KR100639531B1 - 유리 스핑고이드 염기 및 세라미드의 조합으로 이루어지는 조성물 및 그것의 제조방법 - Google Patents

유리 스핑고이드 염기 및 세라미드의 조합으로 이루어지는 조성물 및 그것의 제조방법 Download PDF

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Publication number
KR100639531B1
KR100639531B1 KR1019997006968A KR19997006968A KR100639531B1 KR 100639531 B1 KR100639531 B1 KR 100639531B1 KR 1019997006968 A KR1019997006968 A KR 1019997006968A KR 19997006968 A KR19997006968 A KR 19997006968A KR 100639531 B1 KR100639531 B1 KR 100639531B1
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KR
South Korea
Prior art keywords
ceramide
composition
group
ceramides
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1019997006968A
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English (en)
Korean (ko)
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KR20000070718A (ko
Inventor
람베르즈조하네스윌렘무스자콥스
Original Assignee
코스모페름 베.파우
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Application filed by 코스모페름 베.파우 filed Critical 코스모페름 베.파우
Publication of KR20000070718A publication Critical patent/KR20000070718A/ko
Application granted granted Critical
Publication of KR100639531B1 publication Critical patent/KR100639531B1/ko
Assigned to 에보니크 골드슈미트 게엠베하 reassignment 에보니크 골드슈미트 게엠베하 권리의 전부이전등록 Assignors: 코스모페름 베.파우
Assigned to 에보니크 데구사 게엠베하 reassignment 에보니크 데구사 게엠베하 권리의 전부이전등록 Assignors: 에보니크 골드슈미트 게엠베하
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019997006968A 1997-12-05 1998-12-07 유리 스핑고이드 염기 및 세라미드의 조합으로 이루어지는 조성물 및 그것의 제조방법 Expired - Lifetime KR100639531B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97203824.4 1997-12-05
EP97203824 1997-12-05
PCT/EP1998/008121 WO1999029293A1 (en) 1997-12-05 1998-12-07 Compositions comprising a combination of a free sphingoid base and a ceramide and uses thereof

Publications (2)

Publication Number Publication Date
KR20000070718A KR20000070718A (ko) 2000-11-25
KR100639531B1 true KR100639531B1 (ko) 2006-10-27

Family

ID=8229019

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997006968A Expired - Lifetime KR100639531B1 (ko) 1997-12-05 1998-12-07 유리 스핑고이드 염기 및 세라미드의 조합으로 이루어지는 조성물 및 그것의 제조방법

Country Status (9)

