KR100699396B1 - 자기 공명 연구 방법 - Google Patents
자기 공명 연구 방법 Download PDFInfo
- Publication number
- KR100699396B1 KR100699396B1 KR1020007007423A KR20007007423A KR100699396B1 KR 100699396 B1 KR100699396 B1 KR 100699396B1 KR 1020007007423 A KR1020007007423 A KR 1020007007423A KR 20007007423 A KR20007007423 A KR 20007007423A KR 100699396 B1 KR100699396 B1 KR 100699396B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- formulation
- agent
- magnetic field
- polarization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(c1c(*)c(C(*)=O)c(*)c(C(*)=O)c1*)=O Chemical compound *C(c1c(*)c(C(*)=O)c(*)c(C(*)=O)c1*)=O 0.000 description 11
- CDAISMWEOUEBRE-UHFFFAOYSA-N OC(C(C(C(C1O)O)O)O)C1O Chemical compound OC(C(C(C(C1O)O)O)O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- Signal Processing (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- General Induction Heating (AREA)
- Magnetic Ceramics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800158.9A GB9800158D0 (en) | 1998-01-05 | 1998-01-05 | Method |
| GB9800158.9 | 1998-01-05 | ||
| GB9813795.3 | 1998-06-25 | ||
| GBGB9813795.3A GB9813795D0 (en) | 1998-06-25 | 1998-06-25 | Method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010040318A KR20010040318A (ko) | 2001-05-15 |
| KR100699396B1 true KR100699396B1 (ko) | 2007-03-27 |
Family
ID=26312888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007007423A Expired - Fee Related KR100699396B1 (ko) | 1998-01-05 | 1998-12-23 | 자기 공명 연구 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6278893B1 (https=) |
| EP (2) | EP1046051A1 (https=) |
| JP (1) | JP4764548B2 (https=) |
| KR (1) | KR100699396B1 (https=) |
| CN (2) | CN100347562C (https=) |
| AU (1) | AU752308C (https=) |
| BR (1) | BRPI9813244B1 (https=) |
| CA (1) | CA2317526C (https=) |
| ES (1) | ES2393833T3 (https=) |
| HU (1) | HU229718B1 (https=) |
| IL (1) | IL136780A0 (https=) |
| NO (1) | NO334035B1 (https=) |
| NZ (1) | NZ505151A (https=) |
| RU (1) | RU2221255C2 (https=) |
| WO (1) | WO1999035508A1 (https=) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126347A (en) * | 1996-03-29 | 2003-11-23 | Lawrence Berkeley National Lab | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| WO2009081360A1 (en) * | 2007-12-20 | 2009-07-02 | Koninklijke Philips Electronics N.V. | Magnetic resonance imaging using hyperpolarization of liquids or solids by light with orbital angular momentum |
| US8765099B2 (en) * | 1996-04-08 | 2014-07-01 | Koninklijke Philips N.V. | Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum |
| EP0951650B1 (en) * | 1997-01-08 | 2003-12-10 | Amersham Health AS | Method of magnetic resonance imaging |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| HUP0104279A3 (en) | 1998-06-17 | 2002-05-28 | Medi Physics Inc Princeton | Hyperpolarized gas transport device and associated transport method |
| US6237363B1 (en) * | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| IL143927A0 (en) * | 1998-12-30 | 2002-04-21 | Nycomed Amersham Plc | Nmr spectroscopic in vitro assay using hyperpolarization |
| AU4686899A (en) | 1999-02-23 | 2000-09-14 | Medi-Physics, Inc. | Portable system for monitoring the polarization level of a hyperpolarized gas during transport |
| US6574496B1 (en) * | 1999-05-19 | 2003-06-03 | Amersham Health As | Magnetic resonance imaging |
| US20020058869A1 (en) * | 1999-05-19 | 2002-05-16 | Oskar Axelsson | Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| DE10009166A1 (de) * | 2000-02-26 | 2001-08-30 | Philips Corp Intellectual Pty | Verfahren zur Lokalisierung von Objekten in der interventionellen Radiologie |
| EP1265527A2 (en) | 2000-03-13 | 2002-12-18 | Medi-Physics, Inc. | Diagnostic procedures using direct injection of gaseous hyperpolarized ?129 xe and associated systems and products |
| GB0009353D0 (en) * | 2000-04-14 | 2000-05-31 | Nycomed Imaging As | Method |
| GB0014463D0 (en) * | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| EP1324690A1 (en) * | 2000-07-13 | 2003-07-09 | Medi-Physics, Inc. | DIAGNOSTIC PROCEDURES USING ?129 XE SPECTROSCOPY CHARACTERISTIC CHEMICAL SHIFT TO DETECT PATHOLOGY i IN VIVO /i |
| GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
| NO20004561D0 (no) * | 2000-09-13 | 2000-09-13 | Nycomed Imaging As | Metode for magnetisk resonansavbildning |
| AU1403902A (en) * | 2000-11-03 | 2002-05-15 | Amersham Health As | Methods and devices for polarised nmr samples |
