JP4681116B2 - 胃腸損傷を防止および治療するためのgaba類縁体 - Google Patents

胃腸損傷を防止および治療するためのgaba類縁体 Download PDF

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JP4681116B2
JP4681116B2 JP2000509411A JP2000509411A JP4681116B2 JP 4681116 B2 JP4681116 B2 JP 4681116B2 JP 2000509411 A JP2000509411 A JP 2000509411A JP 2000509411 A JP2000509411 A JP 2000509411A JP 4681116 B2 JP4681116 B2 JP 4681116B2
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gabapentin
ethanol
induced
medicament according
pregabalin
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JP2001515033A (ja
JP2001515033A5 (enExample
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アントニオ・グーリエッタ
チャールズ・プライス・テーラー・ジュニア
チアユーアン・レン
ダブルユー・ピー・ワトスン
マイクル・フランシス・ラファティ
ローラン・ディオー
マリア・ショヴェ
リオネ・ブエノ
ヒラリー・ジェイ・リトル
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ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー
ザ・ボード・オブ・リージェンツ・フォア・ザ・ユニヴァーシティ・オブ・オクラホマ
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Application filed by ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー, ザ・ボード・オブ・リージェンツ・フォア・ザ・ユニヴァーシティ・オブ・オクラホマ filed Critical ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2000509411A 1997-08-20 1998-08-18 胃腸損傷を防止および治療するためのgaba類縁体 Expired - Fee Related JP4681116B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5675397P 1997-08-20 1997-08-20
US60/056,753 1997-08-20
US7479498P 1998-02-16 1998-02-16
US60/074,794 1998-02-16
US8293698P 1998-04-24 1998-04-24
US60/082,936 1998-04-24
PCT/US1998/017082 WO1999008671A1 (en) 1997-08-20 1998-08-18 Gaba analogs to prevent and treat gastrointestinal damage

Publications (3)

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JP2001515033A JP2001515033A (ja) 2001-09-18
JP2001515033A5 JP2001515033A5 (enExample) 2006-01-05
JP4681116B2 true JP4681116B2 (ja) 2011-05-11

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JP2000509411A Expired - Fee Related JP4681116B2 (ja) 1997-08-20 1998-08-18 胃腸損傷を防止および治療するためのgaba類縁体

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US (2) US6242488B1 (enExample)
EP (1) EP1009399B1 (enExample)
JP (1) JP4681116B2 (enExample)
KR (2) KR20050116168A (enExample)
AT (1) ATE461698T1 (enExample)
AU (2) AU8668598A (enExample)
BR (1) BR9812133A (enExample)
CA (1) CA2297163C (enExample)
CO (1) CO4960645A1 (enExample)
CY (1) CY1109981T1 (enExample)
DE (1) DE69841574D1 (enExample)
DK (1) DK1009399T3 (enExample)
ES (1) ES2341154T3 (enExample)
HU (1) HUP0004551A3 (enExample)
IL (1) IL134164A (enExample)
IS (1) IS2749B (enExample)
MY (1) MY155223A (enExample)
NO (1) NO327983B1 (enExample)
NZ (1) NZ502729A (enExample)
PE (1) PE107299A1 (enExample)
PL (1) PL194125B1 (enExample)
PT (1) PT1009399E (enExample)
TW (2) TW570794B (enExample)
UY (1) UY25148A1 (enExample)
WO (2) WO1999008670A1 (enExample)

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JP2001515033A (ja) 2001-09-18
PE107299A1 (es) 1999-12-19
CO4960645A1 (es) 2000-09-25
PL194125B1 (pl) 2007-04-30
KR20050116168A (ko) 2005-12-09
KR20010023084A (ko) 2001-03-26
TW200412938A (en) 2004-08-01
DK1009399T3 (da) 2010-05-31
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CA2297163A1 (en) 1999-02-25
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IS2749B (is) 2011-08-15
TW570794B (en) 2004-01-11
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