EA199900239A1 - Замещенные n-[аминоиминометил или аминометил) фенил] пропиламиды - Google Patents

Замещенные n-[аминоиминометил или аминометил) фенил] пропиламиды

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Publication number
EA199900239A1
EA199900239A1 EA199900239A EA199900239A EA199900239A1 EA 199900239 A1 EA199900239 A1 EA 199900239A1 EA 199900239 A EA199900239 A EA 199900239A EA 199900239 A EA199900239 A EA 199900239A EA 199900239 A1 EA199900239 A1 EA 199900239A1
Authority
EA
Eurasian Patent Office
Prior art keywords
propylamides
aminoiminomethyl
aminomethyl
phenyl
substituted
Prior art date
Application number
EA199900239A
Other languages
English (en)
Other versions
EA002358B1 (ru
Inventor
Скотт И. Клейн
Кевин Р. Гертин
Альфред П. Спада
Хейнц В. Паулс
Енг Гонг
Дэниел Г. Макгарри
Original Assignee
Рон-Пуленк, Рорер Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк, Рорер Фармасьютикалз Инк. filed Critical Рон-Пуленк, Рорер Фармасьютикалз Инк.
Publication of EA199900239A1 publication Critical patent/EA199900239A1/ru
Publication of EA002358B1 publication Critical patent/EA002358B1/ru

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Данное изобретение относится к соединениям формулы (I), которые ингибируют фактор Ха, к фармацевтическим композициям, содержащим эти соединения, и к использованию соединений для лечения пациентов, страдающих от состояний, которые могут быть облегчены путем введения ингибитора фактора Ха.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900239A 1997-06-27 1998-06-26 Замещенные n-[(аминоиминометил или аминометил)фенил] пропиламиды EA002358B1 (ru)

Applications Claiming Priority (2)

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US08/884,405 US6080767A (en) 1996-01-02 1997-06-27 Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
PCT/US1998/013550 WO1999000356A1 (en) 1997-06-27 1998-06-26 Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides

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EA199900239A1 true EA199900239A1 (ru) 1999-08-26
EA002358B1 EA002358B1 (ru) 2002-04-25

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US6080767A (en) 2000-06-27
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CZ299399B6 (cs) 2008-07-16
UA66346C2 (ru) 2004-05-17
EP0931060B1 (en) 2009-11-25
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ZA985664B (en) 1999-01-13
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OA10981A (en) 2001-11-01
WO1999000356A1 (en) 1999-01-07
EP0931060A1 (en) 1999-07-28
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ATE449759T1 (de) 2009-12-15
PL331985A1 (en) 1999-08-16
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