Country Link
US (2) US20030059447A1 (https=)
EP (1) EP0975325B1 (https=)
JP (1) JP2001510487A (https=)
KR (1) KR100639531B1 (https=)
CN (1) CN1112916C (https=)
BR (1) BRPI9807124B8 (https=)
DE (1) DE69818242T2 (https=)
ES (1) ES2207023T3 (https=)
WO (1) WO1999029293A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306383B1 (en) * 1998-09-16 2001-10-23 Wilson T Crandall Method for topical treatment of scars with protein kinase C inhibitors
JP4037577B2 (ja) * 1999-10-07 2008-01-23 ロレアル 少なくとも1種のカチオン界面活性剤、液体脂肪アルコールおよびセラミド型の化合物を含む化粧品用組成物およびこれを用いた方法
US6493559B1 (en) * 2000-01-07 2002-12-10 Motorola, Inc. Method for receiving SMSCB messages during GPRS/EDGE data transfer mode
JP4391668B2 (ja) * 2000-06-06 2009-12-24 高砂香料工業株式会社 液晶構造を有する脂質組成物
JP4619489B2 (ja) * 2000-06-13 2011-01-26 花王株式会社 抗かゆみ皮膚外用剤
EP1372668B1 (en) * 2001-03-26 2011-12-07 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
US6680062B2 (en) 2001-10-05 2004-01-20 Color Access, Inc. Anti-irritating rosacea treatment
JP2003155231A (ja) * 2001-11-20 2003-05-27 Kikkoman Corp 医薬及び抗アレルギー剤
TWI230073B (en) * 2001-12-10 2005-04-01 Kao Corp Ceramide emulsifier
FR2834213B1 (fr) * 2001-12-27 2004-06-04 Pharmascience Lab Composition cosmetique ou pharmaceutique comprenant au moins une alcanolamide pour inhiber la migration des cellules de langerhans, et ses utilisations
FR2834216B1 (fr) * 2001-12-27 2004-04-30 Pharmascience Lab Composition cosmetique ou pharmaceutique comprenant au moins une oxazoline pour inhiber la migration des cellules de langerhans, et ses utilisations
KR100487112B1 (ko) * 2002-08-03 2005-05-03 대한민국(관리부서:농촌진흥청) 백강잠 101a로부터 분리, 정제한 뇌신경성장 촉진물질(4e, 6e, 2s,3r)-2-n-아이코사노일-4,6-테트라데카스핀게닌
KR100487113B1 (ko) * 2002-08-03 2005-05-03 대한민국(관리부서:농촌진흥청) 백강잠 101a로부터 분리, 정제한 뇌신경성장 촉진물질(4e, 6e, 2s,3r)-2-n-도코사노일-4,6-테트라데카스핀가디에닌
WO2004045566A1 (ja) * 2002-11-15 2004-06-03 Kose Corporation 半透明化粧料
DE10255554A1 (de) 2002-11-28 2004-06-17 Goldschmidt Ag Emulgator-Wachs-Gele auf Wasserbasis
GB0301395D0 (en) * 2003-01-21 2003-02-19 Univ Aston Inflammatory disorder treatment
FR2855047B1 (fr) * 2003-05-19 2007-11-30 Oreal Composition comprenant une base sphingoide, un activateur de la voie des 4-et/ou des 6-hydroxylases et un acide gras, utilisation pour renforcer la fonction barriere de la peau
JP3967292B2 (ja) * 2003-06-10 2007-08-29 花王株式会社 油中水型乳化組成物
KR101153576B1 (ko) * 2003-06-10 2012-06-11 가오 가부시키가이샤 수중유형 유화 화장료
WO2005044217A1 (en) * 2003-11-11 2005-05-19 Doosan Corporation Method for preparing phytosphingosine liposome composition
EP1817004A2 (en) * 2004-11-15 2007-08-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
JP4832000B2 (ja) * 2005-06-02 2011-12-07 花王株式会社 油中水型乳化組成物
JP2007001950A (ja) * 2005-06-27 2007-01-11 Pola Chem Ind Inc セラミド含有皮膚外用剤
JP2007104926A (ja) * 2005-10-12 2007-04-26 Hokkaido Univ セラミド合成酵素LASS6を用いたフィトセラミドおよびαハイドロキシセラミドの製造方法
WO2008021829A2 (en) * 2006-08-09 2008-02-21 Lipo Chemicals Inc. Topical ceramide compositions and methos of use
