KR100609359B1 - 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체 - Google Patents

위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체 Download PDF

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Publication number
KR100609359B1
KR100609359B1 KR1020007001703A KR20007001703A KR100609359B1 KR 100609359 B1 KR100609359 B1 KR 100609359B1 KR 1020007001703 A KR1020007001703 A KR 1020007001703A KR 20007001703 A KR20007001703 A KR 20007001703A KR 100609359 B1 KR100609359 B1 KR 100609359B1
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South Korea
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composition
gabapentin
compound
gastrointestinal
treatment
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Expired - Fee Related
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KR1020007001703A
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KR20010023084A (ko
Inventor
안토니오 구글리에타
챨스 프라이스 쥬니어 테일러
지아유안 렌
더블유. 피. 왓슨
마이클 프란시스 래퍼티
라우렌 디오프
마리아 쇼베
리오넬 부에노
힐러리 제이. 리틀
Original Assignee
워너-램버트 캄파니 엘엘씨
더 유니버시티 오브 오클라호마
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Application filed by 워너-램버트 캄파니 엘엘씨, 더 유니버시티 오브 오클라호마 filed Critical 워너-램버트 캄파니 엘엘씨
Publication of KR20010023084A publication Critical patent/KR20010023084A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020007001703A 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체 Expired - Fee Related KR100609359B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5675397P 1997-08-20 1997-08-20
US60/056,753 1997-08-20
US7479498P 1998-02-16 1998-02-16
US60/074,794 1998-02-16
US8293698P 1998-04-24 1998-04-24
US60/082,936 1998-04-24
PCT/US1998/017082 WO1999008671A1 (en) 1997-08-20 1998-08-18 Gaba analogs to prevent and treat gastrointestinal damage

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020057022543A Division KR20050116168A (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체

Publications (2)

Publication Number Publication Date
KR20010023084A KR20010023084A (ko) 2001-03-26
KR100609359B1 true KR100609359B1 (ko) 2006-08-04

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ID=27369092

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020007001703A Expired - Fee Related KR100609359B1 (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체
KR1020057022543A Ceased KR20050116168A (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020057022543A Ceased KR20050116168A (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체

Country Status (25)

Country Link
US (2) US6242488B1 (enExample)
EP (1) EP1009399B1 (enExample)
JP (1) JP4681116B2 (enExample)
KR (2) KR100609359B1 (enExample)
AT (1) ATE461698T1 (enExample)
AU (2) AU8668598A (enExample)
BR (1) BR9812133A (enExample)
CA (1) CA2297163C (enExample)
CO (1) CO4960645A1 (enExample)
CY (1) CY1109981T1 (enExample)
DE (1) DE69841574D1 (enExample)
DK (1) DK1009399T3 (enExample)
ES (1) ES2341154T3 (enExample)
HU (1) HUP0004551A3 (enExample)
IL (1) IL134164A (enExample)
IS (1) IS2749B (enExample)
MY (1) MY155223A (enExample)
NO (1) NO327983B1 (enExample)
NZ (1) NZ502729A (enExample)
PE (1) PE107299A1 (enExample)
PL (1) PL194125B1 (enExample)
PT (1) PT1009399E (enExample)
TW (2) TWI251485B (enExample)
UY (1) UY25148A1 (enExample)
WO (2) WO1999008670A1 (enExample)

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MY155223A (en) 2015-09-30
US6242488B1 (en) 2001-06-05
NZ502729A (en) 2002-10-25
PT1009399E (pt) 2010-05-21
CY1109981T1 (el) 2014-09-10
EP1009399B1 (en) 2010-03-24
PL194125B1 (pl) 2007-04-30
JP2001515033A (ja) 2001-09-18
PL338705A1 (en) 2000-11-20
IS2749B (is) 2011-08-15
UY25148A1 (es) 1999-01-26
WO1999008670A1 (en) 1999-02-25
ATE461698T1 (de) 2010-04-15
HUP0004551A2 (hu) 2001-05-28
DK1009399T3 (da) 2010-05-31
CA2297163C (en) 2001-11-20
CA2297163A1 (en) 1999-02-25
AU9293098A (en) 1999-03-08
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US6426368B2 (en) 2002-07-30
NO20000786L (no) 2000-02-17
US20010014698A1 (en) 2001-08-16
BR9812133A (pt) 2000-07-18
CO4960645A1 (es) 2000-09-25
IL134164A (en) 2005-05-17
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EP1009399A1 (en) 2000-06-21
IL134164A0 (en) 2001-04-30
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AU8668598A (en) 1999-03-08
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