KR100810930B1 - 나테글리니드 ｂ형 결정의 제조방법 - Google Patents

나테글리니드 ｂ형 결정의 제조방법 Download PDF

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Publication number
KR100810930B1
KR100810930B1 KR1020037005671A KR20037005671A KR100810930B1 KR 100810930 B1 KR100810930 B1 KR 100810930B1 KR 1020037005671 A KR1020037005671 A KR 1020037005671A KR 20037005671 A KR20037005671 A KR 20037005671A KR 100810930 B1 KR100810930 B1 KR 100810930B1
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South Korea
Prior art keywords
nateglinide
crystal
crystals
producing
type
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Expired - Fee Related
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KR1020037005671A
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English (en)
Korean (ko)
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KR20030059212A (ko
Inventor
스미카와미치토
마루오마코토
미야자키가즈오
니시나시게히로
마쓰자와유키코
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아지노모토 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020037005671A 2000-10-24 2001-10-23 나테글리니드 ｂ형 결정의 제조방법 Expired - Fee Related KR100810930B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2000-00324375 2000-10-24
JP2000324375 2000-10-24
PCT/JP2001/009293 WO2002034713A1 (en) 2000-10-24 2001-10-23 Process for producing b-form nateglinide crystal

Publications (2)

Publication Number Publication Date
KR20030059212A KR20030059212A (ko) 2003-07-07
KR100810930B1 true KR100810930B1 (ko) 2008-03-10

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KR1020037005671A Expired - Fee Related KR100810930B1 (ko) 2000-10-24 2001-10-23 나테글리니드 ｂ형 결정의 제조방법

Country Status (18)

Country Link
US (2) US20030229249A1 (https=)
EP (1) EP1334964B1 (https=)
JP (1) JP4225057B2 (https=)
KR (1) KR100810930B1 (https=)
CN (1) CN100422143C (https=)
AT (1) ATE370115T1 (https=)
AU (1) AU2001296001A1 (https=)
BR (1) BR0114846A (https=)
CA (1) CA2426745C (https=)
CY (1) CY1106839T1 (https=)
DE (1) DE60130014T2 (https=)
DK (1) DK1334964T3 (https=)
ES (1) ES2288997T3 (https=)
MX (1) MXPA03003575A (https=)
PT (1) PT1334964E (https=)
RU (1) RU2275354C2 (https=)
TW (1) TWI293290B (https=)
WO (1) WO2002034713A1 (https=)

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KR20070104953A (ko) * 2000-03-17 2007-10-29 아지노모토 가부시키가이샤 신경 장애용 약제
PT1334962E (pt) * 2000-10-18 2007-10-09 Ajinomoto Kk ''processo de preparação de acilfenilalaninas''
CA2425538C (en) * 2000-10-18 2010-10-12 Ajinomoto Co., Inc. Methods for producing nateglinide crystals
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
ATE429217T1 (de) * 2000-10-24 2009-05-15 Ajinomoto Kk Nateglinid enthaltende hydrophile arzneimittelpräparate
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
EP2264004A1 (en) * 2002-04-15 2010-12-22 Ajinomoto Co., Inc. New nateglinide crystals
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
EP1467964A1 (en) * 2002-07-18 2004-10-20 Teva Pharmaceutical Industries Limited Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
DE60310734T2 (de) * 2003-11-26 2007-10-11 A.M.S.A. Anonima Matèrie Sintètiche e Affini S.p.A. Verfahren zur Herstellung von Nateglinid in der B-Form
KR20070009726A (ko) * 2004-05-07 2007-01-18 테바 파마슈티컬 인더스트리즈 리미티드 나테글리나이드의 다형태
US20070231393A1 (en) * 2004-05-19 2007-10-04 University Of South Carolina System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles
WO2005113485A2 (en) * 2004-05-20 2005-12-01 Dr. Reddy's Laboratories Ltd. Stable nateglinide form b compositions
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
EP1891971A4 (en) * 2005-01-31 2010-02-03 Ajinomoto Kk MEDICAL COMPOSITION USING HYPERGLY CRAB MEDICAMENT TO TREAT OR TREAT GLUCOSE-INTOLERANCE, BORDERLINE DIABETES, INSULIN RESISTANCE AND HYPERINSULINEMIA
WO2007135533A1 (en) * 2006-05-23 2007-11-29 Aurobindo Pharma Limited Process for preparing nateglinide b-type crystals
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
AU2011266820A1 (en) 2010-06-14 2013-01-24 Cipla Limited A process for the preparation of nateglinide
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CN104364231A (zh) 2012-09-08 2015-02-18 塞利克斯比奥私人有限公司 用于治疗炎症和脂质异常的组合物和方法
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US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them

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CA2425538C (en) * 2000-10-18 2010-10-12 Ajinomoto Co., Inc. Methods for producing nateglinide crystals
PT1334962E (pt) * 2000-10-18 2007-10-09 Ajinomoto Kk ''processo de preparação de acilfenilalaninas''
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
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US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them

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RU2275354C2 (ru) 2006-04-27
DK1334964T3 (da) 2007-09-24
CY1106839T1 (el) 2012-05-23
EP1334964A1 (en) 2003-08-13
KR20030059212A (ko) 2003-07-07
ATE370115T1 (de) 2007-09-15
EP1334964B1 (en) 2007-08-15
PT1334964E (pt) 2007-09-20
WO2002034713A1 (en) 2002-05-02
BR0114846A (pt) 2004-02-25
MXPA03003575A (es) 2003-07-14
US20070232829A1 (en) 2007-10-04
TWI293290B (https=) 2008-02-11
CA2426745C (en) 2009-09-15
JPWO2002034713A1 (ja) 2004-03-04
DE60130014D1 (de) 2007-09-27
US20030229249A1 (en) 2003-12-11
CN100422143C (zh) 2008-10-01
ES2288997T3 (es) 2008-02-01
CA2426745A1 (en) 2003-04-23
JP4225057B2 (ja) 2009-02-18
EP1334964A4 (en) 2005-09-28
CN1483018A (zh) 2004-03-17
AU2001296001A1 (en) 2002-05-06
DE60130014T2 (de) 2008-05-08
US7544834B2 (en) 2009-06-09

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