KR101355343B1 (ko) * 2006-10-13 2014-02-07 에보니크 골트슈미트 게엠베하 피부 치료용 조성물
EP2192904B1 (en) * 2007-08-27 2016-08-17 Auxagen, Inc. METHODS FOR INHIBITING TGF-beta
CN101288640B (zh) * 2008-05-23 2010-12-22 海南京润珍珠生物技术股份有限公司 一种添加珍珠水解液脂质体的祛痘精华液
US8487006B2 (en) * 2008-09-16 2013-07-16 Auxagen, Inc. Method of enhancing TGF-β signalling
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP5503130B2 (ja) * 2008-10-20 2014-05-28 ユニチカ株式会社 コラーゲン産生促進剤
FR2963233B1 (fr) * 2010-07-28 2014-03-14 Oreal Procede pour diminuer les hyperpigmentations post-reactionnelles
FR2972112B1 (fr) * 2011-03-01 2020-11-06 Oreal Utilisation d'un compose pour le traitement des dermatoses inflammatoires
FR2972110B1 (fr) * 2011-03-01 2013-11-15 Oreal Procede de traitement cosmetique des rougeurs cutanees
JP2015529537A (ja) * 2012-05-16 2015-10-08 アーチャー−ダニエルズ−ミッドランド カンパニー 極性溶媒を油およびポリオールに可溶化するための乳化剤
WO2014114342A1 (en) * 2013-01-24 2014-07-31 Danstar Ferment A.G. Yeast cell walls comprising vitamin d2, uses thereof and method of producing the same
US9511144B2 (en) 2013-03-14 2016-12-06 The Proctor & Gamble Company Cosmetic compositions and methods providing enhanced penetration of skin care actives
KR101682452B1 (ko) * 2015-03-04 2016-12-05 주식회사 지오코스 피부장벽 회복을 위한 액정 베이스 및 이를 포함하는 화장료 조성물
AU2016100422A4 (en) * 2015-11-05 2016-05-19 Macau University Of Science And Technology Methods of identifying and quantifying sphingolipids
CN105496886B (zh) * 2015-12-29 2019-06-25 苏州工业园区安诺科斯化妆品研发有限公司 植物鞘氨醇护肤液
CN106420605A (zh) * 2016-09-23 2017-02-22 苏州药基美研医药科技有限公司 基于拟神经酰胺和丹皮酚的皮肤外用制剂及其生产方法
US11000458B2 (en) 2017-03-27 2021-05-11 Evonik Operations Gmbh Method and product for producing formulations containing ceramide
JP6746674B2 (ja) * 2017-12-27 2020-08-26 サンスター株式会社 化粧水組成物
KR101899413B1 (ko) * 2018-05-03 2018-09-18 주식회사 케어사이드 피부 감염의 예방 또는 치료용 조성물
JP6602945B1 (ja) * 2018-12-18 2019-11-06 株式会社ジェヌインR&D セラミド分散組成物
US20200345611A1 (en) 2019-04-30 2020-11-05 Evonik Operations Gmbh Composition comprising at least one ceramide, at least one sphingoid base and triethyl citrate
CN110742842B (zh) * 2019-11-12 2022-09-13 医美生物科技(上海)有限公司 一种延缓皮肤老化的精华组合物及其制备方法
EP4121025A4 (en) 2020-03-17 2024-03-27 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of coronavirus infection
KR102592150B1 (ko) 2020-07-09 2023-10-20 크로다코리아 주식회사 살리실산 유도체를 포함하는 신규한 스핑고지질 및 이를 포함하는 조성물
KR102503769B1 (ko) * 2020-07-10 2023-02-27 솔루스바이오텍 주식회사 측쇄 지방산을 포함하는 신규한 스핑고지질과 그의 용도
KR102502487B1 (ko) * 2020-07-14 2023-02-23 솔루스바이오텍 주식회사 신규한 스핑고지질 및 이를 포함하는 피부외용제 조성물
EP3981378A1 (de) * 2020-10-09 2022-04-13 Evonik Operations GmbH Zusammensetzungen enthaltend ceramid, polyglycerincarbonsäureester und cholesterol
WO2022158533A1 (en) * 2021-01-20 2022-07-28 Ajinomoto Co., Inc. Cosmetic composition
WO2022231448A1 (en) 2021-04-30 2022-11-03 Carbocode S.A. Topical compositions comprising (glyco)sphingolipids and/or (glyco)ceramides
JP2023033269A (ja) * 2021-08-28 2023-03-10 ブルネエズ株式会社 外用組成物
CN115894270B (zh) * 2022-10-10 2024-09-06 深圳市迪克曼生物科技有限公司 一种神经酰胺及其制备方法和应用
