
Korean (ko)
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KR20100005710A (ko
Inventor
로버트 딘 달리
지안핑 후앙
사잔 죠셉
티모시 알란 세퍼드
크리스티안 엘. 홀스트
Original Assignee
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020097023455A 2007-05-11 2008-05-01 Ｐ70 ｓ6 키나제 억제제 Expired - Fee Related KR101088219B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11
US60/917,331 2007-05-11
PCT/US2008/062143 WO2008140947A1 (en) 2007-05-11 2008-05-01 P70 s6 kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20100005710A KR20100005710A (ko) 2010-01-15
KR101088219B1 true KR101088219B1 (ko) 2011-11-30

Family

ID=39765082

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KR1020097023455A Expired - Fee Related KR101088219B1 (ko) 2007-05-11 2008-05-01 Ｐ70 ｓ6 키나제 억제제

Country Status (33)

Country Link
US (2) US8093383B2 (enExample)
EP (1) EP2148880B1 (enExample)
JP (1) JP5503532B2 (enExample)
KR (1) KR101088219B1 (enExample)
CN (1) CN101679439B (enExample)
AR (1) AR066344A1 (enExample)
AU (1) AU2008251692B2 (enExample)
BR (1) BRPI0811212A2 (enExample)
CA (1) CA2687265C (enExample)
CL (1) CL2008001230A1 (enExample)
CO (1) CO6241109A2 (enExample)
CR (1) CR11106A (enExample)
DK (1) DK2148880T3 (enExample)
DO (1) DOP2009000257A (enExample)
EA (1) EA016445B1 (enExample)
EC (1) ECSP099721A (enExample)
ES (1) ES2483726T3 (enExample)
GT (1) GT200900292A (enExample)
HR (1) HRP20140611T1 (enExample)
IL (1) IL201564A (enExample)
MA (1) MA31433B1 (enExample)
MX (1) MX2009012075A (enExample)
MY (1) MY154898A (enExample)
NZ (1) NZ580423A (enExample)
PE (1) PE20090887A1 (enExample)
PL (1) PL2148880T3 (enExample)
PT (1) PT2148880E (enExample)
RS (1) RS53451B (enExample)
SI (1) SI2148880T1 (enExample)
TN (1) TN2009000446A1 (enExample)
TW (1) TWI423805B (enExample)
UA (1) UA99284C2 (enExample)
WO (1) WO2008140947A1 (enExample)

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CN105051043B (zh) 2012-11-16 2017-05-10 默克专利有限公司 用作激酶活性调节剂的新颖的杂环类衍生物
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KR20150124957A (ko) 2013-03-11 2015-11-06 메르크 파텐트 게엠베하 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체
CN105339008A (zh) 2013-04-17 2016-02-17 西格诺药品有限公司 用于治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯酰胺的组合疗法
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WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
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Also Published As

Publication number Publication date
IL201564A (en) 2014-08-31
RS53451B (sr) 2014-12-31
CN101679439A (zh) 2010-03-24
JP5503532B2 (ja) 2014-05-28
SI2148880T1 (sl) 2014-07-31
US8093383B2 (en) 2012-01-10
UA99284C2 (ru) 2012-08-10
MX2009012075A (es) 2009-11-19
PT2148880E (pt) 2014-08-28
US20120071490A1 (en) 2012-03-22
CO6241109A2 (es) 2011-01-20
EA200971051A1 (ru) 2010-06-30
JP2010526814A (ja) 2010-08-05
EA016445B1 (ru) 2012-05-30
CR11106A (es) 2010-04-12
ECSP099721A (es) 2009-12-28
CA2687265C (en) 2012-12-04
GT200900292A (es) 2011-06-24
HK1140767A1 (en) 2010-10-22
WO2008140947A1 (en) 2008-11-20
TN2009000446A1 (en) 2011-03-31
EP2148880A1 (en) 2010-02-03
CN101679439B (zh) 2013-09-11
NZ580423A (en) 2012-02-24
CA2687265A1 (en) 2008-11-20
ES2483726T3 (es) 2014-08-07
PE20090887A1 (es) 2009-07-13
DK2148880T3 (da) 2014-06-16
BRPI0811212A2 (pt) 2014-10-29
AU2008251692A1 (en) 2008-11-20
KR20100005710A (ko) 2010-01-15
MY154898A (en) 2015-08-28
US20090163714A1 (en) 2009-06-25
HRP20140611T1 (hr) 2014-08-15
EP2148880B1 (en) 2014-05-28
MA31433B1 (fr) 2010-06-01
PL2148880T3 (pl) 2014-10-31
IL201564A0 (en) 2010-05-31
TWI423805B (zh) 2014-01-21
DOP2009000257A (es) 2010-03-31
AU2008251692B2 (en) 2012-10-11
CL2008001230A1 (es) 2009-05-22
AR066344A1 (es) 2009-08-12
TW200848053A (en) 2008-12-16

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