KR100567148B1 - 치환된 n-[(아미노이미노메틸 또는 아미노메틸)페닐]프로필 아미드 및 이를 함유하는 약제학적 조성물 - Google Patents
치환된 n-[(아미노이미노메틸 또는 아미노메틸)페닐]프로필 아미드 및 이를 함유하는 약제학적 조성물 Download PDFInfo
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- KR100567148B1 KR100567148B1 KR1019997001592A KR19997001592A KR100567148B1 KR 100567148 B1 KR100567148 B1 KR 100567148B1 KR 1019997001592 A KR1019997001592 A KR 1019997001592A KR 19997001592 A KR19997001592 A KR 19997001592A KR 100567148 B1 KR100567148 B1 KR 100567148B1
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- compound
- carbamimidoyl
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- phenyl
- fused
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- 0 *[C@]1C=CC=C(CCCCC2=CCCN2)C1 Chemical compound *[C@]1C=CC=C(CCCCC2=CCCN2)C1 0.000 description 23
- RUPZMDYHPXLADR-UHFFFAOYSA-N C#CC(C1)=CCCC1[Zn] Chemical compound C#CC(C1)=CCCC1[Zn] RUPZMDYHPXLADR-UHFFFAOYSA-N 0.000 description 1
- NSWWVBDLVRFLOQ-UHFFFAOYSA-N CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(C(CC1)CCN1c1ccncc1)=O Chemical compound CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(C(CC1)CCN1c1ccncc1)=O NSWWVBDLVRFLOQ-UHFFFAOYSA-N 0.000 description 1
- HUIUELFGBAVMNP-UHFFFAOYSA-N CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(c(cc1)cc2c1[nH]cn2)=O Chemical compound CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(c(cc1)cc2c1[nH]cn2)=O HUIUELFGBAVMNP-UHFFFAOYSA-N 0.000 description 1
- DUWBZGDVHHHCQM-UHFFFAOYSA-N CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(c(cc1)ccc1-c1ncc[nH]1)=O Chemical compound CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(c(cc1)ccc1-c1ncc[nH]1)=O DUWBZGDVHHHCQM-UHFFFAOYSA-N 0.000 description 1
- BHIIRZYVCJGBBU-UHFFFAOYSA-N CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(c1cc(-c2ncccc2)c[s]1)=O Chemical compound CC(C(Cc1cccc(C(N)=N)c1)C(OC)=O)NC(c1cc(-c2ncccc2)c[s]1)=O BHIIRZYVCJGBBU-UHFFFAOYSA-N 0.000 description 1
- JNHBNWVUHAEPPA-UHFFFAOYSA-N CC(C(Cc1cccc(C(N)N)c1)C(OC)=O)NC(C1=CSC(C2C=CN=CC2)N1)=O Chemical compound CC(C(Cc1cccc(C(N)N)c1)C(OC)=O)NC(C1=CSC(C2C=CN=CC2)N1)=O JNHBNWVUHAEPPA-UHFFFAOYSA-N 0.000 description 1
- VXHHVXMZKQLZJO-UHFFFAOYSA-N CC(C(Cc1cccc(C(N)N)c1)C(OC)=O)NC(c1ccc(-c2cccnc2)[s]1)=O Chemical compound CC(C(Cc1cccc(C(N)N)c1)C(OC)=O)NC(c1ccc(-c2cccnc2)[s]1)=O VXHHVXMZKQLZJO-UHFFFAOYSA-N 0.000 description 1
- FUFTVVNCOKZFID-UHFFFAOYSA-N CCOC(C=C1)=CCC1(C)c(cc1)ccc1N Chemical compound CCOC(C=C1)=CCC1(C)c(cc1)ccc1N FUFTVVNCOKZFID-UHFFFAOYSA-N 0.000 description 1
- ICPWQNURJPTVSL-ISLYRVAYSA-N COC(C(Cc1cc(C(N)=N)ccc1)C(/C=C/c1ccccc1)NC(c1cccc2ccccc12)=O)=O Chemical compound COC(C(Cc1cc(C(N)=N)ccc1)C(/C=C/c1ccccc1)NC(c1cccc2ccccc12)=O)=O ICPWQNURJPTVSL-ISLYRVAYSA-N 0.000 description 1
- HVHFTVFGSCZWSS-FQLXRVMXSA-N N#Cc1cc(C[C@H]([C@@H](CCc2ccccc2)NC(c(cc2)ccc2C2=CNCC=C2)=O)C(O)=O)ccc1 Chemical compound N#Cc1cc(C[C@H]([C@@H](CCc2ccccc2)NC(c(cc2)ccc2C2=CNCC=C2)=O)C(O)=O)ccc1 HVHFTVFGSCZWSS-FQLXRVMXSA-N 0.000 description 1
- GDVVILRIAIJZKK-UHFFFAOYSA-N NC(c1cc(CC(CO)C(CCc2ccccc2)NC(c(cc2)ccc2-c(cc2)ccc2F)O)ccc1)=N Chemical compound NC(c1cc(CC(CO)C(CCc2ccccc2)NC(c(cc2)ccc2-c(cc2)ccc2F)O)ccc1)=N GDVVILRIAIJZKK-UHFFFAOYSA-N 0.000 description 1
- BKJBGPKSYJNOLO-UHFFFAOYSA-N NC(c1cc(CC(CO)C(Cc2ccccc2)NCOCC(CC2)=CC=C2c(cc2)ccc2[N+]([O-])=O)ccc1)=N Chemical compound NC(c1cc(CC(CO)C(Cc2ccccc2)NCOCC(CC2)=CC=C2c(cc2)ccc2[N+]([O-])=O)ccc1)=N BKJBGPKSYJNOLO-UHFFFAOYSA-N 0.000 description 1
