KR100926723B1 - 둘록세틴의 제조 방법 및 이에 이용하기 위한 중간체 - Google Patents

둘록세틴의 제조 방법 및 이에 이용하기 위한 중간체 Download PDF

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Publication number
KR100926723B1
KR100926723B1 KR1020057011506A KR20057011506A KR100926723B1 KR 100926723 B1 KR100926723 B1 KR 100926723B1 KR 1020057011506 A KR1020057011506 A KR 1020057011506A KR 20057011506 A KR20057011506 A KR 20057011506A KR 100926723 B1 KR100926723 B1 KR 100926723B1
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South Korea
Prior art keywords
duloxetine
acid
iii
salt
acid addition
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Expired - Fee Related
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KR1020057011506A
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English (en)
Korean (ko)
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KR20050089839A (ko
Inventor
다마라즈 라마찬드라 라오
라젠드라 나라얀라오 칸칸
크리스토퍼 폴 와인
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씨아이피엘에이 엘티디.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9949985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100926723(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 씨아이피엘에이 엘티디. filed Critical 씨아이피엘에이 엘티디.
Publication of KR20050089839A publication Critical patent/KR20050089839A/ko
Application granted granted Critical
Publication of KR100926723B1 publication Critical patent/KR100926723B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
KR1020057011506A 2002-12-19 2003-12-10 둘록세틴의 제조 방법 및 이에 이용하기 위한 중간체 Expired - Fee Related KR100926723B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0229583.0 2002-12-19
GBGB0229583.0A GB0229583D0 (en) 2002-12-19 2002-12-19 A process for preparing duloxetine and intermediates for use therein
PCT/GB2003/005357 WO2004056795A1 (en) 2002-12-19 2003-12-10 A process for preparing duloxetine and intermediates for use therein

Publications (2)

Publication Number Publication Date
KR20050089839A KR20050089839A (ko) 2005-09-08
KR100926723B1 true KR100926723B1 (ko) 2009-11-16

Family

ID=9949985

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057011506A Expired - Fee Related KR100926723B1 (ko) 2002-12-19 2003-12-10 둘록세틴의 제조 방법 및 이에 이용하기 위한 중간체

Country Status (24)

