KR101061599B1 - 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 - Google Patents

비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 Download PDF

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KR101061599B1
KR101061599B1 KR1020080122999A KR20080122999A KR101061599B1 KR 101061599 B1 KR101061599 B1 KR 101061599B1 KR 1020080122999 A KR1020080122999 A KR 1020080122999A KR 20080122999 A KR20080122999 A KR 20080122999A KR 101061599 B1 KR101061599 B1 KR 101061599B1
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phenyl
indazole
trifluoromethyl
carboxylate
ethyl
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Korean (ko)
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KR20100064520A (ko
Inventor
심태보
손정범
김환
박동식
최환근
함영진
하정미
유경호
오창현
이소하
하재두
조성윤
권병목
한동초
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한국과학기술연구원
한국생명공학연구원
한국화학연구원
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Priority to KR1020080122999A priority Critical patent/KR101061599B1/ko
Priority to US13/132,772 priority patent/US8754209B2/en
Priority to JP2011539453A priority patent/JP5537561B2/ja
Priority to CN2009801489968A priority patent/CN102239150A/zh
Priority to PCT/KR2009/007247 priority patent/WO2010064875A2/en
Publication of KR20100064520A publication Critical patent/KR20100064520A/ko
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    • A—HUMAN NECESSITIES
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020080122999A 2008-12-05 2008-12-05 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 Expired - Fee Related KR101061599B1 (ko)

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Application Number Priority Date Filing Date Title
KR1020080122999A KR101061599B1 (ko) 2008-12-05 2008-12-05 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
US13/132,772 US8754209B2 (en) 2008-12-05 2009-12-04 Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient
JP2011539453A JP5537561B2 (ja) 2008-12-05 2009-12-04 異常細胞増殖疾患の治療のための蛋白質キナーゼの阻害剤である新規インダゾール誘導体、これの薬学的に許容可能な塩及びこれを有効成分として含有する薬学的組成物
CN2009801489968A CN102239150A (zh) 2008-12-05 2009-12-04 作为用于增殖性疾病治疗的蛋白激酶抑制剂的新型吲唑衍生物或其药学上可接受的盐以及含有其作为活性成分的药物组合物
PCT/KR2009/007247 WO2010064875A2 (en) 2008-12-05 2009-12-04 Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient

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KR1020080122999A KR101061599B1 (ko) 2008-12-05 2008-12-05 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물

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KR20100064520A KR20100064520A (ko) 2010-06-15
KR101061599B1 true KR101061599B1 (ko) 2011-09-02

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KR1020080122999A Expired - Fee Related KR101061599B1 (ko) 2008-12-05 2008-12-05 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물

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US (1) US8754209B2 (enExample)
JP (1) JP5537561B2 (enExample)
KR (1) KR101061599B1 (enExample)
CN (1) CN102239150A (enExample)
WO (1) WO2010064875A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013100672A1 (ko) * 2011-12-29 2013-07-04 제이더블유중외제약㈜ 단백질 키나아제 저해활성을 가지는 3,6-이치환된 인다졸 유도체

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