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
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- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
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- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/08—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing three- or four-membered rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US8/884,405 | 1997-06-27 | ||
| US08/884,405 | 1997-06-27 | ||
| US08/884,405 US6080767A (en) | 1996-01-02 | 1997-06-27 | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20000068367A KR20000068367A (ko) | 2000-11-25 |
| KR100567148B1 true KR100567148B1 (ko) | 2006-04-04 |
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| KR1019997001592A Expired - Fee Related KR100567148B1 (ko) | 1997-06-27 | 1998-06-26 | 치환된 n-[(아미노이미노메틸 또는 아미노메틸)페닐]프로필 아미드 및 이를 함유하는 약제학적 조성물 |
Country Status (27)
Families Citing this family (54)
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| US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| CA2361428A1 (en) * | 1999-02-11 | 2000-08-17 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| DE10012732A1 (de) | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| GB0108903D0 (en) * | 2000-10-05 | 2001-05-30 | Aventis Pharm Prod Inc | Novel crystalline forms of a factor Xa inhibitor |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| IL156422A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
| SI1413331T1 (sl) | 2001-01-26 | 2008-02-29 | Schering Corp | Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| US20020183519A1 (en) * | 2001-03-13 | 2002-12-05 | Herbert Nar | Antithrombotic carboxylic acid amides |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| BRPI0307351B8 (pt) * | 2002-02-12 | 2021-05-25 | Smithkline Beecham Corp | composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| EP1394159A1 (fr) * | 2002-08-13 | 2004-03-03 | Warner-Lambert Company LLC | Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| EP1562582A1 (en) | 2002-11-06 | 2005-08-17 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| SI1569912T1 (sl) | 2002-12-03 | 2015-09-30 | Pharmacyclics Llc | Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia |
| GB0230162D0 (en) * | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
| CN1756756A (zh) * | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP2006519869A (ja) * | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
| WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| EP1669348A4 (en) * | 2003-09-30 | 2009-03-11 | Eisai R&D Man Co Ltd | NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND |
| GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| JP2007531757A (ja) * | 2004-03-30 | 2007-11-08 | カイロン コーポレイション | 抗癌剤としての置換チオフェン誘導体 |
| US20050241110A1 (en) * | 2004-04-09 | 2005-11-03 | Bruce Baker | Ergonomic handles, especially for garden tools |
| US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
| JPWO2006016548A1 (ja) * | 2004-08-09 | 2008-05-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環化合物を含有する新規な抗マラリア剤 |
| US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
| WO2006106711A1 (ja) | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
| GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