| DK1330659T3 (da) | 2000-11-03 | 2006-12-18 | Amersham Health As | Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser |
| US7126332B2 (en) * | 2001-07-20 | 2006-10-24 | Baker Hughes Incorporated | Downhole high resolution NMR spectroscopy with polarization enhancement |
| GB0122049D0 (en) * | 2001-09-12 | 2001-10-31 | Nycomed Imaging As | Method |
| RU2281527C2 (ru) * | 2001-11-02 | 2006-08-10 | Амершем Хелт АС | Способ и устройство для плавления поляризованных ямр-образцов |
| NO20023357D0 (no) * | 2002-04-19 | 2002-07-11 | Amersham Health As | Blanding |
| GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
| NO20025124D0 (no) | 2002-10-25 | 2002-10-25 | Amersham Health As | Metode |
| NO20025711D0 (no) * | 2002-11-27 | 2002-11-27 | Amersham Health As | Magnetisk resonansmetode |
| US20060173283A1 (en) * | 2002-11-27 | 2006-08-03 | Oskar Axelsson | Method of magnetic resonance imaging |
| NO20025738D0 (no) * | 2002-11-29 | 2002-11-29 | Amersham Health As | Metode |
| DE10259793B4 (de) * | 2002-12-19 | 2009-10-15 | Siemens Ag | Verfahren zur Bildgebung eines Stoffwechselvorgangs eines Lebewesens |
| DE10335663A1 (de) * | 2003-08-04 | 2005-03-10 | Siemens Ag | Verfahren zur automatischen Kalibrierung von Perfusionsparameterbildern |
| PL1805186T3 (pl) * | 2004-07-30 | 2015-10-30 | Ge Healthcare As | Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej |
| CN101031811A (zh) * | 2004-07-30 | 2007-09-05 | 通用电气医疗集团股份有限公司 | 肿瘤成像方法 |
| NO338547B1 (no) * | 2004-07-30 | 2016-09-05 | Ge Healthcare As | Fremgangsmåte for fremstilling av en flytende sammensetning omfattende hyperpolarisert 13C-pyruvat, sammensetningen og anvendelse av den for fremstilling av hyperpolarisert 13C-pyruvat |
| WO2006011809A1 (en) * | 2004-07-30 | 2006-02-02 | Ge Healthcare As | Method of producing a composition, composition and its use |
| KR101249634B1 (ko) * | 2004-11-19 | 2013-04-01 | 지이 헬스케어 에이에스 | 과분극화 13c-피루베이트를 사용한 심장 영상화 방법 |
| US7276905B2 (en) * | 2005-07-11 | 2007-10-02 | General Electric Company | Method and system of tracking an intracorporeal device with MR imaging |
| JP2007021008A (ja) | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
| US20070025918A1 (en) * | 2005-07-28 | 2007-02-01 | General Electric Company | Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization |
| WO2007035871A1 (en) * | 2005-09-21 | 2007-03-29 | Massachusetts Institute Of Technology | Systems and methods for tuning properties of nanoparticles |
| WO2007038626A2 (en) * | 2005-09-28 | 2007-04-05 | President And Fellows Of Harvard College | Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging |
| ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
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| NO20055681D0 (no) * | 2005-12-01 | 2005-12-01 | Amersham Health As | Method of dynamic nuclear polarisation |
| JP5475995B2 (ja) * | 2005-12-01 | 2014-04-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極(dnp)法 |
| AU2006326596A1 (en) * | 2005-12-10 | 2007-06-21 | The President And Fellows Of Harvard College | In situ hyperpolarization of imaging agents |
| PL1962912T3 (pl) * | 2005-12-16 | 2013-03-29 | Ge Healthcare As | Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych |
| US20090252686A1 (en) * | 2006-01-11 | 2009-10-08 | President And Fellows Of Harvard College | Ex Vivo Hyperpolarization of Imaging Agents |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
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| KR20090086396A (ko) | 2006-10-03 | 2009-08-12 | 듀크 유니버시티 | 과분극된 129Xe 자기 공명 영상을 이용하여 폐의 가스 이동을 측정하는 시스템 및 방법 |
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| EP2119457A1 (en) | 2009-11-18 |
| HUP0102093A3 (en) | 2004-09-28 |
| HU229718B1 (hu) | 2014-05-28 |
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| JP2002501006A (ja) | 2002-01-15 |
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| US6278893B1 (en) | 2001-08-21 |
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| WO1999035508A1 (en) | 1999-07-15 |
| AU752308B2 (en) | 2002-09-12 |
| CN1285044A (zh) | 2001-02-21 |
| CN1138154C (zh) | 2004-02-11 |
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| AU1775399A (en) | 1999-07-26 |
| CN1527066A (zh) | 2004-09-08 |
| ES2393833T3 (es) | 2012-12-28 |
| HK1069635A1 (zh) | 2005-05-27 |
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