KR100561504B1 - 인터류킨-1 베타 전환 효소의 억제제 - Google Patents

인터류킨-1 베타 전환 효소의 억제제 Download PDF

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KR100561504B1
KR100561504B1 KR1020047011964A KR20047011964A KR100561504B1 KR 100561504 B1 KR100561504 B1 KR 100561504B1 KR 1020047011964 A KR1020047011964 A KR 1020047011964A KR 20047011964 A KR20047011964 A KR 20047011964A KR 100561504 B1 KR100561504 B1 KR 100561504B1
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ring
formula
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KR20040096550A (ko
Inventor
바첼러마크제이.
베빙턴데이비드
베미스가이더블유.
프리드맨올프허만
질스파이로저제이.
골렉줄리안엠.씨.
구용
로퍼데이비드제이.
리빙스턴데이비드제이.
매터루새룹에스
멀리캔마이클디.
먹코마크에이.
머독로버트
나이스필립엘.
로비두스안드레아엘.씨.
수마이클
원너메이커엠.우즈
윌슨키이스피.
질로버트이.
Original Assignee
버텍스 파마슈티칼스 인코포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27534345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100561504(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/575,641 external-priority patent/US6008217A/en
Priority claimed from US08/598,332 external-priority patent/US5874424A/en
Priority claimed from US08/712,878 external-priority patent/US5985863A/en
Application filed by 버텍스 파마슈티칼스 인코포레이티드 filed Critical 버텍스 파마슈티칼스 인코포레이티드
Publication of KR20040096550A publication Critical patent/KR20040096550A/ko
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    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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US08/575,641 US6008217A (en) 1995-12-20 1995-12-20 Inhibitors of interleukin-1β converting enzyme
US08/598,332 US5874424A (en) 1995-12-20 1996-02-08 Inhibitors of interleukin-1β converting enzyme
US08/712,878 US5985863A (en) 1996-09-12 1996-09-12 Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US3149596P 1996-11-26 1996-11-26
US60/031,495 1996-12-06
US08/598,332 1996-12-06
US08/575,641 1996-12-06
US08/761,483 US6204261B1 (en) 1995-12-20 1996-12-06 Inhibitors of interleukin-1β Converting enzyme inhibitors
US08/712,878 1996-12-06
US08/761,483 1996-12-06
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AP0202540A0 (en) 1998-06-20
US20050143436A1 (en) 2005-06-30
WO1997022619A2 (en) 1997-06-26
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CN1229412A (zh) 1999-09-22
IL124850A0 (en) 1999-01-26
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US6423840B1 (en) 2002-07-23
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US8119631B2 (en) 2012-02-21
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