| TWI385169B (zh) * | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| MX2009000286A (es) * | 2006-06-26 | 2009-03-20 | Procter & Gamble | Inhibidores de prolil hidroxilasa y metodos de uso. |
| US8183264B2 (en) * | 2006-09-21 | 2012-05-22 | Eisai R&D Managment Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| TW200841879A (en) * | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| WO2008136279A1 (ja) * | 2007-04-27 | 2008-11-13 | Eisai R & D Management Co., Ltd. | ヘテロ環置換ピリジン誘導体の塩またはその結晶 |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| GB0919194D0 (en) | 2009-11-02 | 2009-12-16 | Lytix Biopharma As | Compounds |
| CN110483499A (zh) | 2009-11-05 | 2019-11-22 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
| NZ602311A (en) * | 2010-03-18 | 2014-08-29 | Pasteur Institut Korea | Anti-infective compounds |
| US8993602B2 (en) * | 2011-03-29 | 2015-03-31 | Sanofi | Benzoic acid salt of otamixaban |
| US20120252852A1 (en) | 2011-03-29 | 2012-10-04 | Sanofi | Otamixaban formulations with improved stability |
| CN105646362B (zh) * | 2011-07-26 | 2019-07-05 | 赛诺菲 | 3-杂芳酰基氨基-丙酸衍生物及其作为药物的用途 |
| US9120776B2 (en) | 2011-09-22 | 2015-09-01 | Takeda Pharmaceutical Company Limited | Condensed heterocyclic compound |
| MX386078B (es) | 2015-09-17 | 2025-03-18 | Marvin J Miller | Compuestos heterociclicos que contienen bencilamina y composiciones utiles contra infeccion por micobacterias |
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| US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
| US5612353A (en) * | 1995-06-07 | 1997-03-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
| DK0906094T3 (da) * | 1996-01-02 | 2003-10-20 | Aventis Pharma Inc | Substituerede N-[(aminoiminomethyl- eller aminomethyl)phenyl]propylamider |
-
1997
- 1997-06-27 US US08/884,405 patent/US6080767A/en not_active Expired - Lifetime
-
1998
- 1998-06-26 CN CNB988010844A patent/CN1221529C/zh not_active Expired - Lifetime
- 1998-06-26 BR BRPI9806060-0A patent/BR9806060B1/pt not_active IP Right Cessation
- 1998-06-26 EA EA199900239A patent/EA002358B1/ru not_active IP Right Cessation
- 1998-06-26 ES ES98931728T patent/ES2335825T3/es not_active Expired - Lifetime
- 1998-06-26 PL PL331985A patent/PL191115B1/pl unknown
- 1998-06-26 DK DK98931728.4T patent/DK0931060T3/da active
- 1998-06-26 KR KR1019997001592A patent/KR100567148B1/ko not_active Expired - Fee Related
- 1998-06-26 WO PCT/US1998/013550 patent/WO1999000356A1/en not_active Ceased
- 1998-06-26 IL IL12865398A patent/IL128653A/en not_active IP Right Cessation
- 1998-06-26 AP APAP/P/1999/001467A patent/AP1061A/en active
- 1998-06-26 HU HU0202655A patent/HU228982B1/hu unknown
- 1998-06-26 CZ CZ0064799A patent/CZ299399B6/cs not_active IP Right Cessation
- 1998-06-26 JP JP50587099A patent/JP4107687B2/ja not_active Expired - Fee Related
- 1998-06-26 CA CA002264556A patent/CA2264556C/en not_active Expired - Lifetime
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- 1998-06-26 SI SI9830924T patent/SI0931060T1/sl unknown
- 1998-06-26 AT AT98931728T patent/ATE449759T1/de active
- 1998-06-26 EP EP98931728A patent/EP0931060B1/en not_active Expired - Lifetime
- 1998-06-26 PT PT98931728T patent/PT931060E/pt unknown
- 1998-06-26 DE DE69841300T patent/DE69841300D1/de not_active Expired - Lifetime
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1999
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