EP4356898A1 (en) * 2022-10-20 2024-04-24 Croda Korea Limited Cosmetic composition comprising ceramides and sphingolipid
CN116041205A (zh) * 2023-02-02 2023-05-02 深圳市迪克曼生物科技有限公司 琉璃苣油神经酰胺及其合成方法与用途
CN116003288A (zh) * 2023-02-02 2023-04-25 深圳市迪克曼生物科技有限公司 南美油藤油神经酰胺及其合成方法与用途
CN117285432A (zh) * 2023-02-02 2023-12-26 深圳市迪克曼生物科技有限公司 亚麻籽油神经酰胺及其合成方法与用途
EP4512485A1 (en) 2023-08-25 2025-02-26 Evonik Operations GmbH Composition comprising ceramide, glycerol and organic acid
WO2025119790A1 (en) 2023-12-07 2025-06-12 Evonik Operations Gmbh Composition comprising ceramide and triglyceride
IT202400002614A1 (it) * 2024-02-08 2025-08-08 Zeta Farm S P A Composto per cosmesi e preparazione per cosmesi contenente detto composto.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6126000A (ja) 1984-07-14 1986-02-05 Furuta Denki Kk 高温気体移送用送風機
US5565207A (en) * 1990-09-19 1996-10-15 Pola Kasei Kogyo Kabushiki Kaisha Scalp moisturizer and external skin preparation
US5631356A (en) 1992-04-03 1997-05-20 Gist-Brocades, N.V. Selective N-acylation of amino alcohols
ES2145052T3 (es) 1992-06-19 2000-07-01 Univ California Lipidos para la humidificacion epidermica y la reparacion de la funcion de barrera.
WO1994010131A1 (en) * 1992-11-03 1994-05-11 Unilever Plc Method of synthesising phytosphingosine-containing ceramides and cosmetic compositions comprising them
GB9308103D0 (en) * 1993-04-20 1993-06-02 Unilever Plc Cosmetic composition
AU8105594A (en) 1993-10-28 1995-05-22 Gist-Brocades N.V. Phytosphingosine-based ceramide i analogs
WO1995025716A1 (en) 1994-03-18 1995-09-28 Gist-Brocades B.V. Linoleoylamide based ceramide derivative and its use in cosmetic preparations for the treatment of dry skin
JPH08512060A (ja) * 1994-04-27 1996-12-17 ギスト ブロカデス ベスローテン フェンノートシャップ 短鎖2−ヒドロキシカルボン酸をベースにしたセラミド誘導体
EP0731785B1 (en) * 1994-09-30 1998-12-30 Gist-Brocades B.V. Ceramide 3 derivatives based on monounsaturated fatty acids
JPH09508925A (ja) * 1994-11-28 1997-09-09 ギスト ブロカデス ベスローテン フェンノートシャップ セラミド類の局所適用
FR2730410B1 (fr) * 1995-02-15 1997-03-21 Oreal Composition cosmetique comprenant une association de ceramides et son utilisation
FR2732680B1 (fr) * 1995-04-05 1997-05-09 Oreal Composes de type ceramides, leur procede de preparation et leur utilisation
ES2144768T3 (es) * 1995-09-01 2000-06-16 Dsm Nv Derivados de bases esfingoides basados en retinoil-amida.

Also Published As

Publication number Publication date
WO1999029293A1 (en) 1999-06-17
DE69818242T2 (de) 2004-07-01
BR9807124B1 (pt) 2013-07-09
EP0975325B1 (en) 2003-09-17
DE69818242D1 (de) 2003-10-23
US20030215414A1 (en) 2003-11-20
EP0975325A1 (en) 2000-02-02
US20030059447A1 (en) 2003-03-27
BRPI9807124B8 (pt) 2021-05-25
BR9807124A (pt) 2000-01-25
JP2001510487A (ja) 2001-07-31
CN1246789A (zh) 2000-03-08
CN1112916C (zh) 2003-07-02
ES2207023T3 (es) 2004-05-16
US7597899B2 (en) 2009-10-06
KR20000070718A (ko) 2000-11-25

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