Country Link
US (1) US7645890B2 (https=)
EP (2) EP1587801B1 (https=)
JP (1) JP5259048B2 (https=)
KR (1) KR100926723B1 (https=)
CN (2) CN101125848B (https=)
AT (1) ATE353081T1 (https=)
AU (2) AU2003292396B2 (https=)
BR (1) BR0316902A (https=)
CA (1) CA2510750A1 (https=)
DE (1) DE60311599T2 (https=)
ES (1) ES2279971T3 (https=)
GB (1) GB0229583D0 (https=)
HR (1) HRP20050657A2 (https=)
IL (1) IL169232A (https=)
IS (1) IS7915A (https=)
MA (1) MA27706A1 (https=)
MX (1) MXPA05006659A (https=)
NZ (2) NZ569874A (https=)
PL (1) PL377380A1 (https=)
PT (1) PT1587801E (https=)
RU (1) RU2351594C2 (https=)
TN (1) TNSN05167A1 (https=)
WO (1) WO2004056795A1 (https=)
ZA (1) ZA200505656B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550605B2 (en) * 2004-08-05 2009-06-23 Sun Pharmaceutical Industries Ltd. Process for preparation of an anitdepressant compound
CZ297560B6 (cs) 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
TWI306858B (en) * 2004-12-23 2009-03-01 Teva Pharma Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
EP1776049A2 (en) * 2005-01-27 2007-04-25 Teva Pharmaceutical Industries Ltd. Duloxetine hcl polymorphs
WO2006096809A1 (en) 2005-03-08 2006-09-14 Teva Pharmaceutical Industries Ltd. Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
TW200639162A (en) * 2005-03-14 2006-11-16 Teva Pharma Pure duloxetine hydrochloride
US8093408B2 (en) * 2005-06-21 2012-01-10 The Company Wockhardt Antidepressant oral pharmaceutical compositions
US8153824B2 (en) * 2005-06-22 2012-04-10 The Wockhardt Company Antidepressant oral liquid compositions
WO2007038253A2 (en) * 2005-09-22 2007-04-05 Teva Pharmaceutical Industries Ltd. Dnt-maleate and methods of preparation thereof
EP1863782A1 (en) * 2005-12-05 2007-12-12 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphtol) thiophene, an imputity of duloxetine hydrochloride
EP1971593A2 (en) * 2005-12-12 2008-09-24 Medichem, S.A. Improved synthesis and preparations of duloxetine salts
CZ299270B6 (cs) * 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
EP1976844A4 (en) * 2006-01-06 2010-11-03 Msn Lab Ltd IMPROVED METHOD FOR PURE DULOXETIN HYDROCHLORIDE
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
CA2640212A1 (en) * 2006-02-13 2007-08-23 Teva Pharmaceutical Industries Ltd. A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
HU228458B1 (en) * 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
SI1857451T1 (sl) 2006-05-05 2010-11-30 Fidia Farmaceutici Postopek priprave intermediata ki je uporaben zaasimetrično sintezo duloksetina
US20080027128A1 (en) * 2006-05-23 2008-01-31 Santiago Ini Duloxetine HCL polymorphs
EP2044049A2 (en) 2006-07-03 2009-04-08 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl- 3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl) propanamine
CZ300116B6 (cs) * 2006-12-05 2009-02-11 Zentiva, A. S. Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
HU227730B1 (en) 2006-12-22 2012-01-30 Richter Gedeon Nyrt Process for the preparation of duloxetine and for their the intermediates
CN101657438A (zh) 2006-12-22 2010-02-24 斯索恩有限公司 制备度洛西汀和相关化合物的方法
US8269023B2 (en) 2007-03-05 2012-09-18 Lupin Ltd. Process for preparation of duloxetine hydrochloride
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
WO2009130708A2 (en) * 2008-04-22 2009-10-29 Shodhana Laboratories Limited Preparation of duloxetine and its salts
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2011033366A2 (en) 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors
CN103360365A (zh) * 2012-04-06 2013-10-23 李晓红 一种抗抑郁症药物原料药盐酸度洛西汀的制备新工艺
CN104230882B (zh) * 2014-08-29 2017-03-08 宁波美诺华药业股份有限公司 一种度洛西汀盐酸盐杂质的制备方法
CN104829587B (zh) * 2015-05-08 2017-07-21 上海万巷制药有限公司 盐酸度洛西汀的制备
CN107382958B (zh) * 2017-07-05 2021-11-09 浙江华海药业股份有限公司 一种度洛西汀中间体的结晶方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273658A1 (en) * 1986-12-22 1988-07-06 Eli Lilly And Company 3-Aryloxy-3-substituted propanamines
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
CH578532A5 (https=) * 1971-08-03 1976-08-13 Cassella Farbwerke Mainkur Ag
PL233786A1 (https=) 1980-11-14 1982-05-24 Lilly Co Eli
US4777291A (en) * 1985-02-27 1988-10-11 Eli Lilly And Company Racemization process
JPS62286959A (ja) * 1986-06-05 1987-12-12 Seitetsu Kagaku Co Ltd 光学活性シアノカルニチン塩の製造方法
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
CA2042346A1 (en) * 1990-05-17 1991-11-18 Michael Alexander Staszak Chiral synthesis of 1-aryl-3-aminopropan-1-ols
JPH09176157A (ja) * 1992-12-09 1997-07-08 Takeda Chem Ind Ltd 光学活性アミノクマラン誘導体
US6458955B1 (en) 1994-12-16 2002-10-01 Uop Llc Process for preparation of pharmaceutically desired enantiomers
US6162949A (en) 1994-12-16 2000-12-19 Uop Llc Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
EP0792649A1 (en) * 1996-02-29 1997-09-03 Eli Lilly And Company Treatment of sleep disorders
HUP0101901A3 (en) * 1998-05-22 2002-06-28 Lilly Co Eli Pharmaceutical composition for combined therapeutic treatment of refractory depression and combined treating process
CA2350531A1 (en) * 1998-11-13 2000-05-25 Smriti Iyengar Method for treating pain
ATE309196T1 (de) * 1999-04-09 2005-11-15 Lilly Co Eli Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte
WO2001044166A1 (en) * 1999-12-17 2001-06-21 Ranbaxy Laboratories Limited Process for the preparation of fluoxetine hydrochloride
WO2003062219A1 (en) 2002-01-24 2003-07-31 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273658A1 (en) * 1986-12-22 1988-07-06 Eli Lilly And Company 3-Aryloxy-3-substituted propanamines
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis

Also Published As

Publication number Publication date
RU2351594C2 (ru) 2009-04-10
EP1690861B1 (en) 2012-09-12
NZ569874A (en) 2009-11-27
DE60311599T2 (de) 2007-10-25
ES2279971T3 (es) 2007-09-01
AU2003292396B2 (en) 2010-05-20
CN1747947A (zh) 2006-03-15
AU2010200142A1 (en) 2010-02-04
PT1587801E (pt) 2007-04-30
NZ540881A (en) 2008-09-26
ATE353081T1 (de) 2007-02-15
EP1690861A2 (en) 2006-08-16
EP1587801A1 (en) 2005-10-26
IL169232A (en) 2010-02-17
WO2004056795A8 (en) 2005-08-11
CA2510750A1 (en) 2004-07-08
KR20050089839A (ko) 2005-09-08
EP1587801B1 (en) 2007-01-31
CN100579975C (zh) 2010-01-13
MXPA05006659A (es) 2006-02-22
ZA200505656B (en) 2006-04-26
HRP20050657A2 (en) 2005-10-31
JP2006514030A (ja) 2006-04-27
JP5259048B2 (ja) 2013-08-07
AU2010200142B2 (en) 2012-04-12
EP1690861A3 (en) 2006-09-06
RU2005122662A (ru) 2006-01-20
DE60311599D1 (de) 2007-03-22
TNSN05167A1 (en) 2007-05-14
MA27706A1 (fr) 2006-01-02
PL377380A1 (pl) 2006-02-06
US7645890B2 (en) 2010-01-12
GB0229583D0 (en) 2003-01-22
AU2003292396A1 (en) 2004-07-14
BR0316902A (pt) 2005-10-25
US20060205956A1 (en) 2006-09-14
IS7915A (is) 2005-06-24
CN101125848B (zh) 2012-09-12
WO2004056795A1 (en) 2004-07-08
CN101125848A (zh) 2008